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1. 发明授权

US4145849A Adjustable shelf system 失效
标题翻译：可调货架系统
公开(公告)号：US4145849A
公开(公告)日：1979-03-27
申请号：US902410
申请日：1978-05-03
申请人： Joseph L. Shindoll , Jerry D. Clark
发明人： Joseph L. Shindoll , Jerry D. Clark
IPC分类号： A47B96/00 , A47B53/00
CPC分类号： A47B96/00
摘要： An adjustable shelf system for installation in combination with a non-load bearing wall which does not require penetration of the wall for support is disclosed. The adjustable shelf system is particularly well suited for use in combination with non-load bearing walls of the type supported intermediate a building foundation and an upstanding load bearing frame which includes a top track member having channels for receiving studs and prefabricated wall panels. Shelves are supported on brackets which are attached to laterally spaced, upstanding tubular support legs having a channel formed within one side wall portion. A cushion strip is confined in the channel intermediate the upstanding tubular support legs and the non-load bearing wall thereby preventing abrasive contact of the tubular support legs against the adjacent wall paneling. In a preferred embodiment, an extendable tubular member is coaxially received within the central chamber of each of the tubular support legs and projects above the tubular support legs to an elevation substantially flush with the top side surface of the top track member. Fastener means are provided for mechanicaly interconnecting the extendable tubular member to the top track member for preventing lateral displacement of the tubular support legs relative to the wall paneling.
摘要翻译：公开了一种用于与不需要穿透壁用于支撑的非承重壁组合安装的可调架架系统。可调节搁架系统特别适用于与建筑基座和直立承重框架之间支撑的类型的非承重墙结合使用，该承载框架包括具有用于接收柱头和预制墙板的通道的顶部轨道构件。搁架被支撑在支架上，支架连接到横向间隔开的直立管状支撑腿，其具有形成在一个侧壁部分内的通道。缓冲带被限制在直立管状支撑腿和非承载壁之间的通道中，从而防止管状支撑腿抵靠相邻壁板的磨损接触。在优选实施例中，可延伸的管状构件同轴地容纳在每个管状支撑腿的中心室内并在管状支撑腿上方突出到与顶部轨道构件的顶侧表面基本齐平的高度。提供紧固件装置用于将可延伸的管状构件与顶部轨道构件机械互连，以防止管状支撑腿相对于墙板的横向位移。

2. 发明授权

US06897318B2 Process for making substituted pyrazoles 失效
标题翻译：制备取代的吡唑的方法
公开(公告)号：US06897318B2
公开(公告)日：2005-05-24
申请号：US10254445
申请日：2002-09-25
申请人： Kimberly K. Allen , Dennis K. Anderson , John E. Baldus , Jerry D. Clark , Albert D. Edeny , Patrick H. Lau , Daniel R. Dukesherer , Lisa McDermott , Michael K. Mao , Gopi Yalamanchili , Jodi L. Moe , Partha Mudipalli , Win Naing , Shaun R. Selness , Christine Seymour , Shekhar Viswanath , John K. Walker
发明人： Kimberly K. Allen , Dennis K. Anderson , John E. Baldus , Jerry D. Clark , Albert D. Edeny , Patrick H. Lau , Daniel R. Dukesherer , Lisa McDermott , Michael K. Mao , Gopi Yalamanchili , Jodi L. Moe , Partha Mudipalli , Win Naing , Shaun R. Selness , Christine Seymour , Shekhar Viswanath , John K. Walker
IPC分类号： C07D403/14 , A61K31/506 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P37/06 , C07D401/14 , C07D401/04
CPC分类号： C07D401/14
摘要： This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R3A, R3B, R3C, Y1, Y2, Y3, Y4, and Y5 are as defined in the specification.
摘要翻译：本发明一般涉及制备取代的吡唑，取代的吡唑的互变异构体和取代的吡唑和互变异构体的盐的方法。取代的吡唑在结构上对应于式（I）：其中R 3A，R 3B，R 3C，Y 1， Y 2，Y 2，Y 3，Y 4和Y 5如说明书中所定义。

3. 发明授权

US06872725B2 Solid-state forms of N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl) pyrazole 失效
标题翻译：固体形式的N-（2-羟基乙酰基）-5-（4-哌啶基）-4-（4-嘧啶基）-3-（4-氯苯基）吡唑
公开(公告)号：US06872725B2
公开(公告)日：2005-03-29
申请号：US10254697
申请日：2002-09-25
申请人： Kimberley C. Allen , Jerry D. Clark , Thomas P. Fraher , Jason A. Hanko , Kimberly L. Kolbert , Clay R. Little , Michael K. Mao , Patricia S. Miyake , Jodi L. Moe , Partha S. Mudipalli , Tobin C. Schilke , Christine B. Seymour , Ahmad Y. Sheikh , Gopichand Yalamanchili
发明人： Kimberley C. Allen , Jerry D. Clark , Thomas P. Fraher , Jason A. Hanko , Kimberly L. Kolbert , Clay R. Little , Michael K. Mao , Patricia S. Miyake , Jodi L. Moe , Partha S. Mudipalli , Tobin C. Schilke , Christine B. Seymour , Ahmad Y. Sheikh , Gopichand Yalamanchili
IPC分类号： A61K31/506 , A61P19/02 , A61P29/00 , A61P43/00 , C07D401/14 , A31K31/506
CPC分类号： C07D401/14
摘要： Crystalline forms of the p38 kinase inhibitor N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole are provided. These crystalline forms include (a) a first anhydrous crystalline form possessing improved physical stability relative to other solid-state forms of the compound; (b) a second anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; (c) a third anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; and (d) solvated crystalline forms, hydrated crystalline forms, and crystalline salt forms of the compound that are useful, for example, as intermediate solid-state forms in the preparation of other crystalline forms of the compound. Also provided are combinations and pharmaceutical compositions comprising at least one of these crystalline forms, processes for preparing these crystalline forms and for preparing compositions comprising these crystalline forms, and methods for the prophylaxis and/or treatment of a p38 kinase-mediated condition comprising administering to a subject a therapeutically effective amount of at least one of these crystalline forms.
摘要翻译：提供p38激酶抑制剂N-（2-羟基乙酰基）-5-（4-哌啶基）-4-（4-嘧啶基）-3-（4-氯苯基）吡唑的结晶形式。这些结晶形式包括（a）相对于化合物的其它固体形式具有改善的物理稳定性的第一无水结晶形式; （b）相对于化合物的其它固态形式具有独特性质的第二无水结晶形式; （c）相对于化合物的其它固体形式具有独特性质的第三无水结晶形式; 和（d）化合物的溶剂化结晶形式，水合结晶形式和结晶盐形式，其可用于制备化合物的其它结晶形式的例如中间体固体形式。还提供了包含这些结晶形式中的至少一种，这些结晶形式的制备方法和用于制备包含这些结晶形式的组合物的组合和药物组合物，以及预防和/或治疗p38激酶介导的病症的方法，受试者治疗有效量的这些结晶形式中的至少一种。

