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1. 发明专利

JP2006508925A Methods and preparations for the treatment of critically ill patients 审中-公开
公开(公告)号：JP2006508925A
公开(公告)日：2006-03-16
申请号：JP2004536697
申请日：2003-09-23
申请人：オーフース・ウニヴァーシテトAarhus Universitet , オーフース・ユニヴァーシティ・ホスピタルAarhus University Hospital , カー・イュー・ルーヴェン・リサーチ・アンド・ディヴェロップメントK.U. Leuven Research And Development
发明人：ステフェン・ティール , トレルス・クラルプ・ハンセン , フレタ・ファン・デル・ベルヘ
IPC分类号： A61K38/36 , A61K38/17 , A61K38/27 , A61P31/04
CPC分类号： A61K38/1709 , A61K38/27
摘要：本発明は、重篤患者を処置または治療するための救命薬を製造するための血液マンナン結合レクチン（ＭＢＬ）レギュレーターの使用に関する。さらに、重篤度ＩＣＵ患者における死亡率を予測するためのＭＢＬの測定の使用を包含する。本発明の１つの別の態様は、集中治療室(ＩＣＵ)に入れられる患者の予防的および／または治療的処置におけるＭＢＬのモノマーおよびオリゴマーの使用である。

2. 发明授权

US09427447B2 Anti-viral pyrimidine nucleoside derivatives 有权
标题翻译：抗病毒嘧啶核苷衍生物
公开(公告)号：US09427447B2
公开(公告)日：2016-08-30
申请号：US14482125
申请日：2014-09-10
申请人： UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED , K.U. LEUVEN RESEARCH AND DEVELOPMENT
发明人： Christopher McGuigan , Jan Balzarini , Marco Migliore
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7068 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/706 , A61K31/7064 , A61K31/7052
CPC分类号： A61K31/7068 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
摘要翻译：用于治疗或预防病毒感染的化合物，例如由水痘带状疱疹病毒引起的水痘或带状疱疹，所述具有通式（II）的化合物：其中X是O，S，NH或CH 2，Y 是O，S或NH，Z是O，S或CH 2，R 1是C 1-6烷基，优选正烷基，例如正戊基或正己基，R 2和R 3之一是OH，另一个是 R3和R2是中性的，非极性的氨基酸部分，或其药学上可接受的盐或水合物。所述中性，非极性氨基酸部分R 2或R 3可以是（Ⅳ）：其中R 4，R 5，R 6和R 7各自独立地为H或C 1-2烷基。在优选的实施方案中，R2或R3之一是缬氨酸，亮氨酸，异亮氨酸或丙氨酸，特别是缬氨酸。

3. 发明申请

US20150072948A1 ANTI-VIRAL PYRIMIDINE NUCLEOSIDE DERIVATIVES 有权
标题翻译：抗虚拟吡啶核苷衍生物
公开(公告)号：US20150072948A1
公开(公告)日：2015-03-12
申请号：US14482125
申请日：2014-09-10
申请人： UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED , K.U. LEUVEN RESEARCH AND DEVELOPMENT
发明人： Christopher McGuigan , Jan Balzarini , Marco Migliore
IPC分类号： A61K31/7068
CPC分类号： A61K31/7068 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
摘要翻译：用于治疗或预防病毒感染的化合物，例如由水痘带状疱疹病毒引起的水痘或带状疱疹，所述具有通式（II）的化合物：其中X是O，S，NH或CH 2，Y 是O，S或NH，Z是O，S或CH 2，R 1是C 1-6烷基，优选正烷基，例如正戊基或正己基，R 2和R 3之一是OH，另一个是 R3和R2是中性的，非极性的氨基酸部分，或其药学上可接受的盐或水合物。所述中性，非极性氨基酸部分R 2或R 3可以是（Ⅳ）：其中R 4，R 5，R 6和R 7各自独立地为H或C 1-2烷基。在优选的实施方案中，R2或R3之一是缬氨酸，亮氨酸，异亮氨酸或丙氨酸，特别是缬氨酸。

4. 发明授权

US08859512B2 Anti-viral pyrimidine nucleoside derivatives 有权
标题翻译：抗病毒嘧啶核苷衍生物
公开(公告)号：US08859512B2
公开(公告)日：2014-10-14
申请号：US13690794
申请日：2012-11-30
申请人： University College Cardiff Consultants Limited , K.U. Leuven Research and Development
发明人： Christopher McGuigan , Jan Balzarini , Marco Migliore
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7068 , C07D487/04 , C07D495/04 , C07D491/04
CPC分类号： A61K31/7068 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
摘要翻译：用于治疗或预防病毒感染的化合物，例如由水痘带状疱疹病毒引起的水痘或带状疱疹，所述具有通式（II）的化合物：其中X是O，S，NH或CH 2，Y 是O，S或NH，Z是O，S或CH 2，R 1是C 1-6烷基，优选正烷基，例如正戊基或正己基，R 2和R 3之一是OH，另一个是 R3和R2是中性的，非极性的氨基酸部分，或其药学上可接受的盐或水合物。所述中性，非极性氨基酸部分R 2或R 3可以是（Ⅳ）：其中R 4，R 5，R 6和R 7各自独立地为H或C 1-2烷基。在优选的实施方案中，R2或R3之一是缬氨酸，亮氨酸，异亮氨酸或丙氨酸，特别是缬氨酸。

