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1. 发明授权

US08298328B2 Amorphous metal salt for facilitating the handling property of portland cements and dental applications thereof 有权
标题翻译：无定形金属盐，用于促进波特兰水泥及其牙科应用的处理性能
公开(公告)号：US08298328B2
公开(公告)日：2012-10-30
申请号：US12591764
申请日：2009-12-01
申请人： Jeng-Chang Yang , Pei-Ying Lee , Dian-Yu Ji , Nai-Chia Teng , Sung-Chih Hsieh , Sheng-Yang Lee
发明人： Jeng-Chang Yang , Pei-Ying Lee , Dian-Yu Ji , Nai-Chia Teng , Sung-Chih Hsieh , Sheng-Yang Lee
IPC分类号： A61K6/06
CPC分类号： C04B24/06 , A61K6/0008 , A61K6/0215 , A61K6/023 , A61K6/0606 , A61K6/0625 , C04B28/04 , C04B2111/00198 , C04B2111/00836 , C04B14/366
摘要： A novel amorphous divalent metal ion salt for enhancing the manageability of a Portland cement and its application in dental field are disclosed. Typical formula (I), (II), or (III) of this amorphous metal ion salt are shown as following: M 2 + ⁢ A x - ⁢ B 2 - x - ( I ) M 2 + ⁢ A y 2 - ⁢ C ( 4 - y ) 4 2 - ( II ) M 2 + ⁢ A z 3 - ⁢ D ( 6 - z ) 9 3 - ( III ) wherein, M2+, A−, B−, C−2, D−3, x, y, and z are defined the same as the specification. A novel tooth filling material comprises: a Portland cement, a bone substitute substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). In addition, a novel root canal filling material comprises: a Portland cement, a radiopaque substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). This amorphous divalent metal ion salt in the filling material of the present invention can improve the sticking together and reduce the setting time, thus offering more convenient in dental applications.
摘要翻译：公开了一种用于提高波特兰水泥的可管理性的新型无定形二价金属离子盐及其在牙科领域的应用。该非晶金属离子盐的典型的式（I），（II）或（III）表示如下：M 2 + A x -B 2-x - （I）M 2 + A y 2 - C（4-y）4 2 - （II）M 2 + A z 3 -D（6-z）9 3 - （III）其中，M2 +，A-，B-，C-2，D-3 ，x，y和z定义与说明书相同。一种新型牙齿填充材料包括：波特兰水泥，骨替代物质和具有式（I），（II）或（III）的式的无定形二价金属离子盐。此外，新颖的根管填充材料包括：波特兰水泥，不透射线的物质和具有式（I），（II）或（III）的式的无定形二价金属离子盐。本发明的填充材料中的这种无定形二价金属离子盐可以改善粘合在一起并缩短凝固时间，从而在牙齿应用中提供更方便。

2. 发明申请

US20100003519A1 Method of fabricating nano-fibers by electrospinning 审中-公开
标题翻译：通过静电纺丝制造纳米纤维的方法
公开(公告)号：US20100003519A1
公开(公告)日：2010-01-07
申请号：US12382840
申请日：2009-03-25
申请人： Chien-Chung Chen , Jeng-Chang Yang , Dien-Yu Ji , Yi Lu
发明人： Chien-Chung Chen , Jeng-Chang Yang , Dien-Yu Ji , Yi Lu
IPC分类号： D02G3/02 , B29C47/00 , C08K5/42 , C08G65/00 , C08G73/00
CPC分类号： C08K5/42 , B82Y30/00 , C08G73/22 , C08K5/09 , C08L77/10 , C08L79/04 , C08L79/08 , D01D1/02 , D01D5/003 , D01F6/74 , Y10T428/298
摘要： A novel solvent system for dissolving rigid-rod like polymers, such as polybenzoxazole (PBO), is disclosed, wherein said solvent system includes: a methanesulfonic acid (MSA) and a trifluoroacetic acid (TFA). Therefore, the rigid-rod like polybenzoxazole (PBO) can be easily dissolved in said solvent system without extra heat treatment. Besides, the polybenzoxazole (PBO) solution of said solvent system is firstly able to apply into electrospinning at room temperature to produce PBO nano-fiber, which has metallic luster and high thermal stability. Evident supported by the WAXD suggested these fibers have their molecular chains well aligned along the fiber spinning direction and has the advantages of heat resistance, flame retardance, and chemical environmental resistance, thus can be applied to a wide usage.
摘要翻译：公开了用于溶解刚性棒状聚合物如聚苯并恶唑（PBO）的新型溶剂体系，其中所述溶剂体系包括：甲磺酸（MSA）和三氟乙酸（TFA）。因此，刚性棒状聚苯并恶唑（PBO）可以容易地溶解在所述溶剂体系中而无需额外的热处理。此外，所述溶剂体系的聚苯并恶唑（PBO）溶液首先能够在室温下进行静电纺丝以制备具有金属光泽和高热稳定性的PBO纳米纤维。 WAXD支持的证据表明，这些纤维的分子链沿纤维纺丝方向良好排列，具有耐热性，阻燃性和耐化学性等优点，因此可广泛应用。

