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1. 发明授权

US08208781B1 Fiber optic connector panel 有权
标题翻译：光纤连接器面板
公开(公告)号：US08208781B1
公开(公告)日：2012-06-26
申请号：US12629919
申请日：2009-12-03
申请人： Joshua Morgan , Jason Crawford
发明人： Joshua Morgan , Jason Crawford
IPC分类号： G02B6/00
CPC分类号： G02B6/4455
摘要： A fiber optic connector panel fits within a telecommunications fiber optic distribution cabinet and terminates and protects outside plant cables. A support panel is pivotally mounted into a telecommunications fiber optic distribution cabinet. A first cylindrically configured cable storage member is supported by the support panel and configured to store any slack fiber optic pigtails. A second cable storage member is supported by the support panel and configured to store any slack outside plant cable and jumpers. A fiber optic connector is supported by the support panel and configured to connect fiber optic pigtails and fiber optic jumpers. A splice storage member is supported by the support panel and configured to store fiber optic cable splices of the fiber optic pigtails and outside plant cable and jumpers of the fiber optic pigtails and outside plant cable and jumpers.
摘要翻译：光纤连接器面板适用于电信光纤配线柜，并终止并保护外部电缆。支撑面板枢转地安装到电信光纤配线柜中。第一圆柱形构造的电缆存储构件由支撑面板支撑并且被配置为存储任何松弛的光纤灯头。第二电缆存储构件由支撑面板支撑并且被配置为存储任何松散的外部植物电缆和跳线。光纤连接器由支撑面板支撑，并配置为连接光纤尾纤和光纤跳线。接头存储构件由支撑面板支撑并且被配置为存储光纤尾纤的光纤电缆接头和光纤尾纤外部设备电缆和跳线以及外部设备电缆和跳线。

2. 发明授权

US07501518B2 Methods of making 2,6-diaryl piperidine derivatives 有权
标题翻译：制备2,6-二芳基哌啶衍生物的方法
公开(公告)号：US07501518B2
公开(公告)日：2009-03-10
申请号：US10977221
申请日：2004-10-28
申请人： Gang Chen , Jason Crawford , Renato Skerlj
发明人： Gang Chen , Jason Crawford , Renato Skerlj
IPC分类号： C07D213/127
CPC分类号： C07D401/14 , C07D211/74 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Methods for preparing 2,6-diaryl piperidine derivatives are described. More particularly, 2,6-diaryl piperidines having formula 1-4 are prepared by cyclocondensation of an aryl or heteroaryl aldehyde with 1,3-acetonedicarboxylic acid.
摘要翻译：描述了制备2,6-二芳基哌啶衍生物的方法。更具体地，具有式1-4的2,6-二芳基哌啶通过芳基或杂芳基醛与1,3-丙酮二羧酸的环化缩合制备。

3. 发明申请

US20080039119A1 RADIOLOCATION IN A WIRELESS NETWORK USING TIME DIFFERENCE OF ARRIVAL 有权
标题翻译：使用时间差异的无线网络中的放射性
公开(公告)号：US20080039119A1
公开(公告)日：2008-02-14
申请号：US11874835
申请日：2007-10-18
申请人： Jason Crawford , John O'Sullivan , Brian Hart
发明人： Jason Crawford , John O'Sullivan , Brian Hart
IPC分类号： H04Q7/20
CPC分类号： G01S5/0289 , G01S5/021
摘要： A method and an apparatus for radiolocation using time differences of arrival. The method includes receiving transmit timestamps from a set of wireless stations of a wireless network. Each station transmits at least once. The transmit timestamp uses a local timestamping clock to indicate when a station transmitted a packet. The method further includes receiving sets of timestamped captured samples from each station that receives one of the transmitted packets. The times of arrival of each packet at each station are determined from the received sets of timestamped captured samples, and, the relative positions of the stations are determined from the determined times of arrival and the received transmit timestamps. The transmitting by the stations is in a round robin manner one station after the other, and several round robins may be used to mutually calibrate local clocks. Also an apparatus for inclusion in a station of a wireless network. The apparatus includes a buffer subsystem and a timestamping subsystem, such that the station can capture and timestamp a set of samples of a received signal, and send the captured timestamped samples to a processing entity for time difference of arrival location determination.
摘要翻译：使用到达时差的无线电定位方法和装置。该方法包括从无线网络的一组无线站接收发送时间戳。每个站至少发送一次。发送时间戳使用本地时间戳来指示电台何时发送数据包。所述方法还包括从接收所发送的分组之一的每个站接收时间戳捕获的采样集。从接收到的时间戳捕获采样集合确定每个分组在每个站的到达时间，并且从确定的到达时间和接收到的发送时间戳确定站的相对位置。台站的发送是一个接一个的循环方式，可以使用几个循环机来相互校准本地时钟。也是用于包括在无线网络的站中的装置。该装置包括缓冲子系统和时间戳子系统，使得该站可以捕获并对时间戳进行一个接收信号的采样，并将所捕获的带时间戳的采样发送到处理实体，用于到达位置确定的时差。

