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1. 发明授权

US06597450B1 Automated Optical Reader for Nucleic Acid Assays 有权
标题翻译：用于核酸测定的自动光学读取器
公开(公告)号：US06597450B1
公开(公告)日：2003-07-22
申请号：US09483686
申请日：2000-01-14
申请人： Jeffrey P. Andrews , Christian V. O'Keefe , Brian G. Scrivens , Willard C. Pope , Timothy Hansen , Frank L. Failing
发明人： Jeffrey P. Andrews , Christian V. O'Keefe , Brian G. Scrivens , Willard C. Pope , Timothy Hansen , Frank L. Failing
IPC分类号： G01J330
CPC分类号： G01N21/6452 , G01N21/64 , G01N35/028 , G01N2021/6419 , G01N2021/6484
摘要： An apparatus and method employing a plurality of light emitting devices which each can get light through a respective optical fiber toward a respective sample of a plurality of samples in a time-staggered manner. Light is generated in each of the samples at different times consistent with the times at which light is irradiated onto the sample. A single detector is used to detect the lights emitted from the plurality of samples at these different times. A plurality of bifurcated optical cable are coupled to the light emitting devices and single light detector, and the integrated end of each bifurcated cable acts as the light emitting port and light detecting port. Multiple targets can be detected from each of the plurality of samples in the same manner by providing an apparatus and method employing a different plurality of light emitting devices and single detector for each target to be detected.
摘要翻译：一种使用多个发光器件的装置和方法，每个发光器件可以通过相应的光纤以时间交错的方式朝向多个样本的相应样本获得光。在与照射到样品上的时间一致的不同时间，在每个样品中产生光。单个检测器用于检测在这些不同时间从多个样品发射的光。多个分叉光缆耦合到发光器件和单个光检测器，并且每个分叉电缆的集成端用作发光端口和光检测端口。可以以相同的方式从多个样本中的每一个检测多个目标，方法是提供使用不同的多个发光装置的装置和方法以及用于每个要检测的目标的单个检测器。

2. 发明授权

US6043880A Automated optical reader for nucleic acid assays 失效
标题翻译：用于核酸测定的自动光学阅读器
公开(公告)号：US6043880A
公开(公告)日：2000-03-28
申请号：US929895
申请日：1997-09-15
申请人： Jeffrey P. Andrews , Christian V. O'Keefe , Brian G. Scrivens , Willard C. Pope , Timothy Hansen , Frank L. Failing
发明人： Jeffrey P. Andrews , Christian V. O'Keefe , Brian G. Scrivens , Willard C. Pope , Timothy Hansen , Frank L. Failing
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68 , G01N21/25 , G01N21/64 , G01N35/02 , G01N21/76 , G01J3/30
CPC分类号： G01N21/6452 , G01N21/64 , G01N35/028
摘要： An apparatus and method employing a plurality of light emitting devices which each can get light through a respective optical fiber toward a respective fluid sample of a plurality of fluid samples in a time-staggered manner. Light is generated in each of the fluid samples at different times consistent with the times at which light is irradiate onto the sample. A single detector is used to detect the lights emitted from the plurality of samples at these different times. A plurality of bifurcated optical cable are coupled to the light emitting devices and single light detecting device, and the integrated end of each bifurcated cable acts as the light emitting port and light detecting port.
摘要翻译：一种使用多个发光器件的装置和方法，每个发光器件可以通过相应的光纤以时间交错的方式朝着多个流体样品的相应流体样品获得光。在与照射到样品上的时间一致的不同时间，在每个流体样品中产生光。单个检测器用于检测在这些不同时间从多个样品发射的光。多个分叉光缆耦合到发光器件和单光检测器件，并且每个分叉电缆的集成端用作发光端口和光检测端口。

3. 发明授权

US5477323A Fiber optic strain sensor and read-out system 失效
标题翻译：光纤应变传感器和读出系统
公开(公告)号：US5477323A
公开(公告)日：1995-12-19
申请号：US194960
申请日：1994-02-14
申请人： Jeffrey P. Andrews , Joseph A. McClintock , Carl F. Guerci, Jr.
发明人： Jeffrey P. Andrews , Joseph A. McClintock , Carl F. Guerci, Jr.
IPC分类号： G01D5/26 , G01B9/02
CPC分类号： G01D5/266
摘要： An optical sensor is described comprising a first optical fiber and a first reflective member. The first optical fiber has a first predetermined length of graded-index multimode optical fiber attached to its end. The first reflective member and the first optical fiber are arranged such that a gap is formed between the unattached end of the graded-index multimode optical fiber and the first reflective member. Also described is a rugged sensor design incorporating the first optical fiber and first reflective sensor as well as a method for providing the predetermined length of graded-index multimode fiber at the end of the first optical fiber. Finally, a readout system for an optical sensor is also described which comprises two optical paths differing in length by an amount equal to an optical path distance in the optical sensor. The readout system also comprises an optical source having a wavelength differing from that of the optical sensor, a modulator and a controller. The readout system provides a linear output signal that is independent of temperature and vibration effects associated with the read-out system.
摘要翻译：描述了包括第一光纤和第一反射构件的光学传感器。第一光纤具有附接到其端部的第一预定长度的渐变折射率多模光纤。第一反射构件和第一光纤布置成使得在渐变折射率多模光纤的未附着端与第一反射构件之间形成间隙。还描述了结合第一光纤和第一反射传感器的坚固的传感器设计以及在第一光纤端部处提供预定长度的渐变折射率多模光纤的方法。最后，还描述了一种用于光学传感器的读出系统，其包括长度不等于光学传感器中的光程距离的量的两个光路。读出系统还包括具有与光学传感器不同的波长的光源，调制器和控制器。读出系统提供与读出系统相关的温度和振动效应无关的线性输出信号。

