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1. 发明申请

US20140206898A1 PROCESS FOR THE ISOMERISATION OF SUBSTITUTED ALKENES 有权
标题翻译：取代替代碱基的方法
公开(公告)号：US20140206898A1
公开(公告)日：2014-07-24
申请号：US14129201
申请日：2012-07-12
申请人： Natascha Sereinig , Michèle Catherine Christianne Janssen , Johannes Gerardus De Vries
发明人： Natascha Sereinig , Michèle Catherine Christianne Janssen , Johannes Gerardus De Vries
IPC分类号： C07C67/333 , B01J31/24
CPC分类号： C07C67/333 , B01J31/24 , C07C69/58 , C07C69/587 , C07C69/716 , C07C69/732
摘要： The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: (a) an unsaturated fatty acid or ester or amide thereof; (b) a source of Pd; (c) a bidentate diphosphine of formula I, R1R2>P1-R-P2
摘要翻译：本发明涉及不饱和脂肪酸或其酯或酰胺异构化的方法，所述方法包括使（a）不饱和脂肪酸或其酯或酰胺反应; （b）Pd源; （c）式I的二齿二膦，R1R2> P1-R-P2

2. 发明申请

US20140172459A1 CLINICAL SUPPORT SYSTEM AND METHOD 审中-公开
标题翻译：临床支持系统与方法
公开(公告)号：US20140172459A1
公开(公告)日：2014-06-19
申请号：US14105633
申请日：2013-12-13
申请人： Jan Johannes Gerardus De Vries , Aleksandra Tesanovic , Gijs Geleijnse
发明人： Jan Johannes Gerardus De Vries , Aleksandra Tesanovic , Gijs Geleijnse
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06Q50/24 , G16H50/30
摘要： The present invention relates to a clinical support system and a corresponding clinical support method. The system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining a health score curve over time of a patient, for whom a recommendation for a moment of discharge from a medical facility shall be provided, obtaining a reference curve to the health score curve, wherein said reference curve indicates a patient stabilization over time, computing a difference between the health score curve and said reference curve, and computing a recommended moment of discharge from the medical facility based on the difference between said health score curve and said reference curve. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program.
摘要翻译：本发明涉及临床支持系统和相应的临床支持方法。所述系统包括处理器和计算机可读存储介质，其中所述计算机可读存储介质包含由所述处理器执行的指令，其中所述指令使所述处理器执行以下步骤：随着患者的时间获得健康评分曲线，应向其提供从医疗设施排出一刻的建议，获得健康评分曲线的参考曲线，其中所述参考曲线表示患者随时间的稳定，计算健康评分曲线与所述参考曲线之间的差异并且基于所述健康评分曲线和所述参考曲线之间的差异来计算来自所述医疗设施的推荐排放时刻。此外，本发明涉及计算机可读的非暂时性存储介质和计算机程序。

3. 发明申请

US20090043112A1 Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid 有权
标题翻译：对映体富集的二氢吲哚-2-羧酸的制备方法
公开(公告)号：US20090043112A1
公开(公告)日：2009-02-12
申请号：US11794246
申请日：2005-12-22
申请人： Andreas Hendrikus Maria De Vries , Johannes Gerardus De Vries , Friso Bernard Jan Van Assema , Ben De Lange , Daniel Mink , David John Hyett , Peter Johannes Maas
发明人： Andreas Hendrikus Maria De Vries , Johannes Gerardus De Vries , Friso Bernard Jan Van Assema , Ben De Lange , Daniel Mink , David John Hyett , Peter Johannes Maas
IPC分类号： C07D209/42
CPC分类号： C07D209/42
摘要： The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.
摘要翻译：本发明涉及一种制备对映体富集的任选取代的二氢吲哚-2-羧酸或其盐的方法，其中将对映异构体富集的手性邻-X取代的苯丙氨酸化合物（其中X为离去基团）在形成对映体富集的二氢吲哚-2-羧酸化合物时，优选在低于约140℃的温度下进行环化。

