专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06553135B1 Method and apparatus for automated image analysis of biological specimens 失效
公开(公告)号：US06553135B1
公开(公告)日：2003-04-22
申请号：US09492101
申请日：2000-02-14
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K900
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.

2. 发明授权

US07133545B2 Method and apparatus for automated image analysis of biological specimens 失效
公开(公告)号：US07133545B2
公开(公告)日：2006-11-07
申请号：US11115847
申请日：2005-04-26
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K9/00 , G09G5/02
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.

3. 发明授权

US06215892B1 Method and apparatus for automated image analysis of biological specimens 失效
标题翻译：生物标本自动图像分析的方法和装置
公开(公告)号：US06215892B1
公开(公告)日：2001-04-10
申请号：US08758436
申请日：1996-11-27
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K900
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后将色彩空间转换的图像进行低通滤波，并将其与阈值进行比较，以从彩色转换图像的候选对象像素中去除伪影和背景对象。候选对象像素被形态地处理以将候选对象对象像素组合成为与斑点参数进行比较的组，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。以与低倍率图像相同的方式分析高倍率图像，以确认作为感兴趣对象的感兴趣的候选对象。存储每个确认的感兴趣对象的高放大图像以供病理学家进行后续检查和评估。

4. 发明授权

US07428325B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物样本自动图像分析的方法和装置
公开(公告)号：US07428325B2
公开(公告)日：2008-09-23
申请号：US11685717
申请日：2007-03-13
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , G01N15/1475 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06K9/20 , G06K9/342 , G06K9/4609 , G06K9/4652 , G06T5/002 , G06T5/005 , G06T5/30 , G06T7/136 , G06T2207/10024 , G06T2207/10056 , G06T2207/20012 , G06T2207/20016 , G06T2207/30024
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then filtered. The candidate interest pixels are morphologically processed and compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后过滤颜色空间转换的图像。候选兴趣像素被形态地处理并与斑点参数进行比较，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。

5. 发明授权

US07177454B2 Automated detection of objects in a biological sample 有权
标题翻译：自动检测生物样品中的物体
公开(公告)号：US07177454B2
公开(公告)日：2007-02-13
申请号：US10358114
申请日：2003-02-03
申请人： Gina McLaren , Robert Ellis , James W. Douglass , Thomas J. Riding , James E. Ring
发明人： Gina McLaren , Robert Ellis , James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K9/00 , G09G5/02
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders.
摘要翻译：提供了用于自动光学显微镜检测与细胞增殖性疾病相关的蛋白质的方法，系统和装置。

6. 发明授权

US06920239B2 Method and apparatus for automated image analysis of biological specimens 失效
标题翻译：生物标本自动图像分析的方法和装置
公开(公告)号：US06920239B2
公开(公告)日：2005-07-19
申请号：US10404921
申请日：2003-03-31
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G01N33/48 , G01N1/31 , G01N15/14 , G02B21/24 , G06K9/00 , G06T1/00 , G06T7/60 , G09G5/02
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后将色彩空间转换的图像进行低通滤波，并将其与阈值进行比较，以从彩色转换图像的候选对象像素中去除伪影和背景对象。候选对象像素被形态地处理以将候选对象对象像素组合成为与斑点参数进行比较的组，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。以与低倍率图像相同的方式分析高倍率图像，以确认作为感兴趣对象的感兴趣的候选对象。存储每个确认的感兴趣对象的高放大图像以供病理学家进行后续检查和评估。

7. 发明申请

US20090060303A1 METHOD AND APPARATUS FOR AUTOMATED IMAGE ANALYSIS OF BIOLOGICAL SPECIMENS 有权
标题翻译：用于生物样本自动图像分析的方法和装置
公开(公告)号：US20090060303A1
公开(公告)日：2009-03-05
申请号：US12201800
申请日：2008-08-29
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.
摘要翻译：一种方法，包括在多个不同焦点位置获取医疗幻灯片的图像，确定相对于像素值平均值产生像素值的最大值的位置，其中所述确定包括使用像素值均值作为粗略焦点的粗略估计位置，随后精炼所述粗焦点位置以找到精细对焦位置，并且其中所述精炼包括拟合到多项式，并且使用多项式的指定部分作为焦点位置的精细估计，并且产生聚焦控制信号与所述最大值有关以控制焦点位置。

