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1. 发明授权

US08852900B2 Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol 有权
标题翻译：用于合成（S）-3-（1-氨基乙基） - 苯酚的生物催化剂和方法
公开(公告)号：US08852900B2
公开(公告)日：2014-10-07
申请号：US13704507
申请日：2011-06-16
申请人： Fabien Cabirol , Anupam Gohel , Seong Ho Oh , Derek Smith , Brian Wong , James Lalonde
发明人： Fabien Cabirol , Anupam Gohel , Seong Ho Oh , Derek Smith , Brian Wong , James Lalonde
IPC分类号： C12P13/00 , C12N9/10 , C07C213/00 , C07C213/08 , C07C269/00
CPC分类号： C12N9/1096 , C07B2200/07 , C07C213/00 , C07C213/08 , C07C269/00 , C07K2319/02 , C07K2319/21 , C07K2319/41 , C12P13/001 , C12Y206/01018 , C07C215/50 , C07C271/44
摘要： The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.
摘要翻译：本公开提供了与天然存在的转氨酶相比具有改进性质的工程改造的转氨酶多肽，其包括以对映体过量和高百分比转化率将底物3'-羟基苯乙酮转化为（S）-3-（1-氨基乙基） - 苯酚的能力。还提供了编码工程改造的转氨酶的多核苷酸，能够表达工程化转氨酶的宿主细胞和使用工程转氨酶合成（S）-3-（1-氨基乙基） - 苯酚的相关化合物和用于生产活性药物的相关化合物配料。

2. 发明申请

US20090155863A1 KETOREDUCTASE POLYPEPTIDES AND USES THEREOF 有权
标题翻译： KETOREDUCTASE POLYPEPTIDES及其用途
公开(公告)号：US20090155863A1
公开(公告)日：2009-06-18
申请号：US12240986
申请日：2008-09-29
申请人： JACK LIANG , BIRTHE BORUP , VESNA MITCHELL , EMILY MUNDORFF , JAMES LALONDE , GJALT W. HUISMAN
发明人： JACK LIANG , BIRTHE BORUP , VESNA MITCHELL , EMILY MUNDORFF , JAMES LALONDE , GJALT W. HUISMAN
IPC分类号： C12P17/12 , C12N9/04 , C07H21/00 , C12N15/63 , C12N1/00
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

3. 发明申请

US20080248539A1 COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR 有权
标题翻译：用于生产立体纯静止物及其合成中间体的组合物和方法
公开(公告)号：US20080248539A1
公开(公告)日：2008-10-09
申请号：US11865696
申请日：2007-10-01
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
IPC分类号： C12P7/62 , C12N9/02 , C07H21/04 , C07D207/34 , C07C69/675 , C12N1/21
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。

4. 发明申请

US20140169791A1 IN-SKIN WAVELENGTH DIVISION MULTIPLEX (WDM) PATH COMPUTATION 有权
标题翻译：皮肤波长分割多路复用（WDM）路径计算
公开(公告)号：US20140169791A1
公开(公告)日：2014-06-19
申请号：US13716673
申请日：2012-12-17
申请人： Gerard LEO SWINKELS , Frederick James LALONDE , Michael Stanley WILGOSH
发明人： Gerard LEO SWINKELS , Frederick James LALONDE , Michael Stanley WILGOSH
IPC分类号： H04J14/02
CPC分类号： H04Q11/0062 , H04J14/0269 , H04L45/04 , H04Q2011/0073
摘要： A method of managing an optical communication network having a plurality of nodes, the plurality of nodes including at least one regeneration site. A respective Path Computation Element (PCE) function is instantiated and associated with each regeneration site in the network. Each PCE function maintains a reach table containing information of viable optical paths extending from transceivers of its regeneration site. The PCE function implements a Recursive Path Computation algorithm to compute end-to-end routes through a physical layer of the network.
摘要翻译：一种管理具有多个节点的光通信网络的方法，所述多个节点包括至少一个再生站点。相应的路径计算元素（PCE）功能被实例化并与网络中的每个再生站点相关联。每个PCE功能维护一个到达表，其中包含从其再生位置的收发器延伸的可行光路的信息。 PCE功能实现递归路径计算算法来计算通过网络物理层的端到端路由。

5. 发明授权

US08574876B2 Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds 有权
标题翻译：用于制备立体异构纯的稠合双环脯氨酸化合物的生物催化方法
公开(公告)号：US08574876B2
公开(公告)日：2013-11-05
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12P7/62 , C12P13/22
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译：本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。