4. 发明授权

US08527041B2 System, method and computer program product for indicating stimulation signals to a user 有权
标题翻译：用于向用户指示刺激信号的系统，方法和计算机程序产品
公开(公告)号：US08527041B2
公开(公告)日：2013-09-03
申请号：US13203984
申请日：2010-02-26
申请人： Floris Maria Hermansz Crompvoets , Jan Johannes Gerardus De Vries , Dirk Brokken , Jacobus Maria Antonius Van Den Eerenbeemd , Paul Marcel Carl Lemmens
发明人： Floris Maria Hermansz Crompvoets , Jan Johannes Gerardus De Vries , Dirk Brokken , Jacobus Maria Antonius Van Den Eerenbeemd , Paul Marcel Carl Lemmens
IPC分类号： A61N1/00
CPC分类号： A61M21/00 , A61B5/02438 , A61B5/0245 , A61B5/1455 , A61B5/486 , A61B5/6805 , A61B5/7475 , A61M21/02 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0061 , A61M2209/088 , A61M2230/04 , A63B23/185
摘要： Stimulation system for indicating stimulation signals to a user, provided with at least one heart beat sensor for converting measured heart beats into a signal, a processing circuit configured to process the measured heart beat signals, a user interface configured to indicate stimulation signals to a user, wherein the processing circuit is configured to calculate intervals between the detected heart beats and register a predetermined number of successive intervals, predict a time interval between a detected heart beat and a predicted future heart beat based on the registered intervals, and instruct the user interface to indicate a stimulation signal to a user non-simultaneously with the predicted heart beat at the end of the predicted time interval so as to change the heart rate and/or heart coherence of the user.
摘要翻译：用于向用户指示刺激信号的刺激系统，设置有至少一个用于将测量的心跳转换为信号的心跳传感器，被配置为处理所测量的心跳信号的处理电路，被配置为向用户指示刺激信号的用户界面其中，所述处理电路被配置为计算检测到的心跳之间的间隔并且登记预定数量的连续间隔，基于所述注册间隔预测检测到的心跳和预测的未来心跳之间的时间间隔，并且指示用户界面以在预测时间间隔结束时与预测的心跳不同时地向用户指示刺激信号，以便改变用户的心率和/或心脏的一致性。

5. 发明申请

US20100069684A1 ASSYMMETRIC HYDROGENERATION OF PROCHIRAL COMPOUNDS 审中-公开
标题翻译：化合物的相对氢化
公开(公告)号：US20100069684A1
公开(公告)日：2010-03-18
申请号：US12520681
申请日：2007-12-21
申请人： Johannes Gerardus De Vries , Bart Stegink
发明人： Johannes Gerardus De Vries , Bart Stegink
IPC分类号： C07C29/143
CPC分类号： C07B53/00 , B01J31/1845 , B01J31/186 , B01J2231/643 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C29/145 , C07C33/22 , C07C33/18 , C07C33/46
摘要： The invention relates to the asymmetric (transfer) hydrogenation of a prochiral keton, prochiral imine, oxime, oxime derivative, hydrazone or hydrazone derivative, using a transition metal catalyst, characterized in that as a catalyst is used a transition metal complex of the general formula [I]: MaL1bL2c(N)dXe wherein a, b, c, d and e are integers; a, b and d can have a value of 1-6; c and e can have a value of 0-6; M is transition metal selected from the group consisting of Ru1 Rh and Ir; L1 is an enantiomerically enriched chiral monodentate phosphor-containing ligand of the general formula [II] or of the general formula [III]; L2 is any monodentate or bidentate neutral or monoanionic ligand, which may be chiral; N is a compound containing at least one primary or secondary amine group; X is a anion.
摘要翻译：本发明涉及使用过渡金属催化剂的前手性酮，前手性亚胺，肟，肟衍生物，腙或腙衍生物的不对称（转移）氢化，其特征在于，作为催化剂，使用通式 [I]：MaL1bL2c（N）dXe其中a，b，c，d和e是整数; a，b和d的值可以是1-6; c和e可以是0-6的值; M是选自Ru1 Rh和Ir的过渡金属; L1是通式[II]或通式[III]的对映异构体富集的手性单齿磷光体配体。 L2是任何单齿或二齿中性或单阴离子配体，其可以是手性的; N是含有至少一个伯或仲胺基的化合物; X是阴离子。