4. 发明授权

US5276501A Fabry-Perot readout technique using wavelength tuning 失效
标题翻译：法布里 - 珀罗读出技术使用波长调谐
公开(公告)号：US5276501A
公开(公告)日：1994-01-04
申请号：US972397
申请日：1992-11-06
申请人： Joseph A. McClintock , Jeffrey P. Andrews
发明人： Joseph A. McClintock , Jeffrey P. Andrews
IPC分类号： G01B9/02 , G01D5/26 , G02B6/24 , G02B6/34
CPC分类号： G02B6/4215 , G01B9/02005 , G01D5/266 , G01D5/268 , G02B6/243 , G02B6/29337 , G02B6/29395 , G01B2290/25 , G02B6/29358
摘要： A method for sensing an environmental parameter includes the step of sensing the environmental parameter with an interferometer sensor that has a light source emitting a tunable wavelength of light and a gap that changes in length in response to the environmental parameter. The interferometer has a sinusoidal output curve that oscillates in intensity in response to changes in gap length. The wavelength of light emitted by the light source is tuned to a first wavelength to provide a first output value. Similarly, the wavelength of light emitted by the light source is next tuned to a second wavelength to provide a second output value. The first and second output values correspond to points on the sinusoidal output curve that differ by at least half a cycle. The gap length is then calculated from the values of the first wavelength and the difference between the first and second wavelengths. Finally, the value of the environmental parameter is determined from the value of the gap length.
摘要翻译：用于感测环境参数的方法包括用干涉仪传感器感测环境参数的步骤，所述干涉仪传感器具有发射可调谐波长的光的光源和响应于环境参数而改变长度的间隙。干涉仪具有响应于间隙长度变化而强度振荡的正弦输出曲线。由光源发射的光的波长被调谐到第一波长以提供第一输出值。类似地，由光源发射的光的波长接下来被调谐到第二波长以提供第二输出值。第一和第二输出值对应于正弦输出曲线上至少半个周期不同的点。然后从第一波长的值和第一和第二波长之间的差计算间隙长度。最后，根据间隙长度的值确定环境参数的值。

5. 发明授权

US5359405A Hybrid fiber optic sensor including a lead out optical fiber having a remote reflective end 失效
标题翻译：混合光纤传感器包括具有远端反射端的导出光纤
公开(公告)号：US5359405A
公开(公告)日：1994-10-25
申请号：US972393
申请日：1992-11-06
申请人： Jeffrey P. Andrews
发明人： Jeffrey P. Andrews
IPC分类号： G01D5/353 , G01B9/02
CPC分类号： G01D5/35312
摘要： A device and method are described for measuring changes association with a gap between a lead-in optical fiber and a lead-out optical fiber. A hybrid fiber optic sensor is created by inserting the lead-in and lead-out optical fibers into a small tube such that a gap is provided between the fibers. Laser pulses incident on the gap create two interfacial reflections that interfere with one another, thus providing a method of measuring changes in gap length in the same was as a typical Fabry-Perot type interferometer. Moreover, a reflection from the far end of the lead-out fiber gives gap information in the same way as typical intensity-based sensor. Together the two measurements overcome the limitations that occur when each technique is used separately, and are made possible by means of the above hybrid fiber optic sensor which contains both a Fabry-Perot interferometer portion and an intensity-based sensor portion.
摘要翻译：描述了用于测量与引入光纤和引出光纤之间的间隙的变化关联的装置和方法。通过将引入和引出光纤插入到小管中以在纤维之间提供间隙来产生混合光纤传感器。入射到间隙上的激光脉冲产生彼此干扰的两个界面反射，因此提供了一种测量间隙长度变化的方法，就像典型的法布里 - 珀罗型干涉仪一样。此外，来自引出光纤的远端的反射以与典型的基于强度的传感器相同的方式提供间隙信息。两个测量结合在一起克服了当每个技术被单独使用时发生的限制，并且通过上述混合光纤传感器成为可能，其中包含法布里 - 珀罗干涉仪部分和基于强度的传感器部分。

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