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1. 发明专利

HRP980082A2 DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS 未知
公开(公告)号：HRP980082A2
公开(公告)日：1998-10-31
申请号：HRP980082
申请日：1998-02-17
申请人： JEAN MARIE STASSEN
发明人： STASSEN JEAN MARIE
IPC分类号： C07D239/74 , A61K31/404 , A61K31/4184 , A61K31/4188 , A61K31/425 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/465 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/14 , C07D209/08 , C07D209/14 , C07D235/06 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/28 , C07D241/44 , C07D277/64 , C07D277/74 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/06 , C07D409/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention relates to new disubstituted bicyclic heterocycles of the general formula (I): Ra-A-Het-B-Ar-E, in which A, B, Ar, Het and Ra are defined as in claim 1. The invention also relates to their tautomers, their stereoisomers, their mixtures, and their salts, which have valuable properties. The compounds of the above general formula (I), in which E is a cyano group, thus represent valuable intermediate products for the production of the other compounds of the general formula (I). Furthermore, the compounds of the above general formula (I), in which E stands for a RbNH-C(=NH)-group, have valuable pharmacological properties, in particular in inhibiting thrombin and prolonging thrombin time.

2. 发明申请

US20140178397A1 ANTI-ANGIOGENIC THERAPY 有权
标题翻译：抗生素治疗
公开(公告)号：US20140178397A1
公开(公告)日：2014-06-26
申请号：US14170997
申请日：2014-02-03
申请人： Jean-Marie STASSEN , Peter CARMELIET , Desire COLLEN
发明人： Jean-Marie STASSEN , Peter CARMELIET , Desire COLLEN
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24
摘要： The present invention provides novel monoclonal antibodies directed to P1GF and fragments and derivatives thereof, more particularly to humanized antibodies and fragments thereof for use in the treatment and/or prevention of pathological angiogenesis.
摘要翻译：本发明提供了针对P1GF的新型单克隆抗体及其片段及其衍生物，更具体地提供用于治疗和/或预防病理性血管发生的人源化抗体及其片段。

3. 发明申请

US20050065346A1 Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译：羧酸酰胺，其制备及其作为药物组合物的用途
公开(公告)号：US20050065346A1
公开(公告)日：2005-03-24
申请号：US10938804
申请日：2004-09-10
申请人： Uwe Ries , Henning Priepke , Armin Heckel , Herbert Nar , Wolfgang Wienen , Jean Marie Stassen
发明人： Uwe Ries , Henning Priepke , Armin Heckel , Herbert Nar , Wolfgang Wienen , Jean Marie Stassen
IPC分类号： C07D295/18 , A61K31/167 , A61K31/18 , A61K31/40 , A61K31/4453 , A61P7/02 , A61P43/00 , C07C257/18 , C07C303/40 , C07C311/21 , C07C311/46 , C07D207/12 , C07D211/46 , C07D213/68 , C07D233/54 , C07D295/135 , C07D295/185 , C07D295/192 , C07D211/32
CPC分类号： C07D295/185 , C07C257/18 , C07C311/21 , C07C311/46 , C07C2601/08 , C07D207/12 , C07D211/46 , C07D213/68 , C07D295/135 , C07D295/192
摘要： The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
摘要翻译：本发明涉及通式的羧酸酰胺，其中R 1至R 5，Ar，m和n如权利要求1所定义，其互变异构体，立体异构体，其混合物，其前药和其盐具有有价值的性质。其中R5表示氰基的上述通式I的化合物是制备其它通式I化合物的有价值的中间产物，其中R5表示权利要求1中提到的脒基之一的上述通式I的化合物具有有价值的药理学特性，特别是抗血栓形成活性和因子Xa抑制活性。

