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    • 2. 发明授权
    • Process for O-acylating phenol derivatives and acylating compositions
for this purpose
    • 用于此目的的O-酰化苯酚衍生物和酰化组合物的方法
    • US4323469A
    • 1982-04-06
    • US201508
    • 1980-10-28
    • Gyorgy LugosiAntal S. MayJanos BodnarIstvan TurcsanIstvan JelinekEva SomfaiLaszlo Simandi
    • Gyorgy LugosiAntal S. MayJanos BodnarIstvan TurcsanIstvan JelinekEva SomfaiLaszlo Simandi
    • C07D307/86C09K3/00
    • C07D307/86
    • The invention relates to a process for the preparation of carbamic acid phenyl esters of the formula (I) ##STR1## by acylating phenol derivatives of the formula (II) ##STR2## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, aralkyl having 7 to 16 carbon atoms which groups can be substituted by one or more alkyl groups,R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms or acylamino,R.sup.2 is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms, or ifR.sup.1 and R.sup.2 represent alkyl and/or alkoxy, they can form together a carbocyclic ring.According to the invention the phenol derivatives of the general formula (II), wherein R.sup.1 and R.sup.2 are as defined above, are reacted with N-carbamoyl-saccharin derivatives of the formula (IV) ##STR3## wherein R has the same meaning as defined above, in the presence of a base.
    • 本发明涉及通过酰化式(II)的苯酚衍生物(II)制备式(I)的氨基甲酸苯酯的方法,其中R是具有1至8个碳原子的烷基 碳原子,芳基,具有5或6个碳原子的环烷基,具有7至16个碳原子的芳基,该基团可以被一个或多个烷基取代,R 1是氢,具有1至4个碳原子的烷基,具有1至4个碳原子的烷氧基 原子或酰氨基,R 2是氢,卤素,具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基,或者如果R 1和R 2表示烷基和/或烷氧基,则它们可以一起形成碳环。 根据本发明,其中R 1和R 2如上定义的通式(II)的酚衍生物与式(Ⅳ)的N-氨基甲酰基 - 糖精衍生物反应其中R具有相同的 意义如上所述,在碱的存在下。
    • 4. 发明授权
    • Process for O-acylating phenol derivatives and acylating compositions
for this purpose
    • 用于此目的的O-酰化苯酚衍生物和酰化组合物的方法
    • US4315861A
    • 1982-02-16
    • US246412
    • 1981-03-23
    • Gyorgy LugosiAntal SimayJanos BodnarIstvan TurcsanIstvan JelinekEva SomfaiLaszlo Simandi
    • Gyorgy LugosiAntal SimayJanos BodnarIstvan TurcsanIstvan JelinekEva SomfaiLaszlo Simandi
    • C07D307/86C07D317/10C07C125/067
    • C07D307/86
    • A process is disclosed for preparing a carbamic acid phenyl ester of the formula (I) ##STR1## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, or aralkyl having 7 to 16 carbon atoms, wherein the aryl, cycloalkyl or aralkyl is unsubstituted or substituted by at least one alkyl group having 1 to 8 carbon atoms;R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, cyanomethyl, 1,3-dioxolan-2-yl, or carboalkoxyamino wherein the alkoxy group contains 1 to 4 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; orR.sub.1 and R.sub.2 form together a carbocyclic ring or a heterocyclic ring fused to the phenyl ring wherein the carbocyclic ring of the heterocyclic ring is unsubstituted or substituted by at least one alkyl having 1 to 8 carbon atoms, which comprises acylating a phenol of the formula (II) ##STR2## with a compound of the formula (IV) ##STR3## in the presence of a base. The compounds obtained are valuable intermediates.
    • 公开了制备式(I)的氨基甲酸苯酯的方法,其中R是具有1至8个碳原子的烷基,具有5或6个碳原子的芳基,环烷基或具有7至16个碳原子的芳烷基, 其中芳基,环烷基或芳烷基是未取代的或被至少一个具有1至8个碳原子的烷基取代; R1是氢,具有1至4个碳原子的烷基,具有1至4个碳原子的烷氧基,氰基甲基,1,3-二氧戊环-2-基或烷氧基氨基,其中烷氧基含有1至4个碳原子; R2是氢,卤素,具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基; 或者R 1和R 2一起形成稠合到苯环的碳环或杂环,其中杂环的碳环是未取代的或被至少一个具有1至8个碳原子的烷基取代,其包括酰化式 (II)的化合物与式(IV)的化合物在碱的存在下反应。 所得化合物是有价值的中间体。