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1. 发明申请

WO2011024428A1 BREAST CANCER RELATED GENE C12ORF32 审中-公开
标题翻译：乳腺癌相关基因C12ORF32
公开(公告)号：WO2011024428A1
公开(公告)日：2011-03-03
申请号：PCT/JP2010/005169
申请日：2010-08-23
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , KATAGIRI, Toyomasa , TSUNODA, Takuya
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa , TSUNODA, Takuya
IPC分类号： C12N15/09 , A61K31/7105 , A61K48/00 , A61P35/00 , C07K7/06 , C07K14/00
CPC分类号： C12Q1/6886 , A61K31/7105 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods for detecting and diagnosing cancer, such methods involving the determination of the expression level of C12orf32 genes. These genes were discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic substances useful in the treatment of cancer. Moreover, the present invention provides siRNAs targeting C12orf32 genes, all of which are useful in the treatment of cancer.
摘要翻译：本发明提供了用于检测和诊断癌症的方法，所述方法涉及确定C12orf32基因的表达水平。发现这些基因可以区别癌细胞与正常细胞。此外，本发明提供筛选用于治疗癌症的治疗物质的方法。此外，本发明提供靶向C12orf32基因的siRNA，所有这些都可用于治疗癌症。

2. 发明申请

WO2007013358A3 VIVIT POLYPEPTIDES, THERAPEUTIC AGENT COMPRISING THE SAME, AND METHOD OF SCREENING FOR ANTI-CANCER AGENT 审中-公开
标题翻译： VIVIT POLYPEPTIDES，包括其的治疗药物以及用于抗癌剂的筛选方法
公开(公告)号：WO2007013358A3
公开(公告)日：2007-07-05
申请号：PCT/JP2006314442
申请日：2006-07-14
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA , INAKI KOICHIRO
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA , INAKI KOICHIRO
IPC分类号： C07K7/04 , A61K38/10 , A61K38/17 , C07K7/08 , C07K14/435 , C12N15/62 , G01N33/50
CPC分类号： G01N33/57438 , A61K38/08 , A61K38/10 , A61K38/1709 , C07K14/47 , G01N33/5011 , G01N33/6893 , G01N2500/00
摘要： The present invention provides polypeptides useful for treating and preventing cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises VIVIT and is preferably a polypeptide in which the motif sequence PxIxIT at positions 37 to 41 of the amino acid sequence of the C1958 protein (SEQ ID NO: 2) is replaced with PVIVIT. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. The present invention provides methods and kits for identifying inhibitors of the interaction between C1958 and PPP3CA which find utility in the treatment and prevention of cancer. Also disclosed herein are compositions for treating or preventing cancer identified by the screening method of the present invention and methods of using same in the treatment and prevention of cancer.
摘要翻译：本发明提供了可用于治疗和预防癌症的多肽。本发明还提供了使用多肽治疗癌症的治疗剂或方法。本发明的多肽由包含VIVIT的氨基酸序列组成，优选其中C1958蛋白（SEQ ID NO：2）的氨基酸序列的第37至41位上的基序序列PxIxIT被替换的多肽与PVIVIT。本发明的多肽可以通过用转染试剂例如聚精氨酸修饰多肽而被引入到癌细胞中。本发明提供用于鉴定C1958和PPP3CA之间相互作用的抑制剂的方法和试剂盒，其可用于治疗和预防癌症。本文还公开了用于治疗或预防由本发明的筛选方法鉴定的癌症的组合物及其在治疗和预防癌症中的使用方法。

3. 发明申请

WO2007013670A2 GENE AND POLYPEPTIDE RELATING TO BREAST CANCER 审中-公开
标题翻译：与乳腺癌相关的基因和多肽
公开(公告)号：WO2007013670A2
公开(公告)日：2007-02-01
申请号：PCT/JP2006/315341
申请日：2006-07-26
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKATSURU, Shuichi
IPC分类号： C12Q1/68
CPC分类号： C12N15/1137 , C12N15/1135 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present application provides novel human gene B7330N whose expression is markedly elevated in breast cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of breast cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of breast cancer.
摘要翻译：本申请提供了在乳腺癌中表达显着升高的新型人基因B7330N。由该基因编码的基因和多肽可用于例如乳腺癌的诊断中，作为用于开发针对该疾病的药物的靶分子，以及用于减轻乳腺癌的细胞生长。

