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1. 发明授权

US07145645B2 Imaging of biological samples using electronic light detector 有权
公开(公告)号：US07145645B2
公开(公告)日：2006-12-05
申请号：US09852375
申请日：2001-05-10
申请人： Martin Blumenfeld , Mark A. Sanders , Joseph J. Talghader , Jesse R. Grenz
发明人： Martin Blumenfeld , Mark A. Sanders , Joseph J. Talghader , Jesse R. Grenz
IPC分类号： G01N21/03
CPC分类号： G06T1/0007 , B01J2219/00529 , B01J2219/00702
摘要： A system and method using an electronic light detector array, e.g., a CCD or a CMOS-based detector array, is used to acquire a visual image of a biological sample that includes biological material associated with a biological material holding structure (e.g., a DNA spot array on a DNA chip, protein bands in a 2-D gel, etc.). For example, fluorescence from a biological sample may be detected.

2. 发明申请

US20110240860A1 DETECTION BEYOND THE STANDARD RADIATION NOISE LIMIT USING SPECTRALLY SELECTIVE ABSORPTION 有权
标题翻译：使用分辨率选择吸收的标准辐射噪声限制之外的检测
公开(公告)号：US20110240860A1
公开(公告)日：2011-10-06
申请号：US12996704
申请日：2009-05-29
申请人： Joseph J. Talghader , Ryan P. Shea , Anand S. Gawarikar
发明人： Joseph J. Talghader , Ryan P. Shea , Anand S. Gawarikar
IPC分类号： G01J5/20 , G01J5/02
CPC分类号： G01J5/02 , G01J5/023 , G01J5/04 , G01J5/046 , G01J5/08 , G01J5/0853
摘要： High sensitivity thermal detectors that perform beyond the blackbody radiation noise limit are described. Thermal detectors, as described herein, use spectrally selective materials that absorb strongly in the wavelength region of the desired signal but only weakly or not at all in the primary thermal emission band. Exemplary devices that can be made in accordance with the present invention include microbolometers containing semiconductors that absorb in the MWIR and/or THz range but not the LWIR.
摘要翻译：描述超高于黑体辐射噪声极限的高灵敏度热探测器。如本文所述的热检测器使用光谱选择性材料，其在所需信号的波长区域中强烈吸收，但仅在初级热发射带中仅弱或不完全吸收。可以根据本发明制造的示例性装置包括含有在MWIR和/或THz范围内而不是LWIR吸收的半导体的微伏热计。

3. 发明授权

US06867851B2 Scanning of biological samples 有权
标题翻译：扫描生物样品
公开(公告)号：US06867851B2
公开(公告)日：2005-03-15
申请号：US10211113
申请日：2002-08-02
申请人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders , Scott A. Nelson , Kraig Anderson , Steven A. Lewis
发明人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders , Scott A. Nelson , Kraig Anderson , Steven A. Lewis
IPC分类号： C12N20060101 , G01N21/00 , G01N21/03 , G01N21/64 , G02B21/06 , G02B21/16
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2021/6484 , G02B21/06 , G02B21/16
摘要： An image detection apparatus comprises a light source and a holding apparatus adapted to hold a substrate on which a biological sample may be mounted. Light from the light source impinges on the biological sample and causes light that is representative of the sample to be emitted from the sample. A light detector is positioned in the path of the emitted light and is scanned across the emitted light. The emitted light may be focused on the light detector with an optical assembly. The emitted light may be generated by chromophores on probes in the biological sample.
摘要翻译：图像检测装置包括光源和适于保持其上可以安装生物样品的基底的保持装置。来自光源的光照射在生物样品上并导致代表样品的光从样品中发射出来。光检测器位于发射光的路径中，并在发射的光线上扫描。发射的光可以用光学组件聚焦在光检测器上。发射的光可以由生物样品中的探针上的发色团产生。

4. 发明授权

US08704179B2 Detection beyond the standard radiation noise limit using reduced emissivity and optical cavity coupling 有权
标题翻译：使用降低的发射率和光学腔耦合来检测超出标准辐射噪声极限
公开(公告)号：US08704179B2
公开(公告)日：2014-04-22
申请号：US12726776
申请日：2010-03-18
申请人： Joseph J. Talghader
发明人： Joseph J. Talghader
IPC分类号： G01J5/00 , G01J5/20
CPC分类号： G01J5/20 , A61B17/00234 , A61B17/205 , A61B17/3478 , A61B2017/00247 , A61B2017/00876 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M5/32 , A61M2025/0086 , A61M2025/0087 , G01J5/061
摘要： The present invention provides thermal detectors having an optical cavity that is optimized to couple light into a sensor. Light that is on resonance is coupled with the sensor with as high as 100% efficiency, while light off resonance is substantially reflected away. Light that strikes the sensor from the sides (i.e. not on the optical cavity axis) only interacts minimally with sensor because of the reduced absorption characteristics of the sensor. Narrowband sensors in accordance with the present invention can gain as much as 100% of the signal from one direction and spectral band, while receiving only a fraction of the normal radiation noise, which originates from all spectral bands and directions.
摘要翻译：本发明提供具有光学腔的热探测器，该光学腔被优化以将光耦合到传感器中。谐振的光与传感器耦合高达100％的效率，而光的共振基本上被反射出来。由于传感器的吸收特性的降低，从侧面（即不在光学腔轴线）上撞击传感器的光只能与传感器最小化。根据本发明的窄带传感器可以从一个方向和频谱带获得多达100％的信号，同时仅接收来自所有频谱带和方向的正常辐射噪声的一部分。

