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1. 发明专利

BRPI0215192B8 peptídeo de fusão, kit e matriz que compreendem o mesmo, e método para criar uma matriz 未知
公开(公告)号：BRPI0215192B8
公开(公告)日：2021-07-27
申请号：BR0215192
申请日：2002-12-18
申请人： EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH , JEFFREY ALAN HUBBELL , UNIV ZUERICH
发明人： ANNA JEN , JASON SCHENSE , JEFFREY ALAN HUBBELL , MATTHIAS LUETOLF
IPC分类号： A61K33/06 , C12N5/06 , A61K38/00 , A61K38/23 , A61K38/29 , A61K38/48 , A61K47/34 , A61K47/42 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K17/14 , C07K19/00 , C12N9/10
摘要： "matrizes de proteína modificadas pelo fator de desenvolvimento para construção do tecido". proteínas são incorporadas em matrizes de proteína ou polissacarídeo para uso em reparo, regeneração e/ou remodelagem de tecido e /ou liberação de droga. as proteínas podem ser incorporadas para que elas sejam liberadas por degradação da matriz, por difusão e/ou ação enzimática. como demonstrado pelos exemplos, um método é para ligar heparina à matriz por métodos ou covalentes ou não-covalentes, para formar uma matriz de heparina. a heparina, em seguida, liga não-covalentemente fatores de desenvolvimento de ligação de heparina à matriz de proteína. alternativamente, uma proteína de fusão pode ser construída a qual contém uma região de reticulação, tal como um substrato de fator xiiia e a seqüência de proteína natural. a incorporação de ligações degradáveis entre a matriz e os fatores bioativos pode ser particularmente útil quando liberação de droga de longa duração é desejada, por exemplo, no caso de regeneração de nervo, onde é desejável variar a taxa de liberação de droga espacialmente como uma função de regeneração, por exemplo, ligeiramente próximo da interface de tecido vivo e mais lentamente afastado dentro da zona de lesão. benefícios adicionais incluem a dose de droga total mais baixa no sistema de liberação, e ajuste espacial de liberação que permite uma porcentagem maior da droga a ser liberada no momento de maior atividade celular.

2. 发明申请

US20090004238A1 IMPLANTATION OF ENCAPSULATED BIOLOGICAL MATERIALS FOR TREATING DISEASES 审中-公开
标题翻译：用于治疗疾病的包埋生物材料的植入
公开(公告)号：US20090004238A1
公开(公告)日：2009-01-01
申请号：US12197040
申请日：2008-08-22
申请人： David Scharp , Paul Latta , Chengyun Yue , Xiaojie Yu , Jeffrey Alan Hubbell
发明人： David Scharp , Paul Latta , Chengyun Yue , Xiaojie Yu , Jeffrey Alan Hubbell
IPC分类号： A61K45/00 , A61P25/00 , A61P9/00 , A61P17/00 , A61P3/00 , A61P37/00 , A61K9/48
CPC分类号： C12N11/08 , A61K9/0024 , A61K9/5031 , A61K9/5036 , A61K2035/126 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/30 , C12N2533/74
摘要： Methods of applying biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials are disclosed. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. Methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site are also disclosed. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.
摘要翻译：公开了在保持生物材料的预包封状态的同时使用光聚合在生物材料周围应用生物相容性涂层材料的方法。涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。还公开了利用这些包封的生物材料通过将它们植入体内包括皮下部位的几个区域来治疗不同的人和动物疾病或病症的方法。可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护封装的生物材料免受宿主炎症和免疫的破坏不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。

3. 发明申请

US20100291215A1 DRUG DELIVERY MATRICES TO ENHANCE WOUND HEALING 有权
标题翻译：药物递送矩阵，以加强伤口愈合
公开(公告)号：US20100291215A1
公开(公告)日：2010-11-18
申请号：US12845354
申请日：2010-07-28
申请人： Jason C. Schense , Hugo Schmoekel , Jeffrey Alan Hubbell , Franz Weber
发明人： Jason C. Schense , Hugo Schmoekel , Jeffrey Alan Hubbell , Franz Weber
IPC分类号： A61K38/18 , A61K9/14 , A61P17/02
CPC分类号： A61L31/046 , A61L24/0015 , A61L24/106 , A61L27/225 , A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45
摘要： Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGFβ superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.
摘要翻译：生物活性分子被包埋在基质内，用于受控递送这些化合物用于治疗性愈合应用。基质可以由天然或合成的化合物形成。捕获生物活性分子的主要方法是通过体外或体内在基质凝胶化过程中沉淀生物活性分子。生物活性分子可以被修饰以降低其在基质中的有效溶解度，以便在基质内更有效地保留生物活性分子，例如通过胱氨酸结生长因子超家族内，特别是在TGF-bgr内的成员的去糖基化; 超家族可以修饰基质以包括对不同生物活性分子具有结合亲和力的位点，例如用于肝素结合的位点。

4. 发明授权

US07427415B2 Implantation of encapsulated biological materials for treating diseases 失效
标题翻译：植入包封的生物材料用于治疗疾病
公开(公告)号：US07427415B2
公开(公告)日：2008-09-23
申请号：US10684859
申请日：2003-10-14
申请人： David Scharp , Paul Latta , Chengyun Yue , Xiaojie Yu , Jeffrey Alan Hubbell
发明人： David Scharp , Paul Latta , Chengyun Yue , Xiaojie Yu , Jeffrey Alan Hubbell
IPC分类号： A61K9/16
CPC分类号： C12N11/08 , A61K9/0024 , A61K9/5031 , A61K9/5036 , A61K2035/126 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/30 , C12N2533/74
摘要： The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.
摘要翻译：本发明涉及通过将包封的生物材料植入需要治疗的患者中来治疗疾病如糖尿病的组合物和方法。本发明提供了使用光聚合在生物材料周围放置生物相容性涂层材料，同时保持生物材料的预包封状态。提出了几种方法来完成涂覆几种不同类型的生物材料。涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。本发明还提供了利用这些封装的生物材料通过将它们植入包括皮下部位在内的身体的若干区域来治疗不同的人和动物疾病或病症的方法。可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护封装的生物材料免受宿主炎症和免疫的破坏不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。

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