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1. 发明专利

GB1184106A Improvements in or relating to Reamers 未知
公开(公告)号：GB1184106A
公开(公告)日：1970-03-11
申请号：GB1771067
申请日：1967-04-18
申请人： JOHN DARBYSHIRE & COMPANY LTD
发明人： DARBYSHIRE LESLIE NOEL
IPC分类号： E21B10/32
摘要： 1,184,106. Reamers. JOHN DARBYSHIRE & CO. Ltd. 9 April, 1968 [18 April, 1967], No. 17710/67. Heading B3C. A reamer for undercutting blind holes in underground workings so as to secure bolts by adhesive, comprises a shank 1, Fig. 1, slidable against a spring 11 in a housing 4, cutter blades 20 pivoted to the shank at 21, and a blade opening stop 6, fixed to the housing at 8. Stop 6 and cutter blades 20 are removable. In a modification, blades 20 are pivoted to housing 4 at 25, Fig. 4, and shank 1 is moved against the blades so as to expand the latter. On retraction of the shank the blades are retracted by rubber or synthetic rubber compression members 27.

2. 发明专利

FR1237585A 未知
公开(公告)号：FR1237585A
公开(公告)日：1960-07-29
申请号：FR807469
申请日：1959-10-14
申请人： JOHN DARBYSHIRE & COMPANY LTD
IPC分类号： E21D15/48 , E21D15/60

3. 发明专利

DE1752177B1 未知
公开(公告)号：DE1752177B1
公开(公告)日：1971-12-30
申请号：DE1752177
申请日：1968-04-13
申请人： JOHN DARBYSHIRE & CO LTD
发明人： NOEL DARBYSHIRE LESLIE
IPC分类号： E21B10/32

4. 发明专利

CA863171A REAMERS 未知
公开(公告)号：CA863171A
公开(公告)日：1971-02-09
申请号：CA863171D
申请人： JOHN DARBYSHIRE AND COMPANY LT
发明人： DARBYSHIRE LESLIE N

5. 发明专利

BE583629A Perfectionnements à ou relatifs à des appareils pour le soutènement de plafonds dans les mines souterraines. 未知
公开(公告)号：BE583629A
公开(公告)日：1960-02-01
申请号：BE583629
申请日：1959-10-15
申请人： JOHN DARBYSHIRE & COMPANY LTD
IPC分类号： E21D

6. 发明授权

US07767705B2 Compounds that inhibit TRPV1 and uses thereof 有权
标题翻译：抑制TRPV1的化合物及其用途
公开(公告)号：US07767705B2
公开(公告)日：2010-08-03
申请号：US11844712
申请日：2007-08-24
申请人： Chih-hung Lee , Richard J Perner , Brian S. Brown , John Darbyshire
发明人： Chih-hung Lee , Richard J Perner , Brian S. Brown , John Darbyshire
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： A61K31/416 , C07D231/56
摘要： Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：在描述中定义R3，R7，R9和L的式（I）化合物是对CYP3A4表现出低抑制活性的TRPV1拮抗剂。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

7. 发明授权

US06953592B2 Water soluble powders and tablets 有权
标题翻译：水溶性粉末和片剂
公开(公告)号：US06953592B2
公开(公告)日：2005-10-11
申请号：US10235671
申请日：2002-09-04
申请人： John Darbyshire , Oliver Chmiel , Johan Bernard Ubbink , Annemarie Schoonman
发明人： John Darbyshire , Oliver Chmiel , Johan Bernard Ubbink , Annemarie Schoonman
IPC分类号： A61K9/36 , A23F5/38 , A23G3/00 , A23G3/02 , A23G3/10 , A23G3/34 , A23G3/36 , A23G3/44 , A23G3/52 , A23K1/00 , A23K1/18 , A23L1/00 , A23L2/395 , A23P1/02 , A61K9/00 , A61K9/20 , C11D3/22 , C11D17/00 , A61K9/14
CPC分类号： A23G3/36 , A23F5/385 , A23G3/0221 , A23G3/10 , A23G3/346 , A23G3/44 , A23G3/52 , A23G2200/00 , A23G2200/10 , A23G2220/02 , A23K40/10 , A23K40/20 , A23K40/25 , A23K50/40 , A23L2/395 , A23L5/55 , A23P10/28 , A23V2002/00 , A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/2059 , C11D3/221 , C11D3/222 , C11D17/0073 , A23V2200/226 , A23V2250/5114 , A23V2250/54246 , A23V2250/10 , A23V2250/124 , A23V2200/224
摘要： The invention relates to water soluble or water dispersible powders, tablets, or precursors therefor based on a carbohydrate matrix with improved dissolution properties in water. These components are subjected to treatment with a gas so that gas is entrapped therein, and sufficient closed porosity is provided so that gas entrapped therein promotes dissolution or dispersion upon contact with water. The powders or tablets may be pharmaceuticals or foods that optionally contain an active ingredient therein.
摘要翻译：本发明涉及基于具有改善的在水中的溶解性质的碳水化合物基质的水溶性或水分散性粉末，片剂或其前体。将这些组分用气体进行处理，使得气体被截留在其中，并且提供足够的闭孔，使得截留在其中的气体促进与水接触时的溶解或分散。粉末或片剂可以是任选地含有活性成分的药物或食品。

