专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11471274B2 Toric lens guide for use in conjunction with a toric intraocular lens so as to properly orient the toric lens in order to properly correct astigmatism 有权
公开(公告)号：US11471274B2
公开(公告)日：2022-10-18
申请号：US16812320
申请日：2020-03-08
申请人： Jeffrey Whitsett
发明人： Jeffrey Whitsett
IPC分类号： A61F2/16
摘要： A tonic lens guide comprises a substantially linear bar member and a pair of crab claw members fixedly attached to opposite ends of the linear bar member. The toric lens guide is adapted to be mounted upon an intraocular lens (IOL) which has been implanted within the capsular bag of a human eye during cataract surgery such that the substantially linear bar member is adapted to be disposed atop the central optic component of the intraocular lens (IOL) while the crab claw members effectively grasp the optica/haptic junctions of the intraocular lens (IOL). After the intraocular lens (IOL) is implanted within the capsular bag, it is rotated within the capsular bag such that the substantially linear bar member of the toric lens guide will effectively define a diametrical vector across the intraocular lens (IOL) such that the cataract surgeon can precisely orient the intraocular lens (IOL) within the capsular bag such that the patient's astigmatism is optimally corrected.

2. 发明申请

US20210244531A1 EXCHANGEABLE LENS PLATFORM 有权
公开(公告)号：US20210244531A1
公开(公告)日：2021-08-12
申请号：US17171558
申请日：2021-02-09
申请人： Jeffrey WHITSETT
发明人： Jeffrey WHITSETT
IPC分类号： A61F2/16
摘要： An exchangeable lens platform (ELP) comprises a horseshoe-shaped ring structure, which has a memory strip incorporated therein, into which the haptic end components of the intraocular lens (IOL) can engage diametrically opposite portions of the ring structure. In this manner, the exchangeable lens platform (ELP) can not only be opened or expanded so as to be disposed within any sized capsular bag in a secure and stabilized manner, but diametrically opposite portions of the exchangeable lens platform (ELP) can effectively fold upon themselves such that the exchangeable lens platform (ELP) will effectively be partially folded in half such that the diametrically opposite folded portions of the exchangeable lens platform (ELP) can effectively engage diametrically opposed internal wall portions of the fornix of the capsular bag so as to permit the intraocular lens (IOL) to then be properly centered, oriented, stabilized, and secured within the eye. In addition, since the haptic components of the intraocular lens (IOL) are disposed upon the exchangeable lens platform (ELP) and do not engage internal peripheral wall portions of the capsular bag, the intraocular lens (IOL) can be removed and replaced with another intraocular lens (IOL).

3. 发明申请

US20210315737A1 ANTERIOR CHAMBER MAINTAINER (ACM) 有权
公开(公告)号：US20210315737A1
公开(公告)日：2021-10-14
申请号：US17220858
申请日：2021-04-01
申请人： JEFFREY WHITSETT
发明人： JEFFREY WHITSETT
IPC分类号： A61F9/007 , A61F9/00
摘要： An anterior chamber maintainer (ACM), which is to be utilized in connection with maintaining physiological intraocular pressure during intraocular surgery is disclosed and is seen to comprise an axially elongated tubular member which is adapted to be fluidically connected at a first end to a supply of balanced salt solution (BSS) for introduction into the anterior chamber of an eye so as to maintain adequate intraocular pressure while performing any intraocular surgery. A second opposite end of the anterior chamber maintainer (ACM) is provided with a sharply pointed end for insertion through a paracentesis formed within the limbus region of the eye, and a deformable bulbous portion is interposed between the first and second ends such that as the second end passes through the paracentesis, the bulbous portion will diametrically deform and then diametrically expand, after also passing through the paracentesis, thereby trapping the anterior chamber maintainer (ACM) within the anterior chamber of the eye.

4. 发明申请

US20120053112A1 METHODS AND COMPOSITIONS RELATED TO THE REGULATION OF GOBLET CELL DIFFERENTIATION, MUCUS PRODUCTION AND MUCUS SECRETION 审中-公开
标题翻译：与细胞分化调节相关的方法和组合，MUCUS生产和MUCUS分泌
公开(公告)号：US20120053112A1
公开(公告)日：2012-03-01
申请号：US13319318
申请日：2010-05-05
申请人： Jeffrey Whitsett
发明人： Jeffrey Whitsett
IPC分类号： A61K38/00 , A61K31/7088 , C12Q1/68
CPC分类号： A61K31/4745 , C07K14/4702 , C12N15/113 , C12N2310/14 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2333/4703 , G01N2500/10 , G01N2800/122
摘要： Disclosed are methods and compositions related to the regulation of goblet cell differentiation, mucus production and mucus secretion. In some embodiments, methods for the treatment of mucus hyperproduction, methods for the treatment of pulmonary inflammation, methods of screening compounds, compositions for the treatment of mucus hyperproduction, or compositions for the treatment of pulmonary inflammation are provided.
摘要翻译：公开了与杯状细胞分化，粘液生成和粘液分泌调节相关的方法和组合。在一些实施方案中，提供了用于治疗粘液超生产的方法，用于治疗肺部炎症的方法，筛选化合物的方法，用于治疗粘液超生产的组合物或用于治疗肺部炎症的组合物。

