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1. 发明申请

US20130183249A1 Stimulus Sensitive Magnetic Nanocomposite Using Pyrene Polymer, and Contrast Medium Composition Containing the Nanocomposite 审中-公开
标题翻译：使用芘聚合物的激发敏感磁性纳米复合材料和包含纳米复合材料的对比介质组成
公开(公告)号：US20130183249A1
公开(公告)日：2013-07-18
申请号：US13812631
申请日：2010-12-27
申请人： Seung Joo Haam , Jin Suck Suh , Yong Min Huh , Jae Moon Yang , Eun Kyung Lim
发明人： Seung Joo Haam , Jin Suck Suh , Yong Min Huh , Jae Moon Yang , Eun Kyung Lim
IPC分类号： A61K49/18 , A61K39/44
CPC分类号： A61K49/1824 , A61K39/44 , A61K47/6923 , A61K49/1839 , A61K49/186
摘要： Provided are a stimuli-sensitive magnetic nanocomposite using a pyrene-conjugated polymer and a method of preparing the same. Particularly, the stimuli-sensitive magnetic nanocomposite includes magnetic nanoparticles, an amphiphilic compound including at least one hydrophobic domain having a material having a pyrene structure and at least one hydrophilic domain and a pharmaceutically active ingredient. Here, the amphiphilic compound surrounds the pharmaceutically active ingredient, and the pharmaceutically active ingredient surrounds the magnetic nanoparticle and is chemically bound to a hydrophobic domain. Accordingly, the magnetic nanoparticles and the pharmaceutically active ingredient are stable in an aqueous solution, have excellent magnetic properties and a rapid drug release behavior due to a specific stimulus, and exhibit targeting according to a tissue-specific binding component. Thus, the stimuli-sensitive magnetic nanocomposite has target specificity and serves as a contrast composition or pharmaceutical composition.
摘要翻译：提供使用芘共轭聚合物的刺激敏感性磁性纳米复合物及其制备方法。特别地，刺激敏感性磁性纳米复合材料包括磁性纳米颗粒，两亲化合物，其包括至少一个具有芘结构的材料和至少一个亲水结构域的药物活性成分的疏水结构域。这里，两亲性化合物包围药物活性成分，并且药物活性成分包围磁性纳米颗粒并与化学结合到疏水结构域。因此，磁性纳米颗粒和药物活性成分在水溶液中是稳定的，具有优异的磁性和由特定刺激引起的快速药物释放行为，并且根据组织特异性结合组分显示靶向。因此，刺激敏感的磁性纳米复合材料具有靶特异性，并且用作造影剂组合物或药物组合物。

2. 发明申请

US20130045160A1 Magnetic Nano-Composite for Contrast Agent, Intelligent Contrast Agent, Drug Delivery Agent for Simultaneous Diagnosis and Treatment, and Separation Agent for Target Substance 审中-公开
标题翻译：用于对比剂的磁性纳米复合物，智能对比剂，同时诊断和治疗的药物递送剂和靶向物质的分离剂
公开(公告)号：US20130045160A1
公开(公告)日：2013-02-21
申请号：US13590958
申请日：2012-08-21
申请人： Seung-Joo HAM , Jin-Suck SUH , Yong-Min HUH , Ho-Geun YOON , Jae-Moon YANG
发明人： Seung-Joo HAM , Jin-Suck SUH , Yong-Min HUH , Ho-Geun YOON , Jae-Moon YANG
IPC分类号： A61K9/51 , A61K39/00 , A61K38/17 , A61K51/12 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/49 , A61P9/00 , A61P1/00 , A61P25/00 , A61K39/395 , A61K38/18 , B82Y5/00
CPC分类号： G01N33/574 , A61K41/0052 , A61K47/593 , A61K47/60 , A61K47/6923 , A61K49/1806 , A61K49/1833 , A61K49/1836 , A61K49/1839 , A61K49/1851 , A61K49/1857 , A61K49/186 , A61K49/1875 , A61K49/1887 , B82Y5/00 , G01N33/5434 , G01N2446/80
摘要： The present invention relates to water soluble magnetic nanocomposite using an amphiphilic compound. Specifically, the present invention relates to water soluble magnetic nanocomposite which may be not only used as a contrast agent for magnetic resonance imaging (MRI), an intelligent contrast agent for diagnosing cancer characterized by binding a tissue-specific binder ingredient, a drug delivery system for simultaneous diagnosis and treatment by polymerizing or enveloping drugs and binding a tissue-specific binder ingredient, but also used for separating a target substance using magnetism, and a process for preparing the same.
摘要翻译：本发明涉及使用两亲性化合物的水溶性磁性纳米复合材料。具体地说，本发明涉及水溶性磁性纳米复合材料，其不仅可以用作磁共振成像（MRI）的造影剂，用于诊断癌症的智能造影剂，其特征在于结合组织特异性粘合剂成分，药物递送系统用于通过聚合或包封药物并结合组织特异性粘合剂成分同时进行诊断和治疗，但也用于使用磁性分离靶物质及其制备方法。

