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1. 发明申请

US20070037872A1 Inducing peripheral blood vesel vasodilation 审中-公开
标题翻译：诱导外周血液血管舒张
公开(公告)号：US20070037872A1
公开(公告)日：2007-02-15
申请号：US11477209
申请日：2006-06-29
申请人： Catherine Kwik-Uribe , Harold Schmitz , Mark Kelm , John Hammerstone
发明人： Catherine Kwik-Uribe , Harold Schmitz , Mark Kelm , John Hammerstone
IPC分类号： A61K31/35 , A01N43/16
CPC分类号： A61K31/353 , A61K31/35 , A61K31/70
摘要： The invention relates to compositions, and methods of use thereof, containing polyphenols such as flavanols, procyanidins, their derivatives and epimers thereof, for inducing peripheral blood vessel vasodilation, for example for treating or preventing peripheral vascular diseases.
摘要翻译：本发明涉及包含多酚如黄烷醇，原花青素，其衍生物和差向异构体的用于诱导外周血管血管舒张的组合物及其使用方法，例如用于治疗或预防外周血管疾病。

2. 发明申请

US20070003640A1 Process for controlling the isomerization of (-)-epicatechin and (+)-catechin in edible products 审中-公开
标题翻译：控制食品中（ - ） - 表儿茶素和（+） - 儿茶素异构化的方法
公开(公告)号：US20070003640A1
公开(公告)日：2007-01-04
申请号：US11170593
申请日：2005-06-29
申请人： John Hammerstone , Valeria Acquarone
发明人： John Hammerstone , Valeria Acquarone
IPC分类号： A23P1/00 , A23L3/015 , C07D311/02 , A61K36/736 , A61K36/48 , A61K36/42 , A61K36/73 , A61K36/20 , A61K36/898
CPC分类号： C07D311/62 , A23B7/005 , A23B9/02 , A23G1/0016 , A23G1/30 , A23L33/105
摘要： A method for controlling the isomerization of (−)-epicatechin to (−)-catechin in an epicatechin-containing product, preferably an edible product, which method comprises the step of heating the product at a temperature of up to about 190° C. and at a pH of up to about 8. A method for controlling the isomerization of (+)-catechin to (+)-epicatechin in a catechin-containing product, preferably an edible product, which method comprises the step of heating the product, at a temperature of up to about 190° C. and at a pH of up to about 8. Preferably, the temperature is from about 72° C. to about 125° C., the pH is from about 4 to about 7, and the time is at least about 15 seconds. Under either method, the isomerization may be carried out in an open food processor in a reduced oxygen atmosphere or in a closed food processor. The edible product may be pasteurized, boiled or sterilized during the isomerization. The isomerization is minimized by lowering the heating temperature, by lowering the pH, and/or by lowering the heating time. Conversely, the isomerization is maximized by increasing the heating temperature, by increasing the pH, and/or by increasing the heating time. The edible product may contain or be a fruit product, a vegetable product, a cereal product, a bean product, a nut product, or a spice product.
摘要翻译：用于控制含表儿茶素的产品（ - ） - 表儿茶素至（ - ） - 儿茶素异构化的方法，优选食用产品，该方法包括在高至约190℃的温度下加热产物的步骤。并且在高达约8的pH下。一种用于控制含儿儿茶素产品中（+） - 儿茶素至（+） - 表儿茶素异构化的方法，优选食用产品，该方法包括加热产物的步骤，在高达约190℃的温度下，pH最高达约8.优选地，温度为约72℃至约125℃，pH为约4至约7，并且时间至少约15秒。在任一方法下，异构化可以在开放的食品加工机中在还原氧气氛中或封闭的食品加工机中进行。在异构化过程中，可食用产品可以进行巴氏杀菌，煮沸或灭菌。通过降低加热温度，降低pH和/或降低加热时间来使异构化最小化。相反，通过增加加热温度，通过增加pH和/或通过增加加热时间来使异构化最大化。可食用产品可以含有水果产品，蔬菜制品，谷类食品，豆制品，坚果制品或香料制品。

