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1. 发明授权

US07901359B2 Ultrasound energy driven intraventricular catheter to treat ischemia 有权
标题翻译：超声能量驱动心室导管治疗缺血
公开(公告)号：US07901359B2
公开(公告)日：2011-03-08
申请号：US11296595
申请日：2005-12-06
申请人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
发明人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
IPC分类号： A61B17/00
CPC分类号： A61N7/022 , A61B2017/00247 , A61B2018/00392
摘要： A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.
摘要翻译：提供了一种用于改善患者血液流向缺血区域（如心肌缺血）的方法和装置。超声换能器位于缺血区附近。以1MHz以上的频率施加超声波能量，以在心肌的缺血区域中产生一个或多个热损伤。热病变可以有一个大小的梯度。超声换能器可以具有弯曲形状，使得由换能器发射的超声能量收敛到心肌内的位置，以产生热损伤而不损伤心外膜或心内膜。

2. 发明申请

US20070093745A1 Medical assembly with transducer for local delivery of a therapeutic substance and method of using same 审中-公开
标题翻译：具有用于局部递送治疗物质的换能器的医疗组件及其使用方法
公开(公告)号：US20070093745A1
公开(公告)日：2007-04-26
申请号：US11635854
申请日：2006-12-08
申请人： Jeffrey Steward , Brandon Gosiengfiao
发明人： Jeffrey Steward , Brandon Gosiengfiao
IPC分类号： A61B17/20
CPC分类号： A61M25/104 , A61M2025/0057 , A61M2025/1086
摘要： A medical Assembly is used to delivery a therapeutic substance to a treatment area. The medical assembly comprises a catheter having a distal end and a proximal end, a transducer supported by at least a portion of the distal end of the catheter assembly, and a delivery lumen mounted on the catheter for delivery of a therapeutic substance. Support for the transducer is provided at a preselected number of anchoring points, wherein an inner surface of the transducer is positioned at a preselected distance from an outer surface of the catheter. The preselected distance defines a gap that is occupied by a low density material such as a gas which reflects acoustic pressure waves directed toward the gap by a transducer when a voltage is applied to the transducer. The reflected pressure wave increases the energy in the system, enhancing transport of therapeutic substances from the delivery lumen to the surrounding tissues and/or cells to be treated. The medical assembly may optionally be used in conjunction with both macroporous and microporous balloons. The medical assembly may optionally be modified so that a plurality of transducers are used, wherein the distal end of a transducer is positioned at a preselected distance from the proximal end of an adjacent transducer.
摘要翻译：医疗组件用于将治疗物质递送到治疗区域。医疗组件包括具有远端和近端的导管，由导管组件的远端的至少一部分支撑的换能器，以及安装在导管上用于输送治疗物质的输送腔。在预选数量的锚固点处提供对换能器的支撑，其中换能器的内表面定位在离导管外表面预定距离处。预选距离限定了由低密度材料例如气体占据的间隙，当将电压施加到换能器时，该气体反射由换能器指向间隙的声压波。反射的压力波增加系统中的能量，增强治疗物质从输送腔向周围组织和/或待治疗细胞的转运。医疗组件可以任选地与大孔和微孔气囊一起使用。可以可选地修改医疗组件，使得使用多个换能器，其中换能器的远端定位在距相邻换能器近端的预选距离处。

3. 发明授权

US07179249B2 Directional needle injection drug delivery device and method of use 有权
标题翻译：定向注射药物输送装置及其使用方法
公开(公告)号：US07179249B2
公开(公告)日：2007-02-20
申请号：US10390942
申请日：2003-03-17
申请人： Jeffrey Steward , Mina Chow
发明人： Jeffrey Steward , Mina Chow
IPC分类号： A61M31/00
CPC分类号： A61B8/12 , A61B5/4839 , A61B8/445 , A61M25/0084 , A61M25/104 , A61M37/0092 , A61M2025/009 , A61M2025/0096
摘要： The invention relates to an apparatus and method for imaging and mapping various structures located at a target area within a patient's lumen using conventional IVUS technology. The mapped images are used to accurately determine and control the location of the device within the lumen relative to the target area and/or target site. Once the drug delivery device is properly positioned within the lumen, additional ultrasonic images are generated and used to control the position and depth of penetration of a retractable needle of the device. Needle position can be precisely determined, both in relationship to the device as well as the target site for drug delivery. This allows accurate delivery of drug to the target site and, thus, enhanced treatment capabilities.
摘要翻译：本发明涉及一种用于使用常规IVUS技术对位于患者管腔内的目标区域的各种结构进行成像和映射的装置和方法。映射的图像用于相对于目标区域和/或目标位置精确地确定和控制流明内的装置的位置。一旦药物输送装置适当地定位在内腔内，则产生附加的超声波图像并用于控制装置的可伸缩针的穿透位置和深度。可以精确地确定针位置，无论是与装置以及药物递送的目标部位有关。这允许将药物准确地递送到目标部位，从而提高治疗能力。