4. 发明申请

WO2005019475A3 HYPOXIA-INDUCIBLE PROTEIN 2 (HIG2), A NOVEL THERAPEUTIC POTENTIAL TARGET OF RENAL CELL CARCINOMA (RCC) 审中-公开
标题翻译：低氧诱导蛋白2（HIG2）是肾细胞癌（RCC）的一种新的治疗潜在靶点
公开(公告)号：WO2005019475A3
公开(公告)日：2005-08-11
申请号：PCT/JP2004012411
申请日：2004-08-20
申请人： ONCOTHERAPY SCIENCE INC , UNIV TOKYO , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides a method for inhibiting growth of a cancer cell, particularly a renal cell carcinoma, by contacting the cell with a composition composed of an HIG2 siRNA or HIG2 antibody. Methods of diagnosing renal cell cancer are also provided within the present invention.
摘要翻译：本发明提供通过使细胞与由HIG2 siRNA或HIG2抗体组成的组合物接触来抑制癌细胞，特别是肾细胞癌生长的方法。本发明还提供了诊断肾细胞癌的方法。

5. 发明申请

WO2005028676A2 METHOD OF DIAGNOSING BREAST CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2005028676A2
公开(公告)日：2005-03-31
申请号：PCT/JP2004/014438
申请日：2004-09-24
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKATSURU, Shuichi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
摘要翻译：本文描述了用于检测和诊断乳腺癌（BRC）的客观方法。在一个实施方案中，诊断方法涉及确定区分BRC细胞和正常细胞的BRC相关基因的表达水平。在另一个实施方案中，诊断方法涉及确定区分BRC细胞，DCIS和IDC细胞之间的BRC相关基因的表达水平。本发明还提供了使用具有淋巴结转移的乳腺癌细胞中具有独特改变的表达模式的BRC相关基因预测和预防乳腺癌转移的方法。最后，本发明提供了筛选用于治疗乳腺癌的治疗剂，乳腺癌治疗方法和接种受试者抵抗乳腺癌的方法。

6. 发明申请

WO2004031412A2 METHOD FOR DIAGNOSING PANCREATIC CANCER 审中-公开
标题翻译：诊断胰腺癌的方法
公开(公告)号：WO2004031412A2
公开(公告)日：2004-04-15
申请号：PCT/JP2003/011817
申请日：2003-09-17
申请人： ONCOTHERAPY SCIENCE, INC. , JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , KATAGIRI, Toyomasa
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa
IPC分类号： C12Q1/68
CPC分类号： G01N33/57438 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
摘要翻译：本文描述了胰腺癌（PNC）检测和诊断的客观方法。在一个实施方案中，诊断方法涉及确定鉴别PNC细胞和正常细胞的PNC相关基因的表达水平。本发明进一步提供筛选用于治疗胰腺癌的治疗剂的方法，胰腺癌治疗方法和疫苗接种胰腺癌的方法。

