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    • 2. 发明申请
    • TRITERPENE DERIVATIVE AND MEDICINAL COMPOSITION
    • TRITERPENE衍生物和药物组合物
    • WO1996000236A1
    • 1996-01-04
    • PCT/JP1995001249
    • 1995-06-22
    • NIPPON SHINYAKU CO., LTD.OHGI, TadaakiYOSHIFUSA, HirotoKANDORI, Kazuhisa
    • NIPPON SHINYAKU CO., LTD.
    • C07J63/00
    • C07J63/008C07J71/0005
    • Hederagenin derivatives represented by general formula (1) and pharmaceutically acceptable salts thereof, and a medicinal composition containing the same as the active ingredient and being efficacious in treating nephritis, wherein R represents OR or NR R , and R and R represent each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heteroaryl; R and R represent each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, optionally substituted monoalkylcarbamoyl, optionally substituted dialkylcarbamoyl or optionally substituted alkoxycarbonyl, or alternatively R and R are combined together to represent carbonyl.
    • 由通式(1)表示的上皮原素衍生物及其药学上可接受的盐,以及含有与活性成分相同的有效治疗肾炎的药物组合物,其中R 1表示OR 11或NR 11 R R 11和R 12各自独立地表示氢,任选取代的烷基,任选取代的环烷基,任选取代的烯基,任选取代的炔基,任选取代的芳基或任选取代的杂芳基; R 2和R 3各自独立地表示氢,任选取代的烷基,任选取代的环烷基,任选取代的烯基,任选取代的炔基,任选取代的酰基,任选取代的单烷基氨基甲酰基,任选取代的二烷基氨基甲酰基或任选取代的烷氧羰基, 2>和R 3结合在一起代表羰基。