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1. 发明申请

US20110124686A1 SULTAM DERIVATIVES 有权
标题翻译： SULTAM衍生物
公开(公告)号：US20110124686A1
公开(公告)日：2011-05-26
申请号：US12905120
申请日：2010-10-15
申请人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号： A61K31/454 , A61K31/425 , C07D275/03 , C07D417/06 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译：本发明涉及具有细胞毒活性的根据式1的化合物。该化合物可用于治疗癌症。

2. 发明授权

US5483744A Method for fabricating a bearing with semi-rhythmic ball spacing 失效
标题翻译：制造具有半节奏球间距的轴承的方法
公开(公告)号：US5483744A
公开(公告)日：1996-01-16
申请号：US567993
申请日：1990-08-16
申请人： John L. Roberts
发明人： John L. Roberts
IPC分类号： F16C33/38 , G01C19/16 , B23P15/00
CPC分类号： F16C33/385 , F16C43/06 , G01C19/16 , Y10T29/49638 , Y10T29/4965 , Y10T29/49696
摘要： A method and apparatus which provides a bearing design with an irregular or semi-rhythmic ball spacing. The method of the invention includes the steps of a) choosing an initial pattern for the position of the balls with an arbitrary irregular spacing therebetween; b) determining the degree to which the bearing is suitable for a given application with the chosen spacing between the balls; c) moving the balls in the pattern to change the spacing therebetween and d) repeating steps b) and c) until the bearing is suitable for a given application.
摘要翻译：提供具有不规则或半节奏球间距的轴承设计的方法和装置。本发明的方法包括以下步骤：a）选择具有任意不规则间距的球的位置的初始图案; b）确定轴承适用于具有球之间所选间距的给定应用的程度; c）以图案移动球以改变它们之间的间隔，并且d）重复步骤b）和c），直到轴承适合于给定的应用。

3. 发明授权

US4976056A Advertising or promotional item 失效
标题翻译：广告或促销品
公开(公告)号：US4976056A
公开(公告)日：1990-12-11
申请号：US356640
申请日：1989-05-11
申请人： John L. Roberts
发明人： John L. Roberts
IPC分类号： G09F3/10 , G09F19/00
CPC分类号： G09F19/00 , G09F3/10 , Y10T428/1405 , Y10T428/1462
摘要： An advertising or promotional item comprises a body (2) from one side of which extends a flag (3) carrying an advertising message, the body (2) having a foot (1) by which it may be adhered to a support. According to the invention the body (2) is a flattened mass of fibers (5), so that the item is small enough to be posted in an envelope in the mail. A face (4) may be adhered to the body (2) to keep the item flat.
摘要翻译：一种广告或促销品包括从其一侧延伸有承载广告消息的标志（3）的主体（2），所述主体（2）具有脚（1），通过该脚可以将其附着到支撑件。根据本发明，主体（2）是扁平的纤维块（5），使得该物品足够小以便张贴在邮件的信封中。面（4）可以粘附到主体（2）上以保持物品平坦。

4. 发明授权

US5469929A Motor vehicle power steering gear 失效
标题翻译：机动车动力舵机
公开(公告)号：US5469929A
公开(公告)日：1995-11-28
申请号：US415805
申请日：1995-04-03
申请人： Tony M. Dadak , John L. Roberts
发明人： Tony M. Dadak , John L. Roberts
IPC分类号： B62D5/083
CPC分类号： B62D5/083
摘要： A motor vehicle power steering gear having a spool shaft connected to a steering wheel, a pinion head connected to a steered wheel, a torsion bar between the spool shaft and the pinion head, a control valve for regulating a hydraulic steering assist boost pressure in response to rotation of the spool shaft from an on-center position relative to the pinion head against a restoring force of the torsion bar, and a quiet preload apparatus including a C-shaped spring around the spool shaft having a pair of resilient jaws, a drive pin on the spool shaft clamped with a preload between the resilient jaws, and a cushioned abutment on the pinion head clamped with the preload between the resilient jaws. The cushioned abutment includes a pair of radial cantilever springs which flex upon engagement with corresponding ones of the resilient jaws during forced oscillation of the pinion head back and forth through the on-center relative position of the spool shaft to minimize audible noise associated with such engagements and a radial reinforcement between the cantilever springs which limits flexure thereof to minimize the effect of the cantilever springs on the performance characteristics of the control valve.
摘要翻译：一种机动车辆动力转向器，其具有连接到方向盘的卷轴，连接到转向轮的小齿轮头，卷轴和小齿轮头之间的扭杆，用于响应于调节液压转向辅助增压压力的控制阀相对于扭杆的恢复力使卷筒轴从相对于小齿轮头的中心位置旋转，并且包括围绕卷轴的C形弹簧的安静的预加载装置具有一对弹性夹爪，驱动装置销轴线夹在弹性夹爪之间的预紧力上，以及与弹性夹爪之间的预载夹紧的小齿轮头上的缓冲支座。缓冲支座包括一对径向悬臂弹簧，其在相应的弹性夹爪的作用下与小齿轮头部的强制摆动相互弹跳，通过卷筒轴的中心相对位置来往复运动，以最小化与这种啮合相关联的可听见的噪音以及在悬臂弹簧之间的径向加强件，其限制其挠曲，以最小化悬臂弹簧对控制阀的性能特性的影响。

