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1. 发明授权

US08080515B2 Method for prevention of platelet aggregation employing and RGD-enriched gelatine-like protein 有权
标题翻译：防止使用富含RGD的明胶样蛋白的血小板聚集的方法
公开(公告)号：US08080515B2
公开(公告)日：2011-12-20
申请号：US12494450
申请日：2009-06-30
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

2. 发明申请

US20110106243A1 Coating Method for Medical Devices 审中-公开
标题翻译：医疗器械涂层方法
公开(公告)号：US20110106243A1
公开(公告)日：2011-05-05
申请号：US12999526
申请日：2009-06-25
申请人： Elisabeth Marianna Wilhelmina Maria Van Dongen , Sebastianus Gerardus Kluijtmans , Jan Bastiaan Bouwstra
发明人： Elisabeth Marianna Wilhelmina Maria Van Dongen , Sebastianus Gerardus Kluijtmans , Jan Bastiaan Bouwstra
IPC分类号： A61F2/82 , B05D5/00 , A61F2/28 , A61C13/00 , A61M25/00 , A61F2/02
CPC分类号： A61L27/34 , A61L2420/02 , C09D189/06
摘要： The invention relates to a method for coating medical devices with a biocompatible protein coating.
摘要翻译：本发明涉及一种用生物相容性蛋白质涂层涂覆医疗器械的方法。

3. 发明申请

US20100273215A1 Secretion Yield of a Protein of Interest by in vivo Proteolytic Processing of a Multimeric Precursor 审中-公开
标题翻译：通过多聚体前体的体内蛋白水解加工获得感兴趣的蛋白质的分泌产率
公开(公告)号：US20100273215A1
公开(公告)日：2010-10-28
申请号：US12808326
申请日：2008-12-17
申请人： Anna Cornelia Hendrika Van Hautum , Arjo Lysander De Boer , Jan Bastiaan Bouwstra , Peter Franciscus Theresius Maria Van Asten
发明人： Anna Cornelia Hendrika Van Hautum , Arjo Lysander De Boer , Jan Bastiaan Bouwstra , Peter Franciscus Theresius Maria Van Asten
IPC分类号： C07H21/04 , C12N15/63 , C12N1/19 , C12P21/00
CPC分类号： C12P21/00 , C07K14/78 , C07K2319/50 , C12N15/62 , C12N15/625 , C12N15/815 , C12P21/02 , C12P21/06
摘要： The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The invention further relates to a cell comprising this nucleic acid molecule and a method for producing a protein of interest using this cell.
摘要翻译：本发明涉及编码多聚体前体的核酸分子，其在体内特异性切割转录以形成感兴趣的蛋白质的多个拷贝。本发明还涉及包含该核酸分子的细胞和使用该细胞产生感兴趣的蛋白质的方法。

4. 发明申请

US20100209366A1 UV ABSORBING COMPOUNDS 失效
标题翻译：紫外吸收化合物
公开(公告)号：US20100209366A1
公开(公告)日：2010-08-19
申请号：US12678698
申请日：2008-09-18
申请人： Sebastianus Gerardus Johannes Maria Kluijtmans , Jan Bastiaan Bouwstra
发明人： Sebastianus Gerardus Johannes Maria Kluijtmans , Jan Bastiaan Bouwstra
IPC分类号： A61K8/46 , C07C317/48 , A61Q17/04 , C07C315/04
CPC分类号： C07C317/48 , A61K8/46 , A61Q17/04 , C07C315/04
摘要： The invention relates to new, highly efficient UV-absorbing compounds, a process for their manufacturing and to uses of these UV-absorbing compounds. The UV-absorbing compounds are in particular UV-A-absorbing compounds according to Formula (VI) or (VII): R2CH2—N(R17)—(CR12)m—N(R17)—CH2R2 (VI) N{(R17)3-n[(CR12)m-N(R17)—CH2R2]n} (VII)
摘要翻译：本发明涉及新的高效紫外线吸收化合物，其制造方法以及这些UV吸收化合物的用途。 UV吸收化合物特别是根据式（VI）或（VII）的UV-A吸收化合物：R2CH2-N（R17） - （CR12）m-N（R17）-CH2R2（VI）N {（R17 ）3-n [（CR12）mN（R17）-CH2R2] n}（VII）

5. 发明授权

US07671016B2 RGD-enriched gelatine-like proteins with enhanced cell binding 有权
标题翻译：具有增强的细胞结合的RGD富集的明胶样蛋白质
公开(公告)号：US07671016B2
公开(公告)日：2010-03-02
申请号：US11770271
申请日：2007-06-28
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

6. 发明申请

US20100048481A1 Controlled Release Composition 失效
标题翻译：控制释放组成
公开(公告)号：US20100048481A1
公开(公告)日：2010-02-25
申请号：US12528071
申请日：2008-02-21
申请人： Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
发明人： Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
IPC分类号： A61K38/16 , A61P29/00 , A61P35/00 , A61P9/00
CPC分类号： A61K9/06 , A61K9/0024 , A61K47/42
摘要： The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition.This invention is related to a controlled release composition comprising a cross-linked gelatin and at least one therapeutic protein wherein the ratio of the average mesh size (ξ) of the gelatin matrix and the average hydrodynamic radius (RH) of the therapeutic protein is smaller than 2, preferably smaller than 1.5.
摘要翻译：本发明涉及药理学领域。更具体地，本发明涉及控释组合物。本发明涉及包含交联明胶和至少一种治疗性蛋白质的控释组合物，其中明胶基质的平均筛网尺寸（＆amp; xgr）与治疗性蛋白质的平均流体动力学半径（RH）之比为小于2，优选小于1.5。

