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1. 发明授权

US5171688A Self-corrected assay device 失效
标题翻译：自我校正测试装置
公开(公告)号：US5171688A
公开(公告)日：1992-12-15
申请号：US396326
申请日：1989-08-23
申请人： Gary E. Hewett , Steven T. Mielke , Judith A. Blunt
发明人： Gary E. Hewett , Steven T. Mielke , Judith A. Blunt
IPC分类号： C12Q1/60 , G01N33/52 , C12M1/36 , G01N21/00
CPC分类号： G01N33/525 , C12Q1/60 , Y10T436/104165
摘要： An assay device and method for determining the concentration of an analyte in a fluid sample. The device includes a porous-matrix reservoir which receives the sample to be assayed, and at least two reaction zones into which sample fluid is drawn from the reservoir. In an embodiment containing two reaction zones, a single-point standard curve which corrects for reduced-signal effects related to loss of reagent activity and linear inhibition effects, is used to determine analyte concentration. In an embodiment containing three reaction zones, a two-point standard curve which corrects for reduced-signal effects related loss of reagent activity and non-linear inhibition effects, is used to determine analyte concentration. Also disclosed is an apparatus which uses the device for automated or semi-automated analyte assay.
摘要翻译：用于确定流体样品中分析物浓度的测定装置和方法。该装置包括接收要测定的样品的多孔基质储存器和从储存器抽取样品流体的至少两个反应区。在包含两个反应区的实施方案中，使用校正与试剂活性丧失和线性抑制作用相关的降低信号效应的单点标准曲线来确定分析物浓度。在包含三个反应区的实施方案中，使用校正减少的信号效应相关的试剂活性丧失和非线性抑制作用的两点标准曲线来确定分析物浓度。还公开了一种使用该装置进行自动或半自动分析物测定的装置。

2. 发明授权

US4777245A Non-human primate monoclonal antibodies and methods 失效
标题翻译：非人灵长类动物单克隆抗体和方法
公开(公告)号：US4777245A
公开(公告)日：1988-10-11
申请号：US767213
申请日：1985-08-19
申请人： Steven K. H. Foung , Judith A. Blunt , Linda B. Rabin , F. Carl Grumet , Edgar G. Engleman
发明人： Steven K. H. Foung , Judith A. Blunt , Linda B. Rabin , F. Carl Grumet , Edgar G. Engleman
IPC分类号： C07K16/08 , C07K16/34 , C12N5/12 , C12N5/26 , C12N15/02 , G01N33/569 , G01N33/80 , C07K15/00 , A61K39/42 , A61K39/44 , C12N5/00
CPC分类号： C07K16/088 , C07K16/08 , C07K16/34 , C12N15/02 , C12N5/12 , C12N5/166 , G01N33/569 , G01N33/56983 , G01N33/80 , Y10S435/948 , Y10S530/864
摘要： A stable trioma cell line capable of secreting a non-human primate monoclonal antibody specific against a selected antigen. An exemplary cell line secretes chimpanzee monoclonal antibody specific against an antigen associated with hepatitis nonA/nonB infection. The cell line is produced, in the method of the invention, by isolating lymphocytes from a primate immunized with the selected antigen, and immortalizing the lymphocytes by fusion with a stable, non-antibody-secreting murine myeloma/human hybridoma cell line having selected-for human characteristics. The trioma fusion products are selected for secretion of the desired antibody, which has a variety of diagnostic and/or therapeutic uses.
摘要翻译：能够分泌针对所选择的抗原特异性的非人灵长类动物单克隆抗体的稳定的三瘤细胞系。一个示例性细胞系分泌针对与非肝/非B型肝炎感染相关的抗原特异性的黑猩猩单克隆抗体。在本发明的方法中，通过从用所选择的抗原免疫的灵长类动物中分离淋巴细胞，并且通过与具有选定抗原的稳定的非抗体分泌的鼠骨髓瘤/人杂交瘤细胞系融合来使淋巴细胞永生化，为人的特点。选择三瘤融合产物用于分泌具有各种诊断和/或治疗用途的所需抗体。

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