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1. 发明申请

US20190185910A1 MULTIPLEX PCR METHODS FOR DETECTING GENE FUSIONS, KITS AND COMPOSITIONS 审中-公开
公开(公告)号：US20190185910A1
公开(公告)日：2019-06-20
申请号：US16225118
申请日：2018-12-19
申请人： Jingfeng Li , Xiaomin Guo
发明人： Jingfeng Li , Xiaomin Guo
IPC分类号： C12Q1/686 , C12Q1/6883
CPC分类号： C12Q1/686 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16
摘要： Methods for detecting presence or absence of at least two known gene fusions in isolated genomic DNA comprise subjecting isolated genomic DNA to multiplex PCR. For each known gene fusion, the multiplex PCR employs one or a plurality of forward primers which hybridize to a first gene adjacent its fusion breakpoint location, and one or a plurality of reverse primers which hybridize to a second gene adjacent its fusion breakpoint location. The primers hybridize to the respective gene at consecutive respective positions separated from one another by a plurality of base pairs. Amplified products are detected and respectively represent the presence of a gene fusion. Amplified products may be Sanger sequenced to determine the fusion breakpoints. The identified specific fusion is monitored by a designed fusion PCR. Drug-resistant mutations are detected using multiplex mutation real-time PCR in patient plasma cell-free DNA during targeted therapy, for example, tyrosine kinase inhibitor-targeted therapy.

2. 发明授权

US09292607B2 Using social-network data for identification and ranking of URLs 有权
标题翻译：使用社交网络数据来识别和排名网址
公开(公告)号：US09292607B2
公开(公告)日：2016-03-22
申请号：US13196008
申请日：2011-08-02
申请人： Sasi Parthasarathy , Junaid Ahmed , Walter Sun , Jingfeng Li , Paul Alexander Dow , Yajie Siamwalla
发明人： Sasi Parthasarathy , Junaid Ahmed , Walter Sun , Jingfeng Li , Paul Alexander Dow , Yajie Siamwalla
IPC分类号： G06F17/30
CPC分类号： G06F17/30867 , G06F17/30876
摘要： Methods, systems, and computer-readable media are provided for updating a search index with new uniform resource locators (URLs) and with metadata for new and known URLs. Data associated with communications made by users using a social network is received. The communications include a URL therein that a user has shared, posted, or otherwise communicated to one or more other users using the social network. When the URL is not found in a search index it is identified as a new URL and is added to the search index. A measure of a trending interest, or virality, of the URL is determined from the data. The determined virality is associated with the URL in a search index as metadata. The virality is useable to inform a ranking of the URL against a plurality of other URLs for identification and presentation as a search result in a search engine results page.
摘要翻译：提供了方法，系统和计算机可读介质，用于使用新的统一资源定位符（URL）更新搜索索引，并为新的和已知的URL使用元数据。收到与使用社交网络的用户进行通信相关联的数据。通信包括其中用户已经使用社交网络共享，发布或以其他方式传送给一个或多个其他用户的URL。当搜索索引中找不到该URL时，将其标识为新的URL，并将其添加到搜索索引中。从数据中确定URL的趋势兴趣或病毒的度量。确定的病毒与搜索索引中的URL作为元数据相关联。所述病毒可用于在搜索引擎结果页面中将用于识别和呈现的URL的排序通知给多个其他URL作为搜索结果。

