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1. 发明授权

US09293821B2 Electronic devices, such as antennas, having fluidic constructs that permit reconfiguration of the devices 有权
标题翻译：电子设备，例如天线，具有允许重新配置设备的流体结构
公开(公告)号：US09293821B2
公开(公告)日：2016-03-22
申请号：US12832587
申请日：2010-07-08
申请人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan Mclaughlin , Frans Spaepen
发明人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan Mclaughlin , Frans Spaepen
IPC分类号： H01Q1/00 , H01Q3/44 , H01Q3/01
CPC分类号： H01Q3/446 , H01Q3/01
摘要： In various embodiments, an actuating mechanism is employed to displace a conductor disposed within a fluidic channel, thereby reconfiguring an electronic component.
摘要翻译：在各种实施例中，使用致动机构来置换设置在流体通道内的导体，从而重新配置电子部件。

2. 发明申请

US20120149021A1 Device for Filtration of Fluids Therethrough and Accompanying Method 有权
标题翻译：流体过滤装置及其附带方法
公开(公告)号：US20120149021A1
公开(公告)日：2012-06-14
申请号：US13144572
申请日：2010-01-15
申请人： Chong Wing Yung , Donald E. Ingber , Jason O. Fiering , Mathew Varghese
发明人： Chong Wing Yung , Donald E. Ingber , Jason O. Fiering , Mathew Varghese
IPC分类号： B03C1/02 , C12Q1/68 , H01J49/26 , C12Q1/18 , C12M1/42 , G01N33/53 , C12Q1/02
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , G01N1/40 , G01N33/54326 , G01N33/54366
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.
摘要翻译：用于从源流体分离目标部件的微流体装置包括通过一个或多个传输通道连接到一个或多个收集通道的一个或多个源通道。源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。收集通道可以包括滞留的收集流体，直到预定量的源流体被处理或者预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分离开收集渠道。随后分析目标成分进行检测和诊断。

3. 发明申请

US20110295194A1 DRUG DELIVERY APPARATUS 有权
标题翻译：药物递送装置
公开(公告)号：US20110295194A1
公开(公告)日：2011-12-01
申请号：US12986067
申请日：2011-01-06
申请人： Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , Michael J. McKenna , William F. Sewell
发明人： Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , Michael J. McKenna , William F. Sewell
IPC分类号： A61M31/00 , A61M1/00
CPC分类号： A61F11/002 , A61M5/14216 , A61M5/14224 , A61M5/14276 , A61M31/002 , A61M2205/0244 , A61M2210/0662 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
摘要翻译：一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括限定用于接收药物并再循环治疗流体的工作室的可变容积容器。流体可以包含体液，例如外淋巴液和药物。该装置允许将治疗流体受控地输送到患者体腔中的预定位置，例如人耳的耳蜗。

4. 发明授权

US07837379B2 Devices for producing a continuously flowing concentration gradient in laminar flow 有权
标题翻译：用于在层流中产生连续流动的浓度梯度的装置
公开(公告)号：US07837379B2
公开(公告)日：2010-11-23
申请号：US12043575
申请日：2008-03-06
申请人： Jason O. Fiering , Mathew Varghese
发明人： Jason O. Fiering , Mathew Varghese
IPC分类号： B01F5/00
CPC分类号： B01J19/0093 , B01F5/0641 , B01F13/0059 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00889 , B01L3/502776 , Y10T137/87281
摘要： The invention generally relates to combining a plurality of flow streams. In various embodiments, a first channel transports a first laminar fluid flow, a second channel transports a second laminar fluid flow, and the first and second channels enter a merging region at an acute angle to one another along separate substantially parallel planes.
摘要翻译：本发明一般涉及组合多个流动流。在各种实施例中，第一通道输送第一层流体流，第二通道输送第二层流体流，并且第一和第二通道以分开的基本上平行的平面彼此成锐角进入锐角。

