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1. 发明申请

US20110318336A1 Identification and Treatment of Aggressive Lung Cancer Tumors 审中-公开
标题翻译：侵袭性肺癌肿瘤的鉴别与治疗
公开(公告)号：US20110318336A1
公开(公告)日：2011-12-29
申请号：US13075163
申请日：2011-03-29
申请人： Emanuel Petricoin, III , Julia Wulfkuhle , Angela Zupa
发明人： Emanuel Petricoin, III , Julia Wulfkuhle , Angela Zupa
IPC分类号： A61K39/395 , A61K31/517 , A61P35/00 , A61K31/506 , A61K31/404 , C40B40/10 , C40B30/04 , A61K31/5377
CPC分类号： G01N33/6884 , A61K31/00 , G01N33/57423 , G01N2800/02
摘要： This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a likelihood of a poor overall survival. The method comprises the step of determining if one or more of certain identified proteins are activated in tumor cells obtained from the patient's tumor, wherein the activation of one or more of the proteins indicates that the patient has an aggressive N0 tumor and is likely to have a poor overall-survival. The invention also provides a method for selecting a treatment for an NSCLC patient with an N0 tumor and a method for treating such patients. It further provides a kit for identifying an NSCLC patient with an aggressive N0 tumor and a likelihood of a poor overall survival and a pharmaceutical composition for treating such patients.
摘要翻译：本发明涉及患者侵袭性肺癌肿瘤的鉴别和治疗。更具体地，其提供了鉴定具有侵袭性淋巴结阴性（N0）肿瘤和总生存差的可能性的非小细胞肺癌（NSCLC）患者的方法。该方法包括确定某些鉴定的蛋白质中的一种或多种是否在从患者肿瘤获得的肿瘤细胞中被活化的步骤，其中一种或多种蛋白质的活化指示患者具有侵略性的N0肿瘤并且可能具有总体生存差本发明还提供了用于选择具有N0肿瘤的NSCLC患者的治疗方法和用于治疗这种患者的方法。它进一步提供了一种用于鉴定具有侵袭性N0肿瘤的NSCLC患者和总体存活差的可能性的试剂盒和用于治疗这种患者的药物组合物。

2. 发明申请

US20130344062A1 Identification and Treatment of Aggressive Lung Cancer Tumors 审中-公开
标题翻译：侵袭性肺癌肿瘤的识别与治疗
公开(公告)号：US20130344062A1
公开(公告)日：2013-12-26
申请号：US13841749
申请日：2013-03-15
申请人： Emanuel Petricoin, III , Julia Wulfkuhle , Angela Zupa
发明人： Emanuel Petricoin, III , Julia Wulfkuhle , Angela Zupa
IPC分类号： G01N33/68
CPC分类号： G01N33/6884 , A61K31/00 , G01N33/57423 , G01N2800/02
摘要： This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a likelihood of a poor overall survival. The method comprises the step of determining if one or more of certain identified proteins are activated in tumor cells obtained from the patient's tumor, wherein the activation of one or more of the proteins indicates that the patient has an aggressive N0 tumor and is likely to have a poor overall-survival. The invention also provides a method for selecting a treatment for an NSCLC patient with an N0 tumor and a method for treating such patients. It further provides a kit for identifying an NSCLC patient with an aggressive N0 tumor and a likelihood of a poor overall survival and a pharmaceutical composition for treating such patients.
摘要翻译：本发明涉及患者侵袭性肺癌肿瘤的鉴别和治疗。更具体地，其提供了鉴定具有侵袭性淋巴结阴性（N0）肿瘤和总生存差的可能性的非小细胞肺癌（NSCLC）患者的方法。该方法包括确定某些鉴定的蛋白质中的一种或多种是否在从患者肿瘤获得的肿瘤细胞中被活化的步骤，其中一种或多种蛋白质的活化指示患者具有侵略性的N0肿瘤并且可能具有总体生存差本发明还提供了用于选择具有N0肿瘤的NSCLC患者的治疗方法和用于治疗这种患者的方法。它进一步提供了一种用于鉴定具有侵袭性N0肿瘤的NSCLC患者和总体存活差的可能性的试剂盒和用于治疗这种患者的药物组合物。

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