5. 发明申请

US20220054313A1 NEW AND IMPROVED VITRECTOR AND METHOD FOR PERFORMING A ONE-STEP POSTERIOR VITRECTOMY USING THE SAME 有权
公开(公告)号：US20220054313A1
公开(公告)日：2022-02-24
申请号：US17519150
申请日：2021-11-04
申请人： Jeffrey Whitsett
发明人： Jeffrey Whitsett
IPC分类号： A61F9/007
摘要： A vitrector for removing material from an eye includes a hand piece, a shaft coupled at a first end to a first end of the hand piece, the shaft having a sharp second end opposite the first end of the shaft, and a cutting device positioned within the shaft and configured for removing the material from the eye. The sharp second end of the shaft is configured for piercing a pars plana of the eye and a sclera of the eye. A method for removing material from an eye includes forming a single opening through a pars plana of the eye and a sclera of the eye using a sharp point of a shaft of a vitrector, cutting the material using a cutting device incorporated within the shaft, and removing the material from the eye using the vitrector.

6. 发明申请

US20200345548A1 VITRECTOR AND METHOD FOR PERFORMING A ONE-STEP POSTERIOR VITRECTOMY USING THE SAME 审中-公开
公开(公告)号：US20200345548A1
公开(公告)日：2020-11-05
申请号：US16812314
申请日：2020-03-08
申请人： JEFFREY WHITSETT
发明人： JEFFREY WHITSETT
IPC分类号： A61F9/007
摘要： A vitrector for performing a vitrectomy comprises a tubular shaft portion which is attached to a distal end of a vitrector hand piece. The shaft portion is provided with a sharply pointed needle tip portion for piercing the pars plana and sclera of the eye, and a pneumatically driven guillotine cutter is incorporated within the shaft portion of the vitrector at a location immediately adjacent to the sharply pointed needle tip portion. A source of pneumatic air is operatively connected to the proximal end of the vitrector hand piece and is pneumatically connected to the guillotine cutter so as to drive the same. In addition, an aspiration line is also operatively connected to the proximal end of the vitrector hand piece and is also fluidically connected to the region immediately adjacent to the pneumatically driven guillotine cutter so as to remove the floater particles, severed from the vitreous cavity by means of the pneumatically driven guillotine cutter, by means of aspiration.

7. 发明申请

US20060194732A1 Recombinant SP-A for the treatment or prevention of pulmonary infection and inflammation 审中-公开
标题翻译：重组SP-A用于治疗或预防肺部感染和炎症
公开(公告)号：US20060194732A1
公开(公告)日：2006-08-31
申请号：US11413197
申请日：2006-04-28
申请人： Wolfram Steinhilber , Jeffrey Whitsett , Ann Levine , Thomas Korfhagen
发明人： Wolfram Steinhilber , Jeffrey Whitsett , Ann Levine , Thomas Korfhagen
IPC分类号： A61K38/17
CPC分类号： C07K14/785 , A61K38/00 , A61K38/1709 , Y10S514/885
摘要： Recombinant surfactant protein A and medicament compositions based thereon are useful for the prevention or treatment of pulmonary infection and inflammation.
摘要翻译：重组表面活性蛋白A及其上的药物组合物可用于预防或治疗肺部感染和炎症。

8. 发明申请

US20060078558A1 Diagnosis, prognosis and treatment of pulmonary diseases 审中-公开
标题翻译：肺部疾病的诊断，预后和治疗
公开(公告)号：US20060078558A1
公开(公告)日：2006-04-13
申请号：US10772716
申请日：2004-02-05
申请人： Jeffrey Whitsett
发明人： Jeffrey Whitsett
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： A61K38/1709 , A61K2039/505 , B82Y5/00 , C07K16/18
摘要： The present invention provides methods to protect a subject from a respiratory disorder involving an airway obstructive disease such as asthma or chronic obstructive pulmonary disease. Provided are methods to protect a subject from an airway obstructive disease using gene therapy. Methods are provided for supplying FoxA2 function to cells of the lung and airway, such as smooth muscle and epithelial cells, by FoxA2 gene therapy. The FoxA2 gene, a modified FoxA2 gene, or a part of the gene may be introduced into the cell in a vector such that the gene remains extrachromosomal or may be integrated into the subjects chromosomal DNA for expression. These methods provide for administering to a subject in need of such treatment a therapeutically effective amount of a FoxA2 gene, or pharmaceutically acceptable composition thereof, for overexpressing the FoxA2 gene. Such methods of expressing the administered FoxA2 gene in the lungs and airway provide for: (1) preventing or alleving bronchial hyperresponsiveness; (2) preventing or alleving of an airway obstructive disease, e.g., bronchial hyperreactivity, airway hyperresponsiveness, asthma or chronic obstructive pulmonary disorder (“COPD”); (3) reducing the airway resistance response to inhaled natural or synthetic bronchoconstrictors or allergens or to exercise; and (4) enhancing responsiveness (relaxation) of airway tissues to β-agonists.
摘要翻译：本发明提供了保护受试者免受涉及气道阻塞性疾病如哮喘或慢性阻塞性肺病的呼吸系统疾病的方法。提供了使用基因治疗来保护受试者免受气道阻塞性疾病的方法。通过FoxA2基因治疗提供FoxA2功能供肺和气道细胞如平滑肌和上皮细胞的方法。可以将FoxA2基因，修饰的FoxA2基因或该基因的一部分引入载体中的细胞中，使得该基因保持染色体外或可以整合入受试者染色体DNA进行表达。这些方法提供了对需要这种治疗的受试者施用用于过表达FoxA2基因的治疗有效量的FoxA2基因或其药学上可接受的组合物。在肺和气道中表达施用的FoxA2基因的这种方法提供：（1）预防或反应支气管高反应性; （2）预防或调节气道阻塞性疾病，例如支气管高反应性，气道高反应性，哮喘或慢性阻塞性肺病（“COPD”）; （3）降低吸入天然或合成支气管收缩剂或过敏原或运动的气道阻力反应; 和（4）增强气道组织对β-激动剂的反应性（松弛）。

