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1. 发明申请

US20090220466A1 VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS AND METHODS OF ISOLATING AND USING THE SAME 审中-公开
标题翻译：非常小的类似（VSEL）干细胞及其分离和使用方法
公开(公告)号：US20090220466A1
公开(公告)日：2009-09-03
申请号：US12096754
申请日：2006-11-02
申请人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak
发明人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak
IPC分类号： A61K35/12 , C12N5/06 , C12N5/08 , G01N33/53 , A01N1/02 , A01K67/027 , C40B30/06
CPC分类号： C12N5/0607 , C12N2501/11 , C12N2501/115 , C12N2501/22 , C12N2501/23
摘要： The presently disclosed subject matter provides populations of stem cells that are purified from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供从骨髓，外周血和/或其他来源纯化的干细胞群体。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

2. 发明申请

US20120114614A1 METHODS AND COMPOSITIONS FOR LONG TERM HEMATOPOIETIC REPOPULATION 审中-公开
标题翻译：长期HEMATOPOIETIC REPOPULATION的方法和组合
公开(公告)号：US20120114614A1
公开(公告)日：2012-05-10
申请号：US13129359
申请日：2009-11-16
申请人： Janina Ratajczak , Ewa K. Zuba-Surma , Mariusz Ratajczak
发明人： Janina Ratajczak , Ewa K. Zuba-Surma , Mariusz Ratajczak
IPC分类号： A61K35/12 , A61N5/00 , C12N5/02 , C12N5/078 , C12N5/07
CPC分类号： A61K35/28 , A61K35/51 , A61K2035/124 , C12N5/0647 , C12N5/0665 , C12N2502/1335 , C12N2502/1394
摘要： Methods for isolating a CD133+/CD45neg/GlyAneg subpopulation of umbilical cord blood cells are disclosed. In some embodiments, the methods include providing an initial population of umbilical cord blood cells; contacting the initial population of cells with a first antibody that is specific for CD133, a second antibody that is specific for CD45, and a third antibody that is specific for Glycophorin A (GIyA) under conditions sufficient to allow binding of each antibody to its target, if present, on each cell of the initial population of cells; and isolating a subpopulation of cells that are CD133+, CD45neg, and GlyAneg. Also provided are isolated populations of CD133+/GlyAneg/CD45neg stem cells isolated from cord blood, methods for repopulating cell types in subjects, methods for bone marrow transplantation, methods for inducing hematopoietic competency in CD133+/GlyAneg/CD45neg stem cells, and cell culture systems that include CD133+/GIyAneg/CD45neg stem cells.
摘要翻译：公开了分离脐带血细胞的CD133 + / CD45neg / GlyAneg亚群的方法。在一些实施方案中，所述方法包括提供脐带血细胞的初始群体; 使初始细胞群与第一抗体CD133特异性接触，第二抗体是CD45特异性的第二抗体，以及在足以允许每种抗体与靶标结合的条件下对Glycophorin A（Gly）特异性的第三抗体如果存在，则在初始细胞群体的每个细胞上; 并分离CD133 +，CD45neg和GlyAneg细胞亚群。还提供了从脐带血分离的CD133 + / GlyAneg / CD45neg干细胞的分离群体，用于重新培养受试者中的细胞类型的方法，用于骨髓移植的方法，在CD133 + / GlyAneg / CD45neg干细胞中诱导造血能力的方法和细胞培养系统其包括CD133 + / GlyYneg / CD45neg干细胞。

