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    • 1. 发明申请
    • PYRAZOLYLMETHYL-THIAZOLIDINES USEFUL AS HYPOGLYCEMIC AGENTS
    • 作为高分子药物有用的吡唑并吡咯啉
    • WO1996011196A1
    • 1996-04-18
    • PCT/JP1995002041
    • 1995-10-05
    • NISSAN CHEMICAL INDUSTRIES, LTD.OHARA, YoshioSUZUKI, MikioMIYACHI, NobuhideKATO, KatsuhiroOHDOI, KeisukeKOBAYASHI, TetsuyaSHIKADA, Ken-ichiNAITO, TakeshiYOTSUMOTO, Takashi
    • NISSAN CHEMICAL INDUSTRIES, LTD.
    • C07D417/14
    • C07D417/06C07D417/14
    • A pyrazole type thiazolidine compound of formula (I) and its salt, wherein X is S or O; X is S, O or NH; Y is CR R (R is a hydrogen atom, a C1-C7 alkyl group or a C3-C7 cycloalkyl group, and R is a hydrogen atom, a C1-C7 alkyl group or a C3-C7 cycloalkyl group, or forms a bond together with R ); R is a C1-C10 alkyl group, a C1-C10 alkoxy group, etc., or -Vk-W1-Z (Z is a C3-C10 cycloalkyl group, a C6-C14 aromatic group, a C4-C12 heterocyclic aromatic group, etc., V is O, S, SO, SO2 or NR (R is a hydrogen atom or a C1-C3 alkyl group), W is a divalent C1-C6 saturated or C2-C6 unsaturated hydrocarbon group which may be substituted with at most 3 of hydroxyl, oxo and C1-C7 alkyl groups, and each of k and l is 0 or 1), -V-W-V-W-Z, -W-V-W-Z, -V-W-V-Z, or -W-V-Z (V, W and Z are as defined above, and two V's and W's may, respectively, be the same or different); each of R and R is independently a hydrogen atom, a C1-C7 alkyl group, etc.; R is a hydrogen atom or a C1-C7 alkyl group, etc.; and R is a hydrogen atom or a carboxymethyl group. The compound of formula (I) and its salt are useful for a preventive or curative agent for diabetes mellites and diabetic complications.
    • 式(I)的吡唑型噻唑烷化合物及其盐,其中X 1为S或O; X 2是S,O或NH; Y是CR 6 R 7(R 6是氢原子,C 1 -C 7烷基或C 3 -C 7环烷基,R 7是氢原子,C 1 -C 7烷基 或C 3 -C 7环烷基,或与R 4一起形成键); R 1是C1-C10烷基,C1-C10烷氧基等,或-Vk-W1-Z(Z是C3-C10环烷基,C6-C14芳族基团,C4-C12 杂环芳基等,V是O,S,SO,SO 2或NR 8(R 8是氢原子或C 1 -C 3烷基),W是二价C1-C6饱和或C2- 可以被至多3个羟基,氧代和C 1 -C 7烷基取代的C 6不饱和烃基,并且k和l各自为0或1),-VWVWZ,-WVWZ,-VWVZ或-WVZ(V, W和Z如上所定义,两个V和W可以相同或不同); R 2和R 3各自独立地为氢原子,C 1 -C 7烷基等; R 4是氢原子或C 1 -C 7烷基等; R 5为氢原子或羧甲基。 式(I)化合物及其盐可用于糖尿病和糖尿病并发症的预防或治疗药物。
    • 3. 发明申请
    • THIAZOLIDINE AND OXAZOLIDINE INDOLES WITH HYPOCLYCEMIC ACTIVITY
    • 噻唑烷和氧杂环丁烷吲哚酚与高血压活性的关系
    • WO1996026207A1
    • 1996-08-29
    • PCT/JP1996000403
    • 1996-02-22
    • NISSAN CHEMICAL INDUSTRIES, LTD.OHARA, YoshioSUZUKI, MikioOHDOI, KeisukeMIYACHI, NobuhideKATO, KatsuhiroKOBAYASHI, TetsuyaSHIKADA, Ken-ichiKITAHARA, MasakiNAITO, TakeshiYOTSUMOTO, TakashiMIYAKOSHI, Chie
    • NISSAN CHEMICAL INDUSTRIES, LTD.