8. 发明申请

US20100249203A1 COMPOUNDS THAT INHIBIT TRPV1 AND USES THEREOF 有权
标题翻译：禁止TRPV1的化合物及其用途
公开(公告)号：US20100249203A1
公开(公告)日：2010-09-30
申请号：US12815259
申请日：2010-06-14
申请人： Chih-hung Lee , Richard J. Perner , Brian S. Brown , John Darbyshire
发明人： Chih-hung Lee , Richard J. Perner , Brian S. Brown , John Darbyshire
IPC分类号： A61K31/415 , C07D231/56 , A61P25/00 , A61P19/02 , A61P35/04 , A61P15/00 , A61P1/00 , A61P29/00
CPC分类号： A61K31/416 , C07D231/56
摘要： Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：在描述中定义R3，R7，R9和L的式（I）化合物是对CYP3A4表现出低抑制活性的TRPV1拮抗剂。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

9. 发明授权

US4579739A Process for the manufacture of a naturally carbonated beverage 失效
标题翻译：用于制造天然碳酸饮料的方法
公开(公告)号：US4579739A
公开(公告)日：1986-04-01
申请号：US561044
申请日：1983-12-13
申请人： John Darbyshire , Jaroslav Dasek , Hugh Hose
发明人： John Darbyshire , Jaroslav Dasek , Hugh Hose
IPC分类号： C12G3/02 , A23L2/00 , A23L2/02 , A23L2/38 , A23L2/84 , C12G3/08 , C12N1/20 , C12G1/00 , A23L2/26 , C12G3/00
CPC分类号： C12G3/08 , A23L2/84 , Y10S435/853 , Y10S435/856 , Y10S435/942 , Y10S435/943
摘要： A must is fermented with a combination of at least one yeast and at least one lactobacillus, the former being selected from the group of Saccharomyces cerevisiae and Kluyveromyces lactis and the latter being selected from the group of Lactobacillus casei and Lactobacillus hilgardii for their symbiotic ability and capability to produce a synergistic organoleptic effect which eliminates all after-taste of yeast. The must is inoculated such that the respective numbers of yeast germs and lactobacilli germs per ml have a ratio of from 1:10 to 1:500.
摘要翻译：必须用至少一种酵母和至少一种乳杆菌的组合发酵，前者选自酿酒酵母和乳酸克鲁维酵母，后者选自干酪乳杆菌和黑麦草乳杆菌的共生能力，能够产生消除酵母的所有后味的协同感官作用。必须接种，使得每毫升的酵母菌和乳杆菌菌的相应数目的比例为1:10至1:500。

10. 发明申请

US20080171751A1 Triazole Compounds Suitable for Treating Disorders that Respond to Modulation of the Dopamine D3 Receptor 失效
标题翻译：适用于治疗多巴胺D3受体调节反应的三唑化合物
公开(公告)号：US20080171751A1
公开(公告)日：2008-07-17
申请号：US11792596
申请日：2005-12-01
申请人： Liliane Unger , Andreas Haupt , Armin Beyerbach , Karla Drescher , Wilfried Braje , John Darbyshire , Sean C. Turner , Gisela Backfisch
发明人： Liliane Unger , Andreas Haupt , Armin Beyerbach , Karla Drescher , Wilfried Braje , John Darbyshire , Sean C. Turner , Gisela Backfisch
IPC分类号： A61K31/496 , C07D403/14 , A61P25/00
CPC分类号： C07D403/12
摘要： The invention relates to compounds of the formula I: wherein n is 1 or 2, Ar is a C-bound 1,2,4-triazol radical which carries a radical R1 on the remaining carbon atom and a radical R1a on one of the nitrogen atoms; R1 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxymethyl, fluorinated C1-C6 alkyl, fluorinated C3-C6 cycloalkyl, fluorinated C1-C4 alkoxymethyl, or optionally substituted phenyl or 5- or 6-membered heteroaryl; R1a is hydrogen or C1-C4 alkyl; and R2 is C1-C6 alkyl, C3-C6 cycloalkyl, fluorinated C1-C6 alkyl or fluorinated C3-C6 cycloalkyl; and to the physiologically tolerated acid addition salts of these compounds. The invention also relates to a pharmaceutical composition that comprises at least one triazole compound of the formula I and/or at least one physiologically tolerated acid addition salt thereof, and further to a method for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists, said method comprising administering an effective amount of at least one triazole compound or physiologically tolerated acid addition salt of the formula I to a subject in need thereof.
摘要翻译：本发明涉及式I化合物：其中n是1或2，Ar是在剩余的碳原子上带有自由基R 1的C结合的1,2,4-三唑基，和其中一个氮原子上的基团R 1a， R 1是氢，C 1 -C 6烷基，C 3 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基，氟化C 1 -C 6烷基，氟化C 1 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基，氟化C 1 -C 4烷氧基甲基或任选取代的苯基或5-或6位的C 1 -C 6烷基，杂芳基; R 1a是氢或C 1 -C 4烷基; R 2是C 1 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，C 3 -C 6烷基，氟化C 1 -C 6烷基或氟化C 3 -C 6环烷基; 以及这些化合物的生理上耐受的酸加成盐。本发明还涉及一种药物组合物，其包含至少一种式I的三唑化合物和/或其至少一种生理上耐受的酸加成盐，还涉及治疗有益于多巴胺D 3的病症的方法受体拮抗剂或多巴胺D 3激动剂，所述方法包括向有需要的受试者施用有效量的至少一种式III的三唑化合物或生理耐受的酸加成盐。

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