5. 发明授权

US08629398B2 Detection beyond the standard radiation noise limit using spectrally selective absorption 有权
标题翻译：使用光谱选择性吸收检测超出标准辐射噪声极限
公开(公告)号：US08629398B2
公开(公告)日：2014-01-14
申请号：US12996704
申请日：2009-05-29
申请人： Joseph J. Talghader , Ryan P. Shea , Anand S. Gawarikar
发明人： Joseph J. Talghader , Ryan P. Shea , Anand S. Gawarikar
IPC分类号： G01J5/20 , G01J5/02
CPC分类号： G01J5/02 , G01J5/023 , G01J5/04 , G01J5/046 , G01J5/08 , G01J5/0853
摘要： High sensitivity thermal detectors that perform beyond the blackbody radiation noise limit are described. Thermal detectors, as described herein, use spectrally selective materials that absorb strongly in the wavelength region of the desired signal but only weakly or not at all in the primary thermal emission band. Exemplary devices that can be made in accordance with the present invention include microbolometers containing semiconductors that absorb in the MWIR and/or THz range but not the LWIR.
摘要翻译：描述超高于黑体辐射噪声极限的高灵敏度热探测器。如本文所述的热检测器使用光谱选择性材料，其在所需信号的波长区域中强烈吸收，但仅在初级热发射带中仅弱或不完全吸收。可以根据本发明制造的示例性装置包括含有在MWIR和/或THz范围内而不是LWIR吸收的半导体的微伏热计。

6. 发明申请

US20100294935A1 DETECTION BEYOND THE STANDARD RADIATION NOISE LIMIT USING REDUCED EMISSIVITY AND OPTICAL CAVITY COUPLING 有权
标题翻译：使用减少的辐射和光学耦合的标准辐射噪声限制之外的检测
公开(公告)号：US20100294935A1
公开(公告)日：2010-11-25
申请号：US12726776
申请日：2010-03-18
申请人： Joseph J. Talghader
发明人： Joseph J. Talghader
IPC分类号： G01J5/08 , G01J5/20
CPC分类号： G01J5/20 , A61B17/00234 , A61B17/205 , A61B17/3478 , A61B2017/00247 , A61B2017/00876 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M5/32 , A61M2025/0086 , A61M2025/0087 , G01J5/061
摘要： The present invention provides thermal detectors having an optical cavity that is optimized to couple light into a sensor. Light that is on resonance is coupled with the sensor with as high as 100% efficiency, while light off resonance is substantially reflected away. Light that strikes the sensor from the sides (i.e. not on the optical cavity axis) only interacts minimally with sensor because of the reduced absorption characteristics of the sensor. Narrowband sensors in accordance with the present invention can gain as much as 100% of the signal from one direction and spectral band, while receiving only a fraction of the normal radiation noise, which originates from all spectral bands and directions.
摘要翻译：本发明提供具有光学腔的热探测器，该光学腔被优化以将光耦合到传感器中。谐振的光与传感器耦合高达100％的效率，而光的共振基本上被反射出来。由于传感器的吸收特性的降低，从侧面（即不在光学腔轴线）上撞击传感器的光只能与传感器最小化。根据本发明的窄带传感器可以从一个方向和频谱带获得多达100％的信号，同时仅接收来自所有频谱带和方向的正常辐射噪声的一部分。

