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1. 发明申请

US20120105791A1 POLYMER-DOPED VERTICALLY-ALIGNED NEMATIC LIQUID CRYSTALS 有权
标题翻译：聚合物垂直垂直对称的液体液晶
公开(公告)号：US20120105791A1
公开(公告)日：2012-05-03
申请号：US13194297
申请日：2011-07-29
申请人： Julia A. Kornfield , Michael Wand , Zuleikha Kurji
发明人： Julia A. Kornfield , Michael Wand , Zuleikha Kurji
IPC分类号： C09K19/02 , C09K19/46 , C09K19/44 , C09K19/42
CPC分类号： C09K19/3847 , C09K19/3003 , C09K19/3842 , C09K19/406 , C09K2019/3004 , C09K2019/3009 , C09K2019/301 , C09K2019/3016
摘要： A system having a vertically-aligned negative delta E nematic liquid crystal host material and a small amount of liquid crystal polymer is provided. The liquid crystal polymer improves the switching speed of a vertically aligned nematic system without sacrificing contrast or viewing angle.
摘要翻译：提供具有垂直排列的负ΔE向列型液晶主体材料和少量液晶聚合物的系统。液晶聚合物改善垂直排列的向列系统的切换速度，而不牺牲对比度或视角。

2. 发明申请

US20100220279A1 FERROELECTRIC LIQUID CRYSTAL (FLC) POLYMERS 有权
标题翻译：电解液晶（FLC）聚合物
公开(公告)号：US20100220279A1
公开(公告)日：2010-09-02
申请号：US12695338
申请日：2010-01-28
申请人： Julia A. Kornfield , Michael Wand , Zuleikha Kurji
发明人： Julia A. Kornfield , Michael Wand , Zuleikha Kurji
IPC分类号： G02F1/1343 , C09K19/06 , C09K19/20 , C09K19/30 , C09K19/32 , C09K19/34
CPC分类号： C09K19/0225 , C09K19/3842 , C09K19/406 , G02F1/13725 , G02F1/141 , Y10T428/10 , Y10T428/1036
摘要： A system having a ferroelectric liquid host material and a small amount of polymer additive is provided. In an embodiment, the polymer additive improves the physical characteristics of the system. In an embodiment, the system can be used in FLC applications.
摘要翻译：提供具有铁电液体主体材料和少量聚合物添加剂的体系。在一个实施方案中，聚合物添加剂改善了体系的物理特性。在一个实施例中，该系统可用于FLC应用。

3. 发明授权

US4948728A Monolith reactor containing a plurality of flow passages and method for carrying out biological reactions 失效
标题翻译：包含多个流动通道的整体反应器和进行生物反应的方法
公开(公告)号：US4948728A
公开(公告)日：1990-08-14
申请号：US166258
申请日：1988-03-10
申请人： Gregory Stephanopoulos , Julia A. Kornfield , Gerald E. Voecks
发明人： Gregory Stephanopoulos , Julia A. Kornfield , Gerald E. Voecks
IPC分类号： C12M1/40
CPC分类号： C12M47/10 , C12M23/20 , C12M23/24 , C12M29/04 , Y10S435/813 , Y10S435/818
摘要： Biological reactions are carried out with a unitary structure, preferably formed of a ceramic material, having a plurality of flow passages including first and second sets of flow passages arranged so that individual passages of the first set are adjacent individual passages of the second set and are separated by walls formed of the ceramic material. The ceramic material is porous to provide mass transfer of gaseous oxygen and biological reaction products while containing liquid in the second set of passages. Walls of the passages may be covered with a gaseous oxygen permeable membrane. Inside walls of the second set of passages may coated with a compound adapted to immobilize biological reaction materials. In a biological reaction, the first set of passages are contacted with a fluid such as an air stream to provide gaseous oxygen, and a fluid flow such as a nutrient medium is established through the second set of flow passages whereby an oxygen flow producing gradient is produced through the porous ceramic material between the first and second sets of flow passages to supply oxygen for cells immobilized on inside walls of the second set of flow passages.
摘要翻译：生物反应采用整体结构进行，优选由陶瓷材料形成，其具有多个流动通道，其包括第一组和第二组流动通道，其布置成使得第一组的各个通道相邻于第二组的各个通道，并且分别是由陶瓷材料形成的壁分隔开。陶瓷材料是多孔的，以提供气态氧和生物反应产物的质量传递，同时在第二组通道中含有液体。通道的壁可以用气体氧气渗透膜覆盖。第二组通道的内壁可涂覆有适于固定生物反应材料的化合物。在生物反应中，第一组通道与诸如空气流的流体接触以提供气态氧，并且通过第二组流动通道建立流体流如营养培养基，由此产生氧气的梯度为通过第一组和第二组流动通道之间的多孔陶瓷材料产生，以便为固定在第二组流动通道的内壁上的细胞供应氧气。

