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1. 发明授权

US08709004B2 Method and device for vascular treatment 有权
标题翻译：用于血管治疗的方法和装置
公开(公告)号：US08709004B2
公开(公告)日：2014-04-29
申请号：US12755948
申请日：2010-04-07
申请人： Julio H. G. Ferreira , Jorge O. Löpez D'Ambola , Wolfgang Neuberger , Antonio C. Reichelt , Jorge E. Soracco
发明人： Julio H. G. Ferreira , Jorge O. Löpez D'Ambola , Wolfgang Neuberger , Antonio C. Reichelt , Jorge E. Soracco
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B18/06 , A61B18/08 , A61B18/1492 , A61B18/24 , A61B2018/00023 , A61B2018/00029 , A61B2018/00404 , A61B2218/002
摘要： A method and device for improved minimally invasive vascular treatments. The method comprises introducing a catheter into a vein to be treated. The catheter is adapted to introduce an energy transmitting member and a fluid into the vein to be treated. The fluid introduced via the catheter can include, but is not limited to: saline solutions, cooled saline solutions, liquids for vapor generation, vasoconstricting agents, anesthetic agents and/or a formulation containing an ingredient which can be activated by the applied energy.
摘要翻译：用于改善微创血管治疗的方法和装置。该方法包括将导管引入待治疗的静脉中。导管适于将能量传递构件和流体引入待治疗的静脉中。通过导管引入的流体可以包括但不限于：盐水溶液，冷却的盐水溶液，用于蒸气产生的液体，血管收缩剂，麻醉剂和/或含有可被施加的能量活化的成分的制剂。

2. 发明申请

US20110275979A1 METHOD/DEVICE FOR TRANSDERMAL VASCULAR TREATMENT 有权
标题翻译：用于超声波血管治疗的方法/装置
公开(公告)号：US20110275979A1
公开(公告)日：2011-11-10
申请号：US12992533
申请日：2009-05-15
申请人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
发明人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61N5/067
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2017/00765 , A61B2018/00452 , A61B2018/00458 , A61B2018/202 , A61B2018/2065 , A61N5/062 , A61N2005/007 , A61N2005/0651 , A61N2005/0659
摘要： Devices and transdermal methods are provided for safe and effective therapeutic treatment of the venous system, such as varicose veins. Present invention provides non-invasive and minimally invasive transdermal methods for treating varicose and spider veins, comprising the use of a radiation source in combination with a chemical fluid/composition to safely and more effectively close or shrink vein walls, providing a transdermal therapeutic method for varicose veins until now only treated with surgery or endovascular laser treatments. In a preferred embodiment a device comprises a radiation source, preferably of wavelength between about 980 and 1940 nm, being effective in causing shrinkage of the vein treated. In other preferred embodiments methods comprise the transdermal delivery of a chemical composition through a patch or gel or the injection of a chemical fluid, preferably a hypertonic solution, to the vein under treatment; and simultaneously or after a dwell time, irradiating with a radiation source transdermally. The treatment performed with the present invention results in blood vessel wall damaged, eventually closing the vein, in lesser time with practically no pain or discomfort to the patient during and after the therapy.
摘要翻译：提供装置和透皮方法用于对静脉系统进行安全和有效的治疗，例如静脉曲张。本发明提供用于治疗静脉曲张和蜘蛛静脉的非侵入性和微创透皮方法，其包括使用辐射源与化学液体/组合物组合以安全且更有效地闭合或收缩静脉壁，提供透皮治疗方法静脉曲张直到目前为止只用手术或血管内激光治疗。在优选实施例中，装置包括辐射源，优选波长在约980和1940nm之间，有效地引起所治疗静脉的收缩。在其它优选实施方案中，方法包括通过贴剂或凝胶透皮递送化学组合物或将化学流体（优选高渗溶液）注射到处理的静脉中; 并且在停留时间之后或之后，经皮肤照射辐射源。用本发明进行的治疗导致血管壁受损，最终在较短的时间内关闭静脉，实际上在治疗期间和之后患者没有疼痛或不适。