4. 发明申请

US20060252795A1 Chemokine receptor binding heterocyclic compounds 失效
公开(公告)号：US20060252795A1
公开(公告)日：2006-11-09
申请号：US11487038
申请日：2006-07-14
申请人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
发明人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
IPC分类号： A61K31/4709
CPC分类号： C07D213/81 , A61K31/4709 , C07D213/38 , C07D213/65 , C07D215/40 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D493/04 , Y02A50/411
摘要： Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.

5. 发明申请

US20060149821A1 Detecting spam email using multiple spam classifiers 审中-公开
标题翻译：使用多个垃圾邮件分类器检测垃圾邮件
公开(公告)号：US20060149821A1
公开(公告)日：2006-07-06
申请号：US11029069
申请日：2005-01-04
申请人： Vadakkedathu Rajan , Mark Wegman , Richard Segal , Jason Crawford , Jeffrey Kephart , Shlomo Hershkop
发明人： Vadakkedathu Rajan , Mark Wegman , Richard Segal , Jason Crawford , Jeffrey Kephart , Shlomo Hershkop
IPC分类号： G06F15/16
CPC分类号： H04L51/12 , G06Q10/107
摘要： A method for detecting undesirable emails is disclosed. The method combines input from two or more spam classifiers to provide improved classification effectiveness and robustness. The method's effectiveness is improved over that of any one constituent classifier in the sense that the detection rate is increased and/or the false positive rate is decreased. The method's robustness is improved in the sense that, if spammers temporarily elude any one constituent classifier, the other constituent classifiers will still be likely to catch the spam. The method includes obtaining a score from each of a plurality of constituent spam classifiers by applying them to a given input email. The method further includes obtaining a combined spam score from a combined spam classifier that takes as input the plurality of constituent spam classifier scores, the combined spam classifier being computed automatically in accordance with a specified false-positive vs. false-negative tradeoff. The method further includes identifying the given input email as an undesirable email if the combined spam score indicates that the input e-mail is undesirable.
摘要翻译：公开了一种用于检测不期望的电子邮件的方法。该方法结合了两个或更多个垃圾邮件分类器的输入，以提供改进的分类有效性和鲁棒性。在检测率提高和/或假阳性率降低的意义上，该方法的有效性比任何一个构成分类器的有效性得到改善。该方法的鲁棒性得到改善，因为如果垃圾邮件发送者暂时排除任何一个构成分类器，则其他组成分类器仍然可能会捕获垃圾邮件。该方法包括通过将其应用于给定的输入电子邮件来从多个组成垃圾邮件分类器中的每一个获得分数。所述方法还包括从组合的垃圾邮件分类器获得组合的垃圾邮件分数，所述组合垃圾邮件分类器将所述多个组成垃圾邮件分类器分数作为输入，所述组合的垃圾邮件分类器根据指定的假阳性与假阴性权衡自动计算。如果组合的垃圾邮件评分指示输入的电子邮件是不期望的，该方法还包括将给定的输入电子邮件识别为不期望的电子邮件。

6. 发明申请

US20060100240A1 Chemokine receptor binding heterocyclic compounds with enhanced efficacy 有权
公开(公告)号：US20060100240A1
公开(公告)日：2006-05-11
申请号：US11301725
申请日：2005-12-13
申请人： Gary Bridger , Ai Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
发明人： Gary Bridger , Ai Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
IPC分类号： A61K31/4709 , C07D403/02 , C07D403/14
CPC分类号： C07D401/14 , C07D235/14 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04
摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

