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    • 6. 发明授权
    • Aryloxy-alkyl-dialkylamines
    • 芳氧基 - 烷基 - 二烷基胺
    • US06242605B1
    • 2001-06-05
    • US09458316
    • 1999-12-10
    • Panolil RaveendranathJoseph ZeldisGalina VidJohn R. PotoskiJianxin RenSilvio Iera
    • Panolil RaveendranathJoseph ZeldisGalina VidJohn R. PotoskiJianxin RenSilvio Iera
    • C07D23702
    • C07D295/088C07C217/48
    • The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: wherein: R1 and R2 are, independently, selected from H; C1-C12 alkyl or C1-C6 perfluorinated alkyl; X represents a leaving group; A is 0 or S; m is an integer from 1 to 3, preferably 2; R3, R4, R5, and R6 are independently selected from H, halogen, —NO2, alkyl, alkoxy, C1-C6 perfluorinated alkyl, OH or the C1-C4 esters or alkyl ethers thereof, —CN, —O—R1, —O—Ar, —S—R1, —S—Ar, —SO—R1, —SO—Ar, —SO2—R1, —SO2—Ar, —CO—R1, —CO—Ar, —CO2—R1, or —CO2—Ar; and Y is selected from a) the moiety: wherein R7 and R8 are independently selected from the group of H, C1-C6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of —O—, —NH—, —N(C1C4 alkyl)—, —N═, and —S(O)n—.
    • 本发明提供了可用于合成生物活性化合物的化合物及其制备方法,具有下式的化合物:其中:R 1和R 2独立地选自H; C1-C12烷基或C1-C6全氟化烷基; X表示离去基团; A为0或S; m为1〜3的整数,优选为2; R 3,R 4,R 5和R 6独立地选自H,卤素,-NO 2,烷基,烷氧基,C 1 -C 6全氟烷基,OH或其C 1 -C 4酯或其烷基醚,-CN,-O-R 1, O-Ar,-S-R 1,-S-Ar,-SO-R 1,-SO-Ar,-SO 2 -R 1,-SO 2 -Ar,-CO-R 1,-CO-Ar,-CO 2 -R -CO 2 -Ar; 并且Y选自a)部分:其中R 7和R 8独立地选自H,C 1 -C 6烷基或苯基; 或b)任选取代的五元,六元或七元饱和的不饱和或部分不饱和的杂环或双环杂环,其含有至多两个选自-O - , - NH - , - N(C 1 -C 4烷基) - , - N =和-S(O)n - 。