5. 发明授权

US5159077A Penam antibacterial compounds 失效
标题翻译： Penam抗菌化合物
公开(公告)号：US5159077A
公开(公告)日：1992-10-27
申请号：US383783
申请日：1989-07-21
申请人： Dennis D. Keith , John L. Roberts , Chung-Chen Wei
发明人： Dennis D. Keith , John L. Roberts , Chung-Chen Wei
IPC分类号： C07D205/085 , C07D401/12 , C07D499/00 , C07D499/21 , C07D501/00 , C07D519/00
CPC分类号： C07D401/12 , C07D205/085 , C07D499/00 , C07D501/00
摘要： Antibacterial compounds of the formula ##STR1## in which R.sub.1 is a cyclic or secondary acyclic amino group which independently has antibacterial activity:R.sub.2 is hydrogen, lower alkoxy, lower alkylthio or formamido;R.sub.3 is hydrogen or an organic group bonded through carbon, oxygen, sulfur or nitrogen;R.sub.4 is an electronegative acidic group; or R.sub.3 and R.sub.4 together form a heterocycle; andR.sub.5 is a hydrogen or lower alkyl, except when R.sub.3 and R.sub.4 form a heterocycle, in which case R.sub.5 is hydrogen only; and methods of using same.
摘要翻译： R1是具有独立具有抗菌活性的环状或次级无环氨基的式Ⅰ的抗菌化合物：R2是氢，低级烷氧基，低级烷硫基或甲酰氨基; R3是氢或通过碳，氧，硫或氮键合的有机基团; R4是电负性酸性基团; 或R3和R4一起形成杂环; 并且R 5是氢或低级烷基，除了当R 3和R 4形成杂环时，其中R 5仅为氢; 和使用方法。

6. 发明授权

US5579804A Tamper-proof handle extension for quarter turn valves 失效
标题翻译：四分之一转阀的防撬手柄延伸
公开(公告)号：US5579804A
公开(公告)日：1996-12-03
申请号：US541687
申请日：1995-10-10
申请人： John L. Roberts
发明人： John L. Roberts
IPC分类号： F16K35/06
CPC分类号： F16K35/06 , Y10T137/7256 , Y10T70/5624 , Y10T70/5637
摘要： A tamper-proof locking mechanism for a rotatable control device, such as a quarter turn valve, including a valve member connected to a stem rotatably mounted in a body housing the valve member and an operating handle connected to the stem via an elongated extension for rotating the valve member between open and closed positions. The locking mechanism includes a bracket mounted on the body and having a flange spaced outwardly from the body and generally perpendicularly to the rotational axis of the stem and including an aperture through which the extension extends and a pair of circumferentially spaced projections extending radially outwardly relative to the rotational axis of the stem at locations corresponding to the open and closed positions of the valve member. A slider member, slidably mounted on the intermediate portion of the handle for reciprocating movement between locked and unlocked positions, includes a latch element having an opening for receiving the projections and arranged to restrain both rotational and axial movement of the handle when the handle is in the open or closed position and the slider member is in the locked position.
摘要翻译：一种用于可旋转控制装置（例如四分之一转换阀）的防篡改锁定机构，其包括连接到可旋转地安装在容纳阀构件的主体中的杆的阀构件和通过细长延伸部连接到杆的操作手柄，阀构件在打开和关闭位置之间。锁定机构包括安装在主体上的支架，其具有从主体向外间隔开并且大致垂直于杆的旋转轴线的凸缘，并且包括一个孔，该延伸部延伸穿过该孔，并且一对周向间隔开的突出部相对于杆的旋转轴线对应于阀构件的打开和关闭位置的位置。滑动构件，可滑动地安装在手柄的中间部分上，用于在锁定位置和未锁定位置之间往复运动，包括一个闩锁元件，该闩锁元件具有用于接收突起的开口，并被布置成当手柄处于手柄时能够抑制手柄的旋转和轴向运动打开或关闭位置和滑动构件处于锁定位置。

