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1. 发明授权

US09056154B2 High-yield activation of polymer surfaces for covalent attachment of molecules 有权
标题翻译：用于共价连接分子的聚合物表面的高产率活化
公开(公告)号：US09056154B2
公开(公告)日：2015-06-16
申请号：US12939736
申请日：2010-11-04
申请人： Jeffrey Schwartz , T. Joseph Dennes
发明人： Jeffrey Schwartz , T. Joseph Dennes
IPC分类号： A61L31/08 , A61L27/30 , C08J7/04 , A61L27/14 , A61L27/28 , A61L27/38 , A61L27/50 , A61L31/00 , C08H1/06 , C09J189/04
CPC分类号： A61L31/082 , A61L27/14 , A61L27/28 , A61L27/30 , A61L27/38 , A61L27/50 , A61L31/005 , C08H1/06 , C08J7/04 , C08J7/045 , C08J2379/02 , C09J189/04 , Y10T428/31504 , Y10T428/31536
摘要： Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of organic overlayers. Coating methods and coated articles are also disclosed.
摘要翻译：涂覆有有机金属层的聚合物表面，其中有机金属层和聚合物表面具有使有机金属层与聚合物表面结合的官能团，有机金属官能团保留未反应用于随后共价连接有机覆盖层。还公开了涂覆方法和涂覆制品。

2. 发明授权

US08372435B2 Modular monolayer coatings for selective attachment of nanoparticles to biomolecules 有权
标题翻译：用于将纳米颗粒选择性附着到生物分子的模块化单层涂层
公开(公告)号：US08372435B2
公开(公告)日：2013-02-12
申请号：US12489242
申请日：2009-06-22
申请人： Jeffrey Schwartz , Christopher A. Traina , Thomas Joseph Dennes
发明人： Jeffrey Schwartz , Christopher A. Traina , Thomas Joseph Dennes
IPC分类号： A61K9/51 , C01F17/00
CPC分类号： A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K49/0093 , G01N33/533 , G01N33/582 , G01N33/587 , Y10T428/2991
摘要： Nanoparticles are functionalized for use as bio-imaging probes using a novel, modular approach. Particle surface modification is based on a phosphonate monolayer platform on which was built a multi-segmented, multi-functional film: the first segment provided hydrolytic stability, the second aqueous suspendability, and the third, selectivity for cell attachment. In vitro imaging experiments visualized nanoparticle-cell surface binding. Peptide-derivatized nano-particles were not displaced from cells by soluble peptide. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.
摘要翻译：使用新颖的模块化方法将纳米颗粒功能化用作生物成像探针。颗粒表面改性是基于一种膦酸盐单层平台，其上建立了多段多功能膜：第一段提供了水解稳定性，第二水性悬浮性，第三段选择性为细胞附着。体外成像实验可视化纳米颗粒细胞表面结合。肽衍生的纳米颗粒不能通过可溶性肽从细胞中移位。还公开了在成像方法和光动力学治疗方法中涂覆主体颗粒和使用稀土离子掺杂颗粒的方法。

3. 发明申请

US20120121661A1 DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY 有权
公开(公告)号：US20120121661A1
公开(公告)日：2012-05-17
申请号：US13349367
申请日：2012-01-12
申请人： Jeffrey Schwartz , Ellen S. Gawalt , Michael J. Avaltroni
发明人： Jeffrey Schwartz , Ellen S. Gawalt , Michael J. Avaltroni
IPC分类号： A61M1/00 , A61N1/362 , A61F9/00 , A61F2/52 , A61P31/00 , A61B17/04 , A61N1/05 , A61M25/10 , A61K9/00 , A61F2/08 , A61J1/10
CPC分类号： A61L27/32 , A61L29/106 , A61L31/086 , B05D1/185 , B82Y30/00 , B82Y40/00 , C03C17/001 , C03C17/23 , C23C14/06 , C23C22/02 , C23C22/48 , Y10T428/12556 , Y10T428/12611 , Y10T428/131 , Y10T428/265
摘要： Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.

