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1. 发明授权

US08220642B2 Polysulfone-based blood treatment membrane and method of producing the same 有权
标题翻译：聚砜类血液处理膜及其制造方法
公开(公告)号：US08220642B2
公开(公告)日：2012-07-17
申请号：US12601543
申请日：2008-05-26
申请人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
发明人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
IPC分类号： B01D69/00 , B01D69/02 , B01D67/00
CPC分类号： B01D71/68 , A61L33/068 , B01D67/0011 , B01D69/141 , B01D2325/00 , B01D2325/24 , C08L81/06
摘要： A polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties, excellent long-term storage stability, and a practical strength, and ensures high productivity, a polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties and long-term storage stability, rarely allows endotoxins to enter a treatment liquid, exhibits a practical strength, and ensures high productivity, and a method of producing the same. A polysulfone-based blood treatment membrane includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant, the membrane containing the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, and the total amount of the lipophilic antioxidant present on the surface of the membrane being 4 to 25 mg per gram of the membrane. Another polysulfone-based blood treatment membrane contains a lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, wherein the inner surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 1.8.times.10.sup.-4 or more, and the outer surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 2.4.times.10.sup.-4 or more. A method of producing a polysulfone-based blood treatment membrane that includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant includes producing a membrane intermediate that contains the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane intermediate, and heating the membrane intermediate at 100 to 180.degree. C. for 0.1 to 360 minutes in a dry state.
摘要翻译：一种聚砜系血液处理膜，其表现出优异的抗氧化性能，优异的长期保存稳定性和实用强度，并且确保高生产率，表现出优异的抗氧化性能和长期保存稳定性的聚砜系血液处理膜，很少允许内毒素进入处理液，具有实用的强度，并且确保高生产率及其制备方法。基于聚砜的血液处理膜包括聚砜系树脂，亲水性聚合物和亲脂性抗氧化剂，每克膜含有30〜76mg的亲脂性抗氧化剂的膜和亲脂性的总量存在于膜表面的抗氧化剂每克膜为4至25mg。

2. 发明申请

US20140158611A1 HOLLOW-FIBER MEMBRANE BLOOD PURIFICATION DEVICE 审中-公开
标题翻译：中空纤维膜血液净化装置
公开(公告)号：US20140158611A1
公开(公告)日：2014-06-12
申请号：US14233239
申请日：2012-06-20
申请人： Junya Satoh , Kumiko Sekine
发明人： Junya Satoh , Kumiko Sekine
IPC分类号： A61M1/16 , B01D71/58 , B01D69/08 , B01D71/68
CPC分类号： A61M1/16 , B01D65/022 , B01D67/0088 , B01D69/02 , B01D69/08 , B01D71/38 , B01D71/44 , B01D71/48 , B01D71/58 , B01D71/68 , B01D2323/12 , B01D2325/28 , B01D2325/30
摘要： (Problem to be Solved)To obtain a hollow-fiber membrane blood purification device having excellent blood compatibility and antioxidative performance and highly stable antioxidative performance under severe environments.(Solution)A hollow-fiber membrane blood purification device provided with a hollow-fiber membrane containing a polysulfone-based resin, a polyvinyl pyrrolidone, a fat-soluble vitamin and a polymer having an ester group, in which an abundance of the fat-soluble vitamin on all surfaces of the hollow-fiber membrane is 2 mg or more and 18 mg or less based on 1 g of the hollow-fiber membrane, when the hollow-fiber membrane is extracted with ethanol, an extract is dried and subjected to measurement of an infrared absorption spectrum (IR), a ratio of absorbance (Abs(A)) of peak A in a vicinity of 1720 to 1730 cm−1 to absorbance (Abs(B)) of peak B in a vicinity of 1660 to 1670 cm−1, (Abs(A)/Abs(B)), is 0.01 or more and 0.3 or less, and a moisture content of the hollow-fiber membrane is 0 mass % or more and 600 mass % or less.
摘要翻译：（待解决的问题）获得在恶劣环境下具有优异的血液相容性和抗氧化性能以及高度稳定的抗氧化性能的中空纤维膜血液净化装置。（溶液）具有含有聚砜系树脂，聚乙烯吡咯烷酮，脂溶性维生素和具有酯基的聚合物的中空纤维膜的中空纤维膜血液净化装置，其中，当中空纤维膜用乙醇萃取时，中空纤维膜的所有表面上的可溶性维生素在1克中空纤维膜上为2mg以上至18mg以下，提取物干燥，红外吸收光谱（IR）的测定，峰值A在1720〜1730cm -1附近的吸光度（Abs（A））与吸光度（Abs（B））的吸光度（Abs（B））在1660〜 1670cm -1，（Abs（A）/ Abs（B））为0.01以上且0.3以下，中空纤维膜的水分含量为0质量％以上至600质量％以下。