4. 发明授权

US06469039B1 Disubstituted bicyclic heterocycles, the preparation and the use thereof as pharmaceutical compositions 有权
标题翻译：二取代的双环杂环，其制备及其作为药物组合物的用途
公开(公告)号：US06469039B1
公开(公告)日：2002-10-22
申请号：US09544931
申请日：2000-04-06
申请人： Norbert Hauel , Henning Priepke , Uwe Ries , Jean Marie Stassen , Wolfgang Wienen
发明人： Norbert Hauel , Henning Priepke , Uwe Ries , Jean Marie Stassen , Wolfgang Wienen
IPC分类号： A61K31415
CPC分类号： C07D401/12 , C07D209/14 , C07D235/06 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/28 , C07D241/44 , C07D277/64 , C07D277/74 , C07D401/14 , C07D403/12 , C07D409/06 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： New disubstituted bicyclic heterocycles of general formula Ra—A—Het—B—Ar—E (I) Compounds of the above general formula I, wherein E denotes an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E denotes a cyano group, are valuable intermediates for preparing the other compounds of general formula I. Exemplary compounds of formula I are: (a) 1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)-amide, (b) 1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(hydroxycarbonylmethyl)-amide, (c) 1-Methyl-2-[N-(4-amidino-2-methoxy-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(hydroxycarbonylmethyl)-amide, and (d) 1-Methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl) amide.
摘要翻译：通式的新二取代双环杂环上述通式I的化合物，其中E表示RbNH-C（= NH） - 基团，具有有价值的药理学性质，特别是凝血酶抑制作用和延长凝血酶时间的作用，其中 E表示氰基，是用于制备其它通式I化合物的有价值的中间体。示例性式I化合物是：（a）1-甲基-2- [N-（4-脒基苯基） - 氨基甲基] - 苯并咪唑-5- （2-羟基羰基乙基） - 酰胺，（b）1-甲基-2- [N-（4-脒基苯基） - 氨基甲基] - 苯并咪唑-5-基 - 羧酸 - N-（2-吡啶基）-N-（羟基羰基甲基） - 酰胺，（c）1-甲基-2- [N-（4-脒基-2-甲氧基 - 苯基） - 氨基甲基] - 苯并咪唑-5-基 - （2-吡啶基）-N-（羟基羰基甲基） - 酰胺和（d）1-甲基-2- [N- [4-（N，N-己氧基羰基脒基）苯基]氨基甲基] - 苯并咪唑-5-基 - 羧酸-N-（2-吡啶基）-N-（2-乙氧羰基乙基）酰胺。

5. 发明授权

US06200976B1 Antithrombotic quinoxazolines 失效
标题翻译：抗血栓喹喔啉
公开(公告)号：US06200976B1
公开(公告)日：2001-03-13
申请号：US09280248
申请日：1999-03-29
申请人： Uwe Ries , Norbert Hauel , Henning Priepke , Herbert Nar , Jean Marie Stassen , Wolfgang Wienen
发明人： Uwe Ries , Norbert Hauel , Henning Priepke , Herbert Nar , Jean Marie Stassen , Wolfgang Wienen
IPC分类号： A61K31498
CPC分类号： C07D215/227 , C07D215/38 , C07D217/24 , C07D239/74 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/08 , C07D401/12 , C07D403/04 , C07D403/08 , C07D403/12 , C07D471/04
摘要： Quinoxazolines having antithrombotic activity. Exemplary of those disclosed are: 4-{[6-(N-carboxymethyl-quinolin-8-yl-sulphonylamino)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine, 4-{[6-(1-(N-cyclopentyl-carboxymethylcarbonylamino)-cyclo-propyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine, and 4-{[7-(N-carboxymethylaminocarbonyl-ethylamino)-4-methyl-quinolin-2-yl]-oxo}-benzamidine.
摘要翻译：喹诺酮类具有抗血栓活性。所公开的实例是：4 - {[6-（N-羧甲基 - 喹啉-8-基 - 磺酰基氨基）-1-甲基-2-氧代-1,2-二氢喹喔啉-3-基] - 甲基} - 苄脒， 4 - {[6-（1-（N-环戊基 - 羧甲基羰基氨基） - 环丙基）-1-甲基-2-氧代-1,2-二氢喹喔啉-3-基] - 甲基} - 苄脒和4 - {[ 7-（N-羧甲基氨基羰基 - 乙基氨基）-4-甲基 - 喹啉-2-基] - 氧代} - 苄脒。