4. 发明授权

US08283438B2 Functionalized polymers using protected thiols 有权
标题翻译：使用受保护的硫醇的官能化聚合物
公开(公告)号：US08283438B2
公开(公告)日：2012-10-09
申请号：US12961136
申请日：2010-12-06
申请人： Ralph L. David , Julia A. Kornfield
发明人： Ralph L. David , Julia A. Kornfield
IPC分类号： C08C2/04
CPC分类号： C07C327/32 , C07C319/02 , C07D209/86 , C07D213/32 , C07D213/59 , Y02P20/55 , C07C323/12
摘要： A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided. The methods may be used to make functional polymers and other molecules. The method of making a functionalized polymer using a thiol-ene reaction comprises: providing a functionalized thioester having the following formula: wherein R is a functional group and COR′ is a protecting group; cleaving the functionalized thioester, forming a functional thiol and an acyl group; providing a polymer having a pendant vinyl group; and reacting the polymer with the functional thiol whereby a functionalized polymer is formed, wherein the functional thiol is not isolated prior to reacting with the polymer.
摘要翻译：提供了使用硫醇 - 烯偶联反应制备功能分子的方法和制备受保护的官能硫醇，特别是硫酯的方法。该方法可用于制备功能性聚合物和其它分子。使用硫醇 - 烯反应制备官能化聚合物的方法包括：提供具有下式的官能化硫酯：其中R是官能团，COR'是保护基; 切断官能化硫酯，形成功能硫醇和酰基; 提供具有乙烯基侧基的聚合物; 并使聚合物与官能硫醇反应，由此形成官能化聚合物，其中功能性硫醇在与聚合物反应之前不分离。

5. 发明申请

US20110217262A1 Treatment of Ocular Surface Disorders by Increasing Conjunctival Vascular Permeability 审中-公开
标题翻译：通过增加结膜血管通透性治疗眼表疾病
公开(公告)号：US20110217262A1
公开(公告)日：2011-09-08
申请号：US13042437
申请日：2011-03-07
申请人： Julia A. Kornfield , Robert H. Grubbs , Choon Woo Lee , Daniel Schwartz , Phoebe Lin , Keith Duncan
发明人： Julia A. Kornfield , Robert H. Grubbs , Choon Woo Lee , Daniel Schwartz , Phoebe Lin , Keith Duncan
IPC分类号： A61K38/20 , A61K31/522 , A61K31/417 , A61K31/4045 , A61K38/18 , A61K38/02 , A61K31/685 , A61K38/19 , A61K31/7076 , A61K31/265 , A61K31/235 , C12Q1/02 , C07C69/96 , A61K31/27 , A61P27/02
CPC分类号： A61K31/235 , A61K31/265 , A61K31/27 , A61K31/4045 , A61K31/417 , A61K31/522 , A61K31/685 , A61K31/7076 , A61K38/02 , A61K38/18 , A61K38/19 , A61K38/20 , C07C69/96 , C12Q1/02
摘要： A method of treating an ocular surface disorder in a subject in need of such treatment is provided. The method includes exposing conjunctival tissue of the subject to an effective amount of a vasopermeability agent that increases conjunctival vascular permeability. In some embodiments, the agent is a nitric oxide donor, which may be in a sustained release form. A method of screening a substance for treating an ocular surface disorder is also provided.
摘要翻译：提供了一种治疗需要这种治疗的受试者的眼表疾病的方法。该方法包括将受试者的结膜组织暴露于有效量的增加结膜血管通透性的血管通透性试剂。在一些实施方案中，所述试剂是可以是持续释放形式的一氧化氮供体。还提供了筛选用于治疗眼表疾病的物质的方法。

6. 发明授权

US07837326B2 Lenses capable of post-fabrication power modification 有权
公开(公告)号：US07837326B2
公开(公告)日：2010-11-23
申请号：US11454472
申请日：2006-06-16
申请人： Jagdish M. Jethmalani , Daniel M. Schwartz , Julia A. Kornfield , Robert H. Grubbs , Christian A. Sandstedt
发明人： Jagdish M. Jethmalani , Daniel M. Schwartz , Julia A. Kornfield , Robert H. Grubbs , Christian A. Sandstedt
IPC分类号： A61B3/00
CPC分类号： G02B3/00 , A61F2/1627 , A61F2/1635 , A61L27/18 , A61L2430/16 , G02B1/043 , G02C7/04 , G02C2202/14 , C08L83/04
摘要： The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.

7. 发明申请

US20080114283A1 PHOTOCHEMICAL THERAPY TO AFFECT MECHANICAL AND/OR CHEMICAL PROPERTIES OF BODY TISSUE 有权
标题翻译：影响身体组织的机械和/或化学特性的光化学治疗
公开(公告)号：US20080114283A1
公开(公告)日：2008-05-15
申请号：US11923575
申请日：2007-10-24
申请人： Matthew S. Mattson , Julia A. Kornfield , Daniel M. Schwartz , Robert K. Maloney
发明人： Matthew S. Mattson , Julia A. Kornfield , Daniel M. Schwartz , Robert K. Maloney
IPC分类号： A61M5/00
CPC分类号： A61K9/0048 , A61F9/0079 , A61F9/008 , A61F2009/00865 , A61F2009/00872 , A61F2009/00893 , A61K9/0051 , A61K9/19 , A61K31/00
摘要： The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.
摘要翻译：本公开涉及改变身体组织，特别是眼组织的机械和/或化学性质。在具体情况下，它涉及改变或稳定角膜的形状，例如患有或具有扩张或圆锥角膜风险的受试者。在其他具体情况下，它涉及加强遭受或面临近视眼的受试者的巩膜。本发明使用例如对组织进行交联的可光活化化合物的光照射。

