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1. 发明授权

US08709441B2 TC-83-derived alphavirus vectors, particles and methods 有权
标题翻译： TC-83衍生的甲病毒载体，颗粒和方法
公开(公告)号：US08709441B2
公开(公告)日：2014-04-29
申请号：US12831017
申请日：2010-07-06
申请人： Jon O. Rayner , Jonathan F. Smith , Bolyn Hubby , Elizabeth A. Reap
发明人： Jon O. Rayner , Jonathan F. Smith , Bolyn Hubby , Elizabeth A. Reap
IPC分类号： A61K39/193 , A61K39/295 , C12N15/86
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , C12N2770/36123 , C12N2770/36134 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/203
摘要： The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.
摘要翻译：本公开提供了TC-83VEE衍生的复制子，甲病毒复制子颗粒和含有TC-83甲病毒复制子颗粒的免疫原性组合物，其在引入合适的宿主细胞时引导至少一种抗原的表达。本文描述的TC-83VEE衍生的ARP被改进，因为它们比现有技术的ARP受到较低的载体特异性免疫应答。

2. 发明授权

US08617533B2 Multi-antigenic alphavirus replicon particles and methods 有权
标题翻译：多抗原甲病毒复制子颗粒和方法
公开(公告)号：US08617533B2
公开(公告)日：2013-12-31
申请号：US12116031
申请日：2008-05-06
申请人： Jonathan F. Smith , Kurt Kamrud , Sergey Dryga , Ian Caley
发明人： Jonathan F. Smith , Kurt Kamrud , Sergey Dryga , Ian Caley
IPC分类号： A01N63/00 , A61K48/00 , C12N15/00 , C12N15/86 , C12N15/88 , C12N15/87
CPC分类号： C12N7/00 , A61K48/00 , A61K2039/5256 , A61K2039/70 , C12N15/86 , C12N2740/16222 , C12N2770/36134 , C12N2770/36143 , C12N2770/36152
摘要： Viral replicon selected nucleic acid expression libraries are useful for analyzing multiple antigens associated with a parasite, pathogen or neoplasia or for preparing immunogenic compositions for generating immune responses specific for the parasite, pathogen or neoplasia. Alphavirus replicon particles representative of the nucleic acid expression library are preferred. The nucleic acid library can be a random library, or it can be prepared after a selection step, for example, by differential hybridization prior to cloning into the replicon vector.
摘要翻译：病毒复制子选择的核酸表达文库可用于分析与寄生虫，病原体或瘤形成相关的多种抗原，或用于制备用于产生对寄生虫，病原体或瘤形成特异性的免疫应答的免疫原性组合物。代表核酸表达文库的甲病毒复制子颗粒是优选的。核酸文库可以是随机文库，或者可以在选择步骤后进行制备，例如在克隆到复制子载体之前通过差异杂交。

3. 发明授权

US07052209B1 Corrugated stormwater chamber 失效
标题翻译：波纹雨水室
公开(公告)号：US07052209B1
公开(公告)日：2006-05-30
申请号：US10402414
申请日：2003-03-28
申请人： Kurt J. Kruger , Jonathan F. Smith , Bryan F. Coppes , Raymond Connors
发明人： Kurt J. Kruger , Jonathan F. Smith , Bryan F. Coppes , Raymond Connors
IPC分类号： E01F5/00
CPC分类号： E03F1/003
摘要： An arch shape cross section chamber for receiving and dispersing stormwater when buried beneath the surface of the earth is corrugated and has a cross section geometry which is a continuous curve. Preferably, the curve is a truncated semi-ellipse. A chamber also has a combination of a standard corrugations along most of the length, in combination with smaller end corrugation with standard corrugations, to enable joining of chambers in overlap fashion, as a string; corrugations which have elliptically curved corrugation widths when viewed from the side of the chamber; and, sidewall base flanges which have turned up outer edges in combination with fins which connect said edges with the curved chamber sidewall. A domed end cap is adapted to both close the end of the chamber and to be positioned within the chamber length to provide a baffle.
摘要翻译：当埋在地表下方时，用于接收和分散雨水的拱形横截面室是波纹状的，并且具有作为连续曲线的横截面几何形状。优选地，曲线是截短的半椭圆形。腔室还具有沿着大部分长度的标准波纹的组合，以及具有标准波纹的较小端部波纹的组合，以使得能够以重叠的方式将腔室连接成弦; 从腔室侧看时具有椭圆形弯曲波纹宽度的波纹; 以及已经将与将所述边缘与弯曲室侧壁连接的翅片组合的外缘翻转的侧壁基部凸缘。圆顶端盖适于封闭室的端部并且被定位在室长度内以提供挡板。