3. 发明申请

US20050164956A1 Compositions and methods of use of A-type procyanidins 有权
标题翻译： A型原花青素的组合物和使用方法
公开(公告)号：US20050164956A1
公开(公告)日：2005-07-28
申请号：US11045648
申请日：2005-01-28
申请人： Harold Schmitz , Catherine Kwik-Uribe , Mark Kelm , John Hammerstone
发明人： Harold Schmitz , Catherine Kwik-Uribe , Mark Kelm , John Hammerstone
IPC分类号： A61K31/353 , A61K31/7048
CPC分类号： A61K31/7048 , A23G2200/04 , A61K31/353
摘要： The invention relates to compositions, such as pharmaceuticals, foods, food additives, or dietary supplements, containing A-type procyanidins, and methods of use thereof, for prophylactic or therapeutic treatment of a human or a veterinary animal to treat or prevent NO-responsive health conditions, treat hypertension, cardiovascular disease, coronary artery disease and/or vascular circulation disorders, prevent or reduce the risk of heart attack, stroke, congestive heart failure and/or kidney failure, or to improve blood flow, for example renal blood flow. The composition may optionally contain an additional NO modulating agent and/or a cardiovascular-protective or therapeutic agent, or may be administered in combination with such an agent.
摘要翻译：本发明涉及包含A型原花青素的药物，食品，食品添加剂或膳食补充剂的组合物及其使用方法，用于预防或治疗人类或兽用动物治疗或预防NO反应性健康状况，治疗高血压，心血管疾病，冠状动脉疾病和/或血管循环障碍，预防或减少心脏病发作，中风，充血性心力衰竭和/或肾衰竭的风险，或改善血流量，例如肾血流量。组合物可以任选地含有另外的NO调节剂和/或心血管保护或治疗剂，或者可以与这种药物组合施用。

4. 发明申请

US20080051587A1 Method for Extracting Cocoa Procyanidins 有权
标题翻译：提取可可原花青素的方法
公开(公告)号：US20080051587A1
公开(公告)日：2008-02-28
申请号：US11865424
申请日：2007-10-01
申请人： John Hammerstone , Mark Chimel
发明人： John Hammerstone , Mark Chimel
IPC分类号： C07D311/04 , C07D407/02 , C07D407/14
CPC分类号： A23G1/02 , A23G1/56 , A23G2200/00 , C07D493/18
摘要： A cocoa extract which is rich in procyanidin monomer and oligomers is made by extracting de-fatted, unroasted, unfermented cocoa beans with organic solvents. The yield of procyanidins in an extract varies with the type of solvent used, reaction temperature, reaction pH and whether or not the solvent is an aqueous solution. Extraction parameters can be optimized to increase procyanidin yield, and different conditions results in the preferential extraction of the higher or lower oligomers. A preferred extraction method is countercurrent extraction method.
摘要翻译：富含原花青素单体和低聚物的可可提取物是通过用有机溶剂提取脱脂，未焙烧的未发酵可可豆制成的。提取物中原花青素的产率随所用溶剂的种类，反应温度，反应pH以及溶剂是否为水溶液而变化。可以优化提取参数以增加原花青素产量，并且不同的条件导致优选提取较高级或低级低聚物。优选的提取方法是逆流萃取法。

5. 发明申请

US20070134400A1 Process for extracting cocoa polyphenols from cocoa beans 有权
标题翻译：从可可豆中提取可可多酚的方法
公开(公告)号：US20070134400A1
公开(公告)日：2007-06-14
申请号：US11639129
申请日：2006-12-14
申请人： Kirk Kealey , Rodney Snyder , Leo Romanczyk , Hans Gever , Mary Myers , Eric Whitacre , John Hammerstone , Harold Schmitz
发明人： Kirk Kealey , Rodney Snyder , Leo Romanczyk , Hans Gever , Mary Myers , Eric Whitacre , John Hammerstone , Harold Schmitz
IPC分类号： A23G1/04
CPC分类号： A23G1/48 , A21D2/36 , A21D13/80 , A23G1/002 , A23G1/02 , A23G1/305 , A23G1/56 , A23G3/48 , A23G2200/14 , A23K50/42 , A23K50/48 , A23L27/11 , A23L33/105 , A23V2002/00 , A23V2250/2132
摘要： Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods of using the cocoa components or the cocoa polyphenols for improving the health of a mammal are described. The cocoa components include partially and fully defatted cocoa solids, cocoa nibs and fractions derived therefrom, cocoa polyphenol extracts, cocoa butter, chocolate liquors, and mixtures thereof. The invention provides processes for extracting fat from cocoa beans and for otherwise processing cocoa beans to yield a cocoa component having conserved concentrations of polyphenols relative to the starting materials.
摘要翻译：可可组分具有增加的可可多元酚水平，生产可可组分的过程同时保留大量的可可多元酚，含有可可组分或可可多元酚的组合物，以及使用可可组分或可可多元酚改善健康的方法描述了哺乳动物。可可组分包括部分和完全脱脂的可可固体，可可可可及其衍生的级分，可可多酚提取物，可可脂，巧克力液及其混合物。本发明提供从可可豆中提取脂肪以及否则加工可可豆以产生相对于起始原料具有保守的多酚浓度的可可组分的方法。