4. 发明申请

US20050051466A1 Monitoring and control system for blood processing 有权
标题翻译：血液处理监控系统
公开(公告)号：US20050051466A1
公开(公告)日：2005-03-10
申请号：US10884877
申请日：2004-07-01
申请人： Lee Carter , Jeremy Kolenbrander , James Ladtkow , Joseph Scibona , Jeffrey Steward , Chris Fletcher
发明人： Lee Carter , Jeremy Kolenbrander , James Ladtkow , Joseph Scibona , Jeffrey Steward , Chris Fletcher
IPC分类号： A61M1/36 , B01D17/12 , B04B13/00 , G01N15/04 , G01N15/05
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods, devices and device components for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. In embodiment, two-dimensional distributions of transmitted light intensities, scattered light intensities or both measured by the methods of the present invention comprise images of a separation chamber or component thereof, such as an optical cell of a separation chamber. In another aspect, the present invention relates to multifunctional monitoring and control systems for blood processing, particularly blood processing via density centrifugation. Feedback control systems are provided wherein two-dimensional distributions of transmitted light intensities, scattered light intensities or both are measured, processed in real time and are used as the basis of output signals for controlling blood processing. In another aspect, optical cells and methods of using optical cells for monitoring and control blood processing are provided.
摘要翻译：本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法，装置和装置部件。在实施例中，通过本发明的方法测量的透射光强度，散射光强度或二者的二维分布包括分离室或其分量（诸如分离室的光学单元）的图像。另一方面，本发明涉及用于血液处理的多功能监测和控制系统，特别是通过密度离心进行血液处理。提供反馈控制系统，其中测量透射光强度，散射光强度或二者的二维分布，实时处理，并用作控制血液处理的输出信号的基础。在另一方面，提供了光学单元和使用光学单元来监测和控制血液处理的方法。

5. 发明申请

US20070083149A1 Medical assembly with transducer for local delivery of a therapeutic substance and method of using same 审中-公开
公开(公告)号：US20070083149A1
公开(公告)日：2007-04-12
申请号：US11635852
申请日：2006-12-08
申请人： Jeffrey Steward , Brandon Gosiengfiao
发明人： Jeffrey Steward , Brandon Gosiengfiao
IPC分类号： A61B17/20
CPC分类号： A61M25/104 , A61M2025/0057 , A61M2025/1086
摘要： A medical Assembly is used to delivery a therapeutic substance to a treatment area. The medical assembly comprises a catheter having a distal end and a proximal end, a transducer supported by at least a portion of the distal end of the catheter assembly, and a delivery lumen mounted on the catheter for delivery of a therapeutic substance. Support for the transducer is provided at a preselected number of anchoring points, wherein an inner surface of the transducer is positioned at a preselected distance from an outer surface of the catheter. The preselected distance defines a gap that is occupied by a low density material such as a gas which reflects acoustic pressure waves directed toward the gap by a transducer when a voltage is applied to the transducer. The reflected pressure wave increases the energy in the system, enhancing transport of therapeutic substances from the delivery lumen to the surrounding tissues and/or cells to be treated. The medical assembly may optionally be used in conjunction with both macroporous and microporous balloons. The medical assembly may optionally be modified so that a plurality of transducers are used, wherein the distal end of a transducer is positioned at a preselected distance from the proximal end of an adjacent transducer.

6. 发明授权

US06860946B2 System for the process of coating implantable medical devices 失效
标题翻译：可植入医疗器械涂层工艺的系统
公开(公告)号：US06860946B2
公开(公告)日：2005-03-01
申请号：US10382722
申请日：2003-03-05
申请人： Syed F. A. Hossainy , Jeffrey Steward
发明人： Syed F. A. Hossainy , Jeffrey Steward
IPC分类号： A61L31/10 , A61L31/16 , B05B13/02 , B05C13/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606
摘要： Methods of coating an implantable device and a system for performing such methods are disclosed. An embodiment of the method includes applying a coating substance to the surface of an implantable device, and rotating the implantable device in a centrifuge. The method can uniformly coat the implantable device with the coating substance and to remove unwanted accumulations of coating substance entrained between struts or crevices in the implantable device body. This system is applicable to methods for coating intraluminal stents, synthetic grafts, and stent coverings with therapeutic compositions comprising therapeutic agents mixed with a polymeric matrix and a solvent.
摘要翻译：公开了涂覆可植入装置的方法和用于执行这种方法的系统。该方法的一个实施例包括将涂层物质施加到可植入装置的表面，以及在离心机中旋转可植入装置。该方法可以均匀地涂覆可植入装置的涂层物质，并且去除可植入装置主体中的支柱或裂缝之间夹带的涂层物质的不期望的积聚。该系统适用于用包含与聚合物基质和溶剂混合的治疗剂的治疗组合物涂覆腔内支架，合成移植物和支架覆盖物的方法。