9. 发明申请

US20210038371A1 TORIC LENS GUIDE FOR USE IN CONJUNCTION WITH A TORIC INTRAOCULAR LENS SO AS TO PROPERLY ORIENT THE TORIC LENS IN ORDER TO PROPERLY CORRECT ASTIGMATISM 有权
公开(公告)号：US20210038371A1
公开(公告)日：2021-02-11
申请号：US16812320
申请日：2020-03-08
申请人： JEFFREY WHITSETT
发明人： JEFFREY WHITSETT
IPC分类号： A61F2/16
摘要： A tonic lens guide comprises a substantially linear bar member and a pair of crab claw members fixedly attached to opposite ends of the linear bar member. The toric lens guide is adapted to be mounted upon an intraocular lens (IOL) which has been implanted within the capsular bag of a human eye during cataract surgery such that the substantially linear bar member is adapted to be disposed atop the central optic component of the intraocular lens (IOL) while the crab claw members effectively grasp the optica/haptic junctions of the intraocular lens (IOL). After the intraocular lens (IOL) is implanted within the capsular bag, it is rotated within the capsular bag such that the substantially linear bar member of the toric lens guide will effectively define a diametrical vector across the intraocular lens (IOL) such that the cataract surgeon can precisely orient the intraocular lens (IOL) within the capsular bag such that the patient's astigmatism is optimally corrected.

10. 发明申请

US20050158747A1 CFTR modifier genes and expressed polypeptides useful in treating cystic fibrosis and methods and products for detecting and/or identifying same 审中-公开
标题翻译：可用于治疗囊性纤维化的CFTR修饰基因和表达的多肽以及用于检测和/或识别其的方法和产品
公开(公告)号：US20050158747A1
公开(公告)日：2005-07-21
申请号：US10999587
申请日：2004-11-30
申请人： Jeffrey Whitsett , Bruce Aronow , Jean Clark
发明人： Jeffrey Whitsett , Bruce Aronow , Jean Clark
IPC分类号： A01K67/00 , A61K31/353 , A61K31/4439 , C07H21/04 , C07K14/47 , C07K14/705 , C12Q1/68
CPC分类号： C07K14/4712 , A01K67/0276 , A01K2227/105 , A01K2267/0306 , A61K31/353 , A61K31/4439
摘要： The discovery that CFTR modifier genes, in particular the Kir4.2 gene, the expressed polypeptide(s), as well as genetic and polypeptide regulators thereof, can be used to treat cystic fibrosis (CF), or at least the conditions that cause CF. Methods and products for detecting and/or identifying CFTR modifier genes, their respective expressed polypeptides, the genetic regulators of such CFTR modifier genes, and the regulators of their respective expressed polypeptides are disclosed. Also disclosed are compositions and methods using these CFTR modifier genes, their respective expressed polypeptides, genetic regulators of these CFTR modifier genes, and/or CFTR modifier polypeptide regulators for the purpose of treating CF, or at least the conditions that cause CF, are disclosed.
摘要翻译：发现CFTR修饰基因，特别是Kir4.2基因，表达多肽及其遗传和多肽调节剂可用于治疗囊性纤维化（CF）或至少导致CF的条件。公开了用于检测和/或鉴定CFTR修饰基因，它们各自表达的多肽，这种CFTR修饰基因的遗传调节剂及其各自表达的多肽的调节剂的方法和产物。还公开了公开了用于治疗CF或至少导致CF的病症的这些CFTR修饰基因，它们各自表达的多肽，这些CFTR修饰基因的遗传调节剂和/或CFTR修饰多肽调节剂的组合物和方法，。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式