5. 发明授权

US06572551B1 Imaging catheters for volumetric intraluminal ultrasound imaging 有权
标题翻译：成像导管体积管腔内超声成像
公开(公告)号：US06572551B1
公开(公告)日：2003-06-03
申请号：US09546721
申请日：2000-04-11
申请人： Stephen W. Smith , Edward D. Light , Jason O. Fiering
发明人： Stephen W. Smith , Edward D. Light , Jason O. Fiering
IPC分类号： A61B800
CPC分类号： A61B8/12 , A61B5/0422 , A61B8/0833 , A61B8/4488 , A61B90/36 , Y10S128/916
摘要： A real time three dimensional ultrasound imaging probe apparatus is configured to be placed inside a body. The apparatus comprises an elongated body having proximal and distal ends with an ultrasonic transducer phased array connected to and positioned on the distal end of the elongated body. The ultrasonic transducer phased array is positioned to emit and receive ultrasonic energy for volumetric forward scanning from the distal end of the elongated body. The ultrasonic transducer phased array includes a plurality of sites occupied by ultrasonic transducer elements. At least one ultrasonic transducer element is absent from at least one of the sites, thereby defining an interstitial site. A tool is positioned at the interstitial site. In particular, the tool can be a fiber optic lead, a suction tool, a guide wire, an electrophysiological electrode, or an ablation electrode. Related systems are also discussed.
摘要翻译：实时三维超声成像探针装置被配置为放置在体内。该装置包括细长体，其具有近端和远端，超声换能器相控阵列连接到并定位在细长体的远端上。超声波换能器相控阵列被定位成从细长体的远端发射和接收用于体积向前扫描的超声波能量。超声波换能器相控阵列包括由超声换能器元件占据的多个位置。至少一个站点不存在至少一个超声波换能器元件，从而限定了间隙位置。工具位于插页式广告位置。特别地，该工具可以是光纤引线，吸引工具，导丝，电生理电极或消融电极。还讨论了相关系统。

6. 发明授权

US09006149B2 High-throughput biological screening 有权
标题翻译：高通量生物筛选
公开(公告)号：US09006149B2
公开(公告)日：2015-04-14
申请号：US12687717
申请日：2010-01-14
申请人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
发明人： Guillermo Garcia-Cardena , Peter Mack , Jeffrey T. Borenstein , Ahmad S. Khalil , Eli J. Weinberg , Jason O. Fiering , Ernest S. Kim , William J. Adams, Jr.
IPC分类号： C40B30/06 , C40B60/12 , C12M1/32 , C12M1/42
CPC分类号： C12M23/12 , C12M35/04
摘要： A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.
摘要翻译：高通量流量系统包括井阵列和位于每个井内的单独机械末端。每个机械末端分别致动以赋予剪切应力模式。单独的套筒可以与每个尖端相关联，以保持尖端与尖端相应的井的底板之间的预定距离，每个尖端可在其对应的套筒内旋转。或者，单独的柱可以与每个末端相关联，以保持尖端与尖端相应的井的底部之间的预定距离，其中每个尖端可围绕其相应的柱转动。

7. 发明申请

US20120007778A1 FLUIDIC CONSTRUCTS FOR ELECTRONIC DEVICES 有权
标题翻译：电子设备流体结构
公开(公告)号：US20120007778A1
公开(公告)日：2012-01-12
申请号：US12832587
申请日：2010-07-08
申请人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan McLaughlin , Frans Spaepen
发明人： Amy E. Duwel , Jason O. Fiering , Douglas W. White , Mark J. Mescher , Joseph M. Bauer , John R. Lachapelle , Bryan McLaughlin , Frans Spaepen
IPC分类号： H01Q3/01 , H01Q3/00 , H01H35/30
CPC分类号： H01Q3/446 , H01Q3/01
摘要： In various embodiments, an actuating mechanism is employed to displace a conductor disposed within a fluidic channel, thereby reconfiguring an electronic component.
摘要翻译：在各种实施例中，使用致动机构来置换设置在流体通道内的导体，从而重新配置电子部件。

