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1. 发明授权

US5508009A Optimum hydrogen peroxide vapor sterilization system 失效
标题翻译：最佳过氧化氢蒸气灭菌系统
公开(公告)号：US5508009A
公开(公告)日：1996-04-16
申请号：US442468
申请日：1995-05-16
申请人： James R. Rickloff , Donald C. Upchurch , Robert W. Childers
发明人： James R. Rickloff , Donald C. Upchurch , Robert W. Childers
IPC分类号： A61L2/20 , A61L2/00
CPC分类号： A61L2/20
摘要： A sterilization method is provided which includes the steps of measuring the pressure within a sterilization chamber injecting a sterilant vapor into a flow of carrier gas, introducing the sterilant vapor and carrier gas into and through a sterilization chamber, and adjusting the rate of sterilant vapor injection to reach a pre-determined percentage of saturation limit for the sterilant vapor in the chamber, immediately following the introduction of sterilant vapor and carrier gas into the chamber, in response to the measured pressure. The predetermined saturation limit is selected to optimize the rate of sterilization, while avoiding substantial condensation of the sterilant.
摘要翻译：提供灭菌方法，其包括以下步骤：测量灭菌室内的压力，将消毒剂蒸气注入载气流中，将消毒剂蒸气和载气引入灭菌室并通过灭菌室，并调节灭菌剂蒸汽注入速率以响应于测量的压力，在灭菌剂蒸气和载气引入到室中之后立即达到室中灭菌蒸气的饱和限度的预定百分比。选择预定的饱和极限以优化灭菌速率，同时避免灭菌剂的大量冷凝。

2. 发明授权

US5492672A Sterilization apparatus and method for multicomponent sterilant 失效
公开(公告)号：US5492672A
公开(公告)日：1996-02-20
申请号：US279688
申请日：1994-07-25
申请人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
发明人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
IPC分类号： A61C19/00 , A61B1/12 , A61C1/00 , A61L2/06 , A61L2/20 , A61L2/24
CPC分类号： A61L2/208 , A61L2/20 , A61L2/24 , A61C1/0076 , A61C19/002 , A61L2202/122 , A61L2202/24
摘要： The present invention provides a sterilization process particularly well suited for sterilizing instruments and other devices having long narrow lumens. Apparatus in which the process can be practiced is also provided. The process uses a multicomponent sterilant vapor wherein one component is water. The lumened instruments are fluidly connected to the exhaust manifold of the sterilizer. A deep vacuum is drawn in the sterilization chamber followed by the injection of pulses of the sterilant vapor until a higher, but still subatmospheric pressure level is reached. When the pressure level reaches a predetermined subatmospheric level, a flow-through sterilization phase begins. It includes successive alternating periods of sterilant flow and the discontinuance of such flow. During sterilant flow periods, there are sterilant injection pulses where the sterilant flows through the chamber and the lumened instruments to exhaust. Each such flow period is followed by a hold period. Following the sterilization phase, there are one or more aeration steps to remove sterilant from the chamber.

3. 发明授权

US5556607A Sterilization apparatus and method for multicomponent sterilant 失效
标题翻译：多组分灭菌剂灭菌装置及方法
公开(公告)号：US5556607A
公开(公告)日：1996-09-17
申请号：US530577
申请日：1995-09-19
申请人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
发明人： Robert W. Childers , James R. Rickloff , Thaddeus J. Mielnik , Kenneth J. Klobusnik
IPC分类号： A61C19/00 , A61B1/12 , A61C1/00 , A61L2/06 , A61L2/20 , A61L2/24 , A61L9/00
CPC分类号： A61L2/208 , A61L2/20 , A61L2/24 , A61C1/0076 , A61C19/002 , A61L2202/122 , A61L2202/24
摘要： The present invention provides a sterilization process particularly well suited for sterilizing instruments and other devices having long narrow lumens. Apparatus in which the process can be practiced is also provided. The process uses a multicomponent sterilant vapor wherein one component is water. The lumened instruments are fluidly connected to the exhaust manifold of the sterilizer. A deep vacuum is drawn in the sterilization chamber followed by the injection of pulses of the sterilant vapor until a higher, but still subatmospheric pressure level is reached. When the pressure level reaches a predetermined subatmospheric level, a flow-through sterilization phase begins. It includes successive alternating periods of sterilant flow and the discontinuance of such flow. During sterilant flow periods, there are sterilant injection pulses where the sterilant flows through the chamber and the lumened instruments to exhaust. Each such flow period is followed by a hold period. Following the sterilization phase, there are one or more aeration steps to remove sterilant from the chamber.
摘要翻译：本发明提供了一种特别适用于消毒器具和其他具有较长腔体的器具的灭菌方法。还提供了可以实施该方法的装置。该方法使用多组分灭菌剂蒸气，其中一种组分是水。流明的仪器与灭菌器的排气歧管流体连接。在灭菌室中抽取深度真空，然后注入灭菌剂蒸气的脉冲，直到达到较高但仍低于大气压的压力水平。当压力水平达到预定的低于大气压水平时，开始流通灭菌阶段。它包括连续的交替周期的灭菌剂流动和这种流动的中断。在灭菌剂流动期间，灭菌剂喷射脉冲，其中消毒剂流过腔室，并且流明的仪器排出。每个这样的流动周期之后是保持期。灭菌阶段之后，有一个或多个曝气步骤从室中除去灭菌剂。

