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1. 发明授权

US08969536B2 Torque teno virus (TTV) isolates and compositions 有权
标题翻译：扭转o病毒（TTV）分离物和组合物
公开(公告)号：US08969536B2
公开(公告)日：2015-03-03
申请号：US12733355
申请日：2009-10-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Olen , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Olen , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N1/00 , C12N7/00 , C07K14/005 , C07K16/08 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译：本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。

2. 发明授权

US08921535B2 Infectious clones of torque teno virus 有权
公开(公告)号：US08921535B2
公开(公告)日：2014-12-30
申请号：US12761568
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N1/00 , C12N7/00 , C07K14/005 , C07K16/08 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.

3. 发明授权

US08846388B2 Infectious clones of torque teno virus 有权
标题翻译：扭转o病毒的传染性克隆
公开(公告)号：US08846388B2
公开(公告)日：2014-09-30
申请号：US13501371
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： C12N15/00 , A01N63/00 , C07K16/08 , C12N7/00 , A61K39/12 , C07K14/005
CPC分类号： A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C07K2317/33 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/10021 , C12N2750/10034
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译：本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。

4. 发明申请

US20140286980A1 INFECTIOUS CLONES OF TORQUE TENO VIRUS 审中-公开
标题翻译：感染性TENO病毒的感染性克隆
公开(公告)号：US20140286980A1
公开(公告)日：2014-09-25
申请号：US14122423
申请日：2012-05-24
申请人： Jacqueline Gayle Marx
发明人： Jacqueline Gayle Marx
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/13 , A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/55566 , C12N7/02 , C12N15/86 , C12N2750/00021 , C12N2750/00034
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length TTV genomes that can replicate efficiently in host animals and tissue culture.
摘要翻译：本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。本发明的特别重要的方面包括在组织培养和宿主猪中复制的多核苷酸构建体。本发明还提供了可以在宿主动物和组织培养中有效复制的新型全长TTV基因组。

5. 发明申请

US20120321654A1 INFECTIOUS CLONES OF TORQUE TENO VIRUS 有权
标题翻译：感染性TENO病毒的感染性克隆
公开(公告)号：US20120321654A1
公开(公告)日：2012-12-20
申请号：US13501371
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： A61K39/12 , C12N15/63 , C12N1/21 , C07K16/08 , C12N5/10 , C12N7/01 , C12N7/04 , C07K14/01 , C12N15/34 , C12N1/19
CPC分类号： A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C07K2317/33 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/10021 , C12N2750/10034
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译：本发明涉及扭矩腱病毒（TTV）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。

6. 发明申请

US20110064758A1 INFECTIOUS CLONES OF TORQUE TENO VIRUS 有权
标题翻译：感染性TENO病毒的感染性克隆
公开(公告)号：US20110064758A1
公开(公告)日：2011-03-17
申请号：US12761568
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： A61K39/12 , C07H21/02 , C12N15/63 , C12N1/00 , C12N7/00 , C07K14/00 , A61P37/00 , C07K16/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译：本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。

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