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    • 5. 发明申请
    • Characterisation of progressive system dysfunction
    • 进行性系统功能障碍的表征
    • US20050065734A1
    • 2005-03-24
    • US10921473
    • 2004-08-19
    • Jerome DeclerckThomas WrightRobert McLaughlin
    • Jerome DeclerckThomas WrightRobert McLaughlin
    • G06T7/00G06F19/00G01N33/48G01N33/50G01R31/00
    • G06T7/0012
    • A technique for assessing the progression of multilateral dysfunction, e.g. bilateral diseases is described. The process consists of two stages: firstly, a ‘health measure’ is computed for each of the features of the multi-lateral dysfunction. One example is in terms of the progression of Parkinson's disease by applying it to the uptake of imaging agent in the two striata of the brain, which can be viewed using SPECT imaging. In this example, a characteristic graph for each striatum is matched to a family of such graphs in order to quantify the state of each striatum as a health measure. Then the lower health measure is plotted against the higher health measure. This point is then projected onto a previously computed disease progression trajectory which is used to assign a percentage to the progression of the disease, from 0% normal to 100% extreme progression of the disease. In addition to the disease progression percentage, the technique also provides a confidence measure of the accuracy of this estimation. The invention is applicable to other forms of multilateral dysfunction, including other human or animal conditions and dysfunction in non-biological systems such as mechanical, electrical or electronic systems.
    • 评估多发功能障碍进展的技术,例如 描述双边疾病。 该过程包括两个阶段:首先,为多侧功能障碍的每个特征计算“健康度量”。 就帕金森氏病的进展而言,一个例子是通过将其应用于大脑两条纹状体中的成像剂的摄取,可以使用SPECT成像进行观察。 在该示例中,每个纹状体的特征图与这样的图的族相匹配,以便将每个纹状体的状态量化为健康度量。 然后,较低的健康指标与较高的健康度量相比较。 然后将该点投影到先前计算的疾病进展轨迹上,该轨迹用于将疾病进展的百分比从疾病的0%正常到100%极端进展分配。 除了疾病进展百分比,该技术还提供了该估计精度的置信度量度。 本发明适用于其他形式的多边功能障碍,包括其他人或动物病症和非生物系统如机械,电气或电子系统中的功能障碍。