3. 发明授权

US09272401B2 Spanner tool 有权
标题翻译：扳手工具
公开(公告)号：US09272401B2
公开(公告)日：2016-03-01
申请号：US14000509
申请日：2012-02-20
申请人： David Tak-Wei Hon , Jingfeng Li , Yiping Mo , Guangji Deng
发明人： David Tak-Wei Hon , Jingfeng Li , Yiping Mo , Guangji Deng
IPC分类号： B25B23/142 , B25B23/00 , B25G1/06
CPC分类号： B25B23/0035 , B25B23/0028 , B25B23/1427 , B25G1/063
摘要： Disclosed is a spanner tool for mounting or dismounting components, which comprises a control piece (2), a connecting piece (1) and a rotating piece (3). The connecting piece (1) is hinged with one end of the control piece (2) and one end of the rotating piece (3) respectively. An angle β formed between the control piece (2) and the connecting piece (1) is less than an angle α formed between the rotating piece (3) and the connecting piece (1) when the control piece (2) and the rotating piece (3) respectively rotate to limit positions at different sides of the connecting piece (1). The spanner tool is practical and reliable. The spanner tool is convenient and rapid-in-use. The spanner tool can be folded for portability when not in use. Additionally, locking tightness of the tool can be adjusted by adjusting a nut.
摘要翻译：公开了一种用于安装或拆卸部件的扳手工具，其包括控制件（2），连接件（1）和旋转件（3）。连接件（1）分别与控制件（2）的一端和旋转件（3）的一端铰接。角＆bgr 当控制件（2）和旋转件（3）之间形成在控制件（2）和连接件（1）之间时形成的角度α小于旋转件（3）和连接件分别旋转以限制连接件（1）的不同侧的位置。扳手工具实用可靠。扳手工具方便快捷。当不使用扳手工具时，可以折叠便携。另外，可以通过调整螺母来调节工具的锁紧性。

4. 发明授权

US09116990B2 Enhancing freshness of search results 有权
标题翻译：提高搜索结果的新鲜度
公开(公告)号：US09116990B2
公开(公告)日：2015-08-25
申请号：US12789020
申请日：2010-05-27
申请人： Walter Sun , Thomas Arthur Ledbetter , Vinay Sudhir Deshpande , Yinzhe Yu , Lin Guo , Abhishek Singh , Junaid Ahmed , Jay Kumar Goyal , Jingfeng Li , Brahm Kiran Singh
发明人： Walter Sun , Thomas Arthur Ledbetter , Vinay Sudhir Deshpande , Yinzhe Yu , Lin Guo , Abhishek Singh , Junaid Ahmed , Jay Kumar Goyal , Jingfeng Li , Brahm Kiran Singh
IPC分类号： G06F17/30 , G06Q10/00
CPC分类号： G06F17/30864 , G06F17/30719 , G06Q10/00
摘要： Methods, systems, and computer-storage media for improving the freshness, or the apparent freshness, of search results are described. In an embodiment, the first portion of search results presented on a search results page are based on responsiveness to the search query and a second portion of results describe only recently published documents that are responsive to the search query. In an embodiment, a more recent version of the document, which is not directly used to determine responsiveness, is used to build the caption for a search result. Another way to make search results appear fresh is to include a publication time within the search result caption. In one embodiment, the publication time is generated by calculating a point in time between when a document is first added to a search index and the previous time the search engine visited the site where the document was found.
摘要翻译：描述了用于提高搜索结果的新鲜度或表观新鲜度的方法，系统和计算机存储介质。在一个实施例中，在搜索结果页面上呈现的搜索结果的第一部分基于对搜索查询的响应，并且结果的第二部分仅描述响应于搜索查询的最近发布的文档。在一个实施例中，使用不直接用于确定响应性的文档的更新版本来构建搜索结果的标题。使搜索结果显示新鲜的另一种方法是在搜索结果标题中包含发布时间。在一个实施例中，发布时间是通过计算文档首次添加到搜索索引的时间点与搜索引擎访问该文档所在的站点的之前的时间点来生成的。