4. 发明申请

US20110303904A1 PHOTOVOLTAIC DEVICE AND METHOD OF MAKING SAME 审中-公开
标题翻译：光电器件及其制造方法
公开(公告)号：US20110303904A1
公开(公告)日：2011-12-15
申请号：US13113606
申请日：2011-05-23
申请人： Sushobhan Avasthi , James C. Sturm , Jeffrey Schwartz
发明人： Sushobhan Avasthi , James C. Sturm , Jeffrey Schwartz
IPC分类号： H01L51/46 , H01L31/11
CPC分类号： H01L51/4213 , H01L51/0052 , H01L51/4273 , Y02E10/549 , Y02P70/521
摘要： A photovoltaic device and method of manufacturing is disclosed. In one embodiment, the device includes a silicon layer and first and second organic layers. The silicon layer has a first face and a second face. First and second electrodes electrically are coupled to the first and second organic layers. A first heterojunction is formed at a junction between the one of the faces of the silicon layer and the first organic layer. A second heterojunction is formed at a junction between one of the faces of the silicon layer and the second organic layer. The silicon layer may be formed without a p-n junction. At least one organic layer may be configured as an electron-blocking layer or a hole-blocking layer. At least one organic layer may be comprised of phenanthrenequinone (PQ). A passivating layer may be disposed between at least one of the organic layers and the silicon layer. The passivating layer may be organic. At least one of the organic layers may passivate a surface of the silicon layer. The device may also include at least one transparent electrode layer coupled to at least one of the electrodes.
摘要翻译：公开了一种光电器件及其制造方法。在一个实施例中，该器件包括硅层和第一和第二有机层。硅层具有第一面和第二面。第一和第二电极电连接到第一和第二有机层。在硅层和第一有机层的一个面之间的接合处形成第一异质结。在硅层和第二有机层的一个面之间的接合处形成第二异质结。可以在没有p-n结的情况下形成硅层。至少一个有机层可以被构造为电子阻挡层或空穴阻挡层。至少一个有机层可以由菲醌（PQ）组成。钝化层可以设置在至少一个有机层和硅层之间。钝化层可以是有机的。有机层中的至少一个可以钝化硅层的表面。该装置还可以包括耦合到至少一个电极的至少一个透明电极层。

5. 发明申请

US20110110986A1 HIGH-YIELD ACTIVATION OF POLYMER SURFACES FOR COVALENT ATTACHMENT OF MOLECULES 有权
标题翻译：用于共价连接分子的聚合物表面的高效激活
公开(公告)号：US20110110986A1
公开(公告)日：2011-05-12
申请号：US12939736
申请日：2010-11-04
申请人： Jeffrey Schwartz , T. Joseph Dennes
发明人： Jeffrey Schwartz , T. Joseph Dennes
IPC分类号： A61K9/00 , A61K35/12 , C12N5/071 , A61P43/00 , A61P35/00 , A61K31/522 , A61K31/196 , A61K31/138 , A61K31/4535 , A61K31/704 , A61K31/137 , A61K31/4748 , A61K31/439 , A61K31/7048 , A61K38/02 , A61K31/401 , A61K31/545 , A61K31/60 , A61K31/192 , A61K31/455
CPC分类号： A61L31/082 , A61L27/14 , A61L27/28 , A61L27/30 , A61L27/38 , A61L27/50 , A61L31/005 , C08H1/06 , C08J7/04 , C08J7/045 , C08J2379/02 , C09J189/04 , Y10T428/31504 , Y10T428/31536
摘要： Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of organic overlayers. Coating methods and coated articles are also disclosed.
摘要翻译：涂覆有有机金属层的聚合物表面，其中有机金属层和聚合物表面具有使有机金属层与聚合物表面结合的官能团，有机金属官能团保留未反应用于随后共价连接有机覆盖层。还公开了涂覆方法和涂覆制品。

6. 发明申请

US20100215643A1 ANTI-INFECTIVE FUNCTIONALIZED SURFACES AND METHODS OF MAKING SAME 审中-公开
标题翻译：抗感染功能表面及其制备方法
公开(公告)号：US20100215643A1
公开(公告)日：2010-08-26
申请号：US12712031
申请日：2010-02-24
申请人： Randell Clevenger , Jeffrey Schwartz
发明人： Randell Clevenger , Jeffrey Schwartz
IPC分类号： A01N59/00 , A01N59/08 , A01N43/66 , A01N59/02 , A01N59/14 , A01N59/12 , A01N31/02 , A01N31/08 , A01N31/14 , A01N37/52 , A01N59/16 , A01N59/18 , A01N59/20 , A01N59/06 , A01N37/18 , A01N43/50 , A01N43/08 , A01N43/20 , A01N57/00 , C23C14/34 , B05D1/18 , C23C16/40
CPC分类号： A61L31/16 , A01N25/08 , A01N25/10 , A61L31/022 , A61L2300/208 , A61L2300/404 , C07F9/3821 , A01N59/16 , A01N59/20 , A01N31/12
摘要： Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.
摘要翻译：提供了功能化以包括具有抗感染剂的表面区域的装置。提供了用于使各种材料表面官能化以包括用于结合抗感染剂的活性表面区域的方法。提供了通过其将抗感染部分或试剂结合到官能化表面的方法。