3. 发明申请

US20090324494A1 MAGNETIC NANO-COMPOSITE FOR CONTRAST AGENT, INTELLIGENT CONTRAST AGENT, DRUG DELIVERY AGENT FOR SIMULTANEOUS DIAGNOSIS AND TREATMENT, AND SEPARATION AGENT FOR TARGET SUBSTANCE 审中-公开
标题翻译：用于对比剂的磁性纳米复合材料，智能对比剂，用于同时诊断和治疗的药物递送剂，以及目标物质的分离剂
公开(公告)号：US20090324494A1
公开(公告)日：2009-12-31
申请号：US12280474
申请日：2007-02-23
申请人： Seung-Joo Ham , Jin-Suck Suh , Yong-Min Huh , Ho-Geun Yoon , Jae-Moon Yang
发明人： Seung-Joo Ham , Jin-Suck Suh , Yong-Min Huh , Ho-Geun Yoon , Jae-Moon Yang
IPC分类号： A61K49/06 , A61K47/48 , A61K38/20 , A61K38/21 , A61K38/18 , A61K38/45 , A61K51/04
CPC分类号： G01N33/574 , A61K41/0052 , A61K47/593 , A61K47/60 , A61K47/6923 , A61K49/1806 , A61K49/1833 , A61K49/1836 , A61K49/1839 , A61K49/1851 , A61K49/1857 , A61K49/186 , A61K49/1875 , A61K49/1887 , B82Y5/00 , G01N33/5434 , G01N2446/80
摘要： The present invention relates to water soluble magnetic nanocomposite using an amphiphilic compound. Specifically, the present invention relates to water soluble magnetic nanocomposite which may be not only used as a contrast agent for magnetic resonance imaging (MRI), an intelligent contrast agent for diagnosing cancer characterized by binding a tissue-specific binder ingredient, a drug delivery system for simultaneous diagnosis and treatment by polymerizing or enveloping drugs and binding a tissue-specific binder ingredient, but also used for separating a target substance using magnetism, and a process for preparing the same.
摘要翻译：本发明涉及使用两亲性化合物的水溶性磁性纳米复合材料。具体地说，本发明涉及水溶性磁性纳米复合材料，其不仅可以用作磁共振成像（MRI）的造影剂，用于诊断癌症的智能造影剂，其特征在于结合组织特异性粘合剂成分，药物递送系统用于通过聚合或包封药物并结合组织特异性粘合剂成分同时进行诊断和治疗，但也用于使用磁性分离靶物质及其制备方法。

4. 发明申请

US20090220431A1 MAGNETIC RESONANCE IMAGING CONTRAST AGENTS CONTAINING WATER-SOLUBLE NANOPARTICLES OF MANGANESE OXIDE OR MANGANESE METAL OXIDE 审中-公开
标题翻译：含有锰氧化物或锰氧化物的水溶性纳米颗粒的磁共振成像对比剂
公开(公告)号：US20090220431A1
公开(公告)日：2009-09-03
申请号：US12095878
申请日：2006-12-01
申请人： Jin-Woo Cheon , Young-Wook Jun , Jae-Hyun Lee , Jung-Wook Suh , Jin-Suck Suh , Seung-Jin Ko , Yong-Min Huh , Ho-Taek Song
发明人： Jin-Woo Cheon , Young-Wook Jun , Jae-Hyun Lee , Jung-Wook Suh , Jin-Suck Suh , Seung-Jin Ko , Yong-Min Huh , Ho-Taek Song
IPC分类号： A61K49/06 , A61P43/00
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0043 , A61K49/0093 , A61K49/1833 , A61K49/1836 , A61K49/1851 , A61K49/1863 , A61K49/1869 , A61K49/1875 , B82Y5/00 , B82Y30/00 , C01G49/00 , C01G49/0072 , C01G49/08 , C01G51/00 , C01G53/00 , C01P2002/86 , C01P2004/03 , C01P2004/64 , C01P2006/42
摘要： The present invention relates to a manganese-containing metal oxide nanoparticle-based magnetic resonance imaging (MRI) contrast agent, which is characterized in that: The core of it comprises 1 to 1000 nm-sized manganese-containing metal oxide nanoparticles which include MnO a (0
摘要翻译：本发明涉及一种含锰金属氧化物纳米粒子磁共振成像（MRI）造影剂，其特征在于：其核心包含1〜1000nm尺寸的含锰金属氧化物纳米粒子，其包括MnO a （0

