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1. 发明申请

US20140139220A1 DEVICES AND PROCESS FOR HIGH-PRESSURE MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE 有权
标题翻译：用于高压魔术角旋转核磁共振的装置和工艺
公开(公告)号：US20140139220A1
公开(公告)日：2014-05-22
申请号：US14165215
申请日：2014-01-27
申请人： David W. Hoyt , Jesse A. Sears , Romulus V.F. Turcu , Kevin M. Rosso , Jian Zhi Hu
发明人： David W. Hoyt , Jesse A. Sears , Romulus V.F. Turcu , Kevin M. Rosso , Jian Zhi Hu
IPC分类号： G01R33/30
CPC分类号： G01R33/307 , G01R33/305 , G01R33/34069
摘要： A high-pressure magic angle spinning (MAS) rotor is detailed that includes a high-pressure sample cell that maintains high pressures exceeding 150 bar. The sample cell design minimizes pressure losses due to penetration over an extended period of time.
摘要翻译：详细介绍了高压魔角旋转（MAS）转子，其包括高压样品池，其保持超过150巴的高压。样品池设计可以最大限度地减少由于在较长时间内渗透造成的压力损失。

2. 发明申请

US20140044598A1 HIGH-PRESSURE, HIGH-TEMPERATURE MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE DEVICES AND PROCESSES FOR MAKING AND USING SAME 有权
标题翻译：高压，高温魔术角旋转核磁共振装置及其制造和使用方法
公开(公告)号：US20140044598A1
公开(公告)日：2014-02-13
申请号：US13961012
申请日：2013-08-07
申请人： Jian Zhi Hu , Mary Y. Hu , Mark R. Townsend , Johannes A. Lercher , Charles H. F. Peden
发明人： Jian Zhi Hu , Mary Y. Hu , Mark R. Townsend , Johannes A. Lercher , Charles H. F. Peden
IPC分类号： G01R33/30 , B23G1/02 , G01R3/00
CPC分类号： G01R33/305 , B23G1/02 , G01R3/00 , G01R33/307 , Y10T29/49996 , Y10T409/300112
摘要： Re-usable ceramic magic angle spinning (MAS) NMR rotors constructed of high-mechanic strength ceramics are detailed that include a sample compartment that maintains high pressures up to at least about 200 atmospheres (atm) and high temperatures up to about least about 300° C. during operation. The rotor designs minimize pressure losses stemming from penetration over an extended period of time. The present invention makes possible a variety of in-situ high pressure, high temperature MAS NMR experiments not previously achieved in the prior art.
摘要翻译：详细描述了由高机械强度陶瓷构成的可重复使用的陶瓷魔角旋转（MAS）NMR转子，其包括保持高达至少约200大气压（atm）的高压和至多约300°的高温的样品室 C.操作期间转子设计可以最大限度地减少长时间内渗透引起的压力损失。本发明使现有技术中以前未实现的各种原位高压，高温MAS NMR实验成为可能。

3. 发明申请

US20130257432A1 SLOW MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE DEVICE AND PROCESS FOR METABOLOMICS PROFILING OF TISSUES AND BIOFLUIDS 有权
标题翻译：慢速魔法角度旋转核磁共振装置和组织构象组织和生物流体分析方法
公开(公告)号：US20130257432A1
公开(公告)日：2013-10-03
申请号：US13433038
申请日：2012-03-28
申请人： Jian Zhi Hu , Ju Feng , Hardeep S. Mehta
发明人： Jian Zhi Hu , Ju Feng , Hardeep S. Mehta
IPC分类号： G01R3/00
CPC分类号： G01R33/307 , G01R33/30 , G01R33/465
摘要： A slow Magic-Angle Spinning NMR device and method are detailed that provide high resolution and high sensitivity metabolic profiling of biological samples. A new 1H-PASS sequence suppresses line broadening in the various biological samples. The device and method allow metabolic changes in small animals to be tracked through continuous investigations of minimally-invasive blood and tissue biopsy samples over a sustained period and allow intact biological objects with sizes up to a few centimeters to be studied.
摘要翻译：详细说明了一种缓慢的魔角旋转NMR装置和方法，其提供生物样品的高分辨率和高灵敏度的代谢分布。新的1H-PASS序列抑制各种生物样品中的品系变宽。该装置和方法允许通过在持续时间内对微创血液和组织活组织检查样品的连续研究来跟踪小动物中的代谢变化，并且允许研究尺寸达几厘米的完整的生物体。