3. 发明授权

US07378484B2 Toughness-increased phenolic resin and preparation thereof 有权
标题翻译：韧性增加的酚醛树脂及其制备
公开(公告)号：US07378484B2
公开(公告)日：2008-05-27
申请号：US11094176
申请日：2005-03-31
申请人： Jeng-Chang Yang , Chen-Chi Martin Ma , Hon-Bin Chen , Chin-Yih Chen
发明人： Jeng-Chang Yang , Chen-Chi Martin Ma , Hon-Bin Chen , Chin-Yih Chen
IPC分类号： C08G8/02 , C08G8/00
CPC分类号： C08G8/28
摘要： A phenolic resin that increases its toughness by polydimethylsiloxane and a process of preparing the same is provided. Polydimethylsiloxane is added as a coupling agent in a γ-glycidoxypropyltrimethoxysilane-modified phenolic resin to improve the compatibility between polydimethylsiloxane and the phenolic resin. Then, tetraethoxysilane is added to conduct hydrolysis condensation and obtain tougher and thermally stable phenolic resin.
摘要翻译：提供了一种通过聚二甲基硅氧烷增加其韧性的酚醛树脂及其制备方法。将聚二甲基硅氧烷作为偶联剂加入到γ-环氧丙氧基丙基三甲氧基硅烷改性酚醛树脂中，以改善聚二甲基硅氧烷和酚醛树脂之间的相容性。然后加入四乙氧基硅烷进行水解缩合，得到更坚韧，热稳定的酚醛树脂。

4. 发明申请

US20060223971A1 Toughness-increased phenolic resin and preparation thereof 有权
标题翻译：韧性增加的酚醛树脂及其制备
公开(公告)号：US20060223971A1
公开(公告)日：2006-10-05
申请号：US11094176
申请日：2005-03-31
申请人： Jeng-Chang Yang , Chen-Chi Ma , Hon-Bin Chen , Chin-Yih Chen
发明人： Jeng-Chang Yang , Chen-Chi Ma , Hon-Bin Chen , Chin-Yih Chen
IPC分类号： C08G8/02
CPC分类号： C08G8/28
摘要： A phenolic resin that increases its toughness by polydimethylsiloxane and a process of preparing the same is provided. Polydimethylsiloxane is added as a coupling agent in a γ-glycidoxypropyltrimethoxysilane-modified phenolic resin to improve the compatibility between polydimethylsiloxane and the phenolic resin. Then, tetraethoxysilane is added to conduct hydrolysis condensation and obtain tougher and thermally stable phenolic resin.
摘要翻译：提供了一种通过聚二甲基硅氧烷增加其韧性的酚醛树脂及其制备方法。将聚二甲基硅氧烷作为偶联剂加入到γ-环氧丙氧基丙基三甲氧基硅烷改性酚醛树脂中，以改善聚二甲基硅氧烷和酚醛树脂之间的相容性。然后加入四乙氧基硅烷进行水解缩合，得到更坚韧，热稳定的酚醛树脂。

