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1. 发明专利

IL279763D0 Crystal of benzoxazole derivative 未知
公开(公告)号：IL279763D0
公开(公告)日：2021-03-01
申请号：IL27976320
申请日：2020-12-24
申请人： MEIJI SEIKA PHARMA CO LTD , KO KUMURA , KEIJI TAMURA , TAKASHI WATANABE , MICHIKO TAKAHASHI
发明人： KO KUMURA , KEIJI TAMURA , TAKASHI WATANABE , MICHIKO TAKAHASHI
IPC分类号： A61K31/4995 , A61P1/04 , A61P3/04 , A61P3/10 , A61P11/00 , A61P11/06 , A61P17/06 , A61P17/10 , A61P17/14 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/08
摘要： Provided are crystals of 1-((2-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-7-(thiazol-2-yl)benzo[d]oxazol-4-yl)oxy)-1,1-difluoro-2-methylpropan-2-ol represented by formula (1),

2. 发明授权

US09139609B2 C-4″ position substituted macrolide derivative 有权
标题翻译： C-4“位取代的大环内酯衍生物
公开(公告)号：US09139609B2
公开(公告)日：2015-09-22
申请号：US14000556
申请日：2012-02-20
申请人： Tomohiro Sugimoto , Naoki Sasamoto , Jun Kurosaka , Masato Hayashi , Kanako Yamamoto , Masato Kashimura , Yasunobu Ushiki , Haruhisa Ogita , Tomoaki Miura , Kenichi Kanemoto , Kou Kumura , Satoshi Yoshida , Keiji Tamura , Eiki Shitara
发明人： Tomohiro Sugimoto , Naoki Sasamoto , Jun Kurosaka , Masato Hayashi , Kanako Yamamoto , Masato Kashimura , Yasunobu Ushiki , Haruhisa Ogita , Tomoaki Miura , Kenichi Kanemoto , Kou Kumura , Satoshi Yoshida , Keiji Tamura , Eiki Shitara
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).
摘要翻译：由式（I）表示的大环内酯化合物对抗红霉素抗性细菌（例如抗性肺炎球菌，链球菌和支原体）有效。

3. 发明授权

US08669535B2 Electron gun 有权
标题翻译：电子枪
公开(公告)号：US08669535B2
公开(公告)日：2014-03-11
申请号：US13322025
申请日：2010-04-14
申请人： Mikio Ichihashi , Takashi Onishi , Shunichi Watanabe , Keiji Tamura
发明人： Mikio Ichihashi , Takashi Onishi , Shunichi Watanabe , Keiji Tamura
IPC分类号： H01J1/50
CPC分类号： H01J37/063 , H01J37/073 , H01J37/141 , H01J2237/06316 , H01J2237/06341 , H01J2237/065 , H01J2237/26
摘要： The present invention has an object to provide a cold cathode field-emission electron gun with low aberration, to thereby provide a high-brightness electron gun even in the case of a large current. The present invention provides a field-emission electron gun which extracts an electron beam from a cathode and converges the extracted electron beam, the field-emission electron gun including: a magnetic field lens which is provided such that the cathode is disposed inside of a magnetic field of the lens; and an extraction electrode for extracting electrons from the cathode, the extraction electrode being formed into a cylindrical shape without an aperture structure. The present invention can provide an electron gun having a function of converging an electron beam using a magnetic field, the electron gun which is capable of reducing an incidental electrostatic lens action and has small aberration and high brightness.
摘要翻译：本发明的目的是提供一种具有低像差的冷阴极场致发射电子枪，从而即使在大电流的情况下也提供高亮度电子枪。本发明提供一种场致发射电子枪，其从阴极提取电子束并使所提取的电子束会聚，该场发射电子枪包括：磁场透镜，其被设置为使得阴极设置在磁性镜头领域; 以及用于从阴极提取电子的引出电极，所述引出电极形成为没有孔结构的圆筒形状。本发明可以提供一种电子枪，其具有使用磁场会聚电子束的功能，该电子枪能够减少偶然的静电透镜作用并且具有小的像差和高亮度。