7. 发明申请

US20050209277A1 Process for the synthesis of CXCR4 antagonist 有权
标题翻译：合成CXCR4拮抗剂的方法
公开(公告)号：US20050209277A1
公开(公告)日：2005-09-22
申请号：US11077896
申请日：2005-03-11
申请人： Jason Crawford , Gang Chen , David Gauthier , Renato Skerlj , Ian Baird , Trevor Wilson
发明人： Jason Crawford , Gang Chen , David Gauthier , Renato Skerlj , Ian Baird , Trevor Wilson
IPC分类号： A61K31/4709 , C07D215/38 , C07D215/40 , C07D401/12 , C07D401/14 , C07D43/02
CPC分类号： C07D401/14 , C07D215/40 , C07D401/12 , Y02P20/55
摘要： This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alkyl aldehyde bearing a phthalimide or a di-tertiary-butoxycarbonyl (di-BOC) protecting group to form an imine; b) reducing the imine to form a secondary amine; c) reacting the secondary amine with a haloalkyl substituted heterocyclic compound, to form a phthalimido-protected or di-tert-butoxycarbonyl protected tertiary amine; and d) hydrolyzing the protected amine to obtain a compound having Formula I′
摘要翻译：本发明涉及一种结合CXCR4趋化因子受体的杂环药物化合物的合成方法。在一个实施方案中，该方法包括：a）使5,6,7,8-四氢喹啉基胺和带有邻苯二甲酰亚胺或二叔丁氧基羰基（二-BOC）保护基团的烷基醛反应以形成亚胺; b）还原亚胺以形成仲胺; c）使仲胺与卤代烷基取代的杂环化合物反应，形成邻苯二甲酰亚氨基保护或二叔丁氧羰基保护的叔胺; 和d）水解受保护的胺以获得具有式I'

8. 发明申请

US20050165895A1 Classification of electronic mail into multiple directories based upon their spam-like properties 有权
标题翻译：根据垃圾邮件的属性将电子邮件分类到多个目录中
公开(公告)号：US20050165895A1
公开(公告)日：2005-07-28
申请号：US10763929
申请日：2004-01-23
申请人： Vadakkedathu Rajan , Jason Crawford , Mark Wegman
发明人： Vadakkedathu Rajan , Jason Crawford , Mark Wegman
IPC分类号： G06F15/16 , G06Q10/00 , H04L12/58
CPC分类号： G06Q10/107 , H04L51/12 , H04L51/14
摘要： In an electronic mail system, an apparatus and method for providing, in addition to the conventional “Inbox” directory in which all incoming e-mails are normally received, a plurality of appropriately labeled directories for containing e-mails suspected of being spam, grading the level of spaminess of the incoming e-mails and then moving or copying the incoming e-mails into one or more of the spam directories based upon the e-mails' respective levels of spaminess.
摘要翻译：在电子邮件系统中，除了通常接收所有传入电子邮件的常规“收件箱”目录之外，还提供了用于包含疑似是垃圾邮件的电子邮件的多个适当标记的目录，分级传入电子邮件的垃圾邮件的级别，然后根据电子邮件的相应的垃圾邮件级别将传入的电子邮件移动或复制到一个或多个垃圾邮件目录中。

9. 发明授权

US06835731B2 Chemokine receptor binding heterocyclic compounds 失效
标题翻译：趋化因子受体结合杂环化合物
公开(公告)号：US06835731B2
公开(公告)日：2004-12-28
申请号：US09957654
申请日：2001-09-17
申请人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
发明人： Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis , Rosaria Maria Di Fluri
IPC分类号： A61K31541
CPC分类号： C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04
摘要： Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
摘要翻译：含有多个杂芳族取代基的叔胺可用作趋化因子受体调节剂。

10. 发明申请

US20100105915A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：化合物受体结合杂环化合物
公开(公告)号：US20100105915A1
公开(公告)日：2010-04-29
申请号：US12612488
申请日：2009-11-04
申请人： Gary J. BRIDGER , Renato Skerlj , Ai Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. Mceachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols
发明人： Gary J. BRIDGER , Renato Skerlj , Ai Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. Mceachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols
IPC分类号： C07D401/02
CPC分类号： C07D239/42 , A61K45/06 , C07D213/38 , C07D215/40 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04
摘要： Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
摘要翻译：公开了结合趋化因子受体并抑制其天然配体结合的杂环化合物。本发明化合物可防止HIV感染并发挥拮抗剂对CXCR4受体特征的作用。

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