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1. 发明申请

US20120070495A1 ORAL FORMULATIONS AND LIPOPHILIC SALTS OF METHYLNALTREXONE 有权
标题翻译：口服制剂和亚硝酸盐的口服盐
公开(公告)号：US20120070495A1
公开(公告)日：2012-03-22
申请号：US13045108
申请日：2011-03-10
申请人： Syed M. SHAH , Christopher Richard DIORIO , Eric C. EHRNSPERGER , Xu MENG , Kadum A. AL SHAREFFI , Jonathan Marc COHEN
发明人： Syed M. SHAH , Christopher Richard DIORIO , Eric C. EHRNSPERGER , Xu MENG , Kadum A. AL SHAREFFI , Jonathan Marc COHEN
IPC分类号： A61K31/485 , B02C23/18 , A61P25/04 , C07D489/08 , A61K9/28
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K47/12 , A61K47/20 , C07D489/08
摘要： The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
摘要翻译：本发明提供了包含甲基纳曲酮或其盐的组合物及其组合物和制剂，用于口服给药。

2. 发明授权

US06900184B2 Compositions containing pipercillin and tazobactam useful for injection 有权
标题翻译：含有哌辛西林和他唑巴坦的组合物可用于注射
公开(公告)号：US06900184B2
公开(公告)日：2005-05-31
申请号：US10413323
申请日：2003-04-14
申请人： Jonathan Marc Cohen , Syed M. Shah , Christian Luther Ofslager , Mahdi Fawzi
发明人： Jonathan Marc Cohen , Syed M. Shah , Christian Luther Ofslager , Mahdi Fawzi
IPC分类号： A61K45/06 , A61K47/02 , A61K47/12 , A61K47/18 , A61K31/70 , A61K31/43
CPC分类号： A61K47/12 , A61K9/0019 , A61K45/06 , A61K47/02 , A61K47/18
摘要： The invention pertains to pharmaceutical compositions of Zosyn® piperacillin with tazobactam in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA optionally an aminoglycoside which when frozen and thawed or lyophilized and reconstituted reform a solution which has decreased particulate formation.
摘要翻译：本发明涉及在缓冲剂，优选柠檬酸盐，颗粒形成抑制剂，优选EDTA任选的氨基糖苷存在下，唑唑内酯的Zosyn（P）哌拉西林的药物组合物，其在冷冻和解冻或冻干并重构时具有降低的颗粒的溶液形成。

3. 发明授权

US08524276B2 Oral formulations and lipophilic salts of methylnaltrexone 有权
标题翻译：口服制剂和甲基纳曲酮的亲脂性盐
公开(公告)号：US08524276B2
公开(公告)日：2013-09-03
申请号：US13045108
申请日：2011-03-10
申请人： Syed M. Shah , Christopher Richard Diorio , Eric C. Ehrnsperger , Xu Meng , Kadum A. Al Shareffi , Jonathan Marc Cohen
发明人： Syed M. Shah , Christopher Richard Diorio , Eric C. Ehrnsperger , Xu Meng , Kadum A. Al Shareffi , Jonathan Marc Cohen
IPC分类号： A61K9/20
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K47/12 , A61K47/20 , C07D489/08
摘要： The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
摘要翻译：本发明提供了包含甲基纳曲酮或其盐的组合物及其组合物和制剂，用于口服给药。

4. 发明申请

US20110166091A1 Compositions Containing Piperacillin and Tazobactam Useful for Injection 有权
标题翻译：含有哌拉西林和他唑巴坦的组合物可用于注射
公开(公告)号：US20110166091A1
公开(公告)日：2011-07-07
申请号：US13033861
申请日：2011-02-24
申请人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
发明人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
IPC分类号： A61K31/496 , A61K31/7036 , A61P31/04
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成。组合物还可以含有缓冲液，优选柠檬酸盐，和任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可以通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

5. 发明授权

US07915229B2 Compositions containing piperacillin and tazobactam useful for injection 有权
标题翻译：含有哌拉西林和他唑巴坦的组合物可用于注射
公开(公告)号：US07915229B2
公开(公告)日：2011-03-29
申请号：US12370794
申请日：2009-02-13
申请人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
发明人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
IPC分类号： A61K31/70 , A61K31/43
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成。组合物还可以含有缓冲液，优选柠檬酸盐，和任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可以通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

