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1. 发明申请

US20070218457A1 Toxicity screening methods 失效
标题翻译：毒性筛选方法
公开(公告)号：US20070218457A1
公开(公告)日：2007-09-20
申请号：US11714526
申请日：2007-03-06
申请人： James McKim
发明人： James McKim
IPC分类号： C12Q1/00 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5014 , G01N33/502 , G01N33/5061 , G01N33/5067
摘要： The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of determining a level of toxicity in normal tissue for an anti-tumor compound. The methods include providing at least one cell type and culturing the cell type in the presence of at least one concentration of the chemical compound, measuring at least one indicator of cell health at the at least one concentration of compound for the at least one cell type, and performing a concentration response analysis, from which a toxic concentration can be determined.
摘要翻译：本发明提供了基于体外测定来确定给定化合物的毒性水平的方法。本发明提供了基于体外测定法确定给定化合物的器官特异性毒性和物种特异性毒性的特定方法。此外，本发明提供了确定抗肿瘤化合物在正常组织中的毒性水平的方法。所述方法包括提供至少一种细胞类型并在存在至少一种浓度的化合物的情况下培养细胞类型，测量所述至少一种细胞类型的至少一种化合物浓度的至少一种细胞健康指示剂，并进行浓度响应分析，从中可以确定毒性浓度。

2. 发明申请

US20050125709A1 Communications system for implementation of synchronous, multichannel, galvanically isolated instrumentation devices 有权
标题翻译：用于实现同步，多通道，电气隔离仪表设备的通信系统
公开(公告)号：US20050125709A1
公开(公告)日：2005-06-09
申请号：US10857134
申请日：2004-05-28
申请人： James McKim , John Hyde , Marko Vulovic , Buck Chan , John Kenny , Richard Carlson
发明人： James McKim , John Hyde , Marko Vulovic , Buck Chan , John Kenny , Richard Carlson
IPC分类号： G06F11/00 , G06F11/273 , G06F13/00 , G06F15/177
CPC分类号： G06F11/273
摘要： An apparatus and method for synchronous communications using a serial data stream employs a housing with a controller and a back plane. The housing accepts one or more modules for interconnection with the back plane. The back plane distributes power to the modules and provides a communication link from the controller to each module. Each communication link includes a data out line, a data in line and a clock line, where each clock line is derived from one clock source.
摘要翻译：使用串行数据流的同步通信的装置和方法采用具有控制器和背板的外壳。壳体接受一个或多个模块以与背板互连。背板将功率分配给模块，并提供从控制器到每个模块的通信链路。每个通信链路包括数据输出线，数据线和时钟线，其中每个时钟线从一个时钟源导出。

3. 发明申请

US20080022165A1 Communications System For Implementation Of Synchronous, Multichannel, Galvanically Isolated Instrumentation Devices 有权
标题翻译：用于实现同步，多通道，电隔离仪表设备的通信系统
公开(公告)号：US20080022165A1
公开(公告)日：2008-01-24
申请号：US11768217
申请日：2007-06-26
申请人： James McKim , John Hyde , Marko Vulovic , Buck Chan , John Kenny , Richard Carlson
发明人： James McKim , John Hyde , Marko Vulovic , Buck Chan , John Kenny , Richard Carlson
IPC分类号： G01R31/28 , G06F3/00
CPC分类号： G06F11/273
摘要： An apparatus and method for synchronous communications using a serial data stream employs a housing with a controller and a back plane. The housing accepts one or more modules for interconnection with the back plane. The back plane distributes power to the modules and provides a communication link from the controller to each module. Each communication link includes a data out line, a data in line and a clock line, where each clock line is derived from one clock source.
摘要翻译：使用串行数据流的同步通信的装置和方法采用具有控制器和背板的外壳。壳体接受一个或多个模块以与背板互连。背板将功率分配给模块，并提供从控制器到每个模块的通信链路。每个通信链路包括数据输出线，数据线和时钟线，其中每个时钟线从一个时钟源导出。

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