4. 发明申请

US20080116889A1 METHODS FOR MAGNETIC RESONANCE ANALYSIS USING MAGIC ANGLE TECHNIQUE 有权
标题翻译：使用魔法角技术进行磁共振分析的方法
公开(公告)号：US20080116889A1
公开(公告)日：2008-05-22
申请号：US11562390
申请日：2006-11-21
申请人： Jian Zhi Hu , Robert A. Wind , Kevin R. Minard , Paul D. Majors
发明人： Jian Zhi Hu , Robert A. Wind , Kevin R. Minard , Paul D. Majors
IPC分类号： G01R33/483
CPC分类号： G01R33/46 , G01R33/445 , G01R33/485
摘要： Methods of performing a magnetic resonance analysis of a biological object are disclosed that include placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54°44′ relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. In particular embodiments the method includes pulsing the radio frequency to provide at least two of a spatially selective read pulse, a spatially selective phase pulse, and a spatially selective storage pulse. Further disclosed methods provide pulse sequences that provide extended imaging capabilities, such as chemical shift imaging or multiple-voxel data acquisition.
摘要翻译：公开了对生物体进行磁共振分析的方法，包括将物体放置在主磁场（具有静磁场方向）和射频场中; 以相对于主磁静电场方向为约54°44'的角度的轴旋转物体，其频率小于约100Hz; 脉冲射频以提供包括相位校正魔术转角脉冲段的序列; 并收集由脉冲射频产生的数据。在特定实施例中，该方法包括脉冲射频以提供空间选择性读取脉冲，空间选择性相位脉冲和空间选择性存储脉冲中的至少两个。进一步公开的方法提供提供扩展成像能力的脉冲序列，例如化学位移成像或多体素数据采集。

5. 发明授权

US09151813B2 High-pressure, high-temperature magic angle spinning nuclear magnetic resonance devices and processes for making and using same 有权
标题翻译：高压，高温魔角旋转核磁共振装置及其制造和使用过程
公开(公告)号：US09151813B2
公开(公告)日：2015-10-06
申请号：US13961012
申请日：2013-08-07
申请人： Jian Zhi Hu , Mary Y. Hu , Mark R. Townsend , Johannes A. Lercher , Charles H. F. Peden
发明人： Jian Zhi Hu , Mary Y. Hu , Mark R. Townsend , Johannes A. Lercher , Charles H. F. Peden
IPC分类号： G01R33/30 , B23G1/02 , G01R3/00
CPC分类号： G01R33/305 , B23G1/02 , G01R3/00 , G01R33/307 , Y10T29/49996 , Y10T409/300112
摘要： Re-usable ceramic magic angle spinning (MAS) NMR rotors constructed of high-mechanic strength ceramics are detailed that include a sample compartment that maintains high pressures up to at least about 200 atmospheres (atm) and high temperatures up to about least about 300° C. during operation. The rotor designs minimize pressure losses stemming from penetration over an extended period of time. The present invention makes possible a variety of in-situ high pressure, high temperature MAS NMR experiments not previously achieved in the prior art.
摘要翻译：详细描述了由高机械强度陶瓷构成的可重复使用的陶瓷魔角旋转（MAS）NMR转子，其包括保持高达至少约200大气压（atm）的高压和至多约300°的高温的样品室 C.操作期间转子设计可以最大限度地减少长时间内渗透引起的压力损失。本发明使现有技术中以前未实现的各种原位高压，高温MAS NMR实验成为可能。

6. 发明授权

US08064982B2 Methods for magnetic resonance analysis using magic angle technique 有权
标题翻译：使用魔法技术进行磁共振分析的方法
公开(公告)号：US08064982B2
公开(公告)日：2011-11-22
申请号：US11562390
申请日：2006-11-21
申请人： Jian Zhi Hu , Robert A. Wind , Kevin R. Minard , Paul D. Majors
发明人： Jian Zhi Hu , Robert A. Wind , Kevin R. Minard , Paul D. Majors
IPC分类号： A61B5/055
CPC分类号： G01R33/46 , G01R33/445 , G01R33/485
摘要： Methods of performing a magnetic resonance analysis of a biological object are disclosed that include placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54°44′ relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. In particular embodiments the method includes pulsing the radio frequency to provide at least two of a spatially selective read pulse, a spatially selective phase pulse, and a spatially selective storage pulse. Further disclosed methods provide pulse sequences that provide extended imaging capabilities, such as chemical shift imaging or multiple-voxel data acquisition.
摘要翻译：公开了对生物体进行磁共振分析的方法，包括将物体放置在主磁场（具有静磁场方向）和射频场中; 以相对于主磁静电场方向为约54°44'的角度的轴旋转物体，其频率小于约100Hz; 脉冲射频以提供包括相位校正魔术转角脉冲段的序列; 并收集由脉冲射频产生的数据。在特定实施例中，该方法包括脉冲射频以提供空间选择性读取脉冲，空间选择性相位脉冲和空间选择性存储脉冲中的至少两个。进一步公开的方法提供提供扩展成像能力的脉冲序列，例如化学位移成像或多体素数据采集。