6. 发明授权

US07498312B2 Compositions containing piperacillin and tazobactam useful for injection 有权
标题翻译：含有哌拉西林和他唑巴坦的组合物可用于注射
公开(公告)号：US07498312B2
公开(公告)日：2009-03-03
申请号：US10553139
申请日：2004-04-07
申请人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
发明人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
IPC分类号： A61K31/70 , A61K31/43
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成。组合物还可以含有缓冲液，优选柠檬酸盐，和任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可以通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

7. 发明申请

US20110060265A1 IMPLANTABLE SHUNT OR CATHETER ENABLING GRADUAL DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：可植入分流器或导管使得治疗药物的分级递送
公开(公告)号：US20110060265A1
公开(公告)日：2011-03-10
申请号：US12949032
申请日：2010-11-18
申请人： Deborah L. Dragoon , Jonathan Marc Cohen
发明人： Deborah L. Dragoon , Jonathan Marc Cohen
IPC分类号： A61M1/00
CPC分类号： A61M27/006 , A61K31/436 , A61L29/16 , A61L31/16 , A61L2300/406 , A61L2300/416
摘要： An implantable catheter or shunt for draining fluid from a body cavity. The catheter or shunt body has a wall structure that carries one or more therapeutic agents in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.
摘要翻译：用于从体腔排出流体的可植入导管或分路器。导管或分流体具有壁结构，该壁结构承载一种或多种治疗剂，其方式是使得在手术植入导管或分流体之后能够从治疗剂释放治疗剂。治疗剂可以随着时间逐渐释放以防止感染，抑制组织向内生长和/或提供一些其它期望的药物用途。作为实例，治疗剂可以是雷帕霉素或mTOR抑制剂。根据本发明的一些预期的实施例，由导管/分流器承载的治疗剂可以在现场进行可再充电或可再填充，使得治疗剂可以在导管/分流器的预期使用寿命期间从导管/分流器逐渐释放。

8. 发明申请

US20090176720A1 COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM USEFUL FOR INJECTION 有权
标题翻译：含有PIPERACILLIN和TAZOBACTAM的组合物可用于注射
公开(公告)号：US20090176720A1
公开(公告)日：2009-07-09
申请号：US12370794
申请日：2009-02-13
申请人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
发明人： Jonathan Marc Cohen , Syed Muzafar Shah , Christian Luther Ofslager , Mahdi Bakir Fawzi
IPC分类号： A61K31/431 , A61K31/7036 , A61P3/04
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成。组合物还可以含有缓冲液，优选柠檬酸盐，和任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可以通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

9. 发明申请

US20080051691A1 Implantable shunt or catheter enabling gradual delivery of therapeutic agents 审中-公开
标题翻译：可植入分流器或导管，能够逐步递送治疗剂
公开(公告)号：US20080051691A1
公开(公告)日：2008-02-28
申请号：US11895770
申请日：2007-08-27
申请人： Deborah L. Dragoon , Jonathan Marc Cohen
发明人： Deborah L. Dragoon , Jonathan Marc Cohen
IPC分类号： A61M27/00 , A61K31/436 , A61P25/00 , A61K9/00
CPC分类号： A61M27/006 , A61K31/436 , A61L29/16 , A61L31/16 , A61L2300/406 , A61L2300/416
摘要： An implantable catheter or shunt for draining fluid from a body cavity. The catheter or shunt body has a wall structure that carries one or more therapeutic agents in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.
摘要翻译：用于从体腔排出流体的可植入导管或分路器。导管或分流体具有壁结构，该壁结构承载一种或多种治疗剂，其方式是使得在手术植入导管或分流体之后能够从治疗剂释放治疗剂。治疗剂可以随着时间逐渐释放以防止感染，抑制组织向内生长和/或提供一些其它期望的药物用途。作为实例，治疗剂可以是雷帕霉素或mTOR抑制剂。根据本发明的一些预期的实施例，由导管/分流器承载的治疗剂可以在现场进行可再充电或可再填充，使得治疗剂可以在导管/分流器的预期使用寿命期间从导管/分流器逐渐释放。

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