4. 发明授权

US06632640B1 Vaccine against Staphylococcus intoxication 失效
标题翻译：针对葡萄球菌中毒的疫苗
公开(公告)号：US06632640B1
公开(公告)日：2003-10-14
申请号：US09350755
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： C12N1509
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译：使用编码来自金黄色葡萄球菌的突变体SEA和SEB外毒素的核酸，用于诱导免疫应答的组合物和方法，其用于保护金黄色葡萄球菌描述了ITALIC> 中毒。

5. 发明授权

US06531135B1 Alphavirus RNA replicon systems 失效
标题翻译：甲病毒RNA复制子系统
公开(公告)号：US06531135B1
公开(公告)日：2003-03-11
申请号：US09598569
申请日：2000-06-21
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.
摘要翻译：本发明提供了用于在甲病毒允许细胞中表达感染性，复制缺陷型甲病毒颗粒的辅助细胞。辅助细胞包括（a）编码（i）至少一种甲病毒结构蛋白的第一辅助RNA，和（ii）不编码至少一种甲病毒属结构蛋白; 和（b）与第一辅助RNA分开的第二辅助RNA，不编码由第一辅助RNA编码的甲病毒结构蛋白的第二辅助RNA（i），和（ii）编码至少一种不是由第一辅助RNA编码的结合蛋白的结构蛋白，第一辅助RNA，使得所有甲病毒结构蛋白聚集在细胞中的甲病毒颗粒中。优选地，辅助细胞还包括编码甲病毒包装序列和插入的异质RNA的复制子RNA。

6. 发明授权

US06156558A Alphavirus RNA replicon systems 失效
公开(公告)号：US06156558A
公开(公告)日：2000-12-05
申请号：US122286
申请日：1998-07-24
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/12 , C07K14/18 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/00 , C12N15/33 , C12N15/86 , C12R1/92
CPC分类号： C07K14/005 , C12N15/86 , C12N7/00 , A61K2039/5254 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.

7. 发明授权

US5505947A Attenuating mutations in Venezuelan Equine Encephalitis virus 失效
标题翻译：委内瑞拉马脑炎病毒的衰减突变
公开(公告)号：US5505947A
公开(公告)日：1996-04-09
申请号：US250445
申请日：1994-05-27
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Franziska B. Grieder
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Franziska B. Grieder
IPC分类号： C12N15/09 , A61K39/00 , A61K39/193 , A61P31/12 , C07H21/04 , C07K14/155 , C07K14/165 , C07K14/18 , C07K14/285 , C12N7/00 , C12N15/40 , C12N15/86 , C12R1/92 , C12N7/04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/193 , C07K14/285 , C12N15/86 , A61K2039/5254 , A61K39/00 , C12N2740/15022 , C12N2760/16122 , C12N2760/16134 , C12N2770/20022 , C12N2770/36143 , C12N2830/38
摘要： Novel attenuating mutations of Venezuelan Equine Encephalitis (VEE) are disclosed. Further aspects of the invention include an infectious VEE virus transcript encoded by cDNA clones, infectious VEE virus particles, and pharmaceutical formulations containing such infectious particles. Also disclosed are recombinant VEE virus containing a heterologous RNA segment.
摘要翻译：披露了委内瑞兰马脑炎（VEE）的新型减毒突变。本发明的其它方面包括由cDNA克隆，感染性VEE病毒颗粒和含有这种感染性颗粒的药物制剂编码的感染性VEE病毒转录物。还公开了含有异源RNA片段的重组VEE病毒。