7. 发明申请

WO2006085684A2 METHOD OF DIAGNOSING BLADDER CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2006085684A2
公开(公告)日：2006-08-17
申请号：PCT/JP2006/302684
申请日：2006-02-09
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa , NAKATSURU, Shuichi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2500/00
摘要： Objective methods for detecting and diagnosing bladder cancer (BLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BLC-associated gene that discriminates between BLC cells and normal cells. The present invention further provides means for predicting and preventing bladder cancer metastasis using BLC-associated genes having unique altered expression patterns in bladder cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of bladder cancer, methods of treating bladder cancer and method for vaccinating a subject against bladder cancer. In particular, the present application provides novel human genes C2093, B5860Ns and C6055s whose expression is markedly elevated in bladder cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of bladder cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of bladder cancer.
摘要翻译：本文描述了膀胱癌（BLC）检测和诊断的客观方法。在一个实施方案中，诊断方法涉及确定鉴别BLC细胞和正常细胞的BLC相关基因的表达水平。本发明还提供了使用具有淋巴结转移的膀胱癌细胞中具有独特改变的表达模式的BLC相关基因来预测和预防膀胱癌转移的手段。最后，本发明提供筛选可用于治疗膀胱癌的治疗剂，治疗膀胱癌的方法和接种疫苗接种膀胱癌的方法。特别地，本申请提供了新的人基因C2093，B5860Ns和C6055，其表达在膀胱癌中显着升高。由该基因编码的基因和多肽可用于例如膀胱癌的诊断，作为用于开发针对该疾病的药物的靶分子，以及用于减轻膀胱癌的细胞生长。

8. 发明申请

WO2005029089A2 METHOD OF DIAGNOSING OVARIAN ENDOMETRIOSIS USING TFPI-2 PROTEIN 审中-公开
标题翻译：使用TFPI-2蛋白诊断卵巢子宫内膜异位症的方法
公开(公告)号：WO2005029089A2
公开(公告)日：2005-03-31
申请号：PCT/JP2004/013718
申请日：2004-09-14
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , KATAGIRI, Toyomasa
发明人： NAKAMURA, Yusuke , KATAGIRI, Toyomasa
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2800/364
摘要： Disclosed are methods of diagnosing ovarian endometriosis using an antibody against the TFPI-2 protein. According to the present invention, this protein is detected at higher levels in the serum of subjects suffering from endometriosis as compared to normal control subjects and thus may serve as diagnostic marker and therapeutic target for ovarian endometriosis. In addition to methods of diagnosing ovarian endometriosis, the present invention provides kits for performing the diagnosis.
摘要翻译：公开了使用针对TFPI-2蛋白的抗体来诊断卵巢子宫内膜异位的方法。根据本发明，与正常对照受试者相比，在患有子宫内膜异位症的受试者的血清中以较高水平检测到该蛋白质，因此可以用作卵巢子宫内膜异位症的诊断标记和治疗靶标。除了诊断卵巢子宫内膜异位症的方法之外，本发明提供用于进行诊断的试剂盒。

9. 发明申请

WO2004031409A3 METHOD FOR DIAGNOSING CHRONIC MYELOID LEUKEMIA 审中-公开
标题翻译：诊断慢性粒细胞白血病的方法
公开(公告)号：WO2004031409A3
公开(公告)日：2005-02-24
申请号：PCT/JP0310256
申请日：2003-08-12
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C12N15/12 , C12Q1/68 , G01N33/574 , A61K35/00 , G01N33/50
CPC分类号： C12Q1/6883 , A61K39/0011 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N2500/04
摘要： Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.
摘要翻译：本文描述了用于检测和诊断慢性骨髓性白血病（CML）的客观方法。在一个实施方案中，诊断方法涉及确定区分CML和正常细胞的CML相关基因的表达水平。本发明进一步提供筛选用于治疗CML的治疗剂，CML治疗方法以及针对CML接种受试者的方法。

10. 发明申请

WO2004031412A3 METHOD FOR DIAGNOSING PANCREATIC CANCER 审中-公开
标题翻译：胰腺癌诊断方法
公开(公告)号：WO2004031412A3
公开(公告)日：2004-07-15
申请号：PCT/JP0311817
申请日：2003-09-17
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , KATAGIRI TOYOMASA
发明人： NAKAMURA YUSUKE , KATAGIRI TOYOMASA
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57438 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
摘要翻译：本文描述了用于检测和诊断胰腺癌（PNC）的客观方法。在一个实施方案中，诊断方法涉及确定区分PNC细胞和正常细胞的PNC相关基因的表达水平。本发明进一步提供筛选用于治疗胰腺癌的治疗剂的方法，治疗胰腺癌的方法以及针对胰腺癌接种受试者的方法。

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