7. 发明授权

US5162523A Cephalosporin antibacterial compounds 失效
标题翻译： CEPHALOSPORIN抗生素化合物
公开(公告)号：US5162523A
公开(公告)日：1992-11-10
申请号：US539359
申请日：1990-06-20
申请人： Dennis D. Keith , John L. Roberts , Chung-Chen Wei
发明人： Dennis D. Keith , John L. Roberts , Chung-Chen Wei
IPC分类号： A61K31/397 , A61K31/40 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , A61P31/12 , C07D205/085 , C07D205/095 , C07D401/02 , C07D401/12 , C07D401/14 , C07D499/00 , C07D499/21 , C07D501/00 , C07D501/16 , C07D501/59 , C07D519/00
CPC分类号： C07D401/12 , C07D205/085 , C07D499/00 , C07D501/00
摘要： Antibacterial compounds of the formula ##STR1## in which R.sub.1 is a cyclic or secondary acyclic amino group which independently has antibacterial activity;R.sub.2 is hydrogen, lower alkoxy, lower alkylthio or formamido;R.sub.3 is hydrogen or an organic group bonded through carbon, oxygen, sulfur or nitrogen;R.sub.4 is an electronegative acidic group; or R.sub.3 and R.sub.4 together form a heterocycle; andR.sub.5 is hydrogen or lower alkyl, except when R.sub.3 and R.sub.4 form a heterocycle, in which case R.sub.5 is hydrogen only; and methods of using same.

8. 发明授权

US5482251A Stem extension for quarter-turn valves 失效
标题翻译：四分之一转阀的阀杆延伸
公开(公告)号：US5482251A
公开(公告)日：1996-01-09
申请号：US288684
申请日：1994-08-11
申请人： John L. Roberts
发明人： John L. Roberts
IPC分类号： F16K5/06 , F16K35/06 , F16K31/46 , F16K51/00
CPC分类号： F16K35/06 , F16K5/0647
摘要： A rotatable control device or valve including a body housing a control mechanism and a rotatably mounted control shaft connected to the control mechanism. Stops are spaced circumferentially relative to the control shaft. A stop arm is operably connected to the control shaft and engages the stops to limit rotational movement of the control mechanism between first and second positions. An elongated extension is drivingly connected to the stop arm, and an elongated operating handle is connected to the extension with the orientation of the longitudinal axis of the operating handle corresponding in a predetermined relationship to the position of the control member. A registration mechanism permits the extension to be drivingly connected to the stop arm only when the orientation of the longitudinal axis of the operating handle corresponds in the predetermined relationship to the position of the control means.
摘要翻译：一种旋转控制装置或阀，包括容纳控制机构的主体和连接到控制机构的可旋转地安装的控制轴。止动件相对于控制轴在周向间隔开。止动臂可操作地连接到控制轴并接合止动件以限制控制机构在第一和第二位置之间的旋转运动。细长的延伸部驱动地连接到止动臂，并且细长的操作手柄连接到延伸部，其中操作手柄的纵向轴线的取向以对应于控制构件的位置的预定关系对应。只有当操作手柄的纵向轴线的取向与控制装置的位置相对应的预定关系时，对准机构允许延伸部被驱动地连接到止动臂。

9. 发明授权

US08314250B2 Sultam derivatives 有权
标题翻译：苏丹衍生物
公开(公告)号：US08314250B2
公开(公告)日：2012-11-20
申请号：US12905120
申请日：2010-10-15
申请人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人： Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号： C07D285/01 , C07D417/06 , A61K31/425 , A61K31/4535 , A61K31/4523
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译：本发明涉及具有细胞毒活性的根据式1的化合物。该化合物可用于治疗癌症。

10. 发明授权

US07081351B2 Method for screening an agent for ability to inhibit heparanase activity 失效
公开(公告)号：US07081351B2
公开(公告)日：2006-07-25
申请号：US10314683
申请日：2002-12-09
申请人： Kuo-Sen Huang , Anthony Neri , John L Roberts
发明人： Kuo-Sen Huang , Anthony Neri , John L Roberts
IPC分类号： C12Q1/34 , G01N33/53 , C12N9/14 , C12N9/24 , C12N9/99
CPC分类号： C12Q1/34 , G01N33/566 , G01N33/573 , G01N2458/40
摘要： The present invention provides a method for testing an agent for its potential to inhibit heparanase catalytic activity, comprising the steps of: interacting immobilized heparanase substrate binding protein on a solid support with labeled heparanase substrate to provide immobilized labeled heparanase substrate, interacting a heparanase enzyme solution with the immobilized labeled heparanase substrate in the presence of the agent, and detecting the presence or absence of label in the solution remote from the solid support. The labeled heparanase substrate may be bound to an immobilization bridge which binds to immobilized molecules on a solid support, to provide bridge-immobilized labeled heparanase substrate. The present invention also provides a method for testing an agent for its ability to inhibit binding between fibroblast growth factor (FGF) and heparanase substrate, comprising the steps of: interacting in solution immobilized FGF on a solid support with the agent and labeled heparanase substrate, and detecting the presence or absence of label in the solution remote from the solid support.

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