5. 发明申请

US20130096079A1 Anti-Viral Pyrimidine Nucleoside Derivatives 有权
标题翻译：抗病毒嘧啶核苷衍生物
公开(公告)号：US20130096079A1
公开(公告)日：2013-04-18
申请号：US13690794
申请日：2012-11-30
申请人： University College Cardiff Consultants Limited , K.U. Leuven Research and Development
发明人： Christopher McGuigan , Jan Balzarini , Marco Migliore
IPC分类号： A61K31/7068
CPC分类号： A61K31/7068 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
摘要翻译：用于治疗或预防病毒感染的化合物，例如由水痘带状疱疹病毒引起的水痘或带状疱疹，所述具有通式（II）的化合物：其中X是O，S，NH或CH 2，Y 是O，S或NH，Z是O，S或CH 2，R 1是C 1-6烷基，优选正烷基，例如正戊基或正己基，R 2和R 3之一是OH，另一个是 R3和R2是中性的，非极性的氨基酸部分，或其药学上可接受的盐或水合物。所述中性，非极性氨基酸部分R 2或R 3可以是（Ⅳ）：其中R 4，R 5，R 6和R 7各自独立地为H或C 1-2烷基。在优选的实施方案中，R2或R3之一是缬氨酸，亮氨酸，异亮氨酸或丙氨酸，特别是缬氨酸。

6. 发明申请

WO2006072150A1 MUSCLE ARTIFACT REMOVAL FROM ENCEPHALOGRAMS 审中-公开
标题翻译：从健康教育中去除肌肉手术
公开(公告)号：WO2006072150A1
公开(公告)日：2006-07-13
申请号：PCT/BE2005/000189
申请日：2005-12-23
申请人： K.U. LEUVEN RESEARCH AND DEVELOPMENT , DE CLERCQ, Wim , VAN HUFFEL, Sabine , VAN PAESSCHEN, Wim , VERGULT, Anneleen
发明人： DE CLERCQ, Wim , VAN HUFFEL, Sabine , VAN PAESSCHEN, Wim , VERGULT, Anneleen
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/04008 , A61B5/04012 , A61B5/0476 , A61B5/7207
摘要： EncephaloGrams, such as ElectroEncephaloGrams (EEG) or MagnetoEncephaloGrams (MEG), are often contaminated by muscle artifacts. Present invention provides a method for muscle artifact removal in EncephaloGrams, based on Canonical Correlation Analysis (CCA) as a Blind Source Separation technique (BSS). This method is for instance demonstrated on a synthetic data set and on a real ictal EEG recording contaminated with muscle artifacts. The method of present invention successfully removes the muscle artifact without altering the recorded underlying brain activity. The method outperformed a low pass filter with different cut-off frequencies and an Independent Component Analysis (ICA) based technique for muscle artifact removal. Moreover, the fast computational time and the ordering of the CCA components make the proposed method applicable in clinical practice.
摘要翻译：脑电图，例如ElectroEncephaloGrams（EEG）或MagnetoElopphaloGrams（MEG），通常被肌肉伪影污染。本发明提供了一种基于经典相关分析（CCA）作为盲源分离技术（BSS）的脑苷神经元去除肌肉伪影的方法。该方法例如在合成数据集上以及被肌肉伪影污染的真实脑电脑记录上证明。本发明的方法成功地去除肌肉伪影而不改变所记录的潜在脑活动。该方法优于具有不同截止频率的低通滤波器和基于独立分量分析（ICA）的肌肉伪影去除技术。此外，CCA组件的快速计算时间和顺序使得所提出的方法适用于临床实践。

7. 发明申请

WO2005109004A3 DISEASE RELATED PROTEIN AGGREGATION 审中-公开
公开(公告)号：WO2005109004A3
公开(公告)日：2005-11-17
申请号：PCT/IB2005/001234
申请日：2005-05-06
申请人： K.U. LEUVEN RESEARCH AND DEVELOPMENT , BAEKELANDT, Veerle , DEBYSER, Zeger , ENGELBORGHS, Yves , GERARD, Melanie
发明人： BAEKELANDT, Veerle , DEBYSER, Zeger , ENGELBORGHS, Yves , GERARD, Melanie
IPC分类号： G01N33/68 , A61K39/395
摘要： Present invention demonstrates that the members of the FKBP family or FK506 Binding Proteins (FKBPs), more specifically FKBP12 or FKBP52 enhance the aggregation of α-SYN. Moreover, it was found that the effect of FKBP on α-SYN aggregation has its origin in the PPIase activity of the enzyme. Immunophilin ligands, specific inhibitors of the activity of FKBPs, inhibit stimulation of the aggregation of a α-SYN by FKBPs.