6. 发明申请

US20090298141A1 Continuous Chemical Proceses in Centrifugal Contact Separators 审中-公开
标题翻译：离心式接触分离器的连续化学处理
公开(公告)号：US20090298141A1
公开(公告)日：2009-12-03
申请号：US11991912
申请日：2006-09-15
申请人： Johannes Gerardus De Vries , Gerald Jan Kwant , Hero Jan Heeres
发明人： Johannes Gerardus De Vries , Gerald Jan Kwant , Hero Jan Heeres
IPC分类号： C12P7/64 , C12M1/00
CPC分类号： B01D17/0217 , B01F3/0807 , B01F7/008 , B01J14/00 , B01J19/1806 , C12P7/18 , C12P7/62 , C12P41/005 , Y02P20/582
摘要： The invention relates to the use of a centrifugal contact-separator for carrying out a non-radioactive reaction in a liquid-liquid emulsion formed from two immiscible liquids. The invention also relates to a process for carrying out a reaction in a centrifugal contact-separator, and to a process for carrying out a catalytic reaction in a centrifugal contact-separator. An example of a process for carrying out a reaction, comprising the following steps: i) continuously introducing a liquid phase A and a liquid phase B into at least one first centrifugal contact separator, where in liquid phases A and B are immiscible and wherein phase A and/or phase B comprise at least one reactant ii) mixing phase A and phase B thereby allowing an emulsion to be formed iii) applying a centrifugal force that allows phase separation of the emulsion, such that phases A′ and B′ are obtained; iv) optionally, recovering a reaction product from at least one or the phases A′ and B′.
摘要翻译：本发明涉及离心接触分离器在由两种不混溶液体形成的液 - 液乳液中进行非放射性反应的用途。本发明还涉及在离心式接触分离器中进行反应的方法以及在离心式分离器中进行催化反应的方法。一种进行反应的方法的实例包括以下步骤：i）将液相A和液相B连续引入到至少一个第一离心接触分离器中，其中液相A和B是不混溶的，其中相 A和/或B相包含至少一种反应物ii）混合A相和B相从而允许形成乳液iii）施加允许乳液相分离的离心力，从而获得相A'和B' ; iv）任选地，从至少一个或相A'和B'回收反应产物。

7. 发明授权

US09199961B2 Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran-dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde 有权
标题翻译：从5-羟甲基-2-糠醛制备己内酯，己内酰胺，2,5-四氢呋喃 - 二甲醇，1,6-己二醇或1,2,6-己三醇
公开(公告)号：US09199961B2
公开(公告)日：2015-12-01
申请号：US13699934
申请日：2011-03-23
申请人： Johannes Gerardus De Vries , Teddy , Pim Huat Phua , Ignacio Vladimiro Melián Cabrera , Hero Jan Heeres
发明人： Johannes Gerardus De Vries , Teddy , Pim Huat Phua , Ignacio Vladimiro Melián Cabrera , Hero Jan Heeres
IPC分类号： C07C29/132 , C07D201/08 , C07D313/04
CPC分类号： C07D313/04 , C07C29/132 , C07D201/08
摘要： The present invention relates to a method for preparing caprolactone, comprising converting 5-hydroxymethyl-2-furfuraldehyde by hydrogenation into at least one intermediate compound selected from the group of 2,5-tetrahydrofuran-dimethanol, 1,6-hexanediol and 1,2,6-hexanetriol, and preparing caprolactone from said intermediate compound.Further, the invention relates to a method for preparing 1,2,6-hexanetriol comprising preparing 5-hydroxymethyl-2-furfaldehyde from a renewable source, converting 5-hydroxymethyl-2-furfaldehyde into 2,5-tetrahydrofuran-dimethanol and converting 2,5-tetrahydrofuran-dimethanol into 1,2,6-hexanetriol.Further, the invention relates to a method for preparing 1,6-hexanediol from 1,2,6-hexanetriol, wherein 1,2,6-hexanetriol is subjected to a ring closure reaction, thereby forming (tetrahydro-2H-pyran-2-yl)methanol, and the (tetrahydro-2H-pyran-2-yl)methanol is hydrogenated, thereby forming 1,6-hexane diol.
摘要翻译：本发明涉及一种制备己内酯的方法，包括通过氢化将5-羟甲基-2-糠醛转化为至少一种选自2,5-四氢呋喃 - 二甲醇，1,6-己二醇和1,2 ，6-己烷三醇，并由所述中间体化合物制备己内酯。此外，本发明涉及一种制备1,2,6-己三醇的方法，包括从可再生来源制备5-羟甲基-2-糠醛，将5-羟甲基-2-糠醛转化为2,5-四氢呋喃 - 二甲醇并将2 ，5-四氢呋喃 - 二甲醇加入到1,2,6-己三醇中。此外，本发明涉及从1,2,6-己三醇制备1,6-己二醇的方法，其中1,2,6-己三醇进行闭环反应，从而形成（四氢-2H-吡喃-2-基） - 基）甲醇，并将（四氢-2H-吡喃-2-基）甲醇氢化，从而形成1,6-己二醇。