6. 发明申请

US20130089898A1 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL 有权
标题翻译：合成（S）-3-（1-氨基乙基） - 苯酚的生物质和方法
公开(公告)号：US20130089898A1
公开(公告)日：2013-04-11
申请号：US13704507
申请日：2011-06-16
申请人： Fabien Cabirol , Anupam Gohel , Seong Ho Oh , Derek Smith , Brian Wong , James Lalonde
发明人： Fabien Cabirol , Anupam Gohel , Seong Ho Oh , Derek Smith , Brian Wong , James Lalonde
IPC分类号： C12N9/10 , C12P13/00
CPC分类号： C12N9/1096 , C07B2200/07 , C07C213/00 , C07C213/08 , C07C269/00 , C07K2319/02 , C07K2319/21 , C07K2319/41 , C12P13/001 , C12Y206/01018 , C07C215/50 , C07C271/44
摘要： The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.
摘要翻译：本公开提供了与天然存在的转氨酶相比具有改进性质的工程改造的转氨酶多肽，其包括以对映体过量和高百分比转化率将底物3'-羟基苯乙酮转化为（S）-3-（1-氨基乙基） - 苯酚的能力。还提供了编码工程改造的转氨酶的多核苷酸，能够表达工程化转氨酶的宿主细胞和使用工程转氨酶合成（S）-3-（1-氨基乙基） - 苯酚的相关化合物和用于生产活性药物的相关化合物配料。

7. 发明申请

US20120276599A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE 有权
标题翻译：用于生产（R）-3-羟基甲硅烷氧基的酮交酯聚合物
公开(公告)号：US20120276599A1
公开(公告)日：2012-11-01
申请号：US13525048
申请日：2012-06-15
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James Lalonde , Gjalt W. Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James Lalonde , Gjalt W. Huisman
IPC分类号： C12N9/04 , C12P17/00 , C12N1/21 , C12N15/53 , C12N15/70
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞以及使用工程化酮还原酶合成手性化合物的方法。

8. 发明授权

US08076107B2 Production of monatin stereoisomers 有权
标题翻译：莫纳甜立体异构体的生产
公开(公告)号：US08076107B2
公开(公告)日：2011-12-13
申请号：US11865456
申请日：2007-10-01
申请人： Subash Buddoo , Amanda Louise Rousseau , Dean Brady , James Lalonde , Yiming Yao , Yifong Wang
发明人： Subash Buddoo , Amanda Louise Rousseau , Dean Brady , James Lalonde , Yiming Yao , Yifong Wang
IPC分类号： C12P17/10 , C12P17/16 , C12P41/00
CPC分类号： C12P41/003 , C12P17/10 , C12P17/16
摘要： Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a monatin-derived lactone ester are disclosed.
摘要翻译：公开了用于生产立体异构纯的或立体异构体富集形式的高强度甜味剂莫纳甜的方法和材料。例如，公开了使用立体异构选择性水解和分离莫纳甜衍生的内酯的方法。

9. 发明授权

US07977078B2 Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane 有权
标题翻译：用于生产（R）-3-羟基硫杂环戊烷的酮还原酶多肽
公开(公告)号：US07977078B2
公开(公告)日：2011-07-12
申请号：US12197286
申请日：2008-08-24
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James Lalonde , Gjalt Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James Lalonde , Gjalt Huisman
IPC分类号： C12N9/02 , C12N9/04 , C12Q1/26 , C12P7/62 , C12P17/10 , C12P17/00 , C07H21/04
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成手性化合物的方法。

10. 发明申请

US20060134763A1 Stereoselective process for the production of dioxolane nucleoside analogues 有权
标题翻译：用于生产二氧戊环核苷类似物的立体选择性方法
公开(公告)号：US20060134763A1
公开(公告)日：2006-06-22
申请号：US10535235
申请日：2003-11-18
申请人： Alex Cimpoia , James Lalonde
发明人： Alex Cimpoia , James Lalonde
IPC分类号： C12P17/16 , C07D473/02 , C07D405/04
CPC分类号： C12P17/16 , C07D317/32 , C12P17/04 , C12P17/188 , C12P41/005
摘要： The present invention relates to a process for producing a compound of formula (I); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compound of formula (I). The invention also provides a process for producing a compound of formula (III); said process comprising the steps of: a) subjecting a compounds of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Candida Antarctica “A” lipase, Candida Antarctica “B”lipase, Candida Lypolitica Lipase or Rhizomucor Miehei Lipase b) recovering said compound of formula (III).
摘要翻译：本发明涉及式（I）化合物的制备方法。所述方法包括以下步骤：a）在合适量的选自猪肝酯酶或猪胰腺脂肪酶的酶的存在下，使式（II）化合物进行酶促非对映异构体拆分b）回收所述式（I）化合物，。本发明还提供了制备式（III）化合物的方法; 所述方法包括以下步骤：a）在适当量的选自南极假丝酵母“A”脂肪酶，南极假丝酵母“B”脂肪酶，假单胞菌脂肪酶假丝酵母属脂肪酶的酶的存在下使式（IV）化合物进行酶促非对映异构体拆分或根瘤菌Miehei脂肪酶b）回收所述式（III）化合物。

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