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    • 1. 发明申请
    • INSTALLATION FOR MAKING A CUT IN THE NECK OF SLAUGHTERED POULTRY
    • 安装在SLAUGHTERED POULTRY的NECK切割
    • WO1998006272A1
    • 1998-02-19
    • PCT/NL1997000466
    • 1997-08-14
    • TIELEMAN FOOD EQUIPMENT B.V.WINKELMOLEN, Antoine, Jean, Herman
    • TIELEMAN FOOD EQUIPMENT B.V.
    • A22C21/06
    • A22C21/06
    • In order to make a cut in the neck of slaughtered poultry, which cut permits access to a tool for removing the crop, use is made of an installation which is provided with a carousel (1) for moving the poultry, arch-shaped tracks (2 to 6) which have horizontal, upward-sloping and downward-sloping sections and running wheels (18, 15, 30) which can be moved on said tracks and are intended to effect a movement of handling units and positioning units. A handling unit consists of a blade (20) which is fitted at the top end of a tilting arm (17), which at its bottom end is provided with a running wheel (18) which is movable on a track (2). Means are provided in order, while the running wheel (18) is moving on its track (2), first to tilt the tilting arm (17) from its sloping, non-operative position into a less sloping or vertical cutting position and then to cause the arm (17) to make a downward movement.
    • 为了切割宰杀的家禽的颈部,切割允许进入用于除去作物的工具,使用设置有设置用于移动家禽的转盘(1),拱形轨道( 2至6),其具有水平的,向上倾斜的和向下倾斜的部分以及能够在所述轨道上移动并且旨在实现处理单元和定位单元的移动的行进轮(18,15,30)。 处理单元由安装在倾斜臂(17)的顶端的叶片(20)组成,在其底端设置有可在轨道(2)上移动的行进轮(18)。 当行驶轮(18)在其轨道(2)上移动时,首先将倾斜臂(17)从其倾斜的非操作位置倾斜到较不倾斜或垂直的切割位置,然后到 使臂(17)向下移动。
    • 5. 发明授权
    • Anti-cancer activity of novel bicyclic heterocycles
    • 新型双环杂环的抗癌活性
    • US09573966B2
    • 2017-02-21
    • US13823413
    • 2011-09-08
    • Jean HermanThierry Louat
    • Jean HermanThierry Louat
    • A61K31/519C07D513/04C07D495/04C07D473/32C07D498/04
    • C07D513/04A61K31/519C07D473/32C07D495/04C07D498/04
    • The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, Formulas (I), (II), (III) and (IV) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent proliferative disorders and their use to manufacture a medicine to treat or prevent proliferative disorders, particularly cancer such as leukemia. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent proliferative disorders. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of proliferative disorders and pathologic conditions such as, but not limited to, cancer such as leukemia.
    • 本发明涉及式I,II,III或IV的化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂化物,式(I),(II),(III )和(IV)其中R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8,R 9,R 11和R 12如权利要求1中所定义或如在本发明的说明书中详细描述的, 使用所述化合物治疗或预防增殖性疾病及其用于制造药物以治疗或预防增殖性疾病,特别是诸如白血病的癌症。 本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防增殖性疾病的用途。 本发明还涉及所述化合物作为生物活性成分的用途,更具体地说,涉及用于治疗增殖性疾病和病理状况(例如但不限于)诸如白血病的癌症的药物。
    • 8. 发明授权
    • Antiviral activity of bicyclic heterocycles
    • 双环杂环的抗病毒活性
    • US09193741B2
    • 2015-11-24
    • US13699258
    • 2011-05-20
    • Steven De JongheLing-Jie GaoPiet HerdewijnJean HermanMiyeon JangPieter LeyssenThierry LouatJohan NeytsChristophe PannecouqueBart Vanderhoydonck
    • Steven De JongheLing-Jie GaoPiet HerdewijnJean HermanMiyeon JangPieter LeyssenThierry LouatJohan NeytsChristophe PannecouqueBart Vanderhoydonck
    • A61K31/519C07D513/04A61K31/52A61K31/551
    • A61K31/551A61K31/519A61K31/52A61K31/5377C07D473/00C07D513/04Y02A50/385Y02A50/465
    • The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus.
    • 本发明涉及式I,II,III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物,其中R1,R2,R3,R4,R5, R6,R7,R8,R9,R11和R12如权利要求1中所定义或如在本发明的描述中详细描述的,以及所述化合物用于治疗或预防病毒感染及其用于制造 治疗或预防病毒感染的药物,特别是属于逆转录病毒科的家族,微病毒科的家族和小核糖核酸病毒科家族的RNA病毒的感染,更优选人免疫缺陷病毒1(HIV1),人类免疫缺陷病毒2 (HIV2),丙型肝炎病毒(HCV),登革热病毒和诸如柯萨奇病毒,鼻病毒和脊髓灰质炎病毒的肠道病毒。 本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防病毒感染的用途。 本发明还涉及所述化合物作为生物活性成分的用途,更具体地说,作为治疗病毒性病症和病理状况的药物,例如但不限于人免疫缺陷病毒1(HIV1),人类免疫缺陷病毒 病毒2(HIV2),丙型肝炎病毒(HCV),登革热病毒和诸如柯萨奇病毒,鼻病毒和脊髓灰质炎病毒的肠道病毒。
    • 9. 发明申请
    • Antiviral Activity of Novel Bicyclic Heterocycles
    • 新型双环杂环的抗病毒活性
    • US20130190297A1
    • 2013-07-25
    • US13699258
    • 2011-05-20
    • Steven De JongheLing-Jie GaoPiet HerdewijnJean HermanMiyeon JangPieter LeyssenThierry LouatJohan NeytsChristophe PannecouqueBart Vanderhoydonck
    • Steven De JongheLing-Jie GaoPiet HerdewijnJean HermanMiyeon JangPieter LeyssenThierry LouatJohan NeytsChristophe PannecouqueBart Vanderhoydonck
    • C07D513/04
    • A61K31/551A61K31/519A61K31/52A61K31/5377C07D473/00C07D513/04Y02A50/385Y02A50/465
    • The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HIV2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus.
    • 本发明涉及式I,II,III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物,其中R1,R2,R3,R4,R5, R6,R7,R8,R9,R11和R12如权利要求1中所定义或如在本发明的描述中详细描述的,以及所述化合物用于治疗或预防病毒感染及其用于制造 治疗或预防病毒感染的药物,特别是属于逆转录病毒科的家族,微病毒科的家族和小核糖核酸病毒科家族的RNA病毒的感染,更优选人免疫缺陷病毒1(HIV1),人类免疫缺陷病毒2 (HIV2),丙型肝炎病毒(HCV),登革热病毒和诸如柯萨奇病毒,鼻病毒和脊髓灰质炎病毒的肠道病毒。 本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防病毒感染的用途。 本发明还涉及所述化合物作为生物活性成分的用途,更具体地说,作为治疗病毒性病症和病理状况的药物,例如但不限于人免疫缺陷病毒1(HIV1),人类免疫缺陷病毒 病毒2(HIV2),丙型肝炎病毒(HCV),登革热病毒和诸如柯萨奇病毒,鼻病毒和脊髓灰质炎病毒的肠道病毒。