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1. 发明公开

EP0382787A1 SYSTEM FOR VOLUMETRIC INTERSTITIAL CONDUCTIVE HYPERTHERMIA 失效
标题翻译：体外间质传导性高热的系统
公开(公告)号：EP0382787A1
公开(公告)日：1990-08-22
申请号：EP89900422.0
申请日：1988-10-20
申请人： MARCHOSKY, Jose, Alexander , MORAN, Christopher J. , FEARNOT, Neal E.
发明人： MARCHOSKY, Jose, Alexander , MORAN, Christopher J. , FEARNOT, Neal E.
IPC分类号： A61F7 , A61N1 , A61N5 , H02J5 , A61B17
CPC分类号： A61F7/00 , A61B2017/00022 , A61B2017/00084 , A61F7/12 , A61F2007/0093 , A61F2007/126 , A61N1/08 , A61N5/1007 , A61N5/1027 , A61N2005/1011 , A61N2005/1012 , H02J5/005 , H02J7/025 , H02J50/10
摘要： A system and method for producing volumetric conductive hyperthermia for the treatment of a cancerous tumor in a patient. The location and volume of the tumor are determined with the aid of a CT scanning system, and an array of probes each containing a heat-emitting element is formed by interstitial implantation in the tumor in a predetermined pattern for volumetric heating using a template for guiding the probes into parallel alignment in the tumor. The template is affixed with respect to the patient's body and with respect to the imaging plane of the CT scanning system. After implantation, the probes are connected to a manifold connector which is in turn connected to an external control system capable of independently controlling the probes while monitoring various analog and digital values representative of system performance.
摘要翻译：一种用于产生体积导热疗法的系统和方法，用于治疗患者的癌性肿瘤。使用CT扫描系统来确定肿瘤的位置和体积，并且通过在下一个肿瘤（308）中的间质植入来形成各自包含发热元件的探针阵列（300）。用于使用模板进行体积加热以在肿瘤中平行排列引导探针的预定构造。模板相对于患者身体和阴极射线管扫描系统的成像平面固定。在植入之后，探针连接到公共连接器（312），公共连接器（312）继而连接到外部控制系统（302），外部控制系统可以独立控制探针，同时控制代表系统操作的不同模拟和数字值。

2. 发明公开

EP0382787A4 SYSTEM FOR VOLUMETRIC INTERSTITIAL CONDUCTIVE HYPERTHERMIA 失效
标题翻译：体积相互作用导致高血压的系统
公开(公告)号：EP0382787A4
公开(公告)日：1990-09-26
申请号：EP89900422
申请日：1988-10-20
申请人： MARCHOSKY, JOSE, ALEXANDER , MORAN, CHRISTOPHER J. , FEARNOT, NEAL E.
发明人： MARCHOSKY, JOSE, ALEXANDER
IPC分类号： A61F7/08 , A61B17/00 , A61F7/00 , A61F7/12 , A61N1/08 , A61N5/10 , H02J5/00
CPC分类号： A61F7/00 , A61B2017/00022 , A61B2017/00084 , A61F7/12 , A61F2007/0093 , A61F2007/126 , A61N1/08 , A61N5/1007 , A61N5/1027 , A61N2005/1011 , A61N2005/1012 , H02J5/005 , H02J7/025 , H02J50/10
摘要： A system and method for producing volumetric conductive hyperthermia for the treatment of a cancerous tumor in a patient. The location and volume of the tumor are determined with the aid of a CT scanning system, and an array of probes each containing a heat-emitting element is formed by interstitial implantation in the tumor in a predetermined pattern for volumetric heating using a template for guiding the probes into parallel alignment in the tumor. The template is affixed with respect to the patient's body and with respect to the imaging plane of the CT scanning system. After implantation, the probes are connected to a manifold connector which is in turn connected to an external control system capable of independently controlling the probes while monitoring various analog and digital values representative of system performance.

3. 发明申请

WO2010026530A2 PROCESS FOR PREPARING CATALYSTS USEFUL IN DIRECT LIQUEFACTION OF CARBON, AND THE RESULTING CATALYST 审中-公开
标题翻译：制备催化剂的方法，用于直接对碳的液化和催化剂
公开(公告)号：WO2010026530A2
公开(公告)日：2010-03-11
申请号：PCT/IB2009053816
申请日：2009-09-02
申请人： UNIV NAC DE COLOMBIA , DIAZ VELASQUEZ JOSE DE JESUS , AGAMEZ PERTUZ YAZMIN YANETH , RODRIGUEZ VARELA LUIS IGNACIO , HERNANDEZ FANDINO ORLANDO , VILLALBA VARON OSCAR ANDRES , JIMENEZ SANCHEZ JOSE ALEXANDER
发明人： DIAZ VELASQUEZ JOSE DE JESUS , AGAMEZ PERTUZ YAZMIN YANETH , RODRIGUEZ VARELA LUIS IGNACIO , HERNANDEZ FANDINO ORLANDO , VILLALBA VARON OSCAR ANDRES , JIMENEZ SANCHEZ JOSE ALEXANDER
IPC分类号： B01J27/02
CPC分类号： B01J21/18 , B01J27/043 , B01J35/1028 , B01J37/0201 , B01J37/0203 , B01J37/0207 , C10G1/08 , C10G1/086
摘要： The present invention relates to a method for obtaining transition-metal catalysts supported on a carbonaceous material via impregnation with a solution from the thiourea metal complex, obtained from the precursor salts. Sulphur is formed on the surface of the substrate by thermal decomposition of the complex. The catalysts obtained by means of the process of the present invention are applicable to the direct liquefaction of carbon.
摘要翻译：本发明涉及通过用由前体盐获得的来自硫脲金属络合物的溶液浸渍而获得负载在碳质材料上的过渡金属催化剂的方法。通过复合物的热分解在基板的表面上形成硫。通过本发明方法获得的催化剂可用于直接液化碳。

