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1. 发明申请

US20060154872A1 Hemiasterlin derivatives and uses thereof 失效
公开(公告)号：US20060154872A1
公开(公告)日：2006-07-13
申请号：US11340256
申请日：2006-01-26
申请人： Silvio Campagna , Francis Fang , James Kowalczyk , Shawn Schiller , Boris Seletsky , Mark Spyvee , Hu Yang
发明人： Silvio Campagna , Francis Fang , James Kowalczyk , Shawn Schiller , Boris Seletsky , Mark Spyvee , Hu Yang
IPC分类号： A61K38/05
CPC分类号： C07D207/04 , C07D207/12 , C07D207/16 , C07D207/42 , C07D209/20 , C07D211/60 , C07D217/26 , C07D223/06 , C07D233/84 , C07D237/04 , C07D241/04 , C07D265/30 , C07D277/06 , C07D279/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D471/04 , C07K5/0205 , C07K5/0207 , C07K5/0821
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.

2. 发明申请

US20080051434A1 Hemiasterlin derivatives and uses thereof in the treatment of cancer 有权
标题翻译：半精球蛋白衍生物及其在癌症治疗中的应用
公开(公告)号：US20080051434A1
公开(公告)日：2008-02-28
申请号：US11701969
申请日：2007-02-02
申请人： James Kowalczyk , Galina Kuznetsov , Shawn Schiller , Boris Seletsky , Mark Spyvee , Hu Yang
发明人： James Kowalczyk , Galina Kuznetsov , Shawn Schiller , Boris Seletsky , Mark Spyvee , Hu Yang
IPC分类号： A61K31/445 , A61K31/164 , A61K31/195 , A61K31/221 , A61P43/00 , C07C233/00 , C07D221/00 , C07C229/00 , A61P35/00 , A61K31/40 , A61K31/426
CPC分类号： C07K7/06 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , C07C237/22 , C07D207/08 , C07D207/16 , C07D211/60 , C07D295/185 , C07D401/14 , C07K5/06078 , C07K5/06156 , C07K5/06165 , C07K5/0808 , C07K5/0821 , C07K5/0823 , C07K5/1016
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译：本发明提供具有式（I）的化合物：另外提供其合成方法及其用于治疗癌症的方法，其中R 1 -R 7 X 1，X 2，R 3，Q 3和n如本文所定义。

3. 发明授权

US06486202B1 Inhibitors of isoprenyl transferase 有权
标题翻译：异戊二烯转移酶抑制剂
公开(公告)号：US06486202B1
公开(公告)日：2002-11-26
申请号：US09835274
申请日：2001-04-13
申请人： Ana Maria Garcia , James Kowalczyk , Michael D. Lewis
发明人： Ana Maria Garcia , James Kowalczyk , Michael D. Lewis
IPC分类号： A61K3134
CPC分类号： C07D307/22 , C07C323/60
摘要： Provided are novel peptidomimetic isoprenyl transferase inhibitors, methods for synthesizing such inhibitors, and methods for the use of such inhibitors for the treatment of tumors.
摘要翻译：提供了新的拟肽异戊二烯转移酶抑制剂，合成这种抑制剂的方法，以及使用这种抑制剂治疗肿瘤的方法。

4. 发明申请

US20050239870A1 Hrmiasterlin derivatives and uses thereof 有权
标题翻译： Hrmiasterlin衍生物及其用途
公开(公告)号：US20050239870A1
公开(公告)日：2005-10-27
申请号：US10508607
申请日：2003-03-21
申请人： James Kowalczyk , Galina Kuznetsov , Shawn Schiller , Boris Seletsky , Mark Spyvee , Hu Yang
发明人： James Kowalczyk , Galina Kuznetsov , Shawn Schiller , Boris Seletsky , Mark Spyvee , Hu Yang
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/197 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/427 , A61K31/4465 , A61K31/454 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P35/00 , C07C237/12 , C07D207/08 , C07D207/16 , C07D211/60 , C07D277/20 , C07D277/56 , C07D295/185 , C07D401/12 , C07D401/14 , C07K5/062 , C07K5/065 , C07K5/078 , C07K5/083 , C07K5/087 , C07K5/097 , C07K5/107 , C07K7/02 , C07K7/06
CPC分类号： C07K7/06 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , C07C237/22 , C07D207/08 , C07D207/16 , C07D211/60 , C07D295/185 , C07D401/14 , C07K5/06078 , C07K5/06156 , C07K5/06165 , C07K5/0808 , C07K5/0821 , C07K5/0823 , C07K5/1016
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
摘要翻译：本发明提供具有式（I）的化合物：另外提供其合成方法及其用于治疗癌症的方法，其中R 1 -R 7 X 1，X 2，R 3，Q 3和n如本文所定义。