3. 发明申请

US20120045758A1 IMPRINTING IN VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：注入非常小的类似（VSEL）干细胞
公开(公告)号：US20120045758A1
公开(公告)日：2012-02-23
申请号：US13129352
申请日：2009-11-16
申请人： Magdalena Kucia , Dong-Myung Shin , Mariusz Ratajczak , Janina Ratajczak
发明人： Magdalena Kucia , Dong-Myung Shin , Mariusz Ratajczak , Janina Ratajczak
IPC分类号： C12Q1/68
CPC分类号： C12N5/0607 , C12Q1/6881 , C12Q2600/154
摘要： Methods for determining a degree of pluripotency in a first putative stem cell relative to a second putative stem cell are provided. In some embodiments the methods include comparing the imprinting status in the first versus the second putative stem cell of a locus selected from among Igf2-H19, Rasgrf1, lgf2R, Kcnq1, and Peg1/Mest. Also provided are methods for distinguishing very small embryonic like (VSEL) stem cells from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), methods for isolating VSELs from sources expected to include VSELs, methods for assessing the purity of a very small embryonic like stem cell (VSEL) preparation, and kits that include oligonucleotide primers that can be employed in the practice of the claimed methods.
摘要翻译：提供了确定第一推定干细胞相对于第二推定干细胞的多能性程度的方法。在一些实施方案中，所述方法包括比较选自Igf2-H19，Rasgrf1，IgG2R，Kcnq1和Peg1 / Mest的基因座的第一和第二推定干细胞中的印记状态。还提供了将非常小的胚胎样（VSEL）干细胞与造血干细胞（HSC）和间充质干细胞（MSC）区分开的方法，从预期包括VSEL的来源分离VSEL的方法，评估非常小的纯度的方法胚胎样干细胞（VSEL）制剂，以及包括可用于所要求保护的方法的实践中的寡核苷酸引物的试剂盒。

4. 发明申请

US20100267107A1 METHODS FOR ISOLATING VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：分离非常小的胚胎样（VSEL）干细胞的方法
公开(公告)号：US20100267107A1
公开(公告)日：2010-10-21
申请号：US12570181
申请日：2009-09-30
申请人： Ewa K. Zuba-Surma , Mariusz Ratajczak , Janina Ratajczak , Magdalena Kucia
发明人： Ewa K. Zuba-Surma , Mariusz Ratajczak , Janina Ratajczak , Magdalena Kucia
IPC分类号： C12N5/074 , C12N13/00
CPC分类号： C12N5/0607 , A61K35/12 , A61K38/193
摘要： The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供了从骨髓，外周血和/或其他来源分离干细胞群体的方法。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

5. 发明申请

US20090155225A1 USES AND ISOLATION OF VERY SMALL OF EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：使用和分离非常小的类似（VSEL）干细胞
公开(公告)号：US20090155225A1
公开(公告)日：2009-06-18
申请号：US12261958
申请日：2008-10-30
申请人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak , Denis O. Rodgerson , George S. Smith , Roberto Bolli , Ronald E. Allen , Wayne A. Marasco
发明人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak , Denis O. Rodgerson , George S. Smith , Roberto Bolli , Ronald E. Allen , Wayne A. Marasco
IPC分类号： A61K35/12 , C12N5/00 , A61P17/02 , A61P9/00
CPC分类号： C12N5/0607 , A61K35/12 , A61K38/193
摘要： The presently disclosed subject matter provides populations of stem cells that are purified from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供从骨髓，外周血和/或其他来源纯化的干细胞群体。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

6. 发明授权

US09155762B2 Uses and isolation of stem cells from bone marrow 有权
标题翻译：使用和分离干细胞从骨髓
公开(公告)号：US09155762B2
公开(公告)日：2015-10-13
申请号：US12740718
申请日：2008-10-30
申请人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak , Roberto Bolli
发明人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak , Roberto Bolli
IPC分类号： A61K35/12 , A61K35/28 , A61K38/18 , A61B10/00
CPC分类号： A61K35/545 , A61B10/00 , A61K35/12 , A61K35/28 , A61K35/34 , A61K38/18 , A61K2035/124 , C12N5/0607
摘要： The presently disclosed subject matter provides populations of stem cells that are purified from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供从骨髓，外周血和/或其他来源纯化的干细胞群体。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

7. 发明申请

US20130323197A1 IFG-1 DEPENDENT MODULATION OF VSELS 审中-公开
标题翻译： VSG的IFG-1相关调制
公开(公告)号：US20130323197A1
公开(公告)日：2013-12-05
申请号：US13877963
申请日：2011-10-07
申请人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak
发明人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： G01N33/5091 , C12Q1/6883 , C12Q2600/154 , C12Q2600/158 , G01N33/56966
摘要： Characteristics of the VSELs stem cell population of a mammal are correlated with aging, including VSEL number, imprinting status of genetic loci, and expression of markers of pluripotent stem cells. The present invention provides VSEL-based methods and compositions for determining the biological age of a mammal.
摘要翻译：哺乳动物VSELs干细胞群体的特征与衰老有关，包括VSEL数，遗传基因座的印记状态以及多能干细胞标志物的表达。本发明提供了用于确定哺乳动物的生物学年龄的基于VSEL的方法和组合物。

