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1. 发明专利

GB9300803D0 DIRECT WATER HEATING BOILER 未知
公开(公告)号：GB9300803D0
公开(公告)日：1993-03-10
申请号：GB9300803
申请日：1993-01-16
申请人： KANE PAUL C O , KANE JOHN J O

2. 发明专利

CA708740A SEAL AND FLEXIBLE GEAR TYPE COUPLING 未知
公开(公告)号：CA708740A
公开(公告)日：1965-05-04
申请号：CA708740D
申请人： SAHLMANN LOUIS H , KANE JOHN J
发明人： KANE JOHN J , SAHLMANN LOUIS H

3. 发明申请

WO2009073445A3 BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES 审中-公开
标题翻译：生物可降解的FUMAGILLIN模拟结合
公开(公告)号：WO2009073445A3
公开(公告)日：2010-01-28
申请号：PCT/US2008084539
申请日：2008-11-24
申请人： MERSANA THERAPEUTICS INC , AKULLIAN LAURA C , PETTER RUSSELL C , KANE JOHN J , HAMMOND CHARLES E , YIN MAO , YURKOVETSKIY ALEKSANDR , STEVENSON CHERI A
发明人： AKULLIAN LAURA C , PETTER RUSSELL C , KANE JOHN J , HAMMOND CHARLES E , YIN MAO , YURKOVETSKIY ALEKSANDR , STEVENSON CHERI A
IPC分类号： A61K47/48 , A61P35/00 , C07D303/22
CPC分类号： C07D303/40 , A61K47/59 , C07D303/18 , C07D303/22 , C07D303/36 , C07D405/14 , C07D487/08
摘要： Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.
摘要翻译：烟曲霉素类似物聚合物共轭物，制备烟曲霉素类似物聚合物共轭物的方法，包含烟曲霉素类似物的聚合物缀合物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病的方法，包括向有需要的受试者施用有效量的烟曲霉素类似物。还描述了新的烟曲霉素类似物，制备烟曲霉素类似物的方法，包含至少一种烟曲霉素类似物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病，包括向有需要的受试者施用有效量的烟曲霉素类似物。

4. 发明申请

WO2009073445A2 BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES 审中-公开
标题翻译：生物可降解的FUMAGILLIN模拟结合
公开(公告)号：WO2009073445A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/084539
申请日：2008-11-24
申请人： MERSANA THERAPEUTICS, INC. , STEVENSON, Cheri, A. , AKULLIAN, Laura, C. , PETTER, Russell C. , KANE, John, J. , HAMMOND, Charles, E. , YIN, Mao , YURKOVETSKIY, Aleksandr
发明人： STEVENSON, Cheri, A. , AKULLIAN, Laura, C. , PETTER, Russell C. , KANE, John, J. , HAMMOND, Charles, E. , YIN, Mao , YURKOVETSKIY, Aleksandr
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： C07D303/40 , A61K47/59 , C07D303/18 , C07D303/22 , C07D303/36 , C07D405/14 , C07D487/08
摘要： Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.
摘要翻译：烟曲霉素类似物聚合物缀合物，制备烟曲霉素类似物聚合物共轭物的方法，包含烟曲霉素类似物的聚合物缀合物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病的方法，包括向有需要的受试者施用有效量的烟曲霉素类似物。还描述了新的烟曲霉素类似物，制备烟曲霉素类似物的方法，包含至少一种烟曲霉素类似物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病，包括向有需要的受试者施用有效量的烟曲霉素类似物。

5. 发明申请

WO2010138719A1 POLYAL DRUG CONJUGATES COMPRISING VARIABLE RATE-RELEASING LINKERS 审中-公开
标题翻译：包括可变速率释放链接器的聚合药物
公开(公告)号：WO2010138719A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036413
申请日：2010-05-27
申请人： MERSANA THERAPEUTICS, INC. , YURKOVETSKIY, Aleksandr , YIN, Mao , LIU, Gui , AKULLIAN, Laura, C. , KANE, John, J. , STEVENSON, Cheri, A. , HAMMOND, Charles, E. , PETTER, Russell, C. , VAN DUZER, John, H. , LOWINGER, Timothy, B.
发明人： YURKOVETSKIY, Aleksandr , YIN, Mao , LIU, Gui , AKULLIAN, Laura, C. , KANE, John, J. , STEVENSON, Cheri, A. , HAMMOND, Charles, E. , PETTER, Russell, C. , VAN DUZER, John, H. , LOWINGER, Timothy, B.
IPC分类号： A61K31/74
CPC分类号： C07D519/04 , A61K47/59 , C07D491/22 , G01N2500/00 , Y10T436/145555
摘要： Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
摘要翻译：描述包含可变速率释放连接体的多价 - 药物共轭物以及制备这种缀合物的方法。也描述了这种多种药物共轭物的用途。

6. 发明授权

US3907250A Sluice gate 失效
标题翻译：闸门
公开(公告)号：US3907250A
公开(公告)日：1975-09-23
申请号：US38491273
申请日：1973-08-02
申请人： KANE JOHN J
发明人： KANE JOHN J
IPC分类号： F16K3/02 , F16K3/316 , F16K51/00
CPC分类号： F16K3/3165 , F16K3/0227
摘要： The disclosure herein shows a means for controlled forces acting to provide one hundred percent horizontal motion on a sluice gate to move a seal or sealing surface on the sluice gate to and from contact or sealing position with a frame, and to provide pressure to maintain sealing and to maintain a seal in a ''''no contact'''' position during hoisting or lowering of the gate. A lock means is provided for top and bottom of the gate and is positioned in accord with the ''''no contact'''' travel position.
摘要翻译：本文的公开内容示出了用于受控力的装置，其用于在闸门上提供百分之一百的水平运动，以将挡板上的密封或密封表面移动到与框架的接触或密封位置之间，并提供压力以保持密封并且在起重或降低闸门期间保持“无接触”位置的密封。为门的顶部和底部提供锁定装置，并且与“无接触”行进位置一致地定位。

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