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1. 发明申请

WO2004049901A3 METHODS OF TREATING CEREBRAL ISCHEMIA 审中-公开
标题翻译：治疗脑缺血的方法
公开(公告)号：WO2004049901A3
公开(公告)日：2004-12-09
申请号：PCT/US0336499
申请日：2003-11-14
申请人： UNIV NORTH CAROLINA , KATZ LAURENCE M
发明人： KATZ LAURENCE M
IPC分类号： A61K38/10 , A61K38/17 , A61K31/137 , A61K31/405 , A61K38/02
CPC分类号： A61K38/10
摘要： The present invention provides methods of treating cerebral ischemia in mammals comprising inducing hypothermia in a mammal before, during, or following cerebral ischemia in the mammal. The hypothermia is induced by administering to the mammal an effective dose of a neurotensin analog that is capable of crossing the blood-brain barrier and the comprises neo-tryptophan.
摘要翻译：本发明提供了治疗哺乳动物脑缺血的方法，包括在哺乳动物脑缺血之前，期间或之后在哺乳动物中诱导低体温。通过向哺乳动物施用有效剂量的能够穿过血脑屏障并包含新色氨酸的神经降压肽类似物来诱导低温。

2. 发明申请

WO2010144535A1 METHODS AND COMPOSITIONS FOR THE INDUCTION OF HYPOTHERMIA 审中-公开
标题翻译：诱导血糖的方法和组合物
公开(公告)号：WO2010144535A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/037908
申请日：2010-06-09
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , KATZ, Laurence, M.
发明人： KATZ, Laurence, M.
IPC分类号： A61K31/045 , A61K31/167 , A61K31/395 , A61P25/00 , A61P43/00
CPC分类号： A61K38/28 , A61K31/045 , A61K31/155 , A61K31/167 , A61K31/195 , A61K31/395 , A61K38/11 , Y10S514/807
摘要： Provided herein are methods for the induction of hypothermia and the treatment of clinical insults in a subject through the administration of a regulated hypothermic multidrug combination. The compositions or multidrug combinations of the invention comprise a regulated hypothermic compound or a dopamine receptor agonist; a vasoactive compound; and an antiarrhythmic compound or a serotonin 5-HT3 receptor antagonist. Additional agents can be included in the composition including at least one of an antioxidant, a vitamin, N-acetylcysteine, and an antihyperglycemic compound. The invention further recognizes that a two phase delivery of multidrug combinations, a rapid infusion of the composition to induce hypothermia followed by a period of slow infusion to maintain the hypothermic state for a sustained period of time. Using the two phase delivery method of the invention, the composition may comprise ethanol and, optionally, at least one of a vasoactive compound, an antiarrhythmic compound, a serotonin 5-HT3 receptor antagonist, an antioxidant, a vitamin, N-acetylcysteine, and an antihyperglycemic compound. This two phase delivery method can be used to deliver any of the compositions of the invention and provides significant benefits to a patient.
摘要翻译：本文提供了通过施用受调节的低温多药物组合来诱导低体温和治疗受试者的临床损伤的方法。本发明的组合物或多药物组合包含调节的低温化合物或多巴胺受体激动剂; 血管活性化合物和抗心律失常化合物或5-羟色胺5-HT 3受体拮抗剂。另外的药剂可以包括在抗氧化剂，维生素，N-乙酰半胱氨酸和抗高血糖化合物中的至少一种的组合物中。本发明进一步认识到，多药物组合的两相递送，快速输注组合物以诱导低温，随后缓慢输注一段时间以维持低温状态持续一段时间。使用本发明的两相递送方法，组合物可以包含乙醇和任选的至少一种血管活性化合物，抗心律失常化合物，5-羟色胺5-HT 3受体拮抗剂，抗氧化剂，维生素，N-乙酰半胱氨酸和抗高血糖化合物。这种两相递送方法可用于递送本发明的任何组合物，并为患者提供显着益处。

3. 发明申请

WO2004049901A2 METHODS OF TREATING CEREBRAL ISCHEMIA 审中-公开
标题翻译：方法治疗脑缺血
公开(公告)号：WO2004049901A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/036499
申请日：2003-11-14
申请人： THE UNIVERSITY OF NORTH CAROLINA - CHAPEL HILL , KATZ, Laurence, M.
发明人： KATZ, Laurence, M.
IPC分类号： A61B
CPC分类号： A61K38/10
摘要： The present invention provides methods of treating cerebral ischemia in mammals comprising inducing hypothermia in a mammal before, during, or following cerebral ischemia in the mammal. The hypothermia is induced by administering to the mammal an effective dose of a neurotensin analog that is capable of crossing the blood-brain barrier and the comprises neo-tryptophan.
摘要翻译：本发明提供治疗哺乳动物脑缺血的方法，其包括在哺乳动物脑缺血之前，期间或之后诱导哺乳动物体温降低。通过向哺乳动物施用能够穿过血脑屏障并且包含新色氨酸的有效剂量的神经降压素类似物来诱导低体温。

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