8. 发明申请

US20120213813A1 ALPHAVIRUS REPLICON PARTICLES AS IMMUNOLOGICAL ADJUVANTS 有权
标题翻译： ALPHAVIRUS REPLICON PARTICLES作为免疫调节剂
公开(公告)号：US20120213813A1
公开(公告)日：2012-08-23
申请号：US11854472
申请日：2007-09-12
申请人： Jonathan F. Smith , Bolyn Hubby , Peter Berglund , Laura Copp , Whitney Ellis
发明人： Jonathan F. Smith , Bolyn Hubby , Peter Berglund , Laura Copp , Whitney Ellis
IPC分类号： A61K39/39 , A61K39/00 , A61K39/145 , A61K39/02 , A61K39/002 , A61P35/00 , A61P31/12 , A61P31/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/02 , A61K39/12 , A61P37/04
CPC分类号： A61K39/39 , A61K38/208 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/55538 , A61K2039/70 , C12N15/86 , C12N2710/16634 , C12N2760/16134 , C12N2760/16234 , C12N2770/36143
摘要： The immune response to an antigen of interest, either in purified form or expressed via an alphavirus replicon particle, can be enhanced by the simultaneous administration of an alphavirus replicon particle which expresses interleukin-12. This allows for the use of significantly smaller quantities of the antigen and this immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.
摘要翻译：可以通过同时施用表达白细胞介素-12的甲病毒复制子颗粒来增强对纯化形式的目的抗原或经α病毒复制子颗粒表达的免疫应答。这允许使用显着更小量的抗原，并且该免疫策略也可以消除对加强抗原的施用的需要，或者可以减少对抗原的有效免疫应答所需的加强次数。

9. 发明授权

US07118306B2 Stormwater management system 有权
公开(公告)号：US07118306B2
公开(公告)日：2006-10-10
申请号：US09849768
申请日：2001-05-04
申请人： Kurt J. Kruger , Bryan A. Coppes , Jonathan F. Smith , Raymond Connors
发明人： Kurt J. Kruger , Bryan A. Coppes , Jonathan F. Smith , Raymond Connors
IPC分类号： E02B11/00 , E01F5/00
CPC分类号： E03F1/003
摘要： Disclosed is a fluid, namely stormwater, management system employing a chamber having an overall substantially constant curve cross-sectional geometry, with an a-semicircular constant curve cross-sectional geometry preferred. This chamber, which preferably follows both AASHTO standard specifications for Highway Bridges, Section 18, and Corrugated Polyethylene Pipe Association (CCPA) specifications, can further comprise corregations, support members and/or connecting elements to further add structural integrity.

10. 发明授权

US06517842B1 Marburg virus vaccines 失效
标题翻译：马尔堡病毒疫苗
公开(公告)号：US06517842B1
公开(公告)日：2003-02-11
申请号：US09336910
申请日：1999-06-21
申请人： Michael C. Hevey , Diane L. Negley , Peter Pushko , Jonathan F. Smith , Alan L. Schmaljohn
发明人： Michael C. Hevey , Diane L. Negley , Peter Pushko , Jonathan F. Smith , Alan L. Schmaljohn
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14222 , C12N2770/36021 , C12N2770/36122 , C12N2770/36123 , C12N2770/36143 , C12N2770/36162
摘要： The invention here relates to recombinant DNA constructs which comprise a Venezuelan equine encephalitis replicon vector and at least one DNA fragment encoding a protective antigen from the Marburg virus. The DNA constructs are useful for inducing an immune response which is protective against infection with Marburg virus in nonhuman primates.
摘要翻译：本发明涉及包含委内瑞拉马脑炎复制子载体和编码来自马尔堡病毒的保护性抗原的至少一个DNA片段的重组DNA构建体。 DNA构建体可用于诱导在非人类灵长类动物中防止马尔堡病毒感染的免疫应答。

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