7. 发明申请

US20090182063A1 RGD-ENRICHED GELATINE-LIKE PROTEINS WITH ENHANCED CELL BINDING 有权
标题翻译：具有增强型细胞结合的RGD-增强的样品蛋白
公开(公告)号：US20090182063A1
公开(公告)日：2009-07-16
申请号：US11770271
申请日：2007-06-28
申请人： Jan Bastiaan BOUWSTRA , Andries Johannes Jozef VAN ES , Yuzo TODA
发明人： Jan Bastiaan BOUWSTRA , Andries Johannes Jozef VAN ES , Yuzo TODA
IPC分类号： A61K47/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

8. 发明申请

US20090130033A1 Dendrimer-Aminobuadiene-Based Uv Screens 审中-公开
标题翻译：基于树枝状聚合物 - 氨基丁二烯的Uv筛网
公开(公告)号：US20090130033A1
公开(公告)日：2009-05-21
申请号：US11572560
申请日：2005-07-25
申请人： Sebastianus Gerardus Kluijtmans , Jan Bastiaan Bouwstra
发明人： Sebastianus Gerardus Kluijtmans , Jan Bastiaan Bouwstra
IPC分类号： A61K8/81 , C08F136/00 , A61Q17/04
CPC分类号： A61K8/84 , A61K2800/54 , A61K2800/57 , A61Q17/04 , C08G83/003 , C08L79/02
摘要： The invention relates to UV-absorbing polymers, said UV-absorbing polymer comprising a synthetic amine rich polymer to which is covalently linked to an aminobutadiene represented by the general formula (I) wherein the UV-absorbing polymer has a number average molecular weight Mn of 1000 g/mol to 100.000 g/mol; and said UV-absorbing polymer having a UV-absorption of at least 5.6 a.u./g.L at 375 nm.
摘要翻译：本发明涉及紫外线吸收聚合物，所述紫外线吸收聚合物包含合成富胺聚合物，其共价连接到由通式（I）表示的氨基丁二烯，其中所述UV吸收聚合物的数均分子量Mn为 1000g / mol至100.000g / mol; 并且所述紫外线吸收聚合物在375nm处具有至少5.6a.u./g.L的UV吸收。

9. 发明申请

US20080260661A1 Aminobutadiene-Based Uv Screens 审中-公开
标题翻译：基于氨基丁二烯的Uv屏
公开(公告)号：US20080260661A1
公开(公告)日：2008-10-23
申请号：US11573120
申请日：2005-08-10
申请人： Sebastianus Gerardus Johannes Maria Kluijtmans , Akihiko Ikegawa , Jan Bastiaan Bouwstra
发明人： Sebastianus Gerardus Johannes Maria Kluijtmans , Akihiko Ikegawa , Jan Bastiaan Bouwstra
IPC分类号： A61K8/40 , A61Q17/04
CPC分类号： A61K8/42 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/4926 , A61Q17/00
摘要： The invention relates to the use of an UV-absorbing compound for the preparation of a cosmetic composition for protection against UV radiation said compound being represented by the general formula (I) wherein less than 10% of the total absorption between 250 and 600 nm of said UV-absorbing compound according to formula (I) is above 400 nm. The invention also relates to sunscreen compositions comprising the UV-absorbing compound according to formula (I).
摘要翻译：本发明涉及紫外线吸收化合物用于制备用于防止紫外线辐射的化妆品组合物的用途，所述化合物由通式（I）表示，其中小于10％的总吸收在250和600nm之间所述根据式（I）的紫外线吸收化合物高于400nm。本发明还涉及包含根据式（I）的UV吸收化合物的防晒组合物。

10. 发明授权

US06627667B2 Process for preparing a modified polymer 失效
标题翻译：制备改性聚合物的方法
公开(公告)号：US06627667B2
公开(公告)日：2003-09-30
申请号：US09898723
申请日：2001-07-03
申请人： Sebastianus Gerardus J. M. Kluijtmans , Jan Bastiaan Bouwstra , Yuzo Toda
发明人： Sebastianus Gerardus J. M. Kluijtmans , Jan Bastiaan Bouwstra , Yuzo Toda
IPC分类号： C08J520
CPC分类号： G03C1/053 , C08B15/06 , C08H1/06 , G03C1/04 , G03C1/047
摘要： The invention is directed to a process for modifying a water soluble polymer, said process comprising modifying a polymer containing amine groups, by reacting at least one of said amine groups with activated ester, said ester being the reaction product of a carboxyl activator and the carboxyl group of a molecule R—COOH, said R-group being a functional group, to produce a reaction mixture containing a polymer, said polymer containing at least one amide group; subjecting said reaction mixture to at least ion exchange chromatography to purify said reaction mixture, said purification comprising at least partly removing the said reaction product, and/or carboxyl activator.
摘要翻译：本发明涉及一种改性水溶性聚合物的方法，所述方法包括通过使至少一种所述胺基与活性酯反应来修饰含有胺基团的聚合物，所述酯是羧基活化剂与羧基的反应产物的分子R-COOH，所述R基团是官能团，以产生含有聚合物的反应混合物，所述聚合物含有至少一个酰胺基团;将所述反应混合物至少进行离子交换色谱以纯化所述反应混合物，所述纯化包括至少部分除去所述反应产物和/或羧基活化剂。

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