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    • 2. 发明授权
    • Thionosalicylic acid anilides and salts thereof
    • 硫代水杨酸苯胺及其盐
    • US3974204A
    • 1976-08-10
    • US549682
    • 1975-02-13
    • Jurgen KurzHeinrich KollingManfred Federmann
    • Jurgen KurzHeinrich KollingManfred Federmann
    • C07C153/067
    • New thionosalicylic acid anilides and salts with bases are provided which have parasiticidal activity in sheep and cattle particularly against adult liver flukes in sheep and cattle and other domestic animals, especially against juvenile liver flukes. The new compounds are produced by the reaction of poly-substituted phenols with substituted aromatic isothiocyanates, the hydrolysis products of oxo-thiono- or dithiono-dihydrobenzoxazines or by the reaction of N-phenyl-salicyl-imide chlorides with thio-compounds. Typical compounds are 3,5-dichloro-4'-bromo-thionosalicylic acid anilide and 2-acetoxy-3,5-dichloro-N-(2'-methyl-4'-chlorophenyl)-thionobenzamide. Novel benzoxazines obtainable from the above anilides are also provided and have similar properties. Typical compounds are 3-(3',5'-bis-trifluoromethyl-phenyl)-6,8-dibromo-2-oxo-4-thionodihydrobenzoxazine-(1,3), 3-(3',4'-dichlorophenyl)-6,8-dichloro-2,4-dithiono-dihydrobenzoxazine-(1,3) and 3-(4'-bromophenyl)-6-chloro-8-bromo-2,4-dithiono-dihydrobenzoxazine-(1,3). Methods for preparing a large number of both types of compounds are described. The compounds are administered orally or subcutaneously in doses of 2.5 to 100 mg/kg, preferably 5 to 15 mg/kg, of body weight.
    • 提供新的硫羟水杨酸和与碱的盐,其在绵羊和牛中具有杀寄生虫活性,特别是针对羊,牛和其他家畜中的成年肝吸虫,特别是针对幼鱼肝吸虫。 新化合物是通过多取代苯酚与取代的芳族异硫氰酸酯的反应,氧代 - 硫代 - 或二硫代 - 二氢苯并恶嗪的水解产物或N-苯基 - 水杨酰基酰亚胺氯化物与硫代化合物的反应制备的。 典型的化合物是3,5-二氯-4'-溴 - 硫代水杨酸酰苯胺和2-乙酰氧基-3,5-二氯-N-(2'-甲基-4'-氯苯基) - 硫代苯甲酰胺。 还提供了可从上述酰苯胺获得的新型苯并恶嗪,具有相似的性质。 典型的化合物是3-(3',5'-双 - 三氟甲基 - 苯基)-6,8-二溴-2-氧代-4-硫代二氢苯并恶嗪 - (1,3),3-(3',4'-二氯苯基 )-6,8-二氯-2,4-二硫代二氢苯并恶嗪 - (1,3)和3-(4'-溴苯基)-6-氯-8-溴-2,4-二硫代 - 二氢苯并恶嗪 - (1, 3)。 描述了制备大量两种类型化合物的方法。 化合物以2.5至100mg / kg,优选5至15mg / kg体重的剂量口服或皮下给药。
    • 3. 发明授权
    • Universal tool for soldering and de-soldering apparatus
    • 用于焊接和脱焊设备的通用工具
    • US4958401A
    • 1990-09-25
    • US220760
    • 1988-08-25
    • Jurgen Kurz
    • Jurgen Kurz
    • B23K3/02B23K3/08
    • B23K3/028B23K3/08
    • A universal tool for maintenance and handling of soldering and de-soldering equipment incorporates a holder for cleaning needles that is inserted into a handle. The holder consists of a number of segments, each of which holds one cleaning needle at any time, that are connected to each other by means of an axis of rotation. The segment that contains the desired cleaning needle at any one time is rotated 180.degree. in relation to the other segments from the holder that has been removed from the handle, at which time the holder is inserted into the handle with the unused cleaning needles facing into the handle. The handle has hexagonal openings at both ends, which are used to screw or unscrew nozzles, suction nozzles, and clamping sleeves. The holder can be inserted into one of these hexagonal openings. The holder can also be fitted with a cap that has a slot through which a selected cleaning needle may pass.