5. 发明授权

US08561822B2 Multi-gallon capacity blow molded container 失效
标题翻译：多加仑容量吹塑容器
公开(公告)号：US08561822B2
公开(公告)日：2013-10-22
申请号：US13190050
申请日：2011-07-25
申请人： Martin Beck , Dennis Connor , Kim Lufkin , James Kowalczyk
发明人： Martin Beck , Dennis Connor , Kim Lufkin , James Kowalczyk
IPC分类号： B65D90/02
CPC分类号： B65D1/44 , B29C49/10 , B65D2501/0027 , B65D2501/0036 , B65D2501/0081
摘要： A multi-gallon capacity container comprising which comprises a substantially rectangular bottom portion having a chime and a plurality of base channels; a shoulder portion with a neck section for facilitating filling and discharging of liquid from the container and a plurality vertically extending shoulder channels; a body portion which seamlessly connects the bottom portion with the shoulder portion and having a plurality of spaced apart horizontal ribs and rib channels for increasing a lateral wall strength of the container. The container includes a first and second primary columns for increasing a top load strength of the container. Each primary column commences in the shoulder portion, extends substantially continuously along the shoulder portion, across the plurality of horizontal ribs, and terminates at the bottom portion. Each one of the horizontal ribs has a column feature formed therein which is aligned with one of the first and the second primary columns and forms a continuation of primary column from the shoulder portion to the bottom portion.
摘要翻译：一种多加仑容量容器，其包括具有钟形和多个基本通道的基本上矩形的底部部分; 肩部，其具有颈部，用于便于从容器中填充和排出液体;以及多个垂直延伸的肩部通道; 身体部分，其使底部部分与肩部部分无缝连接并且具有多个间隔开的水平肋和肋通道，用于增加容器的侧壁强度。容器包括用于增加容器的顶部负载强度的第一和第二主列。每个主列在肩部开始，沿着肩部延伸大致连续穿过多个水平肋，并终止于底部。每个水平肋具有形成在其中的柱特征，其与第一和第二主列中的一个对准，并且形成从所述肩部到底部的主列的延续。

6. 发明申请

US20130026128A1 MULTI-GALLON CAPACITY BLOW MOLDED CONTAINER 失效
标题翻译：多功能容量吹塑成型容器
公开(公告)号：US20130026128A1
公开(公告)日：2013-01-31
申请号：US13190050
申请日：2011-07-25
申请人： Martin BECK , Dennis CONNOR , Kim LUFKIN , James KOWALCZYK
发明人： Martin BECK , Dennis CONNOR , Kim LUFKIN , James KOWALCZYK
IPC分类号： B65D90/02 , B29D22/00
CPC分类号： B65D1/44 , B29C49/10 , B65D2501/0027 , B65D2501/0036 , B65D2501/0081
摘要： A multi-gallon capacity container comprising which comprises a substantially rectangular bottom portion having a chime and a plurality of base channels; a shoulder portion with a neck section for facilitating filling and discharging of liquid from the container and a plurality vertically extending shoulder channels; a body portion which seamlessly connects the bottom portion with the shoulder portion and having a plurality of spaced apart horizontal ribs and rib channels for increasing a lateral wall strength of the container. The container includes a first and second primary columns for increasing a top load strength of the container. Each primary column commences in the shoulder portion, extends substantially continuously along the shoulder portion, across the plurality of horizontal ribs, and terminates at the bottom portion. Each one of the horizontal ribs has a column feature formed therein which is aligned with one of the first and the second primary columns and forms a continuation of primary column from the shoulder portion to the bottom portion.
摘要翻译：一种多加仑容量容器，其包括具有钟形和多个基本通道的基本上矩形的底部部分; 肩部，其具有颈部，用于便于从容器中填充和排出液体;以及多个垂直延伸的肩部通道; 身体部分，其使底部部分与肩部部分无缝连接并且具有多个间隔开的水平肋和肋通道，用于增加容器的侧壁强度。容器包括用于增加容器的顶部负载强度的第一和第二主列。每个主列在肩部开始，沿着肩部延伸大致连续穿过多个水平肋，并终止于底部。每个水平肋具有形成在其中的柱特征，其与第一和第二主列中的一个对准，并且形成从所述肩部到底部的主列的延续。

7. 发明授权

US08323455B1 Vent scraping apparatus for a carbonizing machine 有权
标题翻译：碳化机排气刮板装置
公开(公告)号：US08323455B1
公开(公告)日：2012-12-04
申请号：US12589373
申请日：2009-10-22
申请人： Fred L. Jones , James Kowalczyk
发明人： Fred L. Jones , James Kowalczyk
IPC分类号： C10B43/06
CPC分类号： C10B43/06 , B08B1/005 , C10B7/10 , C10B53/00
摘要： A vent scraping apparatus (10) includes a mount (20) fixably attached a carbonizing machine (14) at an opening (18) in the carbonizing machine. A duct (28) is fixably attached within the mount (20). The duct (28) conducts gas vented from the carbonizing machine. A scraper (24) is movably attached between the mount (20) and the duct (28). The scraper (24) slides between an inner surface (22) of the mount (20) and an outer surface (30) of the duct (28). The scraper (24) includes a leading edge (36) for scraping an inner surface (44) of the carbonizing machine opening (18) as the scraper is extended.
摘要翻译：排气刮刀装置（10）包括在碳化机器的开口（18）处可固定地连接碳化机器（14）的安装件（20）。管道（28）可固定地附接在安装件（20）内。导管28传导从碳化机排出的气体。刮刀（24）可移动地附接在安装件（20）和管道（28）之间。刮刀（24）在安装件（20）的内表面（22）和管道（28）的外表面（30）之间滑动。刮刀（24）包括用于当刮刀延伸时刮擦碳化机开口（18）的内表面（44）的前缘（36）。

8. 外观设计

USD668307S1 Translucent toy bat 有权
标题翻译：半透明玩具棒
公开(公告)号：USD668307S1
公开(公告)日：2012-10-02
申请号：US29403643
申请日：2011-10-07
申请人： Thomas H. Grimm , Martin Beck , Dennis Connor , Kim Lufkin , James Kowalczyk
设计人： Thomas H. Grimm , Martin Beck , Dennis Connor , Kim Lufkin , James Kowalczyk

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