7. 发明授权

US06740040B1 Ultrasound energy driven intraventricular catheter to treat ischemia 有权
公开(公告)号：US06740040B1
公开(公告)日：2004-05-25
申请号：US09774334
申请日：2001-01-30
申请人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
发明人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
IPC分类号： A61B800
CPC分类号： A61N7/022 , A61B2017/00247 , A61B2018/00392
摘要： A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.

8. 发明授权

US06692466B1 Drug delivery catheter with retractable needle 有权
标题翻译：药物输送导管带伸缩针
公开(公告)号：US06692466B1
公开(公告)日：2004-02-17
申请号：US09746498
申请日：2000-12-21
申请人： Mina Chow , Paul John Kawula , Jeffrey Steward
发明人： Mina Chow , Paul John Kawula , Jeffrey Steward
IPC分类号： A61M5178
CPC分类号： A61M25/0084 , A61M25/10 , A61M2025/0086 , A61M2025/0087 , A61M2025/009
摘要： A catheter assembly having a balloon disposed at the distal end thereof and a therapeutic substance delivery assembly, including a needle in fluid communication with a therapeutic substance delivery lumen for allowing a therapeutic substance to be injected into a diseased physiological lumen. A deflector is positioned along an inside wall of the delivery lumen, positioned, such that as a bend region forms caused by the movement of the delivery lumen, the deflector bends to rest on the outside curvature of the bend. As the needle is made to travel through the bend, the ribbon helps to bounce the needle tip off the wall of the delivery lumen, allowing the needle to travel through the bend without digging into and/or gouging the delivery lumen wall.
摘要翻译：一种具有设置在其远端处的气囊的导管组件和包括与治疗物质输送腔流体连通的针的治疗物质输送组件，用于允许将治疗物质注射到患病的生理管腔中。偏转器沿着输送腔的内壁定位，定位成使得由于由输送腔的运动引起的弯曲区域形成，偏转器弯曲以弯曲的外侧曲率。当针被制造成穿过弯曲部时，带状物有助于使针尖从输送腔的壁反弹，从而允许针穿过弯曲部而不会进入和/或凿出输送腔壁。

9. 发明申请

US20060100554A1 Ultrasound energy driven intraventricular catheter to treat ischemia 有权
标题翻译：超声能量驱动心室导管治疗缺血
公开(公告)号：US20060100554A1
公开(公告)日：2006-05-11
申请号：US11296595
申请日：2005-12-06
申请人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
发明人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
IPC分类号： A61H1/00
CPC分类号： A61N7/022 , A61B2017/00247 , A61B2018/00392
摘要： A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.
摘要翻译：提供了一种用于改善患者血液流向缺血区域（如心肌缺血）的方法和装置。超声换能器位于缺血区附近。以1MHz以上的频率施加超声波能量，以在心肌的缺血区域中产生一个或多个热损伤。热病变可以有一个大小的梯度。超声换能器可以具有弯曲形状，使得由换能器发射的超声能量收敛到心肌内的位置，以产生热损伤而不损伤心外膜或心内膜。

10. 发明授权

US07001336B2 Method for treating ischemia 失效
标题翻译：治疗缺血的方法
公开(公告)号：US07001336B2
公开(公告)日：2006-02-21
申请号：US10817358
申请日：2004-04-01
申请人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
发明人： Evgenia Mandrusov , Jeffrey Steward , Marshall Sherman
IPC分类号： A61B8/00
CPC分类号： A61N7/022 , A61B2017/00247 , A61B2018/00392
摘要： A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.
摘要翻译：提供了一种用于改善患者血液流向缺血区域（如心肌缺血）的方法和装置。超声换能器位于缺血区附近。以1MHz以上的频率施加超声波能量，以在心肌的缺血区域中产生一个或多个热损伤。热病变可以有一个大小的梯度。超声换能器可以具有弯曲形状，使得由换能器发射的超声能量收敛到心肌内的位置，以产生热损伤而不损伤心外膜或心内膜。

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