6. 发明授权

US09445078B2 Stereo-vision system 有权
标题翻译：立体视觉系统
公开(公告)号：US09445078B2
公开(公告)日：2016-09-13
申请号：US14114569
申请日：2012-04-27
申请人： Emmanuel Sneyders , Jean Marie Stassen , Hans Nicasy
发明人： Emmanuel Sneyders , Jean Marie Stassen , Hans Nicasy
IPC分类号： G01B11/00 , H04N13/02 , G01B11/25 , A61B5/00 , A61B5/107
CPC分类号： H04N13/207 , A61B5/0073 , A61B5/0095 , A61B5/1079 , A61B2503/42 , G01B11/2545
摘要： This invention concerns a measuring system for the calculation of dimensions, including area and volume, of objects in various shapes. In particular, it concerns miniature 3D measuring equipment that is perfectly suitable for 3D measurements of subcutaneous tumors in mice. The primary objective of this invention then also consists of a measuring system for 3D measurements of objects in various shapes, which includes a handheld device that has at least 1 camera, 1 projector and a measuring chamber. In another implementation, the handheld device will have 2 cameras and a projector and the 3D measurement is based on stereo-vision. Another objective is directed to ensuring that said handheld device also has a processor module, a user interface, a power supply, a data communication interface, and exchangeable measuring chambers which provide the flexibility and autonomy to speed up the measurement procedure, and significantly improve the reproducibility of the measurement.
摘要翻译：本发明涉及用于计算各种形状的物体的尺寸（包括面积和体积）的测量系统。特别涉及微型3D测量设备，非常适用于小鼠皮下肿瘤的三维测量。本发明的主要目的还包括用于对各种形状的物体进行3D测量的测量系统，其包括具有至少1个照相机，1个投影仪和测量室的手持设备。在另一个实现中，手持设备将具有2个摄像机和投影仪，并且3D测量基于立体视觉。另一个目标是确保所述手持设备还具有处理器模块，用户接口，电源，数据通信接口和可交换的测量室，其提供灵活性和自主性以加快测量过程，并且显着改善测量的重现性。

7. 发明申请

US20100104530A1 ANTI-VPAC1 ANTIBODIES AND THEIR USES 审中-公开
标题翻译：抗VPAC1抗体及其用途
公开(公告)号：US20100104530A1
公开(公告)日：2010-04-29
申请号：US12452356
申请日：2008-06-26
申请人： Kathleen Freson , Chris Van Geet , Marc Hoylaerts , Jean-Marie Stassen
发明人： Kathleen Freson , Chris Van Geet , Marc Hoylaerts , Jean-Marie Stassen
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12 , C07H21/04 , C12N15/63 , C12N5/10 , A61K38/20 , A61P7/00
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies, in particular monoclonal antibodies to the VPAC1 receptor protein, compositions containing them and nucleic acid sequences encoding them. Host cells expressing said monoclonal antibodies, recombinant (expression) vectors and methods for producing said antibodies. Prevention or treatment of thrombocytopenia with antibodies to the VPAC1 receptor.
摘要翻译：单克隆抗体，特别是VPAC1受体蛋白的单克隆抗体，含有它们的组合物和编码它们的核酸序列。表达所述单克隆抗体的宿主细胞，重组（表达）载体和用于产生所述抗体的方法。用VPAC1受体抗体预防或治疗血小板减少症。