7. 发明授权

US06784982B1 Direct mapping of DNA chips to detector arrays 有权
标题翻译：将DNA芯片直接映射到检测器阵列
公开(公告)号：US06784982B1
公开(公告)日：2004-08-31
申请号：US09434027
申请日：1999-11-04
申请人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders
发明人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders
IPC分类号： G06K974
CPC分类号： G06T1/0007 , B01J2219/00529 , B01J2219/00702
摘要： A device for detecting the pattern of polynucleic acid hybridization to a surface, the device includes (a) a positioning device for receiving a nucleic acid chip and keeping the chip in a sampling position, the nucleic acid chip being an object with a flat sample surface and an opposed surface that is joined to the sample surface by a thickness, with the sample surface having sequences of nucleic acids immobilized thereto, with each sequence being immobilized to a particular chip address. And, (b) an electronic light detector array, the detector array comprising detector pixels, the detector pixels being sensors located at particular detector pixel addresses, wherein the sampling position places the sample surface of the chip at a well-defined position relative to the electronic light detector array so that light leaving a chip address is substantially directed onto at least one detector pixel with an address that is correlated to the chip address.
摘要翻译：一种用于检测与表面的多核酸杂交的模式的装置，所述装置包括（a）用于接收核酸芯片并将芯片保持在采样位置的定位装置，所述核酸芯片是具有平坦样品表面的物体以及与样品表面连接的相对表面，其中样品表面具有固定在其上的核酸序列，每个序列被固定在特定的芯片地址上。以及（b）电子光检测器阵列，所述检测器阵列包括检测器像素，所述检测器像素是位于特定检测器像素地址处的传感器，其中所述采样位置将所述芯片的样品表面相对于所述检测器像素地址放置在明确定义的位置电子光检测器阵列，使得离开芯片地址的光基本上被引导到具有与芯片地址相关的地址的至少一个检测器像素。

8. 发明授权

US07800066B2 Detection beyond the standard radiation noise limit using reduced emissivity and optical cavity coupling 有权
标题翻译：使用降低的发射率和光学腔耦合来检测超出标准辐射噪声极限
公开(公告)号：US07800066B2
公开(公告)日：2010-09-21
申请号：US11999739
申请日：2007-12-06
申请人： Joseph J. Talghader
发明人： Joseph J. Talghader
IPC分类号： G01J5/20
CPC分类号： G01J5/20 , A61B17/00234 , A61B17/205 , A61B17/3478 , A61B2017/00247 , A61B2017/00876 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M5/32 , A61M2025/0086 , A61M2025/0087 , G01J5/061
摘要： The present invention provides thermal detectors having an optical cavity that is optimized to couple light into a sensor. Light that is on resonance is coupled with the sensor with as high as 100% efficiency, while light off resonance is substantially reflected away. Light that strikes the sensor from the sides (i.e. not on the optical cavity axis) only interacts minimally with sensor because of the reduced absorption characteristics of the sensor. Narrowband sensors in accordance with the present invention can gain as much as 100% of the signal from one direction and spectral band, while receiving only a fraction of the normal radiation noise, which originates from all spectral bands and directions.
摘要翻译：本发明提供具有光学腔的热探测器，该光学腔被优化以将光耦合到传感器中。谐振的光与传感器耦合高达100％的效率，而光的共振基本上被反射出来。由于传感器的吸收特性的降低，从侧面（即不在光学腔轴线）上撞击传感器的光只能与传感器最小化。根据本发明的窄带传感器可以从一个方向和频谱带获得多达100％的信号，同时仅接收来自所有频谱带和方向的正常辐射噪声的一部分。

9. 发明申请

US20080217539A1 Detection beyond the standard radiation noise limit using reduced emissivity and optical cavity coupling 有权
标题翻译：使用降低的发射率和光学腔耦合来检测超出标准辐射噪声极限
公开(公告)号：US20080217539A1
公开(公告)日：2008-09-11
申请号：US11999739
申请日：2007-12-06
申请人： Joseph J. Talghader
发明人： Joseph J. Talghader
IPC分类号： G01J5/02 , G01J5/00
CPC分类号： G01J5/20 , A61B17/00234 , A61B17/205 , A61B17/3478 , A61B2017/00247 , A61B2017/00876 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M5/32 , A61M2025/0086 , A61M2025/0087 , G01J5/061
摘要： The present invention provides thermal detectors having an optical cavity that is optimized to couple light into a sensor. Light that is on resonance is coupled with the sensor with as high as 100% efficiency, while light off resonance is substantially reflected away. Light that strikes the sensor from the sides (i.e. not on the optical cavity axis) only interacts minimally with sensor because of the reduced absorption characteristics of the sensor. Narrowband sensors in accordance with the present invention can gain as much as 100% of the signal from one direction and spectral band, while receiving only a fraction of the normal radiation noise, which originates from all spectral bands and directions.
摘要翻译：本发明提供具有光学腔的热探测器，该光学腔被优化以将光耦合到传感器中。谐振的光与传感器耦合高达100％的效率，而光的共振基本上被反射出来。由于传感器的吸收特性的降低，从侧面（即不在光学腔轴线）上撞击传感器的光只能与传感器最小化。根据本发明的窄带传感器可以从一个方向和频谱带获得多达100％的信号，同时仅接收来自所有频谱带和方向的正常辐射噪声的一部分。

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