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1. 发明授权

US06608045B2 Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient 失效
标题翻译：链霉菌sp产生抗菌素和免疫抑制剂，其包含作为活性成分的抗菌素
公开(公告)号：US06608045B2
公开(公告)日：2003-08-19
申请号：US09308482
申请日：1999-05-17
申请人： Hyoung Sik Chun , Jong Gwan Kim , Hung Bae Chang , Seung Kee Moon , Hyeog Jin Son , Chung Il Hong , Jung Woo Kim , Nam Hyun Lyu
发明人： Hyoung Sik Chun , Jong Gwan Kim , Hung Bae Chang , Seung Kee Moon , Hyeog Jin Son , Chung Il Hong , Jung Woo Kim , Nam Hyun Lyu
IPC分类号： C12P1702
CPC分类号： C12R1/465 , C12P7/22
摘要： The present invention relates to Streptomyces sp. producing tautomycetin which possesses an immunosuppressive or antibacterial activities, a process for preparing tautomycetin from the said microorganism, and an immunosuppressant or immunosuppressive pharmaceutical composition comprising tautomycetin as an active ingredient which suppresses interleukin-2 production, CD69 and interleukin-2 receptor(IL-2R) expression on the cell surface, and graft rejection in the organ transplantation. The present inventors isolated a soil microorganism which produces a substance possessing antibiotic and immunosuppressive activities, and identified the said microorganism and substance as a novel Streptomyces sp. and tautomycetin, respectively. Further, the present inventors developed a method of manufacturing the tautomycetin in a large scale from the culture of the said microorganism and discovered that tautomycetin suppresses mouse mixed lymphocyte reaction(MLR) and the expression of IL-2 based on a series of experiments employing cell line transfected with a recombinant gene.
摘要翻译：本发明涉及链霉菌属（Streptomyces sp。）产生具有免疫抑制或抗菌活性的抗菌素，用于从所述微生物制备抗菌素的方法，以及包含抑制白细胞介素2产生的活性成分的免疫抑制剂或免疫抑制剂或免疫抑制药物组合物，CD69和白细胞介素-2受体（IL-2R ）在细胞表面的表达，以及器官移植中的移植排斥反应。本发明人分离出产生具有抗生素和免疫抑制活性的物质的土壤微生物，并将所述微生物和物质鉴定为新型链霉菌属（Streptomyces sp。）。和tautomycetin。此外，本发明人开发了从所述微生物的培养物大规模制造肠胃菌素的方法，并且发现根据使用细胞的一系列实验，互连霉素抑制小鼠混合淋巴细胞反应（MLR）和IL-2的表达用重组基因转染。

2. 发明授权

US5866377A Aminooligosaccharide derivative and process for preparing the same 失效
标题翻译：氨基寡糖衍生物及其制备方法
公开(公告)号：US5866377A
公开(公告)日：1999-02-02
申请号：US875146
申请日：1997-06-30
申请人： Jung Woo Kim , Kwang Moo Lee , Hyoung Sik Chun , Jong Gwan Kim , Hung Bae Chang , Sun Ho Kim , Kyeong Bok Min , Kyoung Sik Moon
发明人： Jung Woo Kim , Kwang Moo Lee , Hyoung Sik Chun , Jong Gwan Kim , Hung Bae Chang , Sun Ho Kim , Kyeong Bok Min , Kyoung Sik Moon
IPC分类号： C12P19/26 , A61K31/70 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H15/26 , C07H17/04 , C08B37/00 , C12N9/99 , C12P19/28 , C12P19/44 , C12Q1/34 , C12R1/465 , A01N43/04 , C12N1/20
CPC分类号： C07H17/04 , C12P19/28
摘要： The present invention relates to novel aminooligosaccharide derivative and pharmaceutically acceptable non-toxic salts thereof, which possess potent saccharide hydrolase inhibition and antibacterial activities. The invention also relates to a process for preparing the same and to pharmaceutical compositions containing the same as active ingredients. In accordance with the present invention, the inventors isolated novel aminooligosaccharide derivative from a soil microorganism categorized as Streptomyces sp., and discovered that it can be applied as potent inhibitors for saccharide hydrolases and antibacterial agents as well.
摘要翻译： PCT No.PCT / KR95 / 00184 Sec。 371日期：1997年6月30日 102（e）日期1997年6月30日PCT 1995年12月30日PCT PCT。公开号WO96 / 20945 日期1996年7月11日本发明涉及具有强力糖水解酶抑制和抗菌活性的新型氨基寡糖衍生物及其药学上可接受的无毒盐。本发明还涉及其制备方法和含有其作为活性成分的药物组合物。根据本发明，本发明人从分类为链霉菌属的土壤微生物中分离出新的氨基寡糖衍生物，发现它可以作为糖水解酶和抗菌剂的有效抑制剂。

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