8. 发明授权

US06710055B2 Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions 有权
标题翻译：二取代的双环杂环，其制备及其作为药物组合物的用途
公开(公告)号：US06710055B2
公开(公告)日：2004-03-23
申请号：US10192041
申请日：2002-07-10
申请人： Norbert Hauel , Henning Priepke , Uwe Ries , Jean Marie Stassen , Wolfgang Wienen
发明人： Norbert Hauel , Henning Priepke , Uwe Ries , Jean Marie Stassen , Wolfgang Wienen
IPC分类号： A61K31437
CPC分类号： C07D401/12 , C07D209/14 , C07D235/06 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/28 , C07D241/44 , C07D277/64 , C07D277/74 , C07D401/14 , C07D403/12 , C07D409/06 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Disubstituted bicyclic heterocycles of general formula I Ra—A—Het—B—Ar—E (I). Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
摘要翻译：通式I的二取代双环杂环，其中E是RbNH-C（= NH） - 基团，具有有价值的药理学性质，特别是凝血酶抑制作用和延长凝血酶时间的作用，其中E是氰基是用于制备其它通式I化合物的有价值的中间体。

9. 发明申请

US20140111621A1 STEREO-VISION SYSTEM 有权
标题翻译：立体视觉系统
公开(公告)号：US20140111621A1
公开(公告)日：2014-04-24
申请号：US14114569
申请日：2012-04-27
申请人： Emmanuel Sneyders , Jean Marie Stassen , Hans Nicasy
发明人： Emmanuel Sneyders , Jean Marie Stassen , Hans Nicasy
IPC分类号： H04N13/02
CPC分类号： H04N13/207 , A61B5/0073 , A61B5/0095 , A61B5/1079 , A61B2503/42 , G01B11/2545
摘要： This invention concerns a measuring system for the calculation of dimensions, including area and FIG. 4 volume, of objects in various shapes. In particular, it concern miniature 3D measuring equipment that is perfectly suitable for 3D measurements of subcutaneous tumours in mice. The primary objective of this invention then also consists of a measuring system for 3D measurements of objects in various shapes, which includes a handheld device that has at least 1 camera, 1 projector and a measuring chamber. In a more specific implementation, the handheld device will have 2 cameras and a projector and the 3D measurement is based on stereo-vision. It is also the objective of the current invention of a measurement system to ensure that said handheld device also has a processor module, a user interface, power supply and a data communication interface, and exchangeable measuring chambers to give the device the necessary flexibility and autonomy to speed up the measurement procedure, and to significantly improve the reproducibility of the measurement.
摘要翻译：本发明涉及一种用于计算尺寸的测量系统，包括面积和图1。 4卷，各种形状的物体。特别地，它涉及微型3D测量设备，其非常适合于小鼠皮下肿瘤的3D测量。本发明的主要目的还包括用于对各种形状的物体进行3D测量的测量系统，其包括具有至少1个照相机，1个投影仪和测量室的手持设备。在更具体的实现中，手持设备将具有2个摄像机和投影仪，并且3D测量基于立体视觉。测量系统的目前发明也是为了确保所述手持设备还具有处理器模块，用户接口，电源和数据通信接口以及可交换测量室，以给予设备必要的灵活性和自主性。加快测量过程，显着提高测量的重复性。

10. 发明授权

US07875704B2 Anti-PLGF antibody 有权
标题翻译：抗PLGF抗体
公开(公告)号：US07875704B2
公开(公告)日：2011-01-25
申请号：US11909604
申请日：2006-03-24
申请人： Jean-Marie Stassen , Peter Carmeliet , Désiré Collen
发明人： Jean-Marie Stassen , Peter Carmeliet , Désiré Collen
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24
摘要： The present invention provides novel monoclonal antibodies directed to PlGF and fragments and derivatives thereof, more particularly to humanized antibodies and fragments thereof for use in the treatment and/or prevention of pathological angiogenesis.
摘要翻译：本发明提供了针对PlGF及其片段和衍生物的更新的单克隆抗体，更具体地提供用于治疗和/或预防病理性血管生成的人源化抗体及其片段。

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