4. 发明申请

WO2017027892A1 ELECTRICAL CABLE EXTENSION REEL WITH SAFETY SWITCH 审中-公开
标题翻译：带安全开关的电缆延伸圈
公开(公告)号：WO2017027892A1
公开(公告)日：2017-02-16
申请号：PCT/ZA2016/000021
申请日：2016-08-04
申请人： DE PAIVA, Jose Alexander
发明人： DE PAIVA, Jose Alexander
IPC分类号： H02G11/02 , B65H75/40 , H01R13/72 , H01R35/02
CPC分类号： H02G11/02
摘要： This invention relates to an electrical cable extension reel (10) with a safety switch. More specifically, the invention relates to an electrical cable extension reel (10) having a safety switch thereon that renders the extension reel (10) electrically inoperable unless the cable is wholly unwound from the reel. The electrical cable extension reel (10) includes a spool (12) having a first electrical connector (28), a length of cable capable of being wound and unwound from the spool (12) and connected at a first end to the spool (12) and at a second end to a second electrical connector, an actuator (18 A, 18 B) mounted on the spool (12) and a safety switch (20) electrically connected between the cable and first electrical connector (28). The actuator (18 A, 18 B) is co-operative with the safety switch (20) and movable relative to the spool (12) between an operative condition and an inoperative condition. In th operative condition, an end of the actuator (18 A, 18 B) lies in close proximity with the spool (12). In the inoperative condition, the same end of the actuator (18 A, 18 B) is distal from the spool (12), the actuator (18 A, 18 B) being retainable in the operative condition by at least a single winding of the cable onto the spool (12). Consequentially, the safety switch (20) is actuated by the actuator (18 A, 18 B) between an electrically "on" condition, coinciding with the operative condition of the actuator (18 A, 18 B), and an electrically "off" condition, coinciding with the inoperative condition of the actuator (18 A, 18 B). In the electrically "on" condition, electrical continuity between the cable and the first electrical connector (28) in maintained by the safety switch (20). In the electrically "off" condition, the safety switch (20) breaks electrical continuity between the cable and the first electrical connector (28). In this manner, with the cable unwound from the spool (12), the reel is electrically operable while conversely, with the cable wound or partially wound on the spool (12), the reel is rendered electrically inoperable.
摘要翻译：本发明涉及一种具有安全开关的电缆延伸卷轴（10）。更具体地说，本发明涉及一种在其上具有安全开关的电缆延伸卷轴（10），其使得延伸卷轴（10）不可操作，除非电缆从卷轴完全展开。电缆延伸卷轴（10）包括具有第一电连接器（28）的卷轴（12），能够从卷轴（12）卷绕和展开并且在第一端连接到卷轴（12）的电缆长度）并且在第二端连接到第二电连接器，安装在所述线轴（12）上的致动器（18A，18B）和电连接在所述电缆和所述第一电连接器（28）之间的安全开关（20）。致动器（18A，18B）与安全开关（20）配合，并且在操作状态和不工作状态之间可相对于阀芯（12）移动。在操作状态下，致动器（18A，18B）的一端位于阀芯（12）附近。在不工作状态下，致动器（18A，18B）的相同端部远离阀芯（12），致动器（18A，18B）可通过至少一个单独的绕组在操作状态下保持电缆到卷轴（12）上。因此，安全开关（20）由致动器（18A，18B）在电气“接通”状态下与致动器（18A，18B）的操作状态一致并且电“关闭” 与致动器（18A，18B）的不工作状态一致。在电气“开”状态下，由安全开关（20）维持的电缆与第一电连接器（28）之间的电连续性。在电气“关闭”状态下，安全开关（20）断开电缆和第一电连接器（28）之间的电连续性。以这种方式，当电缆从卷轴（12）展开时，卷轴可电动操作，而相反地，当电缆缠绕或部分缠绕在卷轴（12）上时，卷轴变得电不可操作。