7. 发明授权

US07569285B2 Enhanced bonding layers on titanium materials 失效
标题翻译：在钛材料上增强粘结层
公开(公告)号：US07569285B2
公开(公告)日：2009-08-04
申请号：US10179743
申请日：2002-06-24
申请人： Jeffrey Schwartz , Michael P. Danahy , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Michael D. Carolus , Ellen S. Gawalt
发明人： Jeffrey Schwartz , Michael P. Danahy , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Michael D. Carolus , Ellen S. Gawalt
IPC分类号： B32B15/04 , B32B15/00 , A61F2/28 , A61F2/02
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C23C14/06 , Y10T428/12556 , Y10T428/1259 , Y10T428/1266 , Y10T428/12806
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译：本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。

8. 发明申请

US20070196663A1 HIGH-YIELD ACTIVATION OF POLYMER SURFACES FOR COVALENT ATTACHMENT OF MOLECULES 审中-公开
标题翻译：用于共价连接分子的聚合物表面的高效激活
公开(公告)号：US20070196663A1
公开(公告)日：2007-08-23
申请号：US11677576
申请日：2007-02-21
申请人： Jeffrey Schwartz , T. Dennes
发明人： Jeffrey Schwartz , T. Dennes
IPC分类号： B32B27/00 , A61L33/00
CPC分类号： A61L31/082 , A61L27/14 , A61L27/28 , A61L27/30 , A61L27/38 , A61L27/50 , A61L31/005 , C08H1/06 , C08J7/04 , C08J7/045 , C08J2379/02 , C09J189/04 , Y10T428/31504 , Y10T428/31536
摘要： Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of organic overlayers. Coating methods and coated articles are also disclosed.
摘要翻译：涂覆有有机金属层的聚合物表面，其中有机金属层和聚合物表面具有使有机金属层与聚合物表面结合的官能团，有机金属官能团保留未反应用于随后共价连接有机覆盖层。还公开了涂覆方法和涂覆制品。

9. 发明申请

US20060194008A1 Devices with multiple surface functionality 审中-公开
标题翻译：具有多表面功能的设备
公开(公告)号：US20060194008A1
公开(公告)日：2006-08-31
申请号：US11330814
申请日：2006-01-12
申请人： Jeffrey Schwartz , Ellen Gawalt , Michael Alvatroni
发明人： Jeffrey Schwartz , Ellen Gawalt , Michael Alvatroni
IPC分类号： B28B11/00
CPC分类号： A61L27/32 , A61L29/106 , A61L31/086 , B05D1/185 , B82Y30/00 , B82Y40/00 , C03C17/001 , C03C17/23 , C23C14/06 , C23C22/02 , C23C22/48 , Y10T428/12556 , Y10T428/12611 , Y10T428/131 , Y10T428/265
摘要： Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.
摘要翻译：具有多个磷酸酯部分，多个膦酸酯部分或两者的基于磷的涂层共价键合到可植入基底的氧化物表面上，其具有一个或多个以下特征：（a）表面含磷组密度衬底的涂覆区域为至少约0.1nmol / cm 2; （b）磷基涂层的厚度小于约10nm; 或者（c）基材的被覆区域的表面含磷组密度等于或大于基板的氧化物表面的表面羟基密度。还公开了体现涂覆的基底的可植入装置。

10. 发明授权

US5162285A Preparing catalyst for the catalytic oxidation of olefins to carbonyl compounds 失效
标题翻译：制备用于将烯烃催化氧化成羰基化合物的催化剂
公开(公告)号：US5162285A
公开(公告)日：1992-11-10
申请号：US867730
申请日：1992-04-10
申请人： Jeffrey Schwartz , H. Eric Fischer , Jeffrey W. McMillan
发明人： Jeffrey Schwartz , H. Eric Fischer , Jeffrey W. McMillan
IPC分类号： B01J23/46 , C07C45/34 , C07C45/35 , C07C45/36 , C07C205/45
CPC分类号： B01J23/464 , C07C201/12 , C07C45/34 , C07C45/35 , C07C45/36 , C07C2101/14 , C07C2102/42
摘要： A process is disclosed for the catalytic oxydation of olefins to carbonyl compounds with molecular oxygen at elevated temperatures in the presence of rhodium oxide on a support. The process is applicable to a broad variety of olefins and is not limited to special olefins and forms especially ketones in a high selectivity.
摘要翻译：公开了一种用于在载体上的氧化铑存在下在高温下用分子氧将烯烃催化氧化成羰基化合物的方法。该方法适用于各种各样的烯烃，并不限于特殊的烯烃，尤其是以高选择性形成酮。

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