4. 发明授权

US6025492A Synthesis of a hydrazone .beta.-keto ester by the reaction with a diazo ester 失效
标题翻译：通过与重氮酯的反应合成腙β-酮酯
公开(公告)号：US6025492A
公开(公告)日：2000-02-15
申请号：US254016
申请日：1999-05-24
申请人： Ajit S. Shah , Jerry D. Clark , Yinong Ma , James C. Peterson , Lefteris Patelis
发明人： Ajit S. Shah , Jerry D. Clark , Yinong Ma , James C. Peterson , Lefteris Patelis
IPC分类号： C07C249/16 , C07C251/76 , C07D237/24 , C07C229/22 , C07D401/04 , C07D405/04 , C07D409/04
CPC分类号： C07D237/24 , C07C249/16
摘要： The present invention relates to the synthesis of a hydrazone .beta.-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone .beta.-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.
摘要翻译： PCT No.PCT / US97 / 15345 Sec。 371日期1999年5月24日 102（e）1999年5月24日PCT 1997年8月29日PCT公布。公开号WO98 / 08807 1998年3月5日本发明涉及在路易斯酸存在下，通过烷基重氮酯与腙醛的反应来合成腙β-酮酯。在优选的实施方案中，腙β-酮酯通过在碱的存在下与烷基酰氯反应，然后酸化而转化为哒嗪酮化合物。还描述了生产腙醛的方法，其包括使肼和乙二醛接触。

5. 发明授权

US07057049B2 Process for making substituted pyrazoles 失效
标题翻译：制备取代的吡唑的方法
公开(公告)号：US07057049B2
公开(公告)日：2006-06-06
申请号：US10406150
申请日：2003-04-01
申请人： Kimberley C. Allen , Dennis K. Anderson , John E. Baldus , Todd Boehlow , Jerry D. Clark , Dan R. Dukesherer , Albert D. Edney , Tom Fevig , Sastry Kunda , Jon P. Lawson , Patrick H. Lau , Lisa L. McDermott , Michael K. Mao , Jodi L. Moe , Partha Mudipalli , Win Naing , Shaun R. Selness , Christine B. Seymour , Tobin C. Schilke , Shekhar Viswanath , John K. Walker , Gopichand Yalamanchili
发明人： Kimberley C. Allen , Dennis K. Anderson , John E. Baldus , Todd Boehlow , Jerry D. Clark , Dan R. Dukesherer , Albert D. Edney , Tom Fevig , Sastry Kunda , Jon P. Lawson , Patrick H. Lau , Lisa L. McDermott , Michael K. Mao , Jodi L. Moe , Partha Mudipalli , Win Naing , Shaun R. Selness , Christine B. Seymour , Tobin C. Schilke , Shekhar Viswanath , John K. Walker , Gopichand Yalamanchili
IPC分类号： C07D231/12 , C07D211/06 , C07D211/16
CPC分类号： C07D401/06 , C07D401/14
摘要： This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R3A, R3B, R3C, Y1, Y2, Y3, Y4, and Y5 are as defined in the specification.
摘要翻译：本发明一般涉及制备取代的吡唑，取代的吡唑的互变异构体和取代的吡唑和互变异构体的盐的方法。取代的吡唑在结构上对应于式（I）：其中R 3A，R 3B，R 3C，Y 1， Y 2，Y 2，Y 3，Y 4和Y 5如说明书中所定义。

6. 发明授权

US4742049A Semisynthetic erythromycin antibiotics 失效
标题翻译：半合成红霉素抗生素
公开(公告)号：US4742049A
公开(公告)日：1988-05-03
申请号：US870489
申请日：1986-06-04
申请人： William R. Baker , Jerry D. Clark
发明人： William R. Baker , Jerry D. Clark
IPC分类号： C07H17/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08
摘要： Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. 11,12-Cyclic carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced hepatotoxicity compared to the parent compounds.
摘要翻译：公开了具有由红霉素制成的治疗性能改善的半合成抗生素。 11,12-与母体化合物相比，红霉素，其衍生物及其盐和酯的环状氨基甲酸酯显示出优异的体外抗微生物活性和降低的肝毒性。

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