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1. 发明授权

US09235685B2 Brain stimulation models, systems, devices, and methods 有权
标题翻译：脑刺激模型，系统，设备和方法
公开(公告)号：US09235685B2
公开(公告)日：2016-01-12
申请号：US12287471
申请日：2008-10-09
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： A61N1/00 , G06F19/00 , A61N1/36 , A61B19/00 , A61N1/05
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, a target volume of activation (VOA) can be received, a test VOA can be simulated, and at least one of a target electrode location or parameter can be provide using a relationship between the target VOA and the test VOA.
摘要翻译：本文件还讨论了脑刺激模型，系统，设备和方法，例如深部脑刺激（DBS）或其他电刺激。在一个示例中，可以接收目标激活量（VOA），可以模拟测试VOA，并且可以使用目标VOA和测试VOA之间的关系来提供目标电极位置或参数中的至少一个。

2. 发明授权

US09135400B2 Method and system for displaying a volume of influence by an electrode inserted in neural tissue 有权
标题翻译：用于显示插入神经组织中的电极的影响体积的方法和系统
公开(公告)号：US09135400B2
公开(公告)日：2015-09-15
申请号：US13087587
申请日：2011-04-15
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： G06G7/58 , G06G7/48 , G06F7/60 , G06F17/10 , G06F19/00 , A61N1/36 , A61B19/00 , A61N1/05
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, a target volume of activation (VOA) can be received, a test VOA can be simulated, and at least one of a target electrode location or parameter can be provide using a relationship between the target VOA and the test VOA.
摘要翻译：本文件还讨论了脑刺激模型，系统，设备和方法，例如深部脑刺激（DBS）或其他电刺激。在一个示例中，可以接收目标激活量（VOA），可以模拟测试VOA，并且可以使用目标VOA和测试VOA之间的关系来提供目标电极位置或参数中的至少一个。

3. 发明授权

US07860548B2 Tissue stimulation models, systems, devices, and methods 有权
标题翻译：组织刺激模型，系统，装置和方法
公开(公告)号：US07860548B2
公开(公告)日：2010-12-28
申请号：US12008764
申请日：2008-01-14
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： A61N1/39
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as electrode contact selection or location. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.
摘要翻译：本文件讨论了脑刺激模型，系统，设备和方法，如深部脑刺激（DBS）或其他电刺激。模型使用某些刺激参数（例如电极接触选择或位置）计算模拟电刺激的影响区域的体积。该模型使用不均匀的组织电导率。这准确地表示脑组织，其具有产生非均匀和各向异性的组织培养基的高度定向导电的神经元途径。在一个示例中，电位分布的第二差异用于定义激活量（VOA）或类似的影响体积。在另一个例子中，使用神经元或轴突模型来计算影响的体积，而不计算电势分布的第二差异。

4. 发明申请

US20090210208A1 Brains stimulation models, systems, devices, and methods 审中-公开
标题翻译：脑刺激模型，系统，装置和方法
公开(公告)号：US20090210208A1
公开(公告)日：2009-08-20
申请号：US12287471
申请日：2008-10-09
申请人： Cameron C. Mclntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. Mclntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： G06G7/60
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, a target volume of activation (VOA) can be received, a test VOA can be simulated, and at least one of a target electrode location or parameter can be provide using a relationship between the target VOA and the test VOA.
摘要翻译：本文件还讨论了脑刺激模型，系统，设备和方法，例如深部脑刺激（DBS）或其他电刺激。在一个示例中，可以接收目标激活量（VOA），可以模拟测试VOA，并且可以使用目标VOA和测试VOA之间的关系来提供目标电极位置或参数中的至少一个。

5. 发明授权

US07346382B2 Brain stimulation models, systems, devices, and methods 有权
公开(公告)号：US07346382B2
公开(公告)日：2008-03-18
申请号：US10885982
申请日：2004-07-07
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： A61B5/05
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as amplitude, pulsewidth, frequency, pulse morphology, electrode contact selection or location, return path electrode selection, pulse polarity, etc. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, the non-uniform tissue conductivity is obtained from diffusion tensor imaging (DTI) data. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.

