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    • 4. 发明授权
    • Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
    • 氮化杂环衍生物和包含该衍生物作为活性成分的药剂
    • US08003642B2
    • 2011-08-23
    • US12282464
    • 2007-03-09
    • Shinya KusudaToshihiko NishiyamaKazuya HashimuraJunya UedaShiro Shibayama
    • Shinya KusudaToshihiko NishiyamaKazuya HashimuraJunya UedaShiro Shibayama
    • A61K31/5377A61K31/4545C07D413/14C07D401/14
    • C07D401/12C07D401/14C07D417/14C07D419/14
    • The compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof specifically binds CCR5, so it is useful for preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection diabetes cancer metastasis and so on Wherein all symbols in formula are as defined in the specification.
    • 由式(I)表示的化合物,其盐,其N-氧化物,其溶剂合物或其前药特异性结合CCR5,因此其可用于预防和/或治疗CCR5相关疾病,例如各种 炎性疾病(哮喘,肾炎,肾病,肝炎,关节炎,类风湿性关节炎,鼻炎,结膜炎,溃疡性结肠炎等),免疫疾病(器官移植中的自身免疫性疾病,排斥反应,免疫抑制,牛皮癣,多发性硬化症等),感染性 疾病(人体免疫缺陷病毒感染,获得性免疫缺陷综合征等),过敏性疾病(特应性皮炎,荨麻疹,过敏性支气管肺曲霉病,过敏嗜酸性胃肠炎等),缺血再灌注损伤,急性呼吸窘迫综合征,伴随细菌感染糖尿病的休克 癌症转移等等,其中公式中的所有符号如说明书中所定义。