5. 发明申请

US20120150833A1 USING SOCIAL-NETWORK DATA FOR IDENTIFICATION AND RANKING OF URLS 有权
标题翻译：使用社会网络数据来识别和排序URL
公开(公告)号：US20120150833A1
公开(公告)日：2012-06-14
申请号：US13196008
申请日：2011-08-02
申请人： Sasi Parthasarathy , Junaid Ahmed , Walter Sun , Jingfeng Li , Paul Alexander Dow , Yajie Siamwalla
发明人： Sasi Parthasarathy , Junaid Ahmed , Walter Sun , Jingfeng Li , Paul Alexander Dow , Yajie Siamwalla
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30867 , G06F17/30876
摘要： Methods, systems, and computer-readable media are provided for updating a search index with new uniform resource locators (URLs) and with metadata for new and known URLs. Data associated with communications made by users using a social network is received. The communications include a URL therein that a user has shared, posted, or otherwise communicated to one or more other users using the social network. When the URL is not found in a search index it is identified as a new URL and is added to the search index. A measure of a trending interest, or virality, of the URL is determined from the data. The determined virality is associated with the URL in a search index as metadata. The virality is useable to inform a ranking of the URL against a plurality of other URLs for identification and presentation as a search result in a search engine results page.
摘要翻译：提供了方法，系统和计算机可读介质，用于使用新的统一资源定位符（URL）更新搜索索引，并为新的和已知的URL使用元数据。收到与使用社交网络的用户进行通信相关联的数据。通信包括其中用户已经使用社交网络共享，发布或以其他方式传送给一个或多个其他用户的URL。当搜索索引中找不到该URL时，将其标识为新的URL，并将其添加到搜索索引中。从数据中确定URL的趋势兴趣或病毒的度量。确定的病毒与搜索索引中的URL作为元数据相关联。所述病毒可用于在搜索引擎结果页面中将用于识别和呈现的URL的排序通知给多个其他URL作为搜索结果。

6. 发明申请

US20050064406A1 Methods for high throughput genome analysis using restriction site tagged microarrays 审中-公开
标题翻译：使用限制性位点标记的微阵列进行高通量基因组分析的方法
公开(公告)号：US20050064406A1
公开(公告)日：2005-03-24
申请号：US10475352
申请日：2002-04-22
申请人： Eugene Zabarovsky , Ingemar Ernberg , Jingfeng Li , Alexei Protopopov , Claes Wahlestedt , Vladimir Kashuba , Veronika Zabarovska
发明人： Eugene Zabarovsky , Ingemar Ernberg , Jingfeng Li , Alexei Protopopov , Claes Wahlestedt , Vladimir Kashuba , Veronika Zabarovska
IPC分类号： C12N15/09 , C12P19/34 , C12Q1/68 , C12Q1/6806 , C12Q1/6809 , C12Q1/683
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q2565/501 , C12Q2521/301 , C12Q2539/101 , C12Q2521/531
摘要： A method for high-throughput analysis of genomic material originating from complex biological systems, including complex microbial systems and a method of detecting changes in a genomic material using restriction site tagged (RST) microarrays and sequence passporting technique (in particular microarrays containing NotI-clones). Using the present invention method, methylation or silencing of specific alleles, homozygous and hemizygous deletions, epigenetic factors, genetic predisposition, etc, information which is particularly useful in diagnosis and treatment of cancer diseases, can be detected. The RST microarrays and passporting can also be used for qualitative and quantitative analysis of complex microbial systems.
摘要翻译：来自复杂生物系统的基因组材料的高通量分析方法，包括复杂的微生物系统和使用限制性位点标记（RST）微阵列和序列护照技术（特别是含有NotI克隆的微阵列）检测基因组材料的变化的方法）。使用本发明的方法，可以检测特异性等位基因的甲基化或沉默，纯合子和半合子缺失，表观遗传因素，遗传易感性等，特别可用于诊断和治疗癌症疾病的信息。 RST微阵列和护照也可用于复杂微生物系统的定性和定量分析。