8. 发明申请

US20090044619A1 DEVICES AND METHODS FOR PRODUCING A CONTINUOUSLY FLOWING CONCENTRATION GRADIENT IN LAMINAR FLOW 有权
标题翻译：在层流中产生连续流动浓度梯度的装置和方法
公开(公告)号：US20090044619A1
公开(公告)日：2009-02-19
申请号：US12043575
申请日：2008-03-06
申请人： Jason O. Fiering , Mathew Varghese
发明人： Jason O. Fiering , Mathew Varghese
IPC分类号： G01F5/00
CPC分类号： B01J19/0093 , B01F5/0641 , B01F13/0059 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00889 , B01L3/502776 , Y10T137/87281
摘要： The invention generally relates to combining a plurality of flow streams. In various embodiments, a first channel transports a first laminar fluid flow, a second channel transports a second laminar fluid flow, and the first and second channels enter a merging region at an acute angle to one another along separate substantially parallel planes.
摘要翻译：本发明一般涉及组合多个流动流。在各种实施例中，第一通道输送第一层流体流，第二通道输送第二层流体流，并且第一和第二通道沿独立的基本上平行的平面以彼此成锐角进入锐角。

9. 发明授权

US5391269A Method of making an article comprising a silicon body 失效
标题翻译：制造包含硅体的制品的方法
公开(公告)号：US5391269A
公开(公告)日：1995-02-21
申请号：US84689
申请日：1993-06-29
申请人： Jason O. Fiering , Barry Miller , Joseph Shmulovich
发明人： Jason O. Fiering , Barry Miller , Joseph Shmulovich
IPC分类号： H01L21/306 , G02B6/36 , H01L21/3063 , B23H3/00
CPC分类号： H01L21/3063 , Y10T29/49169
摘要： We have found that etching of a body that comprises exposed Si as well as a Ti-comprising metal layer (e.g., a patterned Ti/Pt layer) in an amine-based anisotropic etchant for Si (e.g., 100.degree. C. EDP) frequently results in undesirable changes in the Ti-comprising metal layer. We have also found that the changes can be substantially reduced or eliminated by electrolytic means, namely, by making the metal layer the anode in an electrolytic cell that contains the etchant.
摘要翻译：我们已经发现，在基于胺的各向异性蚀刻剂（例如，100℃EDP）中经常蚀刻包括暴露的Si以及包含Ti的金属层（例如，图案化的Ti / Pt层）的主体导致含Ti的金属层的不期望的变化。我们还发现，通过电解方式，即通过在含有蚀刻剂的电解槽中使金属层成为阳极，可以显着地减少或消除这些变化。

10. 发明授权

US09046192B2 Membrane-based fluid control in microfluidic devices 有权
标题翻译：微流体装置中基于膜的流体控制
公开(公告)号：US09046192B2
公开(公告)日：2015-06-02
申请号：US12023653
申请日：2008-01-31
申请人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
发明人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
IPC分类号： F16K99/00 , A61M5/142 , G05D7/01 , A61M5/14 , A61M5/168
CPC分类号： F16K99/0015 , A61M5/141 , A61M5/14276 , A61M5/16809 , A61M5/16813 , A61M31/002 , A61M39/22 , A61M2039/226 , A61M2205/0244 , A61M2206/22 , F16K99/0001 , F16K99/0034 , F16K99/0042 , F16K99/0055 , F16K2099/0069 , F16K2099/0076 , F16K2099/008 , F16K2099/0088 , G05D7/0113 , G05D7/012 , Y10T137/0318 , Y10T137/0396
摘要： A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.
摘要翻译：微流体装置可以包括限定流量控制腔的衬底和与流量控制腔流体连通的第一和第二通道。用于调节通过流动控制腔的流体流动的柔性膜可以围绕流动控制腔的至少一部分。

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