8. 发明申请

US20080258061A1 METHOD AND APPARATUS FOR AUTOMATED IMAGE ANALYSIS OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：用于生物样本自动图像分析的方法和装置
公开(公告)号：US20080258061A1
公开(公告)日：2008-10-23
申请号：US12102667
申请日：2008-04-14
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G01N23/04
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： An electronic microscope system including a processor, a movable stage movable in two orthogonal directions under control of the processor, the movable stage including at least one part that determines a current position of the movable stage, a microscope part, which magnifies a sample on the movable stage, an electronic camera part, which obtains an image of a magnified sample at a specified position controlled by the movable stage, and at least one vibration isolation mount, coupled to the stage and isolating vibration between the movable stage and the microscope part.
摘要翻译：一种电子显微镜系统，包括处理器，可在所述处理器的控制下在两个正交方向上移动的可移动台，所述可移动台包括确定所述可移动台的当前位置的至少一个部分，所述可移动台将所述可移动台上的样本放大可移动台，电子照相机部件，其获得由可移动台控制的指定位置处的放大样本的图像;以及至少一个隔离支架，耦合到该台并隔离可移动台与显微镜部件之间的振动。

9. 发明授权

US07359548B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物标本自动图像分析的方法和装置
公开(公告)号：US07359548B2
公开(公告)日：2008-04-15
申请号：US11594374
申请日：2006-11-07
申请人： James W. Douglass , Thomas J. Riding , James E. Ring
发明人： James W. Douglass , Thomas J. Riding , James E. Ring
IPC分类号： G06K9/00 , G09G5/02 , H04N9/73
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a first color space to a second color space. The color space converted image is then low pass filtered and compared to a threshold to remove artifacts and background objects from the candidate object of interest pixels of the color converted image. The candidate object of interest pixels are morphologically processed to group candidate object of interest pixels together into groups which are compared to blob parameters to identify candidate objects of interest which correspond to cells or other structures relevant to medical diagnosis of the biological specimen. The location coordinates of the objects of interest are stored and additional images of the candidate cell objects are acquired at high magnification. The high magnification images are analyzed in the same manner as the low magnification images to confirm the candidate objects of interest which are objects of interest. A high magnification image of each confirmed object of interest is stored for later review and evaluation by a pathologist.
摘要翻译：用于生物标本的自动细胞分析的方法和装置以低倍率自动扫描以获取被分析以确定感兴趣的候选细胞对象的图像。低倍率图像从第一颜色空间转换为第二颜色空间。然后将色彩空间转换的图像进行低通滤波，并将其与阈值进行比较，以从彩色转换图像的候选对象像素中去除伪影和背景对象。候选对象像素被形态地处理以将候选对象对象像素组合成为与斑点参数进行比较的组，以识别对应于与生物样本的医学诊断相关的细胞或其他结构的候选对象。存储感兴趣对象的位置坐标，并以高倍率获取候选单元对象的附加图像。以与低倍率图像相同的方式分析高倍率图像，以确认作为感兴趣对象的感兴趣的候选对象。存储每个确认的感兴趣对象的高放大图像以供病理学家进行后续检查和评估。

10. 发明授权

US07783098B2 Method and apparatus for automated image analysis of biological specimens 有权
标题翻译：生物标本自动图像分析的方法和装置
公开(公告)号：US07783098B2
公开(公告)日：2010-08-24
申请号：US12201800
申请日：2008-08-29
申请人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
发明人： James W. Douglass , Thomas J. Riding , James E. Ring , Gina McLaren , William J. Decker , Robert T. Ellis
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G01N1/312 , G01N15/1468 , G01N15/1475 , G01N2015/1472 , G01N2015/1488 , G01N2015/1497 , G02B21/244 , G02B21/367 , G06K9/00127 , G06K9/00134 , G06T7/60
摘要： A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.
摘要翻译：一种方法，包括在多个不同焦点位置获取医疗幻灯片的图像，确定相对于像素值平均值产生像素值的最大值的位置，其中所述确定包括使用像素值均值作为粗略焦点的粗略估计位置，随后精炼所述粗焦点位置以找到精细对焦位置，并且其中所述精炼包括拟合到多项式，并且使用多项式的指定部分作为焦点位置的精细估计，并且产生聚焦控制信号与所述最大值有关以控制焦点位置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式