7. 发明申请

US20110258198A1 USING BEHAVIOR DATA TO QUICKLY IMPROVE SEARCH RANKING 有权
标题翻译：使用行为数据快速改进搜索排名
公开(公告)号：US20110258198A1
公开(公告)日：2011-10-20
申请号：US13169807
申请日：2011-06-27
申请人： WALTER SUN , JAY KUMAR GOYAL , PRATIBHA PERMANDLA , YINZHE YU , JINGFENG LI
发明人： WALTER SUN , JAY KUMAR GOYAL , PRATIBHA PERMANDLA , YINZHE YU , JINGFENG LI
IPC分类号： G06F17/30
CPC分类号： G06F17/30702 , G06F17/30867
摘要： Systems and methods for applying user behavior data to improve serach query result ranking are provided. Upon receiving an update file indicating that recent, significant user behavior data is available for a document associated with an inverted index, the update file is published periodically and frequently to an index server. After filtering out the relevant update information from the update file, the index server extracts identifiers of the documents having the associated user behavior data. The update file and the identifier of the documents are utilized to update an in-memory index containing representations of metadata indicative of the user behavior. The in-memory index is continuously updated and utilized to serve search query results in response to user search queries. Search query results from the in-memory index are ranked using the user behavior data prior to serving. Thus, results associated with recent, significant user-behavior metadata receive prominent placement on the search results page.
摘要翻译：提供了用于应用用户行为数据以改进serach查询结果排名的系统和方法。在接收到指示最近的重要用户行为数据可用于与反向索引相关联的文档的更新文件时，更新文件被周期性地且频繁地发布到索引服务器。在从更新文件中滤除相关更新信息之后，索引服务器提取具有相关用户行为数据的文档的标识符。更新文件和文档的标识符用于更新包含表示用户行为的元数据的内存中索引。内存中索引被不断更新并用于响应于用户搜索查询来提供搜索查询结果。来自内存中索引的搜索查询结果使用用户行为数据进行排序。因此，与最近的重要用户行为元数据相关联的结果在搜索结果页面上接收突出的位置。

8. 发明授权

US08244701B2 Using behavior data to quickly improve search ranking 有权
标题翻译：使用行为数据快速提高搜索排名
公开(公告)号：US08244701B2
公开(公告)日：2012-08-14
申请号：US13169807
申请日：2011-06-27
申请人： Walter Sun , Jay Kumar Goyal , Pratibha Permandla , Yinzhe Yu , Jingfeng Li
发明人： Walter Sun , Jay Kumar Goyal , Pratibha Permandla , Yinzhe Yu , Jingfeng Li
IPC分类号： G06F7/00 , G06F17/00 , G06F17/30
CPC分类号： G06F17/30702 , G06F17/30867
摘要： Systems and methods for applying user behavior data to improve search query result ranking are provided. Upon receiving an update file indicating that recent, significant user behavior data is available for a document associated with an inverted index, the update file is published periodically and frequently to an index server. After filtering out the relevant update information from the update file, the index server extracts identifiers of the documents having the associated user behavior data. The update file and the identifier of the documents are utilized to update an in-memory index containing representations of metadata indicative of the user behavior. The in-memory index is continuously updated and utilized to serve search query results in response to user search queries. Search query results from the in-memory index are ranked using the user behavior data prior to serving. Thus, results associated with recent, significant user-behavior metadata receive prominent placement on the search results page.
摘要翻译：提供了用于应用用户行为数据以改善搜索查询结果排序的系统和方法。在接收到指示最近的重要用户行为数据可用于与反向索引相关联的文档的更新文件时，更新文件被周期性地且频繁地发布到索引服务器。在从更新文件中滤除相关更新信息之后，索引服务器提取具有相关用户行为数据的文档的标识符。更新文件和文档的标识符用于更新包含表示用户行为的元数据的内存中索引。存储器内索引不断更新并用于响应于用户搜索查询来提供搜索查询结果。来自内存中索引的搜索查询结果使用用户行为数据进行排序。因此，与最近的重要用户行为元数据相关联的结果在搜索结果页面上接收突出的位置。