8. 发明授权

US07241009B2 Crosslinking of silicones presence of functionalized silicones 有权
标题翻译：有机硅交联存在官能化硅氧烷
公开(公告)号：US07241009B2
公开(公告)日：2007-07-10
申请号：US10871686
申请日：2004-06-17
申请人： Julia A. Kornfield , Robert H. Grubbs , Shiao H. Chang , Jagdish M. Jethmalani
发明人： Julia A. Kornfield , Robert H. Grubbs , Shiao H. Chang , Jagdish M. Jethmalani
IPC分类号： G02C7/02
CPC分类号： A61F2/1613 , A61F2/16 , A61F2/1627 , A61F2/1635 , A61F2002/1699 , B29D11/00442 , B29D11/023 , G02B1/043 , G02C2202/14 , C08L83/04
摘要： Methods and materials are disclosed for the production of optical elements, in particular intraocular lenses (IOL) that incorporate any amount (0 to 99%) of refraction and/or shape modulating compound into a substantially crosslinked first polymeric matrix. The materials produced according to the inventive methods exhibit certain rheological parameters useful in defining medical lenses. These medical lenses have the ability to change their refractive power via changing the refractive index and/or by altering the shape by stimulus induced polymerization.
摘要翻译：公开了用于生产光学元件的方法和材料，特别是将任何量（0至99％）的折射和/或形状调节化合物掺入基本交联的第一聚合物基质中的眼内透镜（IOL）。根据本发明方法生产的材料表现出用于定义医用透镜的某些流变参数。这些医用透镜具有通过改变折射率和/或通过刺激诱导聚合来改变形状而改变它们的屈光力的能力。

9. 发明授权

US07210783B2 Lenses capable of post-fabrication power modification 失效
标题翻译：能够进行后制造功率修改的镜头
公开(公告)号：US07210783B2
公开(公告)日：2007-05-01
申请号：US10175552
申请日：2002-06-18
申请人： Jagdish M. Jethmalani , Daniel M. Schwartz , Julia A. Kornfield , Robert H. Grubbs , Christian A. Sandstedt
发明人： Jagdish M. Jethmalani , Daniel M. Schwartz , Julia A. Kornfield , Robert H. Grubbs , Christian A. Sandstedt
IPC分类号： A61B3/00
CPC分类号： G02B3/00 , A61F2/1627 , A61F2/1635 , A61L27/18 , A61L2430/16 , G02B1/043 , G02C7/04 , G02C2202/14 , C08L83/04
摘要： The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.
摘要翻译：本发明涉及能够进行后制造功率修改的透镜。通常，本发明的镜片包括（i）第一聚合物基质和（ii）能够刺激诱导的聚合分散在其中的折射调节组合物。当透镜的至少一部分暴露于适当的刺激时，折射调节组合物形成第二聚合物基质。第二聚合物基质的量和位置可以通过改变其折射率和/或通过改变其形状来改变诸如透镜功率的透镜特性。本发明的镜片在电子和医疗领域中有许多应用，分别作为数据存储装置和医疗镜片，特别是眼内透镜。

10. 发明授权

US07192629B2 Devices utilizing self-assembled gel and method of manufacture 有权
标题翻译：使用自组装凝胶的设备和制造方法
公开(公告)号：US07192629B2
公开(公告)日：2007-03-20
申请号：US10269475
申请日：2002-10-11
申请人： Rob G. H. Lammertink , Todd Thorsen , Stephen R. Quake , Julia A. Kornfield
发明人： Rob G. H. Lammertink , Todd Thorsen , Stephen R. Quake , Julia A. Kornfield
IPC分类号： B29D23/00
CPC分类号： B29D23/00 , G01N27/44704 , G01N27/44747 , G01N27/44791 , Y10T428/1352 , Y10T428/139 , Y10T428/31663
摘要： Devices such as capillaries for capillary electrophoresis are formed by contacting a gel precursor with a substrate comprising a permeable material that has higher permeability for organic solvents than water. The gel precursor is made of a water soluble polymer having hydrophobic moieties in a solvent mixture comprising water and an organic solvent, wherein in the absence of the organic solvent, the polymer forms a self-assembled gel. The organic solvent is allowed to permeate through the permeable material resulting in the formation of the self-assembled gel.
摘要翻译：用于毛细管电泳的毛细管的装置通过使凝胶前体与包含对水的有机溶剂具有较高渗透性的渗透性材料的底物接触来形成。凝胶前体由在水和有机溶剂的溶剂混合物中具有疏水部分的水溶性聚合物制成，其中在不存在有机溶剂的情况下，聚合物形成自组装凝胶。允许有机溶剂透过可渗透材料，从而形成自组装凝胶。

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