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1. 发明授权

US07531482B2 Thieno-pyrimidine compounds having fungicidal activity 失效
标题翻译：具有杀真菌活性的噻吩并嘧啶化合物
公开(公告)号：US07531482B2
公开(公告)日：2009-05-12
申请号：US11255448
申请日：2005-10-21
申请人： William Kirkland Brewster , David Anthony Demeter , William Randal Erickson , Carla Jean Rasmussen Klittich , Christian Thomas Lowe , Brent Jeffrey Rieder , Jaime Susanne Nugent , Carla Nanette Yerkes , Yuanming Zhu , Terry William Balko
发明人： William Kirkland Brewster , David Anthony Demeter , William Randal Erickson , Carla Jean Rasmussen Klittich , Christian Thomas Lowe , Brent Jeffrey Rieder , Jaime Susanne Nugent , Carla Nanette Yerkes , Yuanming Zhu , Terry William Balko
IPC分类号： C07D495/04 , A01N43/90
CPC分类号： C07D498/04 , A01N43/90 , C07D519/00
摘要： The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity. Specifically, the present invention relates to compounds having the Formula (I): wherein each R1, R2 and R3 is independently selected from the group consisting of H, halogen, and alkyl; A is selected from the group consisting of H and alkyl; W is selected from the group consisting of NH and O; D is selected from O, NH and S; E is (—C(O)—)p—R′, wherein p is 0 or 1 and R′ is selected from the group consisting of optionally substituted rings selected from phenyl. furanyl, pyridinyl, pyridinyl-N-oxide, pyrimidinyl, pyridazinyl, pyrazinyl, thiazolyl, triazinyl, thiadiazolyl, oxazolyl, isoxazolyl, thienopyrimidinyl, and pyrimidine fused with an aromatic or heteroaromatic ring selected from bejizene, oxazole, isoxazole, furan, thiazole, pyrimidine, pyridine, pyrrole, pyrazine, and thionhene; each ring being ontionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, haloalkyl, alkoxy, haloalkoxy, nitro, cyano, alkylsulfonyl, alkylsulfoxide, alkylthio, alkoxyiminoalkyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, hydroxycarbonyl, phenyicarbonyl, forrnyl, hydrazidocarbonyl, amidoamino, pyrazolyl, triazolonyl, oxadiazolyl, phenyl, nyridinyl, and phenoxyalkyl; B is selected from the group consisting of halogen, alkyl, haloalkyl, and haloalkoxy; n is an integer from 0 to 3; and m is an integer from 0 to 4 with the proviso that when D is O or S and E is phenyl, then E is not further substituted with halogen.
摘要翻译：本发明涉及具有杀真菌活性的噻吩并[2,3-d]嘧啶化合物。具体地，本发明涉及具有式（I）的化合物：其中每个R 1，R 2和R 3独立地选自H，卤素和烷基; A选自H和烷基; W选自NH和O; D选自O，NH和S; E是（-C（O） - ）p -R'，其中p是0或1，R'选自任选取代的选自苯基的环。呋喃基，吡啶基，吡啶基-N-氧化物，嘧啶基，哒嗪基，吡嗪基，噻唑基，三嗪基，噻二唑基，恶唑基，异恶唑基，噻吩并嘧啶基和与选自异丁唑，恶唑，异恶唑，呋喃，噻唑，嘧啶的芳族或杂芳环稠合的嘧啶，吡啶，吡咯，吡嗪和噻吩; 每个环被一个或多个选自烷基，烯基，炔基，卤素，卤代烷基，烷氧基，卤代烷氧基，硝基，氰基，烷基磺酰基，烷基亚砜，烷硫基，烷氧基亚氨基烷基，烷基羰基，烷氧基羰基，氨基羰基，羟基羰基，苯基羰基，芳基，酰肼基，吡唑基，三唑基，恶二唑基，苯基，吡啶基和苯氧基烷基; B选自卤素，烷基，卤代烷基和卤代烷氧基; n为0〜3的整数。且m为0至4的整数，条件是当D为O或S且E为苯基时，E不再被卤素取代。

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