5. 发明申请

US20060222594A1 Smart magnetic nanosphere preparation and manufacturing method thereof 审中-公开
标题翻译：智能磁纳米球的制备及其制备方法
公开(公告)号：US20060222594A1
公开(公告)日：2006-10-05
申请号：US11334957
申请日：2006-01-19
申请人： Seung-Jun Lee , Bong-Sik Jeon , Jong-Duk Kim , Yong-Min Hur , Ho-Taek Song , Jin-Suck Suh
发明人： Seung-Jun Lee , Bong-Sik Jeon , Jong-Duk Kim , Yong-Min Hur , Ho-Taek Song , Jin-Suck Suh
IPC分类号： A61K49/10 , C07K16/46
CPC分类号： A61K49/1857 , A61K9/0009 , A61K9/143 , B82Y5/00
摘要： Disclosed are a targeting magnetic nanosphere preparation capable of diagnosing and treating tumors in mammals and a method of manufacturing the same. The smart magnetic nanosphere preparation contains magnetic nano-sized iron oxide nanoparticles, which can be detected by magnetic resonance imaging (MRI), as a core material. The core material is encapsulated in a size of tens to hundreds of nanometers allowing particles to penetrate into deep areas of biological tissues using a biodegradable polymer having high affinity for biological tissues. The formed capsules are surface-modified with an antibody specific to a specific tumor. The smart magnetic nanosphere preparation can effectively diagnose tumors, as well as treat tumors because it has an antibody to a specific tumor.
摘要翻译：公开了能够诊断和治疗哺乳动物肿瘤的靶向磁性纳米球制剂及其制造方法。智能磁纳米球制备包含磁性纳米尺寸的氧化铁纳米颗粒，可以通过磁共振成像（MRI）作为核心材料进行检测。核心材料被封装成数十至数百纳米的尺寸，允许使用对生物组织具有高亲和力的可生物降解聚合物使颗粒渗入生物组织的深部区域。形成的胶囊用特异性肿瘤特异的抗体进行表面修饰。智能磁性纳米球制剂可以有效诊断肿瘤，以及治疗肿瘤，因为它具有针对特定肿瘤的抗体。

6. 发明申请

US20110151429A1 Bioprobe, Method of Preparing the Bioprobe, and Analysis Apparatus and Method Using the Bioprobe 审中-公开
标题翻译：生物探针，生物探针的制备方法，以及使用生物探针的分析仪器和方法
公开(公告)号：US20110151429A1
公开(公告)日：2011-06-23
申请号：US12681095
申请日：2009-03-31
申请人： Seungjoo Haam , Jin-Suck Suh , Yong-Min Huh , Jaemoon Yang , Eun-Kyung Lim , Yoonah Kang
发明人： Seungjoo Haam , Jin-Suck Suh , Yong-Min Huh , Jaemoon Yang , Eun-Kyung Lim , Yoonah Kang
IPC分类号： C12Q1/70 , B01J19/00 , B05D1/36 , G01N33/53 , G01N33/574 , C12M1/34 , G01N33/48
CPC分类号： G01N33/54346 , Y10T436/143333
摘要： The present invention relates to a bioprobe including a substrate and inorganic nanoparticles attached to the surface of the substrate, a method of preparing the bioprobe, and an analysis apparatus and method using the bioprobe. In the bioprobe according to the present invention, inorganic nanoparticles introduced to the substrate serve as a linker to which a target-specific substance such as an antibody can be bound, and they also increase the surface area of the substrate, thus increasing a surface area where a target substance to be detected can contact the substrate. In this regard, the bioprobe can be effectively used for detection, dosing, or analysis of various biomolecules or other chemical substances.
摘要翻译：本发明涉及一种生物探针，其包括底物和附着于基底表面的无机纳米颗粒，生物探针的制备方法以及使用该生物探针的分析装置和方法。在根据本发明的生物探针中，引入到底物的无机纳米粒子用作能够结合目标特异性物质如抗体的接头，并且还增加了基底的表面积，从而增加了表面积其中待检测的目标物质可以接触基底。在这方面，生物探针可以有效地用于各种生物分子或其他化学物质的检测，给药或分析。

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