8. 发明授权

US08853434B2 Process for the isomerisation of substituted alkenes 有权
标题翻译：取代烯烃异构化的方法
公开(公告)号：US08853434B2
公开(公告)日：2014-10-07
申请号：US14129201
申请日：2012-07-12
申请人： Natascha Sereinig , Michèle Catherine Christianne Janssen , Johannes Gerardus De Vries
发明人： Natascha Sereinig , Michèle Catherine Christianne Janssen , Johannes Gerardus De Vries
IPC分类号： C11C3/14 , C07C67/333 , B01J31/24
CPC分类号： C07C67/333 , B01J31/24 , C07C69/58 , C07C69/587 , C07C69/716 , C07C69/732
摘要： The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: (a) an unsaturated fatty acid or ester or amide thereof; (b) a source of Pd; (c) a bidentate diphosphine of formula I, R1R2>P1-R—P2
摘要翻译：本发明涉及不饱和脂肪酸或其酯或酰胺异构化的方法，所述方法包括使（a）不饱和脂肪酸或其酯或酰胺反应; （b）Pd源; （c）式I的二齿二膦，R1R2> P1-R-P2

9. 发明申请

US20140128631A1 PROCESS FOR THE PREPARATION OF ALKANOIC ACID ESTERS IN A CARBONYLATION PROCESS USING PALLADIUM BIDENTATE BIPHOSPHATE LIGANDS 审中-公开
标题翻译：使用双磷酸双磷酸酯配体在碳化过程中制备碱性酸酯的方法
公开(公告)号：US20140128631A1
公开(公告)日：2014-05-08
申请号：US14008683
申请日：2012-03-30
申请人： Johannes Gerardus De Vries , Natascha Sereinig , Elisabeth Wilhelmina Maria Van De Vondervoort , Michele Catherine Christianne Janssen
发明人： Johannes Gerardus De Vries , Natascha Sereinig , Elisabeth Wilhelmina Maria Van De Vondervoort , Michele Catherine Christianne Janssen
IPC分类号： C07C67/36
CPC分类号： C07C67/36 , C07C51/09 , C07C67/03 , C07C67/38 , C07C209/48 , C07C253/00 , C07D307/33 , C07C211/12 , C07C255/04 , C07C69/533 , C07C69/44 , C07C55/14 , C07C59/185
摘要： The invention relates to a carbonylation process for the preparation of an alkanoic acid ester comprising reacting: (a) an alkene; (b) a source of Pd; (c) a bidentate phosphine ligand of formula I; R1R2P—R3—R—R4—PR5R6 (I) wherein P represents a phosphorus atom; R1, R2, R5 and R6 can independently represent the same or different optionally substituted organic groups containing a tertiary carbon atom through which the group is linked to the phosphorus atom; R3 and R4 independently represent optionally substituted lower alkylene groups and R represents an optionally substituted aromatic group; (d) a source of anions derived from an acid with a pKa
摘要翻译：本发明涉及一种用于制备链烷酸酯的羰基化方法，包括：（a）烯烃; （b）Pd源; （c）式I的二齿膦配体; R1R2P-R3-R-R4-PR5R6（I）其中P表示磷原子; R1，R2，R5和R6可以独立地表示相同或不同的含有叔碳原子的任选取代的有机基团，该基团通过该有机基团与磷原子连接; R3和R4独立地表示任选取代的低级亚烷基，R表示任选取代的芳基; （d）源自pKa <3的酸的阴离子源; （e）一氧化碳; 和（f）链烷醇; 其特征在于该方法在0.1至3重量％的水的存在下进行。该方法有利地具有高转化率，并且适用于生产己二酸二甲酯，己二酸酯和六亚甲基二胺及其衍生产物，例如来自可再生能源的废尼龙6,6，例如植物废物，污水废物等，而不是使用化石来源。

10. 发明申请

US20130310577A1 CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN 审中-公开
标题翻译：雷尼辛抑制剂和中间体的合成合成
公开(公告)号：US20130310577A1
公开(公告)日：2013-11-21
申请号：US13939983
申请日：2013-07-11
申请人： Ben DE LANGE , Anna Maria Cornelia Francisca CASTELIJNS , Johannes Gerardus DE VRIES , Andreas Hendrikus Maria DE VRIES , Jeroen Antonius Franciscus BOOGERS
发明人： Ben DE LANGE , Anna Maria Cornelia Francisca CASTELIJNS , Johannes Gerardus DE VRIES , Andreas Hendrikus Maria DE VRIES , Jeroen Antonius Franciscus BOOGERS
IPC分类号： C07D307/33 , C07C231/02
CPC分类号： C07D307/33 , C07C231/02 , C07C231/18 , C07D307/32 , C07F1/02 , C07F7/1804 , C07C237/22
摘要： Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3-6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).
摘要翻译：描述了制备肾素抑制剂如阿利吉仑的方法和其中有用的中间体。该方法引入含氮中间体如式（8）的内酯。其中R4是支链C 3-6烷基。在内酯或相关中间体的制备中，可以通过从满足式（10）的手性醛开始来控制所需的立体化学构型。

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