8. 发明申请

WO2004029135A2 GLUTEN BIOPOLYMERS 审中-公开
公开(公告)号：WO2004029135A2
公开(公告)日：2004-04-08
申请号：PCT/BE2003/000163
申请日：2003-09-26
申请人： K.U. LEUVEN RESEARCH AND DEVELOPMENT , WOERDEMAN, Dara , VERAVERBEKE, Wim , VERPOEST, Ignace , DELCOUR, Jan
发明人： WOERDEMAN, Dara , VERAVERBEKE, Wim , VERPOEST, Ignace , DELCOUR, Jan
IPC分类号： C08H1/00
CPC分类号： C08L89/00 , B27N3/002 , B27N3/04 , C07K14/415 , C08H1/00 , C08J5/04 , C08J2389/00 , C08L97/02 , C08L2666/26 , C09J189/00
摘要： This invention consists of a modified gluten biopolymer for use in industrial applications, such as composites and foams. In the present work, the fracture toughness of the gluten polymer was improved with the addition of a thiol-containing modifying agent. This work also resulted in the development of a gluten biopolymer-modified fiber bundle, demonstrating the potential to process fully biodegradable composite materials. Qualitative analysis suggests that a reasonably strong interface between the natural fibers and biopolymer matrix can form spontaneously under the proper conditions. Therefore this invention relates to a modified gluten biopolymer for use in industrial applications, such as composites, stabilized foams and molded articles of manufactures. The present invention relates to a new gluten based biopolymer with modified properties, such as an increase in impact strength, and prepared by using thiol-containing molecules. The multifunctional activity of the polythiol-containing molecules generates the potential for the development of a new material base for commodity plastics. The invention furthermore relates to a new composite material comprising gluten-coated fiber, its use and the method for preparing the composite material.
摘要翻译：本发明由用于工业应用的改性谷蛋白生物聚合物组成，例如复合材料和泡沫。在本工作中，通过加入含硫醇的改性剂，提高了麸质聚合物的断裂韧性。这项工作还导致开发面筋生物聚合物改性的纤维束，证明了处理完全可生物降解的复合材料的潜力。定性分析表明天然纤维和生物聚合物基质之间的相当强的界面可以在合适的条件下自发形成。因此，本发明涉及用于工业应用的改性谷蛋白生物聚合物，例如复合材料，稳定的泡沫和制成品的模制品。本发明涉及具有改性性质的新的面筋基生物聚合物，例如冲击强度的增加，并且通过使用含硫醇的分子制备。含多硫醇的分子的多功能活性产生了开发商品塑料新材料基础的潜力。本发明还涉及包含麸质包被纤维的新型复合材料，其用途和制备复合材料的方法。

9. 发明申请

WO2003103893A3 A MONOLITHIC ROTATING TOOL 审中-公开
公开(公告)号：WO2003103893A3
公开(公告)日：2003-12-18
申请号：PCT/BE2003/000104
申请日：2003-06-10
申请人： K.U. LEUVEN RESEARCH AND DEVELOPMENT , AL-BENDER, Farid , GREGOIR, Christophe
发明人： AL-BENDER, Farid , GREGOIR, Christophe
IPC分类号： B24B41/04
摘要： A solution is presented for high speed rotating devices, in particular cutting tools, whereby the said rotating device (1) is made monolithic with its shaft and the bearing system, needed to support it during rotation, uses the surfaces of the rotating device (1) as bearing surfaces. In the preferred embodiment, the fluid film bearing system includes two journal bearings (2,4) on both sides of the cutting tool and two thrust bearings (2,3), which use the faces of the cutting tool (1) as bearing surfaces

10. 发明申请

WO2014005841A1 A METHOD FOR FABRICATING A THIN FILM TRANSISTOR 审中-公开
标题翻译：一种制造薄膜晶体管的方法
公开(公告)号：WO2014005841A1
公开(公告)日：2014-01-09
申请号：PCT/EP2013/062767
申请日：2013-06-19
申请人： IMEC , NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK (TNO) , K.U. LEUVEN RESEARCH AND DEVELOPMENT
发明人： NAG, Manoj , STEUDEL, Sören
IPC分类号： H01L29/66 , H01L29/786
CPC分类号： H01L29/7869 , H01L29/66969
摘要： A method for fabricating a bottom-gate top-contact metal oxide semiconductor thin film transistor, the method comprising: - forming a gate electrode on a substrate; - providing a gate dielectric layer covering the gate electrode; - depositing a metal oxide semiconductor layer on the gate dielectric layer; - depositing a metal layer on top of the metal oxide semiconductor layer; - patterning said metal layer to form source and drain contacts, wherein patterning the metal layer comprises dry etching of the metal layer; and thereafter patterning the metal oxide semiconductor layer.
摘要翻译：一种制造底栅顶接触金属氧化物半导体薄膜晶体管的方法，所述方法包括：在衬底上形成栅电极; - 提供覆盖所述栅电极的栅介质层; - 在所述栅极电介质层上沉积金属氧化物半导体层; - 在所述金属氧化物半导体层的顶部上沉积金属层; - 图案化所述金属层以形成源极和漏极接触，其中图案化所述金属层包括所述金属层的干蚀刻; 然后对金属氧化物半导体层进行图案化。

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