6. 发明申请

US20060293259A1 Compositions and methods of use of derivatized flavanols 审中-公开
标题翻译：衍生黄烷醇的组合物和使用方法
公开(公告)号：US20060293259A1
公开(公告)日：2006-12-28
申请号：US11476500
申请日：2006-06-28
申请人： Catherine Kwik-Uribe , Harold Schmitz , Mark Kelm , John Hammerstone
发明人： Catherine Kwik-Uribe , Harold Schmitz , Mark Kelm , John Hammerstone
IPC分类号： A61K31/7048 , A61K31/353
CPC分类号： A61K31/353 , A61K31/7048
摘要： The invention relates to compositions containing derivatized flavanols such as methylated flavanols, and methods of use thereof for prophylactic or therapeutic treatment of a human or a veterinary animal for example as anti-platelet agents.
摘要翻译：本发明涉及含有衍生化黄烷醇如甲基化黄烷醇的组合物及其用于预防或治疗人类或兽医动物例如抗血小板剂的方法。

7. 发明申请

US20080089997A1 Partially Defatted Cocoa Solids Containing Conserved Amounts of Cocoa Polyphenols 审中-公开
标题翻译：部分脱脂可可固体含有可可多酚的保存量
公开(公告)号：US20080089997A1
公开(公告)日：2008-04-17
申请号：US11926951
申请日：2007-10-29
申请人： Kirk Kealey , Rodney Snyder , Leo Romanczyk , John Hammerstone , Margaret Buck , Giovanni Cipolla
发明人： Kirk Kealey , Rodney Snyder , Leo Romanczyk , John Hammerstone , Margaret Buck , Giovanni Cipolla
IPC分类号： A23G1/00
CPC分类号： A23K50/48 , A21D2/364 , A21D13/80 , A23G1/0006 , A23G1/0009 , A23G1/002 , A23G1/0023 , A23G1/02 , A23G1/04 , A23G1/06 , A23G1/30 , A23G1/36 , A23G1/48 , A23G1/56 , A23G2200/00 , A23K50/42 , A23L7/122 , A23L7/126 , A23L7/17 , A23L7/178 , A23L7/196 , A23L9/10 , A23L19/09 , A23L33/10 , A23L33/105 , C11B1/04 , C11B1/06 , C11B1/10
摘要： The present invention is directed to a method of processing a fat-containing bean, e.g., cocoa beans, for producing solids comprising active polyphenols and/or fat-containing products, comprising extracting the fat to produce solids and fat-containing products. Additionally, the inventive method also provides cocoa compositions comprising at least one active polyphenol, wherein the concentration of the polyphenol(s) with respect to the nonfat solids is conserved with respect to the concentration of the active polyphenol(s) in the bean from which the compositions are derived.
摘要翻译：本发明涉及一种处理含脂肪豆，例如可可豆，用于生产包含活性多酚和/或含脂肪产品的固体的方法，其包括提取脂肪以产生固体和含脂肪的产品。另外，本发明的方法还提供了包含至少一种活性多酚的可可组合物，其中多酚相对于非脂肪固体的浓度相对于豆中的活性多酚的浓度是保守的，衍生出组合物。

8. 发明申请

US20080021227A1 ANTINEOPLASTIC COCOA EXTRACTS AND METHODS FOR MAKING AND USING THE SAME 有权
标题翻译： ANTINEOPLASTIC COCOA提取物及其制备和使用方法
公开(公告)号：US20080021227A1
公开(公告)日：2008-01-24
申请号：US11745698
申请日：2007-05-08
申请人： Leo Romanczyk , John Hammerstone , Margaret Buck
发明人： Leo Romanczyk , John Hammerstone , Margaret Buck
IPC分类号： C07D311/02 , C07C39/12
CPC分类号： A61K31/78 , A23L33/105 , A61K31/353 , A61K36/185 , C07D311/62
摘要： Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topoisomerase-inhibiting compositions and methods.
摘要翻译：披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物和用于治疗使用该组合物的患者的方法。另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。