    • 用于焊接和脱焊设备的维护和处理的通用工具包括用于清洁插入到手柄中的针的保持器。 保持器由多个段组成,每个段在任何时间都保持一个清洁针,其通过旋转轴彼此连接。 在任何一个时间都包含所需清洁针的片段相对于从手柄移除的保持器中的其它片段旋转180度,此时保持器插入手柄中,未使用的清洁针面向 手柄。 手柄两端有六边形开口,用于螺丝或螺丝拧紧喷嘴,吸嘴和夹紧套筒。 支架可以插入这些六边形开口之一。 保持器还可以安装有具有所选清洁针可以通过的狭槽的帽。
    • 4. 发明授权
    • Veterinary composition containing thionosalicylic acid anilides or salts
thereof and methods of using the same
    • 含有硫代水杨酸苯胺或其盐的兽药组合物及其使用方法
    • US3966964A
    • 1976-06-29
    • US549689
    • 1975-02-13
    • Jurgen KurzHeinrich KollingManfred Federmann
    • Jurgen KurzHeinrich KollingManfred Federmann
    • A61K31/235
    • New thionosalicylic acid anilides and salts with bases are provided which have parasiticidal activity in sheep and cattle particularly against adult liver flukes in sheep and cattle and other domestic animals, especially against juvenile liver flukes. The new compounds are produced by the reaction of poly-substituted phenols with substituted aromatic isothiocyanates, the hydrolysis products of oxo-thiono- or dithiono-dihydrobenzoxazines or by the reaction of N-phenyl-salicyl-imide chlorides with thio-compounds. Typical compounds are 3,5-dichloro-4'-bromo-thionosalicylic acid anilide and 2-acetoxy-3,5-dichloro-N-(2'-methyl-4'-chlorophenyl)-thionobenzamide. Novel benzoxazines obtainable from the above anilides are also provided and have similar properties. Typical compounds are 3-(3',5'-bis-trifluoromethyl-phenyl)-6,8-dibromo-2-oxo-4-thiono-dihydrobenzoxazine-(1,3), 3-(3',4'-dichlorophenyl)-6,8-dichloro-2,4-dithiono-dihydrobenzoxazine-(1,3) and 3-(4'-bromophenyl)-6-chloro-8-bromo-2,4-dithiono-dihydrobenzoxazine-(1,3). Methods for preparing a large number of both types of compounds are described. The compounds are administered orally or subcutaneously in doses of 2.5 to 100 mg/kg, preferably 5 to 15 mg/kg, of body weight.
    • 提供新的硫羟水杨酸和与碱的盐,其在绵羊和牛中具有杀寄生虫活性,特别是针对羊,牛和其他家畜中的成年肝吸虫,特别是针对幼鱼肝吸虫。 新化合物是通过多取代苯酚与取代的芳族异硫氰酸酯的反应,氧代 - 硫代 - 或二硫代 - 二氢苯并恶嗪的水解产物或N-苯基 - 水杨酰基酰亚胺氯化物与硫代化合物的反应制备的。 典型的化合物是3,5-二氯-4'-溴 - 硫代水杨酸酰苯胺和2-乙酰氧基-3,5-二氯-N-(2'-甲基-4'-氯苯基) - 硫代苯甲酰胺。 还提供了可从上述酰苯胺获得的新型苯并恶嗪并且具有相似的性质。 典型的化合物是3-(3',5'-双 - 三氟甲基 - 苯基)-6,8-二溴-2-氧代-4-硫杂 - 二氢苯并嗪(1,3),3-(3',4' (1,3)和3-(4'-溴苯基)-6-氯-8-溴-2,4-二硫代 - 二氢苯并恶嗪(((2'-二氯苯基)-6,8-二氯-2,4-二硫代二氢苯并恶嗪 - (1,3) 1,3)。 描述了制备大量两种类型化合物的方法。 化合物以2.5至100mg / kg,优选5至15mg / kg体重的剂量口服或皮下给药。