    • C07D417/06
    • C07D413/06C07D417/06C07D417/14
    • An indole type thiazolidine compound of formula (I) and its salt, wherein X is S or O; X is S, O or NH; Y is CR R (R is a hydrogen atom or a C1-C7 alkyl group); R is a substituent at the 2-, 3-, 4-, 5-, 6- or 7- position of an indole ring and is a C1-C10 alkyl group, -Wk-V?l?-Z (Z is a C3-C10 cycloalkyl group, a C6-C14 aromatic group, a C1-C12 heterocyclic aromatic group, a C1-C6 heterocycloaliphatic group, etc., V is O, S, etc., W is a divalent C1-C6 saturated or C2-C6 unsaturated hydrocarbon group which may be substituted with at most 3 of hydroxyl, oxo and C1-C7 alkyl groups, and each of k and l is 0 or 1), -V-W-Z (V, W and Z are as defined above), -W-V-W-Z (V, W and Z are as defined above, and two W's may be the same or different), or R may be a hydrogen atom when Y is bonded to the 4-, 5-, 6- or 7-position of an indole ring; each of R and R is a substituent at the 2-, 3-, 4-, 5-, 6- or 7-position of an indole ring, and is independently a hydrogen atom, a C -C7 alkyl group, or the like; R is a hydrogen atom or a C1-C7 alkyl group; R is a hydrogen atom or a carboxymethyl group; and R is a substituent at the 1-position of an indole ring, and is a hydrogen atom, a C1-C7 alkyl group, a C1-C7 alkoxy group, an alkylsulfonyl group, an arylsulfonyl group, or the like.
    • 式(I)的吲哚型噻唑烷化合物及其盐,其中X 1为S或O; X 2是S,O或NH; Y是CR 6 R 7(R 6是氢原子或C 1 -C 7烷基); R 1是吲哚环的2-,3-,4-,5-,6-或7-位上的取代基,并且是C 1 -C 10烷基-WK-V 2 l -Z( Z是C 3 -C 10环烷基,C 6 -C 14芳基,C 1 -C 12杂环芳基,C 1 -C 6杂脂环基等,V是O,S等,W是二价C 1 -C 6 饱和或C 2 -C 6不饱和烃基,其可以被至多3个羟基,氧代和C 1 -C 7烷基取代,k和l各自为0或1),-VWZ(V,W和Z如上定义) ),-WWWZ(V,W和Z如上定义,两个W可以相同或不同),或者当Y键合到4-,5-,6时,R 1可以是氢原子 - 或7-位吲哚环; R 2和R 3各自为吲哚环的2-,3-,4-,5-,6-或7-位的取代基,独立地为氢原子,C <1 > -C 7烷基等; R 4是氢原子或C 1 -C 7烷基; R 5是氢原子或羧甲基; R n为吲哚环的1位的取代基,为氢原子,C1-C7烷基,C1-C7烷氧基,烷基磺酰基,芳基磺酰基等。
    • 4. 发明申请
    • METHOD FOR DETECTING POSITIONAL SHIFT AND GAP
    • 检测位移和差距的方法
    • WO1994018522A1
    • 1994-08-18
    • PCT/JP1994000178
    • 1994-02-07
    • SORTEC CORPORATIONKATO, Katsuhiro
    • SORTEC CORPORATION
    • G01B11/00
    • G03F9/70
    • The structure of the optical system of this detection is simple, and the adjustment of this system is easy. The detection range is wide, and the resolution is high. The positional shift in a plane can be detected, and at the same time, the gap between two objects can be detected directly, stably, and continuously even in exposure. Two pairs of monochromatic beams having a slightly different frequencies are used. The beams are directed to diffraction gratings, or first and second objects, by allowing them to shift to the left and right, respectively, on both sides or one side of the optical axis. A plurality of beams of diffracted rays interfered by optical heterodyne emerge from positions symmetrical to the optical axes. The beams of diffracted rays thus formed are allowed to interfere so that one or more beat signals is produced in each pair. The phase variations of the beat signals between the pairs or in the pairs are determined. Hence the positional shift and gap between the two objects are detected at a time by the sum of and difference of the phase variations.
    • 该检测的光学系统的结构简单,该系统的调整容易。 检测范围宽,分辨率高。 可以检测平面中的位置偏移,并且同时即使在曝光中也可以直接,稳定地和连续地检测两个物体之间的间隙。 使用具有稍微不同频率的两对单色光束。 通过允许它们分别在光轴的两侧或一侧上分别向左和向右移动,将光束引导到衍射光栅或第一和第二物体。 被光学外差干涉的多个衍射光束从与光轴对称的位置出现。 这样形成的衍射光束被干扰,使得在每一对中产生一个或多个拍频信号。 确定成对之间或成对中的节拍信号的相位变化。 因此,通过相位变化的总和和差异来一次检测两个对象之间的位置偏移和间隙。