9. 发明申请

US20070264417A1 Method for Solvent Extracting Cocoa Butter from Cocoa Nibs 审中-公开
标题翻译：从可可可可提取可可脂的溶剂方法
公开(公告)号：US20070264417A1
公开(公告)日：2007-11-15
申请号：US11745766
申请日：2007-05-08
申请人： Kirk Kealey , Rodney Snyder , Leo Romanczyk , John Hammerstone , Margaret Buck , Giovanni Cipolla
发明人： Kirk Kealey , Rodney Snyder , Leo Romanczyk , John Hammerstone , Margaret Buck , Giovanni Cipolla
IPC分类号： A23G1/02
CPC分类号： A23K50/48 , A21D2/364 , A21D13/80 , A23G1/0006 , A23G1/0009 , A23G1/002 , A23G1/0023 , A23G1/02 , A23G1/04 , A23G1/06 , A23G1/30 , A23G1/36 , A23G1/48 , A23G1/56 , A23G2200/00 , A23K50/42 , A23L7/122 , A23L7/126 , A23L7/17 , A23L7/178 , A23L7/196 , A23L9/10 , A23L19/09 , A23L33/10 , A23L33/105 , C11B1/04 , C11B1/06 , C11B1/10
摘要： The present invention is directed to a method of processing a fat-containing bean, e.g., cocoa beans, for producing solids comprising active polyphenols and/or fat-containing products, comprising extracting the fat to produce solids and fat-containing products. Additionally, the inventive method also provides cocoa compositions comprising at least one active polyphenol, wherein the concentration of the polyphenol(s) with respect to the nonfat solids is conserved with respect to the concentration of the active polyphenol(s) in the bean from which the compositions are derived.
摘要翻译：本发明涉及一种处理含脂肪豆，例如可可豆，用于生产包含活性多酚和/或含脂肪产品的固体的方法，其包括提取脂肪以产生固体和含脂肪的产品。另外，本发明的方法还提供了包含至少一种活性多酚的可可组合物，其中多酚相对于非脂肪固体的浓度相对于豆中的活性多酚的浓度是保守的，衍生出组合物。

10. 发明申请

US20050277600A1 Compositions and methods of use of dimer digallates 审中-公开
标题翻译：二聚物二氧化物的组合物和使用方法
公开(公告)号：US20050277600A1
公开(公告)日：2005-12-15
申请号：US11153698
申请日：2005-06-14
申请人： Harold Schmitz , Catherine Kwik-Uribe , Mark Kelm , John Hammerstone , Leo Romanczyk
发明人： Harold Schmitz , Catherine Kwik-Uribe , Mark Kelm , John Hammerstone , Leo Romanczyk
IPC分类号： A61K31/353 , A61K31/7048
CPC分类号： A61K31/7048 , A61K31/353
摘要： The invention relates to compositions, such as pharmaceuticals, foods, food additives, or dietary supplements, containing dimer digallates, and methods of use thereof, for prophylactic or therapeutic treatment of a human or a veterinary animal to treat or prevent NO-responsive health conditions, treat hypertension, cardiovascular disease, coronary artery disease, diabetes, cognitive dysfunction or disorder and/or vascular circulation disorders, prevent or reduce the risk of heart attack, stroke, congestive heart failure and/or kidney failure, or to improve blood flow, for example renal blood flow. The composition may optionally contain an additional NO modulating agent and/or a vascular-protective or therapeutic agent, or may be administered in combination with such an agent.
摘要翻译：本发明涉及包含二聚物二胆酸盐的组合物，例如药物，食品，食品添加剂或膳食补充剂及其使用方法，用于预防或治疗人类或兽医动物治疗或预防NO反应性健康状况治疗高血压，心血管疾病，冠状动脉疾病，糖尿病，认知功能障碍或障碍和/或血管循环障碍，预防或降低心脏病发作，中风，充血性心力衰竭和/或肾衰竭的风险，或改善血流量，例如肾血流量。组合物可以任选地含有另外的NO调节剂和/或血管保护性或治疗剂，或者可以与这种药物组合施用。

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