3. 发明申请

US20110158863A1 HOLDING MATERIAL FOR CATALYTIC CONVERTER 审中-公开
标题翻译：保温材料用于催化转化器
公开(公告)号：US20110158863A1
公开(公告)日：2011-06-30
申请号：US12979540
申请日：2010-12-28
申请人： Nobuya TOMOSUE , Kazutoshi Isomura , Junya Satoh
发明人： Nobuya TOMOSUE , Kazutoshi Isomura , Junya Satoh
IPC分类号： B01J8/06
CPC分类号： F01N3/2853 , F01N2450/28
摘要： The present invention relates to a holding material for a catalytic converter containing a catalyst carrier, a metal casing for receiving the catalyst carrier, and the holding material wound around the catalyst carrier and interposed in a gap between the catalyst carrier and the metal casing, in which the holding material contains an organic substrate and a protective film having a plurality of pores, and the protective film is joined to a metal casing-side surface of the substrate.
摘要翻译：本发明涉及一种用于催化转化器的保持材料，其包含催化剂载体，用于接收催化剂载体的金属壳体和缠绕在催化剂载体上的保持材料，并置于催化剂载体和金属壳体之间的间隙中所述保持材料含有有机基材和具有多个孔的保护膜，所述保护膜与所述基板的金属壳体侧面接合。

4. 发明申请

US20100133170A1 POLYSULFONE-BASED BLOOD TREATMENT MEMBRANE AND METHOD OF PRODUCING THE SAME 有权
标题翻译：基于聚合物的血液处理膜及其制造方法
公开(公告)号：US20100133170A1
公开(公告)日：2010-06-03
申请号：US12601543
申请日：2008-05-26
申请人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
发明人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
IPC分类号： B01D71/68 , C08J5/00 , B29C47/00 , D04H3/16 , B01D69/08 , B01D67/00 , B01D69/02
CPC分类号： B01D71/68 , A61L33/068 , B01D67/0011 , B01D69/141 , B01D2325/00 , B01D2325/24 , C08L81/06
摘要： A polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties, excellent long-term storage stability, and a practical strength, and ensures high productivity, a polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties and long-term storage stability, rarely allows endotoxins to enter a treatment liquid, exhibits a practical strength, and ensures high productivity, and a method of producing the same. A polysulfone-based blood treatment membrane includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant, the membrane containing the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, and the total amount of the lipophilic antioxidant present on the surface of the membrane being 4 to 25 mg per gram of the membrane. Another polysulfone-based blood treatment membrane contains a lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, wherein the inner surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 1.8×10−4 or more, and the outer surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 2.4×10−4 or more. A method of producing a polysulfone-based blood treatment membrane that includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant includes producing a membrane intermediate that contains the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane intermediate, and heating the membrane intermediate at 100 to 180° C. for 0.1 to 360 minutes in a dry state.
摘要翻译：一种聚砜系血液处理膜，其表现出优异的抗氧化性能，优异的长期保存稳定性和实用强度，并且确保高生产率，表现出优异的抗氧化性能和长期保存稳定性的聚砜系血液处理膜，很少允许内毒素进入处理液，具有实用的强度，并且确保高生产率及其制备方法。基于聚砜的血液处理膜包括聚砜系树脂，亲水性聚合物和亲脂性抗氧化剂，每克膜含有30〜76mg的亲脂性抗氧化剂的膜和亲脂性的总量存在于膜表面的抗氧化剂每克膜为4至25mg。另一种基于聚砜的血液处理膜包含每克膜30至76mg的亲脂性抗氧化剂，其中膜的内表面具有1.8×10-4的亲脂性抗氧化剂的TOF-SIMS归一化峰强度以上，膜的外表面的亲油性抗氧化剂的TOF-SIMS归一化峰强度为2.4×10 -4以上。包含聚砜系树脂，亲水性聚合物和亲脂性抗氧化剂的聚砜系血液处理膜的制造方法包括：制造含有亲油性抗氧化剂的膜中间体，其含量为每克膜30〜76mg 中间体，并在100〜180℃下加热膜中间体0.1〜360分钟。

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