6. 发明申请

US20090208073A1 Brain stimulation models, systems, devices, and methods 有权
标题翻译：脑刺激模型，系统，设备和方法
公开(公告)号：US20090208073A1
公开(公告)日：2009-08-20
申请号：US12287389
申请日：2008-10-09
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： G06K9/00
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
摘要翻译：本文件还讨论了脑刺激模型，系统，设备和方法，例如深部脑刺激（DBS）或其他电刺激。在一个示例中，可以获得表示患者脑的解剖体积的体积成像数据并将其转换为脑图集数据。可以使用转换的逆向创建患者特异性脑图谱，以将脑图谱数据映射到体积成像数据，并且可以使用患者特异性脑图谱计算体积的影响。在某些实例中，影响的体积可以包括由相应的至少一个候选电极目标位置处的电极传递的电刺激所影响的组织的预测体积。

7. 发明授权

US09238150B2 Optical tissue interface method and apparatus for stimulating cells 有权
标题翻译：用于刺激细胞的光学组织界面方法和装置
公开(公告)号：US09238150B2
公开(公告)日：2016-01-19
申请号：US12185624
申请日：2008-08-04
申请人： Karl Deisseroth , Alexander Aravanis , Feng Zhang , M. Bret Schneider , Jaimie M. Henderson
发明人： Karl Deisseroth , Alexander Aravanis , Feng Zhang , M. Bret Schneider , Jaimie M. Henderson
IPC分类号： A61K50/00 , A61N5/06 , A61K48/00
CPC分类号： A61N5/0622 , A61K36/05 , A61K38/16 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N5/062 , A61N2005/063 , A61N2005/0651 , C12N7/00 , C12N2710/10043 , C12N2710/16643 , G06F19/00
摘要： In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
摘要翻译：在一个实例中，系统使用由光纤布置提供的细长结构，调制电路和光通路电刺激活动物体的靶细胞。细长结构用于插入到动物中的狭窄通道中，使得细长结构的端部足够靠近靶细胞以向其施加刺激。调制电路用于在细长结构处于窄通道中时调制靶细胞，其中调制电路适于通过细长结构递送病毒载体，用于在靶细胞中表达光响应蛋白。光通路用于通过将光传递到靶细胞中的光响应蛋白来刺激靶细胞。

8. 发明授权

US08983155B2 Method and device for displaying predicted volume of influence with patient-specific atlas of neural tissue 有权
标题翻译：用于显示患者特异性神经组织图谱的影响预测体积的方法和装置
公开(公告)号：US08983155B2
公开(公告)日：2015-03-17
申请号：US13573439
申请日：2012-09-14
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： G06K9/00 , G06F19/00 , A61N1/36 , A61N1/05
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
摘要翻译：本文件还讨论了脑刺激模型，系统，设备和方法，例如深部脑刺激（DBS）或其他电刺激。在一个示例中，可以获得表示患者脑的解剖体积的体积成像数据并将其转换为脑图集数据。可以使用转换的逆向创建患者特异性脑图谱，以将脑图谱数据映射到体积成像数据，并且可以使用患者特异性脑图谱计算体积的影响。在某些实例中，影响的体积可以包括由相应的至少一个候选电极目标位置处的电极传递的电刺激所影响的组织的预测体积。

9. 发明申请

US20130030276A1 Method and device for displaying predicted volume of influence with patient-specific atlas of neural tissue 有权
公开(公告)号：US20130030276A1
公开(公告)日：2013-01-31
申请号：US13573439
申请日：2012-09-14
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： A61B5/053
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.

10. 发明授权

US07680526B2 System and method for obtaining a volume of influence based on non-uniform tissue conductivity data 有权
标题翻译：基于非均匀组织电导率数据获得影响体积的系统和方法
公开(公告)号：US07680526B2
公开(公告)日：2010-03-16
申请号：US12008760
申请日：2008-01-14
申请人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
发明人： Cameron C. McIntyre , Christopher R. Butson , John D. Hall , Jaimie M. Henderson
IPC分类号： G06T17/20
CPC分类号： G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要： This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as amplitude, pulsewidth, frequency, pulse morphology, electrode contact selection or location, return path electrode selection, pulse polarity, etc. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, the non-uniform tissue conductivity is obtained from diffusion tensor imaging (DTI) data. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.
摘要翻译：本文件还讨论了脑刺激模型，系统，设备和方法，例如深部脑刺激（DBS）或其他电刺激。模型使用某些刺激参数（如幅度，脉冲宽度，频率，脉冲形态，电极接触选择或位置，返回路径电极选择，脉冲极性等）来计算模拟电刺激的影响区域的体积。该模型使用非 - 组织电导率不均匀。这准确地表示脑组织，其具有产生非均匀和各向异性的组织培养基的高度定向导电的神经元途径。在一个示例中，从扩散张量成像（DTI）数据获得非均匀组织电导率。在一个示例中，电位分布的第二差异用于定义激活量（VOA）或类似的影响体积。在另一个例子中，使用神经元或轴突模型来计算影响的体积，而不计算电势分布的第二差异。

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