7. 发明授权

US06836115B2 Method for high resolution magnetic resonance analysis using magic angle technique 有权
标题翻译：使用魔法技术的高分辨率磁共振分析方法
公开(公告)号：US06836115B2
公开(公告)日：2004-12-28
申请号：US10456272
申请日：2003-06-05
申请人： Robert A. Wind , Jian Zhi Hu
发明人： Robert A. Wind , Jian Zhi Hu
IPC分类号： G01V300
CPC分类号： G01R33/307 , G01R33/54
摘要： A method of performing a magnetic resonance analysis of a biological object that includes placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54°44′ relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. The object may be reoriented about the magic angle axis between three predetermined positions that are related to each other by 120°. The main magnetic field may be rotated mechanically or electronically. Methods for magnetic resonance imaging of the object are also described.
摘要翻译：一种对生物体进行磁共振分析的方法，包括将物体放置在主磁场（具有静磁场方向）和射频场中; 以相对于主磁静电场方向为大约54°44'的角度的轴旋转物体，其频率小于约100Hz; 脉冲射频以提供包括相位校正魔术转角脉冲段的序列; 并收集由脉冲射频产生的数据。物体可以关于彼此相关120°的三个预定位置之间的魔角轴重新定向。主磁场可以机械地或电子地旋转。还描述了对象的磁共振成像的方法。

8. 发明授权

US06653832B2 Method for high resolution magnetic resonance analysis using magic angle technique 失效
公开(公告)号：US06653832B2
公开(公告)日：2003-11-25
申请号：US09803381
申请日：2001-03-09
申请人： Robert A. Wind , Jian Zhi Hu
发明人： Robert A. Wind , Jian Zhi Hu
IPC分类号： G01L300
CPC分类号： G01R33/307 , G01R33/54
摘要： A method of performing a magnetic resonance analysis of a biological object that includes placing the biological object in a main magnetic field and in a radio frequency field, the main magnetic field having a static field direction; rotating the biological object at a rotational frequency of less than about 100 Hz around an axis positioned at an angle of about 54°44′ relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. According to another embodiment, the radio frequency is pulsed to provide a sequence capable of producing a spectrum that is substantially free of spinning sideband peaks.

9. 发明授权

US09063196B2 Slow magic angle spinning nuclear magnetic resonance device and process for metabolomics profiling of tissues and biofluids 有权
标题翻译：慢魔法旋转核磁共振装置和组织和生物流体代谢组学分析方法
公开(公告)号：US09063196B2
公开(公告)日：2015-06-23
申请号：US13433038
申请日：2012-03-28
申请人： Jian Zhi Hu , Ju Feng , Hardeep S. Mehta
发明人： Jian Zhi Hu , Ju Feng , Hardeep S. Mehta
IPC分类号： G01V3/00 , G01R33/30 , G01R33/465
CPC分类号： G01R33/307 , G01R33/30 , G01R33/465
摘要： A slow Magic-Angle Spinning NMR device and method are detailed that provide high resolution and high sensitivity metabolic profiling of biological samples. A new 1H-PASS sequence suppresses line broadening in the various biological samples. The device and method allow metabolic changes in small animals to be tracked through continuous investigations of minimally-invasive blood and tissue biopsy samples over a sustained period and allow intact biological objects with sizes up to a few centimeters to be studied.
摘要翻译：详细说明了一种缓慢的魔角旋转NMR装置和方法，其提供生物样品的高分辨率和高灵敏度的代谢分布。新的1H-PASS序列抑制各种生物样品中的品系变宽。该装置和方法允许通过在持续时间内对微创血液和组织活组织检查样品的连续研究来跟踪小动物中的代谢变化，并且允许研究尺寸达几厘米的完整的生物体。

10. 发明申请

US20120146636A1 DEVICES AND PROCESS FOR HIGH-PRESSURE MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE 有权
标题翻译：用于高压魔术角旋转核磁共振的装置和工艺
公开(公告)号：US20120146636A1
公开(公告)日：2012-06-14
申请号：US13193172
申请日：2011-07-28
申请人： David W. Hoyt , Jesse A. Sears, JR. , Romulus V. F. Turcu , Kevin M. Rosso , Jian Zhi Hu
发明人： David W. Hoyt , Jesse A. Sears, JR. , Romulus V. F. Turcu , Kevin M. Rosso , Jian Zhi Hu
IPC分类号： G01R33/46 , G01R33/30
CPC分类号： G01R33/307 , G01R33/305 , G01R33/34069
摘要： A high-pressure magic angle spinning (MAS) rotor is detailed that includes a high-pressure sample cell that maintains high pressures exceeding 150 bar. The sample cell design minimizes pressure losses due to penetration over an extended period of time.
摘要翻译：详细介绍了高压魔角旋转（MAS）转子，其包括高压样品池，其保持超过150巴的高压。样品池设计可以最大限度地减少由于在较长时间内渗透造成的压力损失。

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