4. 发明申请

US20090218508A1 COLD CATHODE FIELD EMISSION ELECTRON GUN AND ITS APPLICATION TO ELECTRON BEAM INSTRUMENTS 审中-公开
标题翻译：冷阴极场发射电子枪及其应用于电子束仪器
公开(公告)号：US20090218508A1
公开(公告)日：2009-09-03
申请号：US12392460
申请日：2009-02-25
申请人： Keiji TAMURA , Shun-ichi WATANABE , Takashi ONISHI
发明人： Keiji TAMURA , Shun-ichi WATANABE , Takashi ONISHI
IPC分类号： H01J3/14 , H01J9/02
CPC分类号： H01J37/063 , H01J37/073 , H01J2237/06341 , H01J2237/0653 , H01J2237/26
摘要： The present invention provides an electron beam instrument in which variation of the trajectory of the electron beams can be suppressed even when the voltage applied to the first extractor electrode is controlled in order to stabilize the emission current amount of the electron beams. The electron beam instrument has a cold cathode field emission electron gun. The cold cathode field emission electron gun has a cold cathode, a first extractor electrode and a second extractor electrode. Distance between the cold cathode and the first extractor electrode is set to be shorter than distance between the first extractor electrode and the second extractor electrode. Voltage applied to the first extractor electrode is increased when current amount of the electron beams emitted from the cold cathode is attenuated.
摘要翻译：本发明提供一种电子束装置，其中即使控制施加到第一提取器电极的电压，也可以抑制电子束轨迹的变化，以便稳定电子束的发射电流量。电子束仪器具有冷阴极场发射电子枪。冷阴极场致发射电子枪具有冷阴极，第一提取器电极和第二提取器电极。冷阴极和第一提取电极之间的距离设定为比第一提取电极和第二提取电极之间的距离短。当从冷阴极发射的电子束的电流量减弱时，施加到第一提取器电极的电压增加。

5. 发明授权

US06333160B1 Method and specific diagnostic system for objectively assessing and monitoring the relative homeostasis and health of animals 失效
标题翻译：用于客观评估和监测动物相对稳态和健康的方法和具体诊断系统
公开(公告)号：US06333160B1
公开(公告)日：2001-12-25
申请号：US08041428
申请日：1993-03-31
申请人： Keiji Tamura
发明人： Keiji Tamura
IPC分类号： G01N3353
CPC分类号： G01N33/68
摘要： A method for objectively assessing and monitoring the relative health and homeostatic balance of a group of animals or the individual animals in the group as a basis for animal management decisions is provided. The objective assessment and monitoring method quantitatively determines the upper limit of normal for &agr;1-acid glycoprotein values in a selected body fluid of a selected species of animals. The &agr;1-acid glycoprotein levels of the animals to be evaluated are quantitatively determined and compared with the normal &agr;1-acid glycoprotein upper limit to identify animals whose immune systems or health has been compromised by stress or disease to provide a basis for animal management decisions to promote and maintain the optimum health and well being of the group.
摘要翻译：提供了一种客观评估和监测组中一组动物或个体动物的相对健康和体内平衡的方法，作为动物管理决策的基础。客观评估和监测方法定量地确定所选动物种类的所选体液中α1-酸性糖蛋白值的正常上限。定量测定待评估动物的α1-酸性糖蛋白水平，并将其与正常的α1-酸性糖蛋白上限进行比较，以鉴别其免疫系统或健康受到压力或疾病的损害，为动物管理决策提供依据的动物促进和保持团体的最佳健康和福祉。