4. 发明授权

US4935371A Sterilizable gas permeable container for use in culturing living cells 失效
标题翻译：用于培养活细胞的可灭菌气体渗透性容器
公开(公告)号：US4935371A
公开(公告)日：1990-06-19
申请号：US139894
申请日：1987-12-30
申请人： James R. Rickloff
发明人： James R. Rickloff
IPC分类号： A61L2/00 , A61L2/20 , A61L2/24 , C12M1/12 , C12M1/20 , C12M1/24
CPC分类号： C12M23/08 , A61L2/0094 , A61L2/20 , A61L2/24 , C12M23/12 , C12M23/38 , C12M37/02 , Y10S436/81
摘要： A container for use in culturing living cells includes an enclosable portion, or base, and a cover for enclosing the enclosable portion, a path defined between the junction of the enclosable portion and the cover and a gas permeable filter positioned within the path. Gases flow into and out of the container through the filter. Vapor phase hydrogen peroxide is degraded into water vapor and oxygen by a material associated with the filter to prevent hydrogen peroxide from entering the container.
摘要翻译：用于培养活细胞的容器包括封闭部分或底部，以及用于封闭可封闭部分的盖子，限定在可封闭部分和盖子的接合部之间的路径和位于路径内的透气过滤器。气体通过过滤器流入和流出容器。气相过氧化氢通过与过滤器相关的材料降解成水蒸汽和氧气，以防止过氧化氢进入容器。

5. 发明授权

US5445792A Optimum hydrogen peroxide vapor sterlization method 失效
标题翻译：最佳过氧化氢蒸气灭菌方法
公开(公告)号：US5445792A
公开(公告)日：1995-08-29
申请号：US237406
申请日：1994-05-02
申请人： James R. Rickloff , Donald C. Upchurch , Robert W. Childers
发明人： James R. Rickloff , Donald C. Upchurch , Robert W. Childers
IPC分类号： A61L2/20 , A61L2/00 , A61L2/16
CPC分类号： A61L2/20
摘要： A sterilization method is provided which includes the steps of measuring the pressure within a sterilization chamber injecting a sterilant vapor into a flow of carrier gas, introducing the sterilant vapor and carrier gas into and through a sterilization chamber, and adjusting the rate of sterilant vapor injection to reach a pre-determined percentage of saturation limit for the sterilant vapor in the chamber, immediately following the introduction of sterilant vapor and carrier gas into the chamber, in response to the measured pressure. The predetermined saturation limit is selected to optimize the rate of sterilization, while avoiding substantial condensation of the sterilant.
摘要翻译：提供灭菌方法，其包括以下步骤：测量灭菌室内的压力，将消毒剂蒸气注入载气流中，将消毒剂蒸气和载气引入灭菌室并通过灭菌室，并调节灭菌剂蒸汽注入速率以响应于测量的压力，在灭菌剂蒸气和载气引入到室中之后立即达到室中灭菌蒸气的饱和限度的预定百分比。选择预定的饱和极限以优化灭菌速率，同时避免灭菌剂的大量冷凝。

6. 发明授权

US4863688A Method of decontaminating surfaces on or near living cells with vapor hydrogen peroxide 失效
标题翻译：用蒸汽过氧化氢去除活细胞上或附近表面的方法
公开(公告)号：US4863688A
公开(公告)日：1989-09-05
申请号：US948368
申请日：1986-12-31
申请人： William C. Schmidt , James R. Rickloff
发明人： William C. Schmidt , James R. Rickloff
IPC分类号： A61L2/00 , A61L2/20 , A61L2/24
CPC分类号： A61L2/24 , A61L2/0094 , A61L2/20
摘要： A method of selectively destroying organisms within a predetermined area is comprised of the steps of introducing vapor phase hydrogen peroxide into the predetermined area at a rate sufficient to cause a predetermined concentration of hydrogen peroxide to be reached while preventing any substantial change in pressure or condensation of the hydrogen peroxide within the predetermined area. The predetermined concentration is maintained for a period of time sufficient for destroying undesirable organisms but insufficient for harming desirable organisms. When the predetermined period of time has elapsed, the vapor phase hydrogen peroxide is removed from the area.
摘要翻译：选择性地破坏预定区域内生物体的方法包括以下步骤：将气相过氧化氢以足以引起预定浓度的过氧化氢达到的速率引入预定区域，同时防止压力或冷凝的任何显着变化在预定区域内的过氧化氢。预定浓度保持足以破坏不需要的生物体的时间，但不足以伤害所需生物体。当经过预定时间段时，从该区域去除汽相过氧化氢。

7. 发明授权

US4648978A Process for the continuous preparation of sterile, depyrogenated solutions 失效
标题翻译：连续制备无菌，去热原化溶液的方法
公开(公告)号：US4648978A
公开(公告)日：1987-03-10
申请号：US726422
申请日：1985-04-24
申请人： Ralph W. Makinen , James R. Rickloff
发明人： Ralph W. Makinen , James R. Rickloff
IPC分类号： C02F1/02 , C02F1/72 , C02F1/78
CPC分类号： C02F1/722 , C02F1/02 , C02F1/78 , Y10S210/90
摘要： A process for sterilizing and depyrogenating a pretreated solution, such as water, by adding an oxidant selected from the group consisting of hydrogen peroxide and ozone and heating the solution and the oxidant to a temperature sufficient to sterilize and depyrogenate the solution for a period of time, preferably less than 5 minutes. The oxidant is thereafter removed and the sterilized, depyrogenated solution is cooled for dispensing.
摘要翻译：通过添加选自过氧化氢和臭氧的氧化剂和将溶液和氧化剂加热至足以使溶液灭菌和去氢化一段时间的温度来对预处理溶液（例如水）进行灭菌和去热原化的方法，优选小于5分钟。然后除去氧化剂，并将灭菌的去热原化溶液冷却以进行分配。

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