8. 发明申请

US20110189136A1 USES AND ISOLATION OF VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 有权
标题翻译：使用和分离非常小的类似（VSEL）干细胞
公开(公告)号：US20110189136A1
公开(公告)日：2011-08-04
申请号：US12740718
申请日：2008-10-30
申请人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak , George Smith , Ronald Allen , Wayne Marasco , Roberto Bolli
发明人： Mariusz Ratajczak , Magdalena Kucia , Janina Ratajczak , George Smith , Ronald Allen , Wayne Marasco , Roberto Bolli
IPC分类号： A61K35/12 , C12N5/02 , A61K38/18 , A61B10/00
CPC分类号： A61K35/545 , A61B10/00 , A61K35/12 , A61K35/28 , A61K35/34 , A61K38/18 , A61K2035/124 , C12N5/0607
摘要： The presently disclosed subject matter provides populations of stem cells that are purified from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供从骨髓，外周血和/或其他来源纯化的干细胞群体。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

9. 发明申请

US20140154219A1 METHODS AND COMPOSITIONS FOR LARGE-SCALE ISOLATION OF VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：用于大规模分离非常小的类似（VSEL）干细胞的方法和组合物
公开(公告)号：US20140154219A1
公开(公告)日：2014-06-05
申请号：US14008796
申请日：2012-04-02
申请人： Janina Ratajczak , Mariusz Z. Ratajczak
发明人： Janina Ratajczak , Mariusz Z. Ratajczak
IPC分类号： A61K35/12
CPC分类号： A61K35/12 , C12N5/0607 , C12N5/0647
摘要： Methods for purifying very small embryonic-like (VSEL) stem cells from populations of cells suspected of including VSEL stem cells are provided. In some embodiments, the methods include (a) providing a population of cells suspected of including a VSEL stem cell; and (b) isolating a CD45neg/GlyAneg/CD133+/ALDHhigh subpopulation, a CD45neg/GiyAneg/CD133+/ALDlow subpopulation, a CD45neg/Linneg/SSEA-4+/ALDHhigh subpopulation, a CD45neg/Linneg/SSEA-4/AiOlow subpopulation, or any combination thereof from the population, whereby a VSEL stem cell is purified from the population. Also provided are methods for generating in vitro hematopoietic colonies derived from VSEL stem cells and methods for generating lympho-hematopoietic chimerism in a subject.
摘要翻译：提供了从怀疑包括VSEL干细胞的细胞群体纯化非常小的胚胎样（VSEL）干细胞的方法。在一些实施方案中，所述方法包括（a）提供疑似包含VSEL干细胞的细胞群; CD45neg / GlyAneg / CD133 + / ALDH高亚组，CD45neg / GiyAneg / CD133 + / ALDlow亚群，CD45neg / Linneg / SSEA-4 + / ALDHhigh亚群，CD45neg / Linneg / SSEA-4 / AiOlow亚群，或其群体的任何组合，从而从群体中纯化VSEL干细胞。还提供了用于产生源自VSEL干细胞的体外造血菌落的方法和在受试者中产生淋巴造血嵌合体的方法。

10. 发明申请

US20120021482A1 METHODS FOR ISOLATING VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS 审中-公开
标题翻译：分离非常小的胚胎样（VSEL）干细胞的方法
公开(公告)号：US20120021482A1
公开(公告)日：2012-01-26
申请号：US13121913
申请日：2009-09-30
申请人： Ewa K. Zuba-Surma , Mariusz Ratajczak , Janina Ratajczak , Magdalena Kucia
发明人： Ewa K. Zuba-Surma , Mariusz Ratajczak , Janina Ratajczak , Magdalena Kucia
IPC分类号： C12N5/0735 , C12N13/00
CPC分类号： C12N5/0607
摘要： The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.
摘要翻译：目前公开的主题提供了从骨髓，外周血和/或其他来源分离干细胞群体的方法。还提供了使用干细胞治疗受试者的组织和/或器官损伤的方法。

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