3. 发明授权

US08906079B2 Method/device for transdermal vascular treatment 有权
标题翻译：用于透皮血管治疗的方法/装置
公开(公告)号：US08906079B2
公开(公告)日：2014-12-09
申请号：US12992533
申请日：2009-05-15
申请人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
发明人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61B18/20 , A61B18/22 , A61B18/00 , A61N5/00 , A61B17/00
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2017/00765 , A61B2018/00452 , A61B2018/00458 , A61B2018/202 , A61B2018/2065 , A61N5/062 , A61N2005/007 , A61N2005/0651 , A61N2005/0659
摘要： Devices and transdermal methods are provided for safe and effective therapeutic treatment of the venous system, such as varicose veins. Present invention provides non-invasive and minimally invasive transdermal methods for treating varicose and spider veins, comprising the use of a radiation source in combination with a chemical fluid/composition to safely and more effectively close or shrink vein walls, providing a transdermal therapeutic method for varicose veins until now only treated with surgery or endovascular laser treatments. In a preferred embodiment a device comprises a radiation source, preferably of wavelength between about 980 and 1940 nm, being effective in causing shrinkage of the vein treated. In other preferred embodiments methods comprise the transdermal delivery of a chemical composition through a patch or gel or the injection of a chemical fluid, preferably a hypertonic solution, to the vein under treatment; and simultaneously or after a dwell time, irradiating with a radiation source transdermally. The treatment performed with the present invention results in blood vessel wall damaged, eventually closing the vein, in lesser time with practically no pain or discomfort to the patient during and after the therapy.
摘要翻译：提供装置和透皮方法用于对静脉系统进行安全和有效的治疗，例如静脉曲张。本发明提供用于治疗静脉曲张和蜘蛛静脉的非侵入性和微创透皮方法，其包括使用辐射源与化学液体/组合物组合以安全且更有效地闭合或收缩静脉壁，提供透皮治疗方法静脉曲张直到目前为止只用手术或血管内激光治疗。在优选实施例中，装置包括辐射源，优选波长在约980和1940nm之间，有效地引起所治疗静脉的收缩。在其它优选实施方案中，方法包括通过贴剂或凝胶将化学组合物透皮递送或将化学流体（优选高渗溶液）注射至处理的静脉; 并且在停留时间之后或之后，经皮肤照射辐射源。用本发明进行的治疗导致血管壁受损，最终在较短的时间内关闭静脉，实际上在治疗期间和之后患者没有疼痛或不适。

4. 发明申请

US20110196354A1 METHOD AND DEVICE FOR VASCULAR TREATMENT 有权
公开(公告)号：US20110196354A1
公开(公告)日：2011-08-11
申请号：US12755948
申请日：2010-04-07
申请人： Julio H. G. Ferreira , Jorge O. López D'Ambola , Wolfgang Neurberger , Antonio C. Reichelt , Jorge E. Soracco
发明人： Julio H. G. Ferreira , Jorge O. López D'Ambola , Wolfgang Neurberger , Antonio C. Reichelt , Jorge E. Soracco
IPC分类号： A61B18/20 , A61B18/02
CPC分类号： A61B18/00 , A61B18/06 , A61B18/08 , A61B18/1492 , A61B18/24 , A61B2018/00023 , A61B2018/00029 , A61B2018/00404 , A61B2218/002
摘要： A method and device are disclosed for improved minimally invasive vascular treatments. The procedure comprises introducing a mono-channel or multichannel catheter into a vein to be treated, under local anesthesia, where the multichannels can be essentially concentric. This special catheter receives an energy transmitting elongate member in a channel and a fluid in another channel, or in the case of a mono-channel fluid flows around the member. Fluids that can be used, but not limited to, are saline solutions, cooled saline solutions, liquids for vapor generation, vasoconstricting agents, anesthetic agents and/or a formulation containing an ingredient which can be activated by the applied energy. Anesthesia, where used, is introduced into the inside of the vein, thus eliminating the need of external or tumescent anesthesia. In addition, the previously mentioned substances can also be combined according to the treatment requirements for different purposes and effects. After catheter and energy-transmitting elongate member are correctly placed and locked, fluid is delivered at member's tip and energy is emitted while withdrawing the elongate member-catheter set, choosing appropriate energy parameters for each case. In a preferred embodiment an optical fiber is used as the elongate member and a laser as a light energy source. In a preferred embodiment 20 ml of 1% lidocaine are used. In another preferred embodiment, fluid is delivered by means of an infusion pump. In a preferred embodiment, the optical fiber is a radial emitting fiber and the wavelength used is 1470±30 nm. This new vascular treatment has advantages over prior art, including: less procedure time, an easier and more versatile technique and the possibility to check vein closure echographically during and after the energy treatment. The method and device can be used with a variety of energy sources including lasers, other light sources, RF power sources and thermo-electric means.

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