9. 发明申请

US20140033881A1 Spanner Tool 有权
标题翻译：扳手工具
公开(公告)号：US20140033881A1
公开(公告)日：2014-02-06
申请号：US14000509
申请日：2012-02-20
申请人： David Tak-Wei Hon , Jingfeng Li , Yiping Mo , Guangji Deng
发明人： David Tak-Wei Hon , Jingfeng Li , Yiping Mo , Guangji Deng
IPC分类号： B25B23/142 , B25B23/00
CPC分类号： B25B23/0035 , B25B23/0028 , B25B23/1427 , B25G1/063
摘要： Disclosed is a spanner tool for mounting or dismounting components, which comprises a control piece (2), a connecting piece (1) and a rotating piece (3). The connecting piece (1) is hinged with one end of the control piece (2) and one end of the rotating piece (3) respectively. An angle β formed between the control piece (2) and the connecting piece (1) is less than an angle α formed between the rotating piece (3) and the connecting piece (1) when the control piece (2) and the rotating piece (3) respectively rotate to limit positions at different sides of the connecting piece (1). The spanner tool is practical and reliable. During use, a user does not need to swing his/her arm and only needs to rotate his/her wrist to operate the spanner tool, so the spanner tool is convenient and rapid-in-use. The spanner tool can be folded for portability when not in use. Additionally, locking tightness of the tool can be adjusted by adjusting a nut.
摘要翻译：公开了一种用于安装或拆卸部件的扳手工具，其包括控制件（2），连接件（1）和旋转件（3）。连接件（1）分别与控制件（2）的一端和旋转件（3）的一端铰接。当控制件（2）和旋转件（2）之间形成在控制件（2）和连接件（1）之间的角度β小于旋转件（3）和连接件（1）之间形成的角度α （3）分别旋转以限制连接件（1）的不同侧的位置。扳手工具实用可靠。在使用过程中，用户不需要摆动他的手臂，只需要旋转他/她的手腕来操作扳手工具，所以扳手工具方便快捷。当不使用扳手工具时，可以折叠便携。另外，可以通过调整螺母来调节工具的锁紧性。

10. 发明申请

US20110295844A1 ENHANCING FRESHNESS OF SEARCH RESULTS 有权
标题翻译：增强搜索结果的清晰度
公开(公告)号：US20110295844A1
公开(公告)日：2011-12-01
申请号：US12789020
申请日：2010-05-27
申请人： WALTER SUN , THOMAS ARTHUR LEDBETTER , VINAY SUDHIR DESHPANDE , YINZHE YU , LIN GUO , ABHISHEK SINGH , JUNAID AHMED , JAY KUMAR GOYAL , JINGFENG LI , BRAHM KIRAN SINGH
发明人： WALTER SUN , THOMAS ARTHUR LEDBETTER , VINAY SUDHIR DESHPANDE , YINZHE YU , LIN GUO , ABHISHEK SINGH , JUNAID AHMED , JAY KUMAR GOYAL , JINGFENG LI , BRAHM KIRAN SINGH
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30719 , G06Q10/00
摘要： Methods, systems, and computer-storage media for improving the freshness, or the apparent freshness, of search results are described. In an embodiment, the first portion of search results presented on a search results page are based on responsiveness to the search query and a second portion of results describe only recently published documents that are responsive to the search query. In an embodiment, a more recent version of the document, which is not directly used to determine responsiveness, is used to build the caption for a search result. Another way to make search results appear fresh is to include a publication time within the search result caption. In one embodiment, the publication time is generated by calculating a point in time between when a document is first added to a search index and the previous time the search engine visited the site where the document was found.
摘要翻译：描述了用于提高搜索结果的新鲜度或表观新鲜度的方法，系统和计算机存储介质。在一个实施例中，在搜索结果页面上呈现的搜索结果的第一部分基于对搜索查询的响应，并且结果的第二部分仅描述响应于搜索查询的最近发布的文档。在一个实施例中，使用不直接用于确定响应性的文档的更新版本来构建搜索结果的标题。使搜索结果显示新鲜的另一种方法是在搜索结果标题中包含发布时间。在一个实施例中，发布时间是通过计算文档首次添加到搜索索引的时间点与搜索引擎访问该文档所在的站点的之前的时间点来生成的。

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