5. 发明申请

US20100139524A1 Novel amorphous metal salt for facilitating the handling property of portland cements and dental applications thereof 有权
标题翻译：新型无定形金属盐，用于促进波特兰水泥及其牙科应用的处理性能
公开(公告)号：US20100139524A1
公开(公告)日：2010-06-10
申请号：US12591764
申请日：2009-12-01
申请人： Jeng-Chang Yang , Pei-Ying Lee , Dain-Yu Ji , Nain-Chia Teng , Sung-Chih Hsieh , Sheng-Yang Lee
发明人： Jeng-Chang Yang , Pei-Ying Lee , Dain-Yu Ji , Nain-Chia Teng , Sung-Chih Hsieh , Sheng-Yang Lee
IPC分类号： C09K3/00 , C07C69/68 , C07C303/24
CPC分类号： C04B24/06 , A61K6/0008 , A61K6/0215 , A61K6/023 , A61K6/0606 , A61K6/0625 , C04B28/04 , C04B2111/00198 , C04B2111/00836 , C04B14/366
摘要： A novel amorphous divalent metal ion salt for enhancing the manageability of a Portland cement and its application in dental field are disclosed. Typical formula (I), (II), or (III) of this amorphous metal ion salt are shown as following: M 2 +  A x -  B 2 - x - ( I ) M 2 +  A y 2 -  C ( 4 - y ) 4 2 - ( II ) M 2 +  A z 3 -  D ( 6 - z ) 9 3 - ( III ) wherein, M2+, A−, B−, C−2, D−3, x, y, and z are defined the same as the specification. A novel tooth filling material comprises: a Portland cement, a bone substitute substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). In addition, a novel root canal filling material comprises: a Portland cement, a radiopaque substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). This amorphous divalent metal ion salt in the filling material of the present invention can improve the sticking together and reduce the setting time, thus offering more convenient in dental applications.
摘要翻译：公开了一种用于提高波特兰水泥的可管理性的新型无定形二价金属离子盐及其在牙科领域的应用。该无定形金属离子盐的典型式（I），（II）或（III）表示如下：M 2 + A X - B 2 - x - （I）M 2 + A y 2 - C（4-y）4 2 - （II）M 2 + A 3 Z 3 - D（6-z）9 3 - （III）其中，M2 +，A-，B-，C-2，D-3 ，x，y和z定义与说明书相同。一种新型牙齿填充材料包括：波特兰水泥，骨替代物质和具有式（I），（II）或（III）的式的无定形二价金属离子盐。此外，新颖的根管填充材料包括：波特兰水泥，不透射线的物质和具有式（I），（II）或（III）的式的无定形二价金属离子盐。本发明的填充材料中的这种无定形二价金属离子盐可以改善粘合在一起并缩短凝固时间，从而在牙齿应用中提供更方便。

6. 发明申请

US20100047310A1 Bio-acceptable conduits and method providing the same 审中-公开
标题翻译：生物可接受的管道和提供它的方法
公开(公告)号：US20100047310A1
公开(公告)日：2010-02-25
申请号：US12458526
申请日：2009-07-15
申请人： Chien-Chung CHEN , Jeng-Chang YANG , Suhan LI , En-Sheng KE , Yung-Sheng LIN
发明人： Chien-Chung CHEN , Jeng-Chang YANG , Suhan LI , En-Sheng KE , Yung-Sheng LIN
IPC分类号： A61F2/04 , C12N5/06 , A61F2/02 , B29C47/00
CPC分类号： A61L27/58 , A61B17/1128 , A61L27/383 , A61L27/3878 , A61L27/48 , A61L2430/32 , D01D5/0069 , D01D5/24
摘要： Disclosed is a bio-electrospinning technique for preparing a cell-containing, oriented, continuous tubular scaffold, made of biodegradable polymer, designed for use as a nerve guide conduit (NGC) in nerve regeneration. With a coaxial spinneret, the PC-12 cell medium solution was co-electrospun into a core of tubular fibers, with PLA on the outer shell. The resulted fibers' morphology was characterized via SEM and optical microscopy, and following structural characteristics were found: 1. the larger, hollow fibers had diameters in tenth of microns and wall thicknesses around few microns, 2. an orientation in a preferred direction with the aid of a high-rotating collection device. The fluorescent PC12 cells embedded within the scaffold were cultured and nerve growth factor was added. We observed cells could not only survive the process, but also sustain their viability by undergoing differentiation process, extending neurite along the micro tubular scaffold in the desired direction. All these results demonstrate its potential application for advanced NGC.
摘要翻译：公开了一种生物电纺丝技术，用于制备由可生物降解的聚合物制成的含细胞定向的连续管状支架，设计用于神经再生中的神经导管（NGC）。使用同轴喷丝头，将PC-12细胞培养基溶液共同电纺丝成管状纤维的核心，PLA在外壳上。通过SEM和光学显微镜对所得纤维的形态进行了表征，并发现了以下结构特征：1.较大的中空纤维的直径为十分之一微米，壁厚约为几微米，2.优选方向的取向为辅助高旋转收集装置。培养嵌入支架内的荧光PC12细胞，加入神经生长因子。我们观察到细胞不仅可以在该过程中存活，而且通过进行分化过程维持其活力，沿着所需方向沿着微管状支架延伸神经突。所有这些结果表明其潜在应用于先进的NGC。

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