5. 发明申请

WO1989003665A1 SYSTEM FOR VOLUMETRIC INTERSTITIAL CONDUCTIVE HYPERTHERMIA 审中-公开
标题翻译：用于体积相互作用导联的超导体系统
公开(公告)号：WO1989003665A1
公开(公告)日：1989-05-05
申请号：PCT/US1988003676
申请日：1988-10-20
申请人： MARCHOSKY, Jose, Alexander , MORAN, Christopher, J. , FEARNOT, Neal, E.
IPC分类号： A61F07/12
CPC分类号： A61F7/00 , A61B2017/00022 , A61B2017/00084 , A61F7/12 , A61F2007/0093 , A61F2007/126 , A61N1/08 , A61N5/1007 , A61N5/1027 , A61N2005/1011 , A61N2005/1012 , H02J5/005 , H02J7/025 , H02J50/10
摘要： A system and method for producing volumetric conductive hyperthermia for the treatment of a cancerous tumor in a patient. The location and volume of the tumor are determined with the aid of a CT scanning system, and an array of probes each containing a heat-emitting element is formed by interstitial implantation in the tumor in a predetermined pattern for volumetric heating using a template for guiding the probes into parallel alignment in the tumor. The template is affixed with respect to the patient's body and with respect to the imaging plane of the CT scanning system. After implantation, the probes are connected to a manifold connector which is in turn connected to an external control system capable of independently controlling the probes while monitoring various analog and digital values representative of system performance.

6. 发明授权

US4963525A Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments 失效
标题翻译：酰基肉碱作为吸收增强剂，用于通过鼻，颊，舌下和阴道隔室的粘膜药物递送
公开(公告)号：US4963525A
公开(公告)日：1990-10-16
申请号：US353739
申请日：1989-05-16
申请人： Jose Alexander , Joseph A. Fix , A. J. Repta
发明人： Jose Alexander , Joseph A. Fix , A. J. Repta
IPC分类号： A61K47/18
CPC分类号： A61K47/186 , Y10S514/946 , Y10S514/947
摘要： Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.
摘要翻译：酰基肉碱用作吸收不良药物的鼻，颊，舌下和阴道药物吸收增强载体。

7. 发明授权

US4835138A Choline esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities 失效
标题翻译：胆碱酯作为吸收增强剂，用于通过鼻，颊，舌下和阴道腔的粘膜药物递送
公开(公告)号：US4835138A
公开(公告)日：1989-05-30
申请号：US50643
申请日：1987-05-18
申请人： Jose Alexander , A. J. Repta , Joseph A. Fix
发明人： Jose Alexander , A. J. Repta , Joseph A. Fix
IPC分类号： A61K9/00 , A61K47/18
CPC分类号： A61K47/186 , A61K9/0034 , A61K9/0043 , A61K9/006 , Y10S514/946 , Y10S514/947 , Y10S930/27
摘要： Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
摘要翻译：胆碱酯用作药物吸收增强剂，用于从鼻腔，口腔和阴道腔吸收不良的药物。

8. 发明授权

US4762851A Pyroglutamic acid esters used as dermal penetration enhancers for drugs 失效
公开(公告)号：US4762851A
公开(公告)日：1988-08-09
申请号：US802907
申请日：1985-11-29
申请人： Jose Alexander , Takeru Higuchi
发明人： Jose Alexander , Takeru Higuchi
IPC分类号： A61K47/22 , A61K31/19 , A61K31/20 , A61K31/40
CPC分类号： A61K47/22 , A61K9/0014
摘要： The invention relates to pyroglutamic acid esters used as dermal penetration enhancers for therapeutic agents having poor skin permeation.

9. 发明授权

US4692441A Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities 失效
标题翻译：氯酸酯作为吸收增强剂，用于通过鼻，颊，舌下和阴道腔的粘膜药物递送
公开(公告)号：US4692441A
公开(公告)日：1987-09-08
申请号：US766377
申请日：1985-08-16
申请人： Jose Alexander , A. J. Repta , Joseph A. Fix
发明人： Jose Alexander , A. J. Repta , Joseph A. Fix
IPC分类号： A61K9/00 , A61K47/18 , A61K31/43 , A61K31/545
CPC分类号： A61K47/186 , A61K9/0034 , A61K9/0043 , A61K9/006 , Y10S514/946 , Y10S514/947 , Y10S930/27
摘要： Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
摘要翻译：胆碱酯用作药物吸收增强剂，用于从鼻腔，口腔和阴道腔吸收不良的药物。

10. 发明授权

US4425337A Adjuvants for rectal delivery of drug 失效
标题翻译：佐剂用于直肠给药
公开(公告)号：US4425337A
公开(公告)日：1984-01-10
申请号：US335498
申请日：1981-12-30
申请人： Jose Alexander , Joseph A. Fix
发明人： Jose Alexander , Joseph A. Fix
IPC分类号： A61K9/02 , A61K31/54 , A61K47/22
CPC分类号： A61K47/22 , A61K31/54 , A61K9/02 , Y10S514/946
摘要： A method and drug form enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a drug form capable of being rectally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and phenothiazines or salts thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.
摘要翻译：一种提高直肠给药的药物从直肠隔室吸入温血动物血液的方法和药物形式。该方法包括制备能够被直肠给药的药物形式的步骤。药物形式包括治疗有效的单位剂量的所选择的能够被吸收到来自直肠隔室的血液中的药物，吩噻嗪或其盐以足够的量存在于药物形式中当将该药物形式直接给予温血动物时，提高药物吸收率。

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