6. 发明授权

US5559211A Biologically active product produced by streptococcus pyogenes and method of purification 失效
标题翻译：由化脓性链球菌产生的生物活性产物和纯化方法
公开(公告)号：US5559211A
公开(公告)日：1996-09-24
申请号：US198345
申请日：1994-02-18
申请人： Katsuo Kumagai , Hidemi Rikiishi , Keiji Tamura , Shunji Sugawara , Eiji Nemoto , Shigefumi Okamoto , Tokio Onta
发明人： Katsuo Kumagai , Hidemi Rikiishi , Keiji Tamura , Shunji Sugawara , Eiji Nemoto , Shigefumi Okamoto , Tokio Onta
IPC分类号： A61K35/74 , A61K31/00 , A61K38/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K14/315 , C07K14/41 , C07K14/52 , C12P21/00 , C12R1/46 , C07K1/36 , C12N1/20 , C12Q1/02
CPC分类号： C07K14/315 , A61K38/00 , Y10S435/803 , Y10S435/885
摘要： A biologically active, stable protein with a molecular weight of 20,000 to 30,000 and an isoelectric point of 8.0-10.0 is produced from the culture fluid of Streptococcus pyogenes and purified. The purified biologically active protein produces lymphocyte proliferation, provides protection against bacterial and viral infection and restricts minor metastasis.
摘要翻译：从化脓性链球菌培养液中产生分子量为20,000〜30,000，等电点为8.0〜10.0的生物活性稳定的蛋白质，并进行纯化。纯化的生物活性蛋白产生淋巴细胞增殖，提供针对细菌和病毒感染的保护并限制轻微转移。

7. 发明申请

US20120062094A1 ELECTRON GUN 有权
标题翻译：电子枪
公开(公告)号：US20120062094A1
公开(公告)日：2012-03-15
申请号：US13322025
申请日：2010-04-14
申请人： Mikio Ichihashi , Tadashi Onishi , Shunichi Watanabe , Keiji Tamura
发明人： Mikio Ichihashi , Tadashi Onishi , Shunichi Watanabe , Keiji Tamura
IPC分类号： H01J29/48 , H01J29/00
CPC分类号： H01J37/063 , H01J37/073 , H01J37/141 , H01J2237/06316 , H01J2237/06341 , H01J2237/065 , H01J2237/26
摘要： The present invention has an object to provide a cold cathode field-emission electron gun with low aberration, to thereby provide a high-brightness electron gun even in the case of a large current. The present invention provides a field-emission electron gun which extracts an electron beam from a cathode and converges the extracted electron beam, the field-emission electron gun including: a magnetic field lens which is provided such that the cathode is disposed inside of a magnetic field of the lens; and an extraction electrode for extracting electrons from the cathode, the extraction electrode being formed into a cylindrical shape without an aperture structure. The present invention can provide an electron gun having a function of converging an electron beam using a magnetic field, the electron gun which is capable of reducing an incidental electrostatic lens action and has small aberration and high brightness.
摘要翻译：本发明的目的是提供一种具有低像差的冷阴极场致发射电子枪，从而即使在大电流的情况下也提供高亮度电子枪。本发明提供一种场致发射电子枪，其从阴极提取电子束并使所提取的电子束会聚，该场发射电子枪包括：磁场透镜，其被设置为使得阴极设置在磁性镜头领域; 以及用于从阴极提取电子的引出电极，所述引出电极形成为没有孔结构的圆筒形状。本发明可以提供一种电子枪，其具有使用磁场会聚电子束的功能，该电子枪能够减少偶然的静电透镜作用并且具有小的像差和高亮度。

8. 发明授权

US4269765A Immune serum for diagnosis of cancer and preparation thereof 失效
标题翻译：免疫血清用于诊断癌症及其制备
公开(公告)号：US4269765A
公开(公告)日：1981-05-26
申请号：US891645
申请日：1978-03-30
申请人： Yoshiji Matsuda , Keiji Tamura , Hiroaki Motoki , Fumio Kitame , Nakao Ishida
发明人： Yoshiji Matsuda , Keiji Tamura , Hiroaki Motoki , Fumio Kitame , Nakao Ishida
IPC分类号： G01N33/574 , A61K39/395 , C07K14/435 , C07K16/00 , C07K16/06 , A61K39/00 , A61K39/44 , C07G7/00 , G01N33/54
CPC分类号： C07K16/06 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/851
摘要： The present invention provides a method for the preparation of a specific immune serum by immunizing IAP in animals other than humans and absorbing the thus obtained serum with normal human serum.
摘要翻译：本发明提供了通过在除人以外的动物中免疫IAP而制备特异性免疫血清的方法，并用正常人血清吸收由此获得的血清。

9. 发明授权

US4661415A Hydrogen absorbing zirconium alloy 失效
标题翻译：吸氢锆合金
公开(公告)号：US4661415A
公开(公告)日：1987-04-28
申请号：US790190
申请日：1985-10-22
申请人： Kazuo Ebato , Yasuaki Osumi , Keiji Tamura , Hiroshi Yoshida
发明人： Kazuo Ebato , Yasuaki Osumi , Keiji Tamura , Hiroshi Yoshida
IPC分类号： C01B3/00 , C22C16/00 , C22C38/00 , C22C38/28 , C01B6/00 , B22F1/02
CPC分类号： C22C16/00 , C01B3/0031 , C01B3/0078 , Y02E60/327 , Y02P20/129 , Y10S420/90 , Y10T428/12181
摘要： A zirconium alloy having a plateau region of equilibrium hydrogen dissociation pressure and a small hysteresis, whose hydrogen dissociation pressure is in a range of 0.6 to 3 atm at 20.degree. C., 1 to 5 atm at 40.degree. C., and 1 to 17 atm at 80.degree. C., the activation of which can be effected according to a single procedure of vacuum evacuation at room temperature and pressurization under a hydrogen pressure of 30 atm at room temperature, and which is comparable or superior in the rates of hydrogen absorption and release, the maximum hydrogen absorbing capacity and effective hydrogen releasing capacity to conventional zirconium alloys. A hydrogen absorbing and releasing material comprising an alloy as mentioned above and thin films of one element selected from Pd, Cu, and Ni, which allows only hydrogen to permeate, and covering the surfaces of particles of the alloy.
摘要翻译：具有平衡氢解离压力的平台区和滞后小的锆合金，其氢解离压力在20℃为0.6〜3atm，40℃为1〜5atm，1〜17 atm在80℃，其活化可以根据在室温下的单次真空抽真空过程和在室温下在30atm的氢气压力下加压进行，并且其吸氢速率相当或更高并释放出常规锆合金的最大吸氢能力和有效的氢释放能力。包含如上所述的合金的氢吸收和释放材料和选自Pd，Cu和Ni的一种元素的薄膜，其仅允许氢渗透并覆盖合金颗粒的表面。

10. 发明申请

US20140046043A1 C-4" POSITION SUBSTITUTED MACROLIDE DERIVATIVE 有权
标题翻译： C-4“位置取代大理石衍生物
公开(公告)号：US20140046043A1
公开(公告)日：2014-02-13
申请号：US14000556
申请日：2012-02-20
申请人： Tomohiro Sugimoto , Naoki Sasamoto , Jun Kurosaka , Masato Hayashi , Kanako Yamamoto , Masato Kashimura , Yasunobu Ushiki , Haruhisa Ogita , Tomoaki Miura , Kenichi Kanemoto , Kou Kumura , Satoshi Yoshida , Keiji Tamura , Eiki Shitara
发明人： Tomohiro Sugimoto , Naoki Sasamoto , Jun Kurosaka , Masato Hayashi , Kanako Yamamoto , Masato Kashimura , Yasunobu Ushiki , Haruhisa Ogita , Tomoaki Miura , Kenichi Kanemoto , Kou Kumura , Satoshi Yoshida , Keiji Tamura , Eiki Shitara
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).
摘要翻译：由式（I）表示的大环内酯化合物对抗红霉